NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|973153887|gb|KUK95466|]
View 

N6-adenine-specific methylase [Thermotogales bacterium 46_20]

Protein Classification

RsmD family RNA methyltransferase( domain architecture ID 10002368)

RsmD family RNA methyltransferase similar to 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD, which specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:0003676|GO:0031167|GO:0008168

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 4-185 3.87e-49

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 157.55  E-value: 3.87e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887   4 ITGGRFKGRHVRTLSSHKTRYTPALARRAFFDMI--DITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKS 81
Cdd:COG0742    3 IIGGKARGRKLKVPKGPGTRPTTDRVREALFNILgpDIEGARVLDLFAGSGALGLEALSRGAASVVFVEKDRKAAAVIRK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  82 NRDSLGiASDEIRIVCTDFRRALKSFAtsSQSFDVIFADPPFEKGFFSDLVKNFGKFvDYLR-DSLIVIETSgeylAEFT 160
Cdd:COG0742   83 NLEKLG-LEDRARVIRGDALRFLKRLA--GEPFDLVFLDPPYAKGLLEKALELLAEN-GLLApGGLIVVEHS----KREE 154

                        170       180
                 ....*....|....*....|....*
gi 973153887 161 TCLESSDFVLTRNKSYSGVNLVFLE 185
Cdd:COG0742  155 LPELPAGLELLKERKYGDTRLSFYR 179
 
Name Accession Description Interval E-value
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 4-185 3.87e-49

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 157.55  E-value: 3.87e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887   4 ITGGRFKGRHVRTLSSHKTRYTPALARRAFFDMI--DITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKS 81
Cdd:COG0742    3 IIGGKARGRKLKVPKGPGTRPTTDRVREALFNILgpDIEGARVLDLFAGSGALGLEALSRGAASVVFVEKDRKAAAVIRK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  82 NRDSLGiASDEIRIVCTDFRRALKSFAtsSQSFDVIFADPPFEKGFFSDLVKNFGKFvDYLR-DSLIVIETSgeylAEFT 160
Cdd:COG0742   83 NLEKLG-LEDRARVIRGDALRFLKRLA--GEPFDLVFLDPPYAKGLLEKALELLAEN-GLLApGGLIVVEHS----KREE 154

                        170       180
                 ....*....|....*....|....*
gi 973153887 161 TCLESSDFVLTRNKSYSGVNLVFLE 185
Cdd:COG0742  155 LPELPAGLELLKERKYGDTRLSFYR 179
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
4-183 6.52e-37

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 126.20  E-value: 6.52e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887    4 ITGGRFKGRHVRTLSSHKTRYTPALARRAFFDMI--DITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKS 81
Cdd:pfam03602   3 IIGGKARGRKLKVPPGPGTRPTTDRVREALFNWLapYIEGARVLDLFAGSGALGLEALSRGAKRVTLVEKDKRAVQILKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887   82 NRDSLGIASDEIRivcTDFRRALKSFATSSQSFDVIFADPPFEKGffsDLVKNFgkfvDYLR-------DSLIVIETSGE 154
Cdd:pfam03602  83 NLQLLGLPGAVLV---MDALLALLRLAGKGPVFDIVFLDPPYAKG---LIEEVL----DLLAekgwlkpNALIYVETEKR 152

                         170       180       190
                  ....*....|....*....|....*....|
gi 973153887  155 ylaefTTCLESSD-FVLTRNKSYSGVNLVF 183
Cdd:pfam03602 153 -----GELPEQPGnLELVREKKYGQTTLAF 177
TIGR00095 TIGR00095
16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; This model represents a family of ...
 1-185 4.12e-35

16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; This model represents a family of uncharacterized bacterial proteins. Members are present in nearly every complete bacterial genome, always in a single copy. PSI-BLAST analysis shows homology to several families of SAM-dependent methyltransferases, including ribosomal RNA adenine dimethylases. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188022 [Multi-domain]  Cd Length: 190  Bit Score: 122.13  E-value: 4.12e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887    1 MLTITGGRFKGRHVRTLSSHKTRYTPALARRAFFDMI--DITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSV 78
Cdd:TIGR00095   9 KIRIIGGQYRGRKLKVPPGPSTRPTTDRVRESLFNILrpDIVGAHFLDLFAGSGALGLEALSRGAASAVFVEQDRKVAQT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887   79 IKSNRDSLGiASDEIRIVCTDFRRALKSFATSSQSFDVIFADPPFEKGFFSDLVKNFGKFVDYLRDSLIVIETSGEYlaE 158
Cdd:TIGR00095  89 LKENLSTLK-KSGEQATVLNDAVRALLFLAKKQTPFDIIYLDPPFNRGLLEALLELLGENKWLNPKGLIVVEYDREN--E 165

                         170       180
                  ....*....|....*....|....*..
gi 973153887  159 FTTCLESsdFVLTRNKSYSGVNLVFLE 185
Cdd:TIGR00095 166 LPTVPET--WSLLRQKVYGQSALRLYQ 190
rsmD PRK10909
16S rRNA m(2)G966-methyltransferase; Provisional
 4-154 6.30e-20

16S rRNA m(2)G966-methyltransferase; Provisional


Pssm-ID: 236793  Cd Length: 199  Bit Score: 82.85  E-value: 6.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887   4 ITGGRFKGRHVRTLSSHKTRYTPALARRAFFD--MIDITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKS 81
Cdd:PRK10909  15 IIGGQWRGRKLPVPDSPGLRPTTDRVRETLFNwlAPVIVDARCLDCFAGSGALGLEALSRYAAGATLLEMDRAVAQQLIK 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 973153887  82 NRDSLGiaSDEIRIVCTDfrrALKSFATSSQSFDVIFADPPFEKGFFSD---LVKNFGKFVDylrDSLIVIETSGE 154
Cdd:PRK10909  95 NLATLK--AGNARVVNTN---ALSFLAQPGTPHNVVFVDPPFRKGLLEEtinLLEDNGWLAD---EALIYVESEVE 162
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 43-143 4.12e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 46.65  E-value: 4.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  43 TFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKSNRDSLGIasDEIRIVCTDFRRALKSfatSSQSFDVIFADPP 122
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLA--DNVEVLKGDAEELPPE---ADESFDVIISDPP 75

                         90       100
                 ....*....|....*....|.
gi 973153887 123 FEkGFFSDLVKNFGKFVDYLR 143
Cdd:cd02440   76 LH-HLVEDLARFLEEARRLLK 95
 
Name Accession Description Interval E-value
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 4-185 3.87e-49

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 157.55  E-value: 3.87e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887   4 ITGGRFKGRHVRTLSSHKTRYTPALARRAFFDMI--DITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKS 81
Cdd:COG0742    3 IIGGKARGRKLKVPKGPGTRPTTDRVREALFNILgpDIEGARVLDLFAGSGALGLEALSRGAASVVFVEKDRKAAAVIRK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  82 NRDSLGiASDEIRIVCTDFRRALKSFAtsSQSFDVIFADPPFEKGFFSDLVKNFGKFvDYLR-DSLIVIETSgeylAEFT 160
Cdd:COG0742   83 NLEKLG-LEDRARVIRGDALRFLKRLA--GEPFDLVFLDPPYAKGLLEKALELLAEN-GLLApGGLIVVEHS----KREE 154

                        170       180
                 ....*....|....*....|....*
gi 973153887 161 TCLESSDFVLTRNKSYSGVNLVFLE 185
Cdd:COG0742  155 LPELPAGLELLKERKYGDTRLSFYR 179
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
4-183 6.52e-37

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 126.20  E-value: 6.52e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887    4 ITGGRFKGRHVRTLSSHKTRYTPALARRAFFDMI--DITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKS 81
Cdd:pfam03602   3 IIGGKARGRKLKVPPGPGTRPTTDRVREALFNWLapYIEGARVLDLFAGSGALGLEALSRGAKRVTLVEKDKRAVQILKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887   82 NRDSLGIASDEIRivcTDFRRALKSFATSSQSFDVIFADPPFEKGffsDLVKNFgkfvDYLR-------DSLIVIETSGE 154
Cdd:pfam03602  83 NLQLLGLPGAVLV---MDALLALLRLAGKGPVFDIVFLDPPYAKG---LIEEVL----DLLAekgwlkpNALIYVETEKR 152

                         170       180       190
                  ....*....|....*....|....*....|
gi 973153887  155 ylaefTTCLESSD-FVLTRNKSYSGVNLVF 183
Cdd:pfam03602 153 -----GELPEQPGnLELVREKKYGQTTLAF 177
TIGR00095 TIGR00095
16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; This model represents a family of ...
 1-185 4.12e-35

16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; This model represents a family of uncharacterized bacterial proteins. Members are present in nearly every complete bacterial genome, always in a single copy. PSI-BLAST analysis shows homology to several families of SAM-dependent methyltransferases, including ribosomal RNA adenine dimethylases. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188022 [Multi-domain]  Cd Length: 190  Bit Score: 122.13  E-value: 4.12e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887    1 MLTITGGRFKGRHVRTLSSHKTRYTPALARRAFFDMI--DITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSV 78
Cdd:TIGR00095   9 KIRIIGGQYRGRKLKVPPGPSTRPTTDRVRESLFNILrpDIVGAHFLDLFAGSGALGLEALSRGAASAVFVEQDRKVAQT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887   79 IKSNRDSLGiASDEIRIVCTDFRRALKSFATSSQSFDVIFADPPFEKGFFSDLVKNFGKFVDYLRDSLIVIETSGEYlaE 158
Cdd:TIGR00095  89 LKENLSTLK-KSGEQATVLNDAVRALLFLAKKQTPFDIIYLDPPFNRGLLEALLELLGENKWLNPKGLIVVEYDREN--E 165

                         170       180
                  ....*....|....*....|....*..
gi 973153887  159 FTTCLESsdFVLTRNKSYSGVNLVFLE 185
Cdd:TIGR00095 166 LPTVPET--WSLLRQKVYGQSALRLYQ 190
rsmD PRK10909
16S rRNA m(2)G966-methyltransferase; Provisional
 4-154 6.30e-20

16S rRNA m(2)G966-methyltransferase; Provisional


Pssm-ID: 236793  Cd Length: 199  Bit Score: 82.85  E-value: 6.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887   4 ITGGRFKGRHVRTLSSHKTRYTPALARRAFFD--MIDITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKS 81
Cdd:PRK10909  15 IIGGQWRGRKLPVPDSPGLRPTTDRVRETLFNwlAPVIVDARCLDCFAGSGALGLEALSRYAAGATLLEMDRAVAQQLIK 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 973153887  82 NRDSLGiaSDEIRIVCTDfrrALKSFATSSQSFDVIFADPPFEKGFFSD---LVKNFGKFVDylrDSLIVIETSGE 154
Cdd:PRK10909  95 NLATLK--AGNARVVNTN---ALSFLAQPGTPHNVVFVDPPFRKGLLEEtinLLEDNGWLAD---EALIYVESEVE 162
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
24-123 6.29e-10

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 56.07  E-value: 6.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  24 YTPA-LARRAFFDMI---DITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKSNRDSLGiasDEIRIVCTD 99
Cdd:COG2263   25 PTPAeLAAELLHLAYlrgDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIARENAERLG---VRVDFIRAD 101

                         90       100
                 ....*....|....*....|....
gi 973153887 100 FRRalksfATSSQSFDVIFADPPF 123
Cdd:COG2263  102 VTR-----IPLGGSVDTVVMNPPF 120
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 41-122 2.19e-07

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 49.79  E-value: 2.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  41 GRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKSNRDSLGIAsDEIRIVCTDFRRALKSFATSSQSFDVIFAD 120
Cdd:COG1092  217 GKRVLNLFSYTGGFSVHAAAGGAKSVTSVDLSATALEWAKENAALNGLD-DRHEFVQADAFDWLRELAREGERFDLIILD 295


                 ..
gi 973153887 121 PP 122
Cdd:COG1092  296 PP 297
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 43-143 4.12e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 46.65  E-value: 4.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  43 TFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKSNRDSLGIasDEIRIVCTDFRRALKSfatSSQSFDVIFADPP 122
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLA--DNVEVLKGDAEELPPE---ADESFDVIISDPP 75

                         90       100
                 ....*....|....*....|.
gi 973153887 123 FEkGFFSDLVKNFGKFVDYLR 143
Cdd:cd02440   76 LH-HLVEDLARFLEEARRLLK 95
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 25-122 6.55e-06

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 45.55  E-value: 6.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  25 TPALARRAFfDMIDITG-RTFLDLFAGSGIMSLeALSRQASLAVPVEVSRSACSVIKSNRDSLGIasDEIRIVCTDFRRA 103
Cdd:COG2265  218 AEALYAAAL-EWLDLTGgERVLDLYCGVGTFAL-PLARRAKKVIGVEIVPEAVEDARENARLNGL--KNVEFVAGDLEEV 293

                         90
                 ....*....|....*....
gi 973153887 104 LKSFAtSSQSFDVIFADPP 122
Cdd:COG2265  294 LPELL-WGGRPDVVVLDPP 311
PRK14967 PRK14967
putative methyltransferase; Provisional
 39-123 6.61e-05

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 41.96  E-value: 6.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  39 ITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSAcsVIKSNRDSLGiASDEIRIVCTDFRRALKsfatsSQSFDVIF 118
Cdd:PRK14967  35 GPGRRVLDLCTGSGALAVAAAAAGAGSVTAVDISRRA--VRSARLNALL-AGVDVDVRRGDWARAVE-----FRPFDVVV 106


                 ....*
gi 973153887 119 ADPPF 123
Cdd:PRK14967 107 SNPPY 111
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 28-122 1.72e-04

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 40.90  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  28 LARRAFFDMIDITGRTFLDLFAGSGIMSLE-ALSRQASLAVPVEVSRSACSVIKSNRDSLGIAsDEIRIVCTDFRRALKs 106
Cdd:COG2890  100 LVELALALLPAGAPPRVLDLGTGSGAIALAlAKERPDARVTAVDISPDALAVARRNAERLGLE-DRVRFLQGDLFEPLP- 177

                         90
                 ....*....|....*.
gi 973153887 107 fatSSQSFDVIFADPP 122
Cdd:COG2890  178 ---GDGRFDLIVSNPP 190
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
41-122 4.27e-04

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 39.89  E-value: 4.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  41 GRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKSNRDSLGIASDEIRIVCTDFRRALKSFAtsSQSFDVIFAD 120
Cdd:COG2521  133 GDRVLDTCTGLGYTAIEALKRGAREVITVEKDPNVLELAELNPWSRELANERIKIILGDASEVIKTFP--DESFDAIIHD 210


                 ..
gi 973153887 121 PP 122
Cdd:COG2521  211 PP 212
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 41-123 6.32e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 39.36  E-value: 6.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  41 GRTFLDLFAGSGIMSLEALSRQASLAV-PVEVSRSACSVIKSNRDSLGIAsDEIRIVCTDFRRALKSFATssQSFDVIFA 119
Cdd:COG4123   38 GGRVLDLGTGTGVIALMLAQRSPGARItGVEIQPEAAELARRNVALNGLE-DRITVIHGDLKEFAAELPP--GSFDLVVS 114


                 ....
gi 973153887 120 DPPF 123
Cdd:COG4123  115 NPPY 118
Methyltransf_15 pfam09445
RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as ...
 41-122 6.97e-04

RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.


Pssm-ID: 370496  Cd Length: 165  Bit Score: 38.47  E-value: 6.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887   41 GRTFLDLFAGSGIMSLE-ALSRQASLAVpvEVSRSACSVIKSNRDSLGIaSDEIRIVCTDFRRALKSFATSSQSFDVIFA 119
Cdd:pfam09445   1 ATRILDVFCGGGGNTIQfANVFDSVISI--DINLEHLACAQHNAEVYGV-SDRIWLIHGDWFELLAKLKFEKIKYDCVFA 77


                  ...
gi 973153887  120 DPP 122
Cdd:pfam09445  78 SPP 80
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
94-150 7.15e-04

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 39.14  E-value: 7.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 973153887  94 RIVCTDFRRALKSFAtsSQSFDVIFADPPF----EKGFFSDLVKNFGKFVDYLRDSLIVIE 150
Cdd:COG0863    1 RLICGDCLEVLKELP--DESVDLIVTDPPYnlgkKYGLGRREIGNELSFEEYLEFLREWLA 59
PRK15128 PRK15128
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;
20-122 1.43e-03

23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;


Pssm-ID: 185082 [Multi-domain]  Cd Length: 396  Bit Score: 38.66  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  20 HKTRY-----TPALARRAFfdmidITGRTFLDLFAGSGIMSLEALSRQASLAVPVEVSRSACSVIKSNRDSLGIASDEIR 94
Cdd:PRK15128 200 HKTGYyldqrDSRLATRRY-----VENKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKLDLSKAE 274

                         90       100
                 ....*....|....*....|....*...
gi 973153887  95 IVCTDFRRALKSFATSSQSFDVIFADPP 122
Cdd:PRK15128 275 FVRDDVFKLLRTYRDRGEKFDVIVMDPP 302
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 26-123 1.53e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 37.62  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973153887  26 PALARRaffdMIDIT----GRTFLDLFAGSGIMSLEALSRQASlAVPVEVSRSACSVIKSNRDSLGIasDEIRIVCTDFR 101
Cdd:COG1041   12 PRLARA----LVNLAgakeGDTVLDPFCGTGTILIEAGLLGRR-VIGSDIDPKMVEGARENLEHYGY--EDADVIRGDAR 84

                         90       100
                 ....*....|....*....|..
gi 973153887 102 RalksFATSSQSFDVIFADPPF 123
Cdd:COG1041   85 D----LPLADESVDAIVTDPPY 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH