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Conserved domains on  [gi|746702784|gb|KIE93456|]
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putative transferrin-binding protein 1 [Actinobacillus pleuropneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TonB-tbp-lbp super family cl36969
TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors ...
 1-214 1.40e-105

TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors are responsible for import of iron from the mammalian iron carriers lactoferrin and transferrin across the outer membrane. These receptors are found only in bacteria which can infect mammals such as Moraxella, Mannheimia, Neisseria, Actinobacillus, Pasteurella, Haemophilus and Histophilus species. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


The actual alignment was detected with superfamily member TIGR01776:

Pssm-ID: 273799 [Multi-domain]  Cd Length: 932  Bit Score: 324.46  E-value: 1.40e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784    1 MKQFKLSLSYIAIQSAFLILSAQTYAKQNETE-------LDTVTVKAKTEIHRRQNEVTGLGKVTKISKDLDKEQVQNIR 73
Cdd:TIGR01776   3 MKKHVLNLSILALSLLFATLSFQTADADSAKDtanqavyLDEITVTATKVAHRRSNEVTGLGKVVKTAETLSKEQVLGIR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   74 DLTRYDPGISVVEQGRGASSGYSIRGVDRNRVALLVDGLPQIQSYK---SLSLFAQSGAINEIEYENIRSIEFSKGASSQ 150
Cdd:TIGR01776  83 DLTRYDPGISVVEQGRGASSGYSIRGVDKNRVAVTVDGIPQIQSYTsqgSRSGTAGSGAINEIEYENVRSVEISKGANSS 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746702784  151 EYGSGALGGAVGFRTKNPDDVIKEGQNWGLDSKTAYSSKNKQFSESLSFSDRSGGFEALVQYTH 214
Cdd:TIGR01776 163 EYGSGALGGSVAFRTKDASDIIKPGKHWGLQSKTAYSSKNRHFLQSLAAAGKAGGFEGLVIYTK 226
 
Name Accession Description Interval E-value
TonB-tbp-lbp TIGR01776
TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors ...
 1-214 1.40e-105

TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors are responsible for import of iron from the mammalian iron carriers lactoferrin and transferrin across the outer membrane. These receptors are found only in bacteria which can infect mammals such as Moraxella, Mannheimia, Neisseria, Actinobacillus, Pasteurella, Haemophilus and Histophilus species. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273799 [Multi-domain]  Cd Length: 932  Bit Score: 324.46  E-value: 1.40e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784    1 MKQFKLSLSYIAIQSAFLILSAQTYAKQNETE-------LDTVTVKAKTEIHRRQNEVTGLGKVTKISKDLDKEQVQNIR 73
Cdd:TIGR01776   3 MKKHVLNLSILALSLLFATLSFQTADADSAKDtanqavyLDEITVTATKVAHRRSNEVTGLGKVVKTAETLSKEQVLGIR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   74 DLTRYDPGISVVEQGRGASSGYSIRGVDRNRVALLVDGLPQIQSYK---SLSLFAQSGAINEIEYENIRSIEFSKGASSQ 150
Cdd:TIGR01776  83 DLTRYDPGISVVEQGRGASSGYSIRGVDKNRVAVTVDGIPQIQSYTsqgSRSGTAGSGAINEIEYENVRSVEISKGANSS 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746702784  151 EYGSGALGGAVGFRTKNPDDVIKEGQNWGLDSKTAYSSKNKQFSESLSFSDRSGGFEALVQYTH 214
Cdd:TIGR01776 163 EYGSGALGGSVAFRTKDASDIIKPGKHWGLQSKTAYSSKNRHFLQSLAAAGKAGGFEGLVIYTK 226
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 57-214 1.43e-33

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 126.41  E-value: 1.43e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  57 VTKIS-KDLDKEQVQNIRDLTRYDPGISVVEQGRGASSGYSIRGVDRNRVALLVDGLPQIQSYkslslFAQSGAINEIEY 135
Cdd:cd01347    2 VSVITaEDIEKQPATSLADLLRRIPGVSVTRGGGGGGSTISIRGFGPDRTLVLVDGLPLASSN-----YGRGVDLNTIPP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784 136 ENIRSIEFSKGASSQEYGSGALGGAVGFRTKNPDDviKEGQNWGLD--SKTAYSSKNKQFSESLSFS-DRSGGFEALVQY 212
Cdd:cd01347   77 ELIERVEVLKGPSSALYGSGAIGGVVNIITKRPTD--EFGGSVTAGygSDNSGSSGGGGFDVSGALAdDGAFGARLYGAY 154


                 ..
gi 746702784 213 TH 214
Cdd:cd01347  155 RD 156
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 8-214 4.22e-25

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 102.24  E-value: 4.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   8 LSYIAIQSAFLILSAQTYAKQNETELDTVTVKAKteiHRRQNEVTGLGKVTKIS-KDLDKEQVQNIRDLTRYDPGISVVE 86
Cdd:COG4771    2 LLASLLLLLALAAQAADALAEDATELEEVVVTAT---RTEQSLSDAPASVSVITaEEIEKLGATDLADALRLLPGVSVTR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  87 Q-GRGASSGYSIRGVDRNRVALLVDGLPQIQSYkslslFAQSGAINEIEYENIRSIEFSKGASSQEYGSGALGGAVGFRT 165
Cdd:COG4771   79 SgGRGGSSGISIRGLGGDRVLVLIDGVPVNNPA-----LGGGGDLSYIPPDDIERIEVIRGPASALYGSDAIGGVINIIT 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 746702784 166 KNPDDviKEGQNWGLdskTAYSSKNKQFSESLSFSDRSGGFEALVQYTH 214
Cdd:COG4771  154 KKPTD--ELEGSVSL---GYGSNGNGTYSGSLSLGGPGDKLSFLLSGSY 197
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 57-160 2.61e-23

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 89.64  E-value: 2.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   57 VTKIS-KDLDKEQVQNIRDLTRYDPGISVVEQGRGASSGYSIRGVDRNRVALLVDGLPQIQSYKSlslfaqSGAINEIEY 135
Cdd:pfam07715   9 VSVVTaEDIEDQGATNLADALRGVPGVSVSSGGGGGGSSISIRGFGSNRVLVLVDGVPLNSGGGG------SVDLNSIDP 82

                          90       100
                  ....*....|....*....|....*
gi 746702784  136 ENIRSIEFSKGASSQEYGSGALGGA 160
Cdd:pfam07715  83 EDIERVEVLKGPASALYGSGAIGGV 107
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 30-178 2.74e-12

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 64.91  E-value: 2.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  30 ETELDTVTVKAKTeihRRQNEVTGLGKVTKIS-KDLDKEQVQNIRDLTRYDPGISVVEQGRGaSSGYSIRGVDRNRVALL 108
Cdd:PRK10064  27 DDDGETMVVTASA---VEQNLKDAPASISVITqEDLQRKPVQNLKDVLKEVPGVQLTNEGDN-RKGVSIRGLDSSYTLIL 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784 109 VDGlPQIQSyKSLSLFAQSGAINEIEYENIRSIEFSKGASSQEYGSGALGGAVGFRTKnpddviKEGQNW 178
Cdd:PRK10064 103 IDG-KRVNS-RNAVFRHNDFDLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITK------KIGQKW 164
 
Name Accession Description Interval E-value
TonB-tbp-lbp TIGR01776
TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors ...
 1-214 1.40e-105

TonB-dependent lactoferrin and transferrin receptors; This family of TonB-dependent receptors are responsible for import of iron from the mammalian iron carriers lactoferrin and transferrin across the outer membrane. These receptors are found only in bacteria which can infect mammals such as Moraxella, Mannheimia, Neisseria, Actinobacillus, Pasteurella, Haemophilus and Histophilus species. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273799 [Multi-domain]  Cd Length: 932  Bit Score: 324.46  E-value: 1.40e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784    1 MKQFKLSLSYIAIQSAFLILSAQTYAKQNETE-------LDTVTVKAKTEIHRRQNEVTGLGKVTKISKDLDKEQVQNIR 73
Cdd:TIGR01776   3 MKKHVLNLSILALSLLFATLSFQTADADSAKDtanqavyLDEITVTATKVAHRRSNEVTGLGKVVKTAETLSKEQVLGIR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   74 DLTRYDPGISVVEQGRGASSGYSIRGVDRNRVALLVDGLPQIQSYK---SLSLFAQSGAINEIEYENIRSIEFSKGASSQ 150
Cdd:TIGR01776  83 DLTRYDPGISVVEQGRGASSGYSIRGVDKNRVAVTVDGIPQIQSYTsqgSRSGTAGSGAINEIEYENVRSVEISKGANSS 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746702784  151 EYGSGALGGAVGFRTKNPDDVIKEGQNWGLDSKTAYSSKNKQFSESLSFSDRSGGFEALVQYTH 214
Cdd:TIGR01776 163 EYGSGALGGSVAFRTKDASDIIKPGKHWGLQSKTAYSSKNRHFLQSLAAAGKAGGFEGLVIYTK 226
TonB-hemlactrns TIGR01786
TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model ...
 34-214 1.63e-70

TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273808 [Multi-domain]  Cd Length: 715  Bit Score: 227.68  E-value: 1.63e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   34 DTVTVKAKT--EIHRRQNEVTGLGKVTKISKDLDKEQVQNIRDLTRYDPGISVVEQGRGASSGYSIRGVDRNRVALLVDG 111
Cdd:TIGR01786   1 DTITVTATRtaDPQRRDLSVTPASVSVISREQLKSQQVRNLRDLLRYEPGVSVVEGGRGGSQGINIRGLDKNRVAVLVDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  112 LPQIQSYKSLSlfAQSGAINEIEYENIRSIEFSKGASSQEYGSGALGGAVGFRTKNPDDVIKEGQNWGLDSKTAYSSKNK 191
Cdd:TIGR01786  81 IRQNTSYGGQG--STFYAINSIDPELIKSIEIVKGASSSLYGSGALGGVVAFRTKDAADLLKPGKDLGGLSKLGYSSANN 158

                         170       180
                  ....*....|....*....|...
gi 746702784  192 QFSESLSFSDRSGGFEALVQYTH 214
Cdd:TIGR01786 159 RFTQSVAAAGRNDDVDALVQATY 181
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 33-213 3.15e-34

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 128.28  E-value: 3.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   33 LDTVTVKAKteiHRRQNEVTGLGKVTKISKD-LDKEQVQNIRDLTRYDPGISVVEQGRGASSGYSIRGVDRNRVALLVDG 111
Cdd:TIGR01785   1 LDTVTVTAT---RTRQVLSEAPASVSVISGEqIESKQANNLADALNTVPGVDVTGGGRPPGQSINIRGLQDNRVLVVVDG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  112 LPQIqsykslslFAQSGAINEIEY---ENIRSIEFSKGASSQEYGSGALGGAVGFRTKNPDDVIKEGQNWGLDSKTAYSS 188
Cdd:TIGR01785  78 ARQN--------YQRGGAHNGSLFvdpELLKRIEIVKGPSSSLYGSGALGGVVAFRTKDAADLLRPGQLFGGLAKLSYGS 149

                         170       180
                  ....*....|....*....|....*.
gi 746702784  189 KNKQFSESLSFSDRSG-GFEALVQYT 213
Cdd:TIGR01785 150 NNNSFGGSVAVAGRLDdNLDALVAAT 175
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 57-214 1.43e-33

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 126.41  E-value: 1.43e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  57 VTKIS-KDLDKEQVQNIRDLTRYDPGISVVEQGRGASSGYSIRGVDRNRVALLVDGLPQIQSYkslslFAQSGAINEIEY 135
Cdd:cd01347    2 VSVITaEDIEKQPATSLADLLRRIPGVSVTRGGGGGGSTISIRGFGPDRTLVLVDGLPLASSN-----YGRGVDLNTIPP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784 136 ENIRSIEFSKGASSQEYGSGALGGAVGFRTKNPDDviKEGQNWGLD--SKTAYSSKNKQFSESLSFS-DRSGGFEALVQY 212
Cdd:cd01347   77 ELIERVEVLKGPSSALYGSGAIGGVVNIITKRPTD--EFGGSVTAGygSDNSGSSGGGGFDVSGALAdDGAFGARLYGAY 154


                 ..
gi 746702784 213 TH 214
Cdd:cd01347  155 RD 156
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 8-214 4.22e-25

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 102.24  E-value: 4.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   8 LSYIAIQSAFLILSAQTYAKQNETELDTVTVKAKteiHRRQNEVTGLGKVTKIS-KDLDKEQVQNIRDLTRYDPGISVVE 86
Cdd:COG4771    2 LLASLLLLLALAAQAADALAEDATELEEVVVTAT---RTEQSLSDAPASVSVITaEEIEKLGATDLADALRLLPGVSVTR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  87 Q-GRGASSGYSIRGVDRNRVALLVDGLPQIQSYkslslFAQSGAINEIEYENIRSIEFSKGASSQEYGSGALGGAVGFRT 165
Cdd:COG4771   79 SgGRGGSSGISIRGLGGDRVLVLIDGVPVNNPA-----LGGGGDLSYIPPDDIERIEVIRGPASALYGSDAIGGVINIIT 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 746702784 166 KNPDDviKEGQNWGLdskTAYSSKNKQFSESLSFSDRSGGFEALVQYTH 214
Cdd:COG4771  154 KKPTD--ELEGSVSL---GYGSNGNGTYSGSLSLGGPGDKLSFLLSGSY 197
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 57-160 2.61e-23

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 89.64  E-value: 2.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   57 VTKIS-KDLDKEQVQNIRDLTRYDPGISVVEQGRGASSGYSIRGVDRNRVALLVDGLPQIQSYKSlslfaqSGAINEIEY 135
Cdd:pfam07715   9 VSVVTaEDIEDQGATNLADALRGVPGVSVSSGGGGGGSSISIRGFGSNRVLVLVDGVPLNSGGGG------SVDLNSIDP 82

                          90       100
                  ....*....|....*....|....*
gi 746702784  136 ENIRSIEFSKGASSQEYGSGALGGA 160
Cdd:pfam07715  83 EDIERVEVLKGPASALYGSGAIGGV 107
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
33-214 1.52e-22

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 94.89  E-value: 1.52e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  33 LDTVTVKAKTEIHRRQNEVTGLGKVTKisKDLDKEQVQNIRDLTRYDPGISVvEQGRGASSGYSIRGVD--RNRVALLVD 110
Cdd:COG1629    1 LEEVVVTATRTDESLQDVPGSVSVISR--EQLEDQPATDLGDLLRRVPGVSV-TSAGGGAGQISIRGFGggGNRVLVLVD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784 111 GLPQiqsyksLSLFAQSGAINEIEYENIRSIEFSKGASSQEYGSGALGGAVGFRTKNPDDvikegqNWGLDSKTAYSSKN 190
Cdd:COG1629   78 GVPL------NDPSGGDGGLSYIDPEDIERVEVLRGPSSALYGSGALGGVINIVTKKPKD------GKGGEVSASYGSYG 145

                        170       180
                 ....*....|....*....|....
gi 746702784 191 kQFSESLSFSDRSGGFEALVQYTH 214
Cdd:COG1629  146 -TYRASLSLSGGNGKLAYRLSASY 168
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
16-214 5.85e-22

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 93.07  E-value: 5.85e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  16 AFLILSAQTYAKQNETELDTVTVKAKTEIHRRQNEVTGlgKVTKIS-KDLDKEQVQNIRDLTRYDPGISVV-EQGRGASS 93
Cdd:COG4772    6 AAALLLAAAAAAEAATTLETVVVTGSRAAEARLKDVPG--SVSVVDrEELENQAATSLREVLRRVPGVNVQeEDGFGLRP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  94 GYSIRGVDRNRVA---LLVDGLP-------QIQSYKSLSLfaqsgaineieyENIRSIEFSKGASSQEYGSGALGGAVGF 163
Cdd:COG4772   84 NIGIRGLGPRRSRgitLLEDGIPiapapygDPAAYYFPDL------------ERMERIEVLRGAAALRYGPQTVGGAINF 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 746702784 164 RTKNPDDvikegqNWGLDSKTAYSSKNKqFSESLSFSDRSGGFEALVQYTH 214
Cdd:COG4772  152 VTRTIPT------AFGGELRVTGGSFGY-RRTHASVGGTVGNFGYLVEYSR 195
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
36-206 3.80e-19

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 83.00  E-value: 3.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  36 VTVKAkTEIHRRQNEVTGlgKVTKIS-KDLDKEQVQNIRDLTRYDPGISVVEQGR-GASSGYSIRGVDRNRVALLVDGLP 113
Cdd:COG4206    1 VVVTA-TRLEQSKSDLTG--SVTVIDaEELERSGATSLADALRRVPGVQVSSSGGpGSAASISIRGLGSNQTLVLIDGVP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784 114 QIqsykslSLFAQSGAINEIEYENIRSIEFSKGASSQEYGSGALGGAVGFRTKNPDDVIK-----EGQNWGLDSKTA-YS 187
Cdd:COG4206   78 LN------DPSLGGVDLSLIPPDDIERIEVLKGAASALYGSDAIGGVINITTKKGKKGFKgsvsaSYGSFGTRRLSAsLS 151

                        170       180
                 ....*....|....*....|
gi 746702784 188 SKNKQFSESLSFS-DRSGGF 206
Cdd:COG4206  152 GGAGKFSYSLSASyRRSDGY 171
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 6-170 1.10e-16

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 78.01  E-value: 1.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   6 LSLSYIAIQSAFLILSAQTYAKQNETELDTVTVKAKTE-----IHRRQNEVTGLGK--------VTKISKD-LDKEQVQN 71
Cdd:COG4773    5 LAGSGLAAAAAGALAQAAAAAAAEATTLPEVTVTGTAEgtggyTAKSSSTATKLDTplretpqsVSVVTRQlIEDQGATT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  72 IRDLTRYDPGISVVEQGRGASSGYSIRGVDRNRValLVDGLPQIQSYKSLslfaqsgaineIEYENIRSIEFSKGASSQE 151
Cdd:COG4773   85 LDDALRNVPGVTVSSYDGGGRDSFSIRGFSIDNY--LRDGLPLGGFGGGQ-----------PDTANLERVEVLKGPAGLL 151

                        170
                 ....*....|....*....
gi 746702784 152 YGSGALGGAVGFRTKNPDD 170
Cdd:COG4773  152 YGAGSPGGLVNLVTKRPTA 170
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
57-170 4.99e-14

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 69.91  E-value: 4.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  57 VTKISKDLDKEQ-VQNIRDLTRYDPGISVVEQGRGASSGYSIRGVDrNRVALLVDGLPQIQSYkslslfaqsgainEIEY 135
Cdd:COG4774   13 VTVVTRELIEDQgATSLADALRNVPGVTFGAGEGGNGDSFSIRGFS-ASGDIYVDGLRDPGQY-------------RRDT 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 746702784 136 ENIRSIEFSKGASSQEYGSGALGGAVGFRTKNPDD 170
Cdd:COG4774   79 FNLERVEVLKGPASVLYGRGSPGGVINLVTKRPTD 113
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 30-178 2.74e-12

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 64.91  E-value: 2.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  30 ETELDTVTVKAKTeihRRQNEVTGLGKVTKIS-KDLDKEQVQNIRDLTRYDPGISVVEQGRGaSSGYSIRGVDRNRVALL 108
Cdd:PRK10064  27 DDDGETMVVTASA---VEQNLKDAPASISVITqEDLQRKPVQNLKDVLKEVPGVQLTNEGDN-RKGVSIRGLDSSYTLIL 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784 109 VDGlPQIQSyKSLSLFAQSGAINEIEYENIRSIEFSKGASSQEYGSGALGGAVGFRTKnpddviKEGQNW 178
Cdd:PRK10064 103 IDG-KRVNS-RNAVFRHNDFDLNWIPVDAIERIEVVRGPMSSLYGSDALGGVVNIITK------KIGQKW 164
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 62-170 4.21e-09

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 55.50  E-value: 4.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   62 KDLDKEQVQNIRDLTRYDPGISVVE-QGRGASSGYSIRGVDRN--RVALLVDGLPQiqsykslsLFAQSGAIneIEYENI 138
Cdd:TIGR01783  12 QELEDQQAGSLSEALQRVPGVVVGGsGGTTQFGNITIRGFGLEvdIDNVYLDGVPL--------LSRGNLAI--VDPAMV 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 746702784  139 RSIEFSKGASSQEYGSGALGGAVGFRTKNPDD 170
Cdd:TIGR01783  82 ERVEVLRGPASLLYGGSAPGGVINIVTKRPQD 113
btuB PRK10641
TonB-dependent vitamin B12 receptor BtuB;
63-196 6.39e-09

TonB-dependent vitamin B12 receptor BtuB;


Pssm-ID: 236730 [Multi-domain]  Cd Length: 614  Bit Score: 55.00  E-value: 6.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  63 DLDKEQVQNIRDLTRYDPGISVVEQG-RGASSGYSIRGVDRNRVALLVDGLPqiqsyksLSLFAQSGA--INEIEYENIR 139
Cdd:PRK10641  53 DIDRWQSKSVNDVLRRLPGVDIAQNGgLGQLSSLFIRGTNSSHVLVLIDGVR-------LNQAGISGSadLSQIPISLVQ 125

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 746702784 140 SIEFSKGASSQEYGSGALGGAVGFRTKNPDDVIKEGQNWGLDSKTAYS-SKNKQFSES 196
Cdd:PRK10641 126 RIEYIRGPRSAVYGSDAIGGVVNIITTRDKPGTTLSAGWGSNGYQNYDgSTQQQLGDN 183
PRK13524 PRK13524
FepA family TonB-dependent siderophore receptor;
1-170 7.19e-08

FepA family TonB-dependent siderophore receptor;


Pssm-ID: 237410 [Multi-domain]  Cd Length: 744  Bit Score: 51.95  E-value: 7.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   1 MKQFKLSLSYIAIQSAFLILSAQT----YAKQNETELDTVTVKAKTEIhrRQnevtGLGKVTKISKDLDKEQVQN-IRDL 75
Cdd:PRK13524   2 NKKIHSLALLVNLGIYGVAQAAEAedakTDDTPASHEDTIVVTAAEQN--LQ----APGVSTITAEDIRKRPPANdVSEI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  76 TRYDPGI-----SVVEQgRGASSGYSIRGVDRNRVALLVDGLPqIQSYKSLSLFAQS-----GAINEIEYENIRSIEFSK 145
Cdd:PRK13524  76 IRTMPGVnltgnSTSGQ-RGNNRQIDIRGMGPENTLILIDGKP-VSSRNSVRYGWRGerdtrGDTNWVPPEMIERIEVLR 153

                        170       180
                 ....*....|....*....|....*
gi 746702784 146 GASSQEYGSGALGGAVGFRTKNPDD 170
Cdd:PRK13524 154 GPAAARYGNGAAGGVVNIITKKPTG 178
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
1-166 1.89e-06

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 47.69  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   1 MKQFKLSLSYIAIQSAFLILSAqtYAKQNETElDTVTVKAKTEIHRRQNEVTGLGKVTKisKDLDKEQVQNIRDLTRYDP 80
Cdd:PRK13484   1 MKNKYIIAPGIAVMCSAVISSG--YASSDKKE-DTLVVTASGFTQQLRNAPASVSVITS--EQLQKKPVSDLVDAVKDVE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  81 GISVveQGRGASSGYSIRGVDRNRVALLVDGLPQI--QSYKSLSLFAQSGAINEIEyeNIRSIEFSKGASSQEYGSGALG 158
Cdd:PRK13484  76 GISI--TGGNEKPDISIRGLSGDYTLILVDGRRQSgrESRPNGSGGFEAGFIPPVE--AIERIEVIRGPMSSLYGSDAIG 151


                 ....*...
gi 746702784 159 GAVGFRTK 166
Cdd:PRK13484 152 GVINIITK 159
PRK13513 PRK13513
ligand-gated channel protein;
1-179 2.21e-06

ligand-gated channel protein;


Pssm-ID: 184104 [Multi-domain]  Cd Length: 659  Bit Score: 47.46  E-value: 2.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   1 MKQFKLSLSYIAIQSAFLILSAQTyakQNETELDTVTVKAKTEIHRRQNEVTGLGKVTKisKDLDKEQVQNIRDLTRYDP 80
Cdd:PRK13513   6 RKTHKAALVIAAAISSQAYAAEKT---NTATPTDTMVVTASGFQQRIQDAPASISVVTR--EQLENKAYRDVTDALKDVP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  81 GisVVEQGRGASSGYSIRGVDRNRVALLVDGlPQIQSYKSLSLFAQSGaineIE------YENIRSIEFSKGASSQEYGS 154
Cdd:PRK13513  81 G--VVVTGGGSTSDISIRGMAAKYTLILVDG-KRVDTRSTRPNSDGSG----IEqgwlppLAAIERIEVVRGPMSSLYGS 153

                        170       180
                 ....*....|....*....|....*
gi 746702784 155 GALGGAVGFRTKnpddviKEGQNWG 179
Cdd:PRK13513 154 DAMGGVINIITR------KVQKEWH 172
PRK13486 PRK13486
TonB-dependent receptor;
57-202 7.92e-05

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 43.09  E-value: 7.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  57 VTKISK-DLDKEQVQNIRDLTRYDPGISVvEQGRGASSGY--SIRGVDRNRVALLVDGLPQIQSYK-SLSLFAQSGAINE 132
Cdd:PRK13486  46 VSVISQeELQSSQYHDLAEALRSVEGVDV-ESGTGKTGGLeiSIRGMPASYTLILIDGVRQGGSSDvTPNGFSAMNTGFM 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784 133 IEYENIRSIEFSKGASSQEYGSGALGGAVGFRTKNPDDV----------IKEGQNWGLDSKTAYSSKNKQFSESLSFSDR 202
Cdd:PRK13486 125 PPLAAIERIEVIRGPMSTLYGSDAMGGVVNIITRKNADKwlssvnaglnLQESNKWGNSSQFNFWSSGPLVDDSVSLQVR 204
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 18-171 1.19e-04

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 42.44  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  18 LILSAQTYAKQNETEL-DTVTVKAKTEIHRRQNevTGLGKVTkiSKDLDKEQ-VQNIRDLTRYDPGISVVeqGRGASSGY 95
Cdd:PRK13528  18 GLNSPVSAAESSDDDNgETMVVEATAEQELKQQ--PGVSIIT--AEDIKKRPpVNDLSDIIRKMPGVNLT--GNSASGTR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  96 ------SIRGVDRNRVALLVDGLPqIQSYKSLSlFAQSGA------INEIEYENIRSIEFSKGASSQEYGSGALGGAVGF 163
Cdd:PRK13528  92 gnnrqiDIRGMGPENTLILIDGVP-VTSRNSVR-YSWRGErdtrgdTNWVPPEMVERIEVIRGPAAARYGSGAAGGVVNI 169


                 ....*...
gi 746702784 164 RTKNPDDV 171
Cdd:PRK13528 170 ITKRPTND 177
PRK14050 PRK14050
TonB-dependent siderophore receptor;
2-170 1.66e-04

TonB-dependent siderophore receptor;


Pssm-ID: 237595 [Multi-domain]  Cd Length: 728  Bit Score: 42.10  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   2 KQFKLSLSYIAIQSAFLILSAQTYAK-QNETELDTVTV--------------------------KAKTEIHRRQNEVTGL 54
Cdd:PRK14050   7 GLHFMMLLAAGVALAALVLSGLVAAQeGNTTQLETIVVeggnaasatatgpvdgyvakatatgsKTDTPITEIPQSVSVV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  55 GKvtkisKDLDKEQVQN-IRDLTRYDPGISVVEQGR-GASSGYSIRGVDRNRVALLVDGLPqiqsykslsLFAQSGAINE 132
Cdd:PRK14050  87 GR-----QEMDDRGVTNkVDEALRYTPGVLSQPFGTdGDTDWFYIRGFDATQTGVFLDGLN---------LFSYGFGGFQ 152

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 746702784 133 IEYENIRSIEFSKGASSQEYGSGALGGAVGFRTKNPDD 170
Cdd:PRK14050 153 IDPFMLERVEVLKGPASVLYGGSNPGGIVNMVSKRPLD 190
PRK09840 PRK09840
catecholate siderophore receptor Fiu; Provisional
 22-168 2.25e-04

catecholate siderophore receptor Fiu; Provisional


Pssm-ID: 182105 [Multi-domain]  Cd Length: 761  Bit Score: 41.72  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  22 AQTYAKQNETELDTVTVKAKTEIHRRQNEVTGLGKVTK-----------ISKDLDKEQ-VQNIRDLTRYDPGISVVEQGR 89
Cdd:PRK09840  29 AQALAAEGQTNADDTLVVEASTPSLYAPDQSADPKFSQpladttqtitvISEQVIKDQgATNLTEALRNVPGVGTFFAGE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  90 GASS--GYSI--RGVDRNRvALLVDGLPQIQSYkSLSLFaqsgaineieyeNIRSIEFSKGASSQEYGSGALGGAVGFRT 165
Cdd:PRK09840 109 NGNTttGDAIymRGFDTSN-SIYVDGIRDIGSI-SRDTF------------NTEQVEVIKGPSGTDYGRSAPTGSINMIS 174


                 ...
gi 746702784 166 KNP 168
Cdd:PRK09840 175 KQP 177
PRK13483 PRK13483
ligand-gated channel protein;
1-169 1.21e-03

ligand-gated channel protein;


Pssm-ID: 184080 [Multi-domain]  Cd Length: 660  Bit Score: 39.37  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784   1 MKQFKLS-LSYIAIQSAFLILSAQTyAKQNETELDTVTVKAKTEIHRRQNEVTGLGKVTKisKDLDKEQVQNIRDLTRYD 79
Cdd:PRK13483   1 MKKYLAQvISALCLLPAVFVTHALA-QAAPDKTMETVVVTASGYEQQIRDAPASISVITR--EDLENRFYRDLTDALLDV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746702784  80 PGISVVeqGRGASSGYSIRGVDRNRVALLVDGlpQIQSYKSLSLFAQSGAINEI---EYENIRSIEFSKGASSQEYGSGA 156
Cdd:PRK13483  78 PGVVVT--GGGDRTDISLRGMGSQYTLILVDG--KRQSSRETRPNSDGPGVEQAwtpPLAAIERIEVIRGPMSSLYGSDA 153

                        170
                 ....*....|....
gi 746702784 157 LGGAVGFRT-KNPD 169
Cdd:PRK13483 154 IGGVINIITrKVPN 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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