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Conserved domains on  [gi|966689734|gb|KTG22566|]
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calmodulin [Pseudoalteromonas sp. XI10]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1000101)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
25-70 8.99e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.46  E-value: 8.99e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966689734  25 FDTLDVDGNGVVSKSE--AAVDAKIMSQ------FKTLDVNGDGVLTEAEFSEA 70
Cdd:COG5126   75 FDLLDTDGDGKISADEfrRLLTALGVSEeeadelFARLDTDGDGKISFEEFVAA 128
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
25-70 8.99e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.46  E-value: 8.99e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966689734  25 FDTLDVDGNGVVSKSE--AAVDAKIMSQ------FKTLDVNGDGVLTEAEFSEA 70
Cdd:COG5126   75 FDLLDTDGDGKISADEfrRLLTALGVSEeeadelFARLDTDGDGKISFEEFVAA 128
EFh_SPARC_SMOC cd16234
EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding ...
 25-69 1.52e-04

EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein SMOC-1, SMOC-2, and similar proteins; SMOC proteins corresponds to a group matricellular proteins that are involved in direct or indirect modulation of growth factor signaling pathways and play diverse roles in physiological processes involving extensive tissue remodeling, migration, proliferation, and angiogenesis. They may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development. SMOC-1 is localized in basement membranes. Its mutations have been found to be associated with individuals with Warrdenburg Anopthalmia Syndrome. SMOC-2 is ubiquitously expressed and is involved in angiogenesis and the regulation of cell cycle progression. It enhances the angiogenic effect of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF). It has also been implicated in generalized vitiligo. SMOC proteins consist of a follistatin-like (FS) domain, two thyroglobulin-like (TY) domains, a novel domain conserved only in SMOC proteins, and an extracellular calcium-binding (EC) domain with two EF-hand calcium-binding motifs.


Pssm-ID: 320013  Cd Length: 104  Bit Score: 36.49  E-value: 1.52e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689734  25 FDTLDVDGNGVVSKSEAAVDAKIMSQFKTL-----------DVNGDGVLTEAEFSE 69
Cdd:cd16234   45 FSQLDKNKNGVLERKEWKPFKRLLKKAVKPkkcarkfpkycDVNKDKKISLTEWLN 100
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
25-70 7.43e-04

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 35.43  E-value: 7.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966689734  25 FDTLDVDGNGVVSKSE--AAVDAKIMSQ-----FKTLDVNGDGVLTEAEFSEA 70
Cdd:NF041410 109 LSALDTDGDGSISSDElsAGLTSAGSSAdssqlFSALDSDGDGSVSSDELAAA 161
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
25-70 1.92e-03

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 34.27  E-value: 1.92e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689734  25 FDTLDVDGNGVVSKSE--AAVDAK--------IMSQFKTLDVNGDGVLTEAEFSEA 70
Cdd:NF041410  33 FAKLDSDGDGSVSQDElsSALSSKsddgslidLSELFSDLDSDGDGSLSSDELAAA 88
EF-hand_7 pfam13499
EF-hand domain pair;
25-70 6.01e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 31.84  E-value: 6.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966689734  25 FDTLDVDGNGVVSKSEAAV------------DAKIMSQFKTLDVNGDGVLTEAEFSEA 70
Cdd:pfam13499  8 FKLLDSDGDGYLDVEELKKllrkleegeplsDEEVEELFKEFDLDKDGRISFEEFLEL 65
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
25-70 8.99e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.46  E-value: 8.99e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966689734  25 FDTLDVDGNGVVSKSE--AAVDAKIMSQ------FKTLDVNGDGVLTEAEFSEA 70
Cdd:COG5126   75 FDLLDTDGDGKISADEfrRLLTALGVSEeeadelFARLDTDGDGKISFEEFVAA 128
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
25-67 1.15e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.46  E-value: 1.15e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 966689734  25 FDTLDVDGNGVVSKSE--AAVDAKIMSQFKTLDVNGDGVLTEAEF 67
Cdd:COG5126   11 FDLLDADGDGVLERDDfeALFRRLWATLFSEADTDGDGRISREEF 55
EFh_SPARC_SMOC cd16234
EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding ...
 25-69 1.52e-04

EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein SMOC-1, SMOC-2, and similar proteins; SMOC proteins corresponds to a group matricellular proteins that are involved in direct or indirect modulation of growth factor signaling pathways and play diverse roles in physiological processes involving extensive tissue remodeling, migration, proliferation, and angiogenesis. They may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development. SMOC-1 is localized in basement membranes. Its mutations have been found to be associated with individuals with Warrdenburg Anopthalmia Syndrome. SMOC-2 is ubiquitously expressed and is involved in angiogenesis and the regulation of cell cycle progression. It enhances the angiogenic effect of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF). It has also been implicated in generalized vitiligo. SMOC proteins consist of a follistatin-like (FS) domain, two thyroglobulin-like (TY) domains, a novel domain conserved only in SMOC proteins, and an extracellular calcium-binding (EC) domain with two EF-hand calcium-binding motifs.


Pssm-ID: 320013  Cd Length: 104  Bit Score: 36.49  E-value: 1.52e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689734  25 FDTLDVDGNGVVSKSEAAVDAKIMSQFKTL-----------DVNGDGVLTEAEFSE 69
Cdd:cd16234   45 FSQLDKNKNGVLERKEWKPFKRLLKKAVKPkkcarkfpkycDVNKDKKISLTEWLN 100
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
25-70 7.43e-04

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 35.43  E-value: 7.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966689734  25 FDTLDVDGNGVVSKSE--AAVDAKIMSQ-----FKTLDVNGDGVLTEAEFSEA 70
Cdd:NF041410 109 LSALDTDGDGSISSDElsAGLTSAGSSAdssqlFSALDSDGDGSVSSDELAAA 161
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
25-70 1.16e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 34.77  E-value: 1.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689734  25 FDTLDVDGNGVVSKSE----------AAVDAKIMSQFKTLDVNGDGVLTEAEFSEA 70
Cdd:COG5126   39 FSEADTDGDGRISREEfvagmeslfeATVEPFARAAFDLLDTDGDGKISADEFRRL 94
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 25-70 1.71e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 32.90  E-value: 1.71e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689734 25 FDTLDVDGNGVVSKSEAA----------VDAKIMSQFKTLDVNGDGVLTEAEFSEA 70
Cdd:cd00051   6 FRLFDKDGDGTISADELKaalkslgeglSEEEIDEMIREVDKDGDGKIDFEEFLEL 61
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
25-70 1.92e-03

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 34.27  E-value: 1.92e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689734  25 FDTLDVDGNGVVSKSE--AAVDAK--------IMSQFKTLDVNGDGVLTEAEFSEA 70
Cdd:NF041410  33 FAKLDSDGDGSVSQDElsSALSSKsddgslidLSELFSDLDSDGDGSLSSDELAAA 88
EF-hand_7 pfam13499
EF-hand domain pair;
25-70 6.01e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 31.84  E-value: 6.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966689734  25 FDTLDVDGNGVVSKSEAAV------------DAKIMSQFKTLDVNGDGVLTEAEFSEA 70
Cdd:pfam13499  8 FKLLDSDGDGYLDVEELKKllrkleegeplsDEEVEELFKEFDLDKDGRISFEEFLEL 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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