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Conserved domains on  [gi|746702779|gb|KIE93451|]
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hypothetical protein AP460_00368 [Actinobacillus pleuropneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
33-102 2.68e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.10  E-value: 2.68e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702779  33 YDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG0457   65 YEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYE 134
RfaF COG0859
ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];
308-371 1.73e-09

ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440620  Cd Length: 336  Bit Score: 58.83  E-value: 1.73e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746702779 308 DFSDTAALIAQMDLVISVDTSVAHLAAAMSKPTWVMLSYHPDFRWlltrqdSPWYDSVKLFRQD 371
Cdd:COG0859  242 SLRELAALLARADLVVGNDTGPMHLAAALGTPTVALFGPTDPARW------GPYGDRHRVLRAD 299
PH-like super family cl17171
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
 118-165 3.17e-03

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


The actual alignment was detected with superfamily member cd13178:

Pssm-ID: 473070  Cd Length: 117  Bit Score: 37.24  E-value: 3.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 746702779 118 NIPQWRGENIGDTKILFHVEQGFgdniqfvrYALEMKRQGLNVVVLNH 165
Cdd:cd13178   22 DVGQWKERGVGDIKILFHPSKHY--------YRILMRRDQVLKVCANH 61
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
33-102 2.68e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.10  E-value: 2.68e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702779  33 YDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG0457   65 YEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYE 134
RfaF COG0859
ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];
308-371 1.73e-09

ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440620  Cd Length: 336  Bit Score: 58.83  E-value: 1.73e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746702779 308 DFSDTAALIAQMDLVISVDTSVAHLAAAMSKPTWVMLSYHPDFRWlltrqdSPWYDSVKLFRQD 371
Cdd:COG0859  242 SLRELAALLARADLVVGNDTGPMHLAAALGTPTVALFGPTDPARW------GPYGDRHRVLRAD 299
GT9_LPS_heptosyltransferase cd03789
lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide ...
 308-369 2.87e-08

lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340821  Cd Length: 277  Bit Score: 54.66  E-value: 2.87e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 746702779 308 DFSDTAALIAQMDLVISVDTSVAHLAAAMSKPTWVMLSYHPDFRWlltrqdSPWYDSVKLFR 369
Cdd:cd03789  186 SLRELAALLARADLVVGNDSGPMHLAAALGTPTVALFGPTDPART------GPYGSNHVVVR 241
heptsyl_trn_I TIGR02193
lipopolysaccharide heptosyltransferase I; This family consists of examples of ADP-heptose:LPS ...
 310-344 4.37e-07

lipopolysaccharide heptosyltransferase I; This family consists of examples of ADP-heptose:LPS heptosyltransferase I, an enzyme of LPS inner core region biosynthesis. LPS, composed of lipid A, a core region, and O antigen, is found in the outer membrane of Gram-negative bacteria. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274025  Cd Length: 319  Bit Score: 51.18  E-value: 4.37e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 746702779  310 SDTAALIAQMDLVISVDTSVAHLAAAMSKPTwVML 344
Cdd:TIGR02193 246 AEVAALLAGADAVVGVDTGLTHLAAALDKPT-VTL 279
Glyco_transf_9 pfam01075
Glycosyltransferase family 9 (heptosyltransferase); Members of this family belong to ...
 308-369 2.02e-05

Glycosyltransferase family 9 (heptosyltransferase); Members of this family belong to glycosyltransferase family 9. Lipopolysaccharide is a major component of the outer leaflet of the outer membrane in Gram-negative bacteria. It is composed of three domains; lipid A, Core oligosaccharide and the O-antigen. All of these enzymes transfer heptose to the lipopolysaccharide core.


Pssm-ID: 395853  Cd Length: 247  Bit Score: 45.78  E-value: 2.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 746702779  308 DFSDTAALIAQMDLVISVDTSVAHLAAAMSKPTWVMLSYHPDFRWlltrqdSPWYDSVKLFR 369
Cdd:pfam01075 173 SLEEAAALLAGADLVVGNDSGLMHLAAALDRPVIGLYGPTDPGRT------PPYSDNATIVS 228
TPR_1 pfam00515
Tetratricopeptide repeat;
44-77 7.23e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.63  E-value: 7.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 746702779   44 AVLYHNRCTVLQNLGLYQLALKDINKAVELAPNY 77
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
RanBD4_RanBP2-like cd13178
Ran-binding protein 2, Ran binding domain repeat 4; RanBP2 (also called E3 SUMO-protein ligase ...
 118-165 3.17e-03

Ran-binding protein 2, Ran binding domain repeat 4; RanBP2 (also called E3 SUMO-protein ligase RanBP2, 358 kDa nucleoporin, and nuclear pore complex (NPC) protein Nup358) is a giant nucleoporin that localizes to the cytosolic face of the NPC. RanBP2 contains a leucine-rich region, 8 zinc-finger motifs, a cyclophilin A homologous domain, and 4 RanBDs. Ran is a Ras-like nuclear small GTPase, which regulates receptor-mediated transport between the nucleus and the cytoplasm. RanGTP hydrolysis is stimulated by RanGAP together with the Ran-binding domain containing acessory proteins RanBP1 and RanBP2. These accessory proteins stabilize the active GTP-bound form of Ran. All eukaryotic cells contain RanBP1, but in vertebrates however, the main RanBP seems to be RanBP2. There is no RanBP2 ortholog in yeast. Transport complex disassembly is accomplished by a small ubiquitin-related modifier-1 (SUMO-1)-modified version of RanGAP that is bound to RanBP2. RanBP1 acts as a second line of defense against exported RanGTP-importin complexes which have escaped from dissociation by RanBP2. RanBP2 also interacts with the importin subunit beta-1. RabBD shares structural similarity to the PH domain, but lacks detectable sequence similarity. The members here include human, chicken, frog, tunicates, sea urchins, ticks, sea anemones, and sponges. RanBD repeat 4 is present in this hierarchy.


Pssm-ID: 269999  Cd Length: 117  Bit Score: 37.24  E-value: 3.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 746702779 118 NIPQWRGENIGDTKILFHVEQGFgdniqfvrYALEMKRQGLNVVVLNH 165
Cdd:cd13178   22 DVGQWKERGVGDIKILFHPSKHY--------YRILMRRDQVLKVCANH 61
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
33-102 2.68e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.10  E-value: 2.68e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702779  33 YDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG0457   65 YEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYE 134
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
30-102 4.43e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.64  E-value: 4.43e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 746702779  30 LRKYDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG0457   28 IEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYD 100
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
30-106 5.24e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.25  E-value: 5.24e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 746702779  30 LRKYDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYEWRWQ 106
Cdd:COG0457   96 LEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEA 172
RfaF COG0859
ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];
308-371 1.73e-09

ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440620  Cd Length: 336  Bit Score: 58.83  E-value: 1.73e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746702779 308 DFSDTAALIAQMDLVISVDTSVAHLAAAMSKPTWVMLSYHPDFRWlltrqdSPWYDSVKLFRQD 371
Cdd:COG0859  242 SLRELAALLARADLVVGNDTGPMHLAAALGTPTVALFGPTDPARW------GPYGDRHRVLRAD 299
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
31-102 2.67e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.85  E-value: 2.67e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 746702779  31 RKYDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG4785   60 AERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFD 131
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
37-102 4.09e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.55  E-value: 4.09e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 746702779  37 IRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYE 66
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
33-94 9.73e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 55.31  E-value: 9.73e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 746702779  33 YDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDY 94
Cdd:COG4785   96 FDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 30-102 1.18e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.93  E-value: 1.18e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 746702779  30 LRKYDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG3914  132 LAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYR 204
GT9_LPS_heptosyltransferase cd03789
lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide ...
 308-369 2.87e-08

lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340821  Cd Length: 277  Bit Score: 54.66  E-value: 2.87e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 746702779 308 DFSDTAALIAQMDLVISVDTSVAHLAAAMSKPTWVMLSYHPDFRWlltrqdSPWYDSVKLFR 369
Cdd:cd03789  186 SLRELAALLARADLVVGNDSGPMHLAAALGTPTVALFGPTDPART------GPYGSNHVVVR 241
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1-102 5.10e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.00  E-value: 5.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702779   1 MSEITFEQYLALLVEEQDSAATPFEWLTILRKYDE-------IIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVEL 73
Cdd:COG3914   62 LAAGEAAAAAAALLLLAALLELAALLLQALGRYEEalalyrrALALNPDNAEALFNLGNLLLALGRLEEALAALRRALAL 141

                         90       100
                 ....*....|....*....|....*....
gi 746702779  74 APNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG3914  142 NPDFAEAYLNLGEALRRLGRLEEAIAALR 170
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 30-102 5.52e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.35  E-value: 5.52e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 746702779  30 LRKYDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG4783   24 EALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLE 96
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 30-102 1.26e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.73  E-value: 1.26e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 746702779  30 LRKYDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG5010   74 LALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQ 146
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
33-102 1.28e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.01  E-value: 1.28e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702779  33 YDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKdINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG3063   15 YEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLE 83
heptsyl_trn_I TIGR02193
lipopolysaccharide heptosyltransferase I; This family consists of examples of ADP-heptose:LPS ...
 310-344 4.37e-07

lipopolysaccharide heptosyltransferase I; This family consists of examples of ADP-heptose:LPS heptosyltransferase I, an enzyme of LPS inner core region biosynthesis. LPS, composed of lipid A, a core region, and O antigen, is found in the outer membrane of Gram-negative bacteria. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274025  Cd Length: 319  Bit Score: 51.18  E-value: 4.37e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 746702779  310 SDTAALIAQMDLVISVDTSVAHLAAAMSKPTwVML 344
Cdd:TIGR02193 246 AEVAALLAGADAVVGVDTGLTHLAAALDKPT-VTL 279
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 33-102 9.91e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 9.91e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702779  33 YDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG4783   61 LHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALE 130
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 9-102 7.90e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.72  E-value: 7.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702779   9 YLALLVEEQDSAATPFEWLTILRKYDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLH 88
Cdd:COG5010   19 KLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLY 98

                         90
                 ....*....|....
gi 746702779  89 NLLGDYSQGWQAYE 102
Cdd:COG5010   99 SRSGDKDEAKEYYE 112
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 33-102 1.55e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 44.23  E-value: 1.55e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702779  33 YDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG4235   40 YEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQ 109
Glyco_transf_9 pfam01075
Glycosyltransferase family 9 (heptosyltransferase); Members of this family belong to ...
 308-369 2.02e-05

Glycosyltransferase family 9 (heptosyltransferase); Members of this family belong to glycosyltransferase family 9. Lipopolysaccharide is a major component of the outer leaflet of the outer membrane in Gram-negative bacteria. It is composed of three domains; lipid A, Core oligosaccharide and the O-antigen. All of these enzymes transfer heptose to the lipopolysaccharide core.


Pssm-ID: 395853  Cd Length: 247  Bit Score: 45.78  E-value: 2.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 746702779  308 DFSDTAALIAQMDLVISVDTSVAHLAAAMSKPTWVMLSYHPDFRWlltrqdSPWYDSVKLFR 369
Cdd:pfam01075 173 SLEEAAALLAGADLVVGNDSGLMHLAAALDRPVIGLYGPTDPGRT------PPYSDNATIVS 228
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 10-102 7.91e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.60  E-value: 7.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702779  10 LALLVEEQDSAATPFEWLTILRKYDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHN 89
Cdd:COG3914   44 ALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLL 123

                         90
                 ....*....|...
gi 746702779  90 LLGDYSQGWQAYE 102
Cdd:COG3914  124 ALGRLEEALAALR 136
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
53-96 1.43e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.54  E-value: 1.43e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 746702779  53 VLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQ 96
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDE 44
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
33-107 6.10e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.05  E-value: 6.10e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 746702779  33 YDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPN--YAIAWCNkamLHNLLGDYSQGWQAYEWRWQT 107
Cdd:COG4785  130 FDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNdpERALWLY---LAERKLDPEKALALLLEDWAT 203
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 25-102 6.27e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 6.27e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 746702779  25 EWLTILRKYDEIIRLLPDKAVLYHNRCTVLQNLGLYQLALKDINKAVELAPNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:COG2956  125 DWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALE 202
TPR_1 pfam00515
Tetratricopeptide repeat;
44-77 7.23e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.63  E-value: 7.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 746702779   44 AVLYHNRCTVLQNLGLYQLALKDINKAVELAPNY 77
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR_12 pfam13424
Tetratricopeptide repeat;
42-102 1.62e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.98  E-value: 1.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 746702779   42 DKAVLYHNRCTVLQNLGLYQLALKDINKAVELA--------PNYAIAWCNKAMLHNLLGDYSQGWQAYE 102
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLE 69
RanBD4_RanBP2-like cd13178
Ran-binding protein 2, Ran binding domain repeat 4; RanBP2 (also called E3 SUMO-protein ligase ...
 118-165 3.17e-03

Ran-binding protein 2, Ran binding domain repeat 4; RanBP2 (also called E3 SUMO-protein ligase RanBP2, 358 kDa nucleoporin, and nuclear pore complex (NPC) protein Nup358) is a giant nucleoporin that localizes to the cytosolic face of the NPC. RanBP2 contains a leucine-rich region, 8 zinc-finger motifs, a cyclophilin A homologous domain, and 4 RanBDs. Ran is a Ras-like nuclear small GTPase, which regulates receptor-mediated transport between the nucleus and the cytoplasm. RanGTP hydrolysis is stimulated by RanGAP together with the Ran-binding domain containing acessory proteins RanBP1 and RanBP2. These accessory proteins stabilize the active GTP-bound form of Ran. All eukaryotic cells contain RanBP1, but in vertebrates however, the main RanBP seems to be RanBP2. There is no RanBP2 ortholog in yeast. Transport complex disassembly is accomplished by a small ubiquitin-related modifier-1 (SUMO-1)-modified version of RanGAP that is bound to RanBP2. RanBP1 acts as a second line of defense against exported RanGTP-importin complexes which have escaped from dissociation by RanBP2. RanBP2 also interacts with the importin subunit beta-1. RabBD shares structural similarity to the PH domain, but lacks detectable sequence similarity. The members here include human, chicken, frog, tunicates, sea urchins, ticks, sea anemones, and sponges. RanBD repeat 4 is present in this hierarchy.


Pssm-ID: 269999  Cd Length: 117  Bit Score: 37.24  E-value: 3.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 746702779 118 NIPQWRGENIGDTKILFHVEQGFgdniqfvrYALEMKRQGLNVVVLNH 165
Cdd:cd13178   22 DVGQWKERGVGDIKILFHPSKHY--------YRILMRRDQVLKVCANH 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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