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Conserved domains on  [gi|998177827|gb|KXH77203|]
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hypothetical protein AM326_12590 [Candidatus Thorarchaeota archaeon SMTZ-45]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
3-146 4.44e-38

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 126.05  E-value: 4.44e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998177827   3 ELDDKDNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRFTIDIDGKKIGKGLVAYILCTVSYRSARge 82
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 998177827  83 kinqlEVAQVIKELQDVEEVFIVTGDNDMIVKVAVKDVDALNDFVIFTLRNIEGVERTVTSVVL 146
Cdd:COG1522   80 -----EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
3-146 4.44e-38

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 126.05  E-value: 4.44e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998177827   3 ELDDKDNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRFTIDIDGKKIGKGLVAYILCTVSYRSARge 82
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 998177827  83 kinqlEVAQVIKELQDVEEVFIVTGDNDMIVKVAVKDVDALNDFVIFTLRNIEGVERTVTSVVL 146
Cdd:COG1522   80 -----EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-117 5.28e-25

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 91.81  E-value: 5.28e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998177827     4 LDDKDNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRFTIDIDGKKIGKGLVAYILCTVSYRSArgek 83
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDK---- 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 998177827    84 inQLEVAQVIKELQDVEEVFIVTGDNDMIVKVAV 117
Cdd:smart00344  77 --LEEFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 88-148 3.05e-15

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 66.01  E-value: 3.05e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 998177827   88 EVAQVIKELQDVEEVFIVTGDNDMIVKVAVKDVDALNDFVIFTLRNIEGVERTVTSVVLSE 148
Cdd:pfam01037  13 EFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-146 7.82e-15

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 67.04  E-value: 7.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998177827   1 MNELDDKDNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRFTIDIDGKKIGKGLVAYIlcTVSYRSAR 80
Cdd:PRK11179   4 NYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFI--GIILKSAK 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 998177827  81 gekinqlEVAQVIKELQDVEEV---FIVTGDNDMIVKVAVKDVDALNDFVIFTLRNIEGVERTVTSVVL 146
Cdd:PRK11179  82 -------DYPSALAKLESLDEVveaYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISL 143
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
3-146 4.44e-38

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 126.05  E-value: 4.44e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998177827   3 ELDDKDNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRFTIDIDGKKIGKGLVAYILCTVSYRSARge 82
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 998177827  83 kinqlEVAQVIKELQDVEEVFIVTGDNDMIVKVAVKDVDALNDFVIFTLRNIEGVERTVTSVVL 146
Cdd:COG1522   80 -----EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-117 5.28e-25

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 91.81  E-value: 5.28e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998177827     4 LDDKDNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRFTIDIDGKKIGKGLVAYILCTVSYRSArgek 83
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDK---- 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 998177827    84 inQLEVAQVIKELQDVEEVFIVTGDNDMIVKVAV 117
Cdd:smart00344  77 --LEEFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 88-148 3.05e-15

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 66.01  E-value: 3.05e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 998177827   88 EVAQVIKELQDVEEVFIVTGDNDMIVKVAVKDVDALNDFVIFTLRNIEGVERTVTSVVLSE 148
Cdd:pfam01037  13 EFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-146 7.82e-15

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 67.04  E-value: 7.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998177827   1 MNELDDKDNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRFTIDIDGKKIGKGLVAYIlcTVSYRSAR 80
Cdd:PRK11179   4 NYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFI--GIILKSAK 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 998177827  81 gekinqlEVAQVIKELQDVEEV---FIVTGDNDMIVKVAVKDVDALNDFVIFTLRNIEGVERTVTSVVL 146
Cdd:PRK11179  82 -------DYPSALAKLESLDEVveaYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISL 143
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-149 8.09e-11

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 56.69  E-value: 8.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998177827   3 ELDDKDNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRFTIDIDGKKIGKGLVAYILCTVSyrsaRGE 82
Cdd:PRK11169  11 DLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLN----RGA 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 998177827  83 KINQLEVAQVIKELQDVEEVFIVTGDNDMIVKVAVKDVDALNDFVIFTLRNIEGVERTVTSVVLSEI 149
Cdd:PRK11169  87 PDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEV 153
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
5-44 2.97e-07

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 44.28  E-value: 2.97e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 998177827    5 DDKDNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNL 44
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRL 40
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
6-50 5.21e-07

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 43.96  E-value: 5.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 998177827    6 DKDNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGII 50
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 3-53 7.32e-07

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 44.52  E-value: 7.32e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 998177827   3 ELDDKDNRILLLLKENS-RMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRF 53
Cdd:COG2512   12 ELLEDERRVLELLRENGgRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKE 63
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
8-62 1.89e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 42.17  E-value: 1.89e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 998177827   8 DNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRftiDIDGKKI 62
Cdd:COG3398   99 PRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVER---ERDGRNV 150
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 10-51 3.83e-05

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 39.44  E-value: 3.83e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 998177827   10 RILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIK 51
Cdd:pfam12840  14 RILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVE 55
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
10-62 3.54e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.57  E-value: 3.54e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 998177827    10 RILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRFTIDIDGKKI 62
Cdd:smart00347  14 LVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSV 66
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
10-54 6.70e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 38.37  E-value: 6.70e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 998177827  10 RILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRFT 54
Cdd:COG2345   17 RILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
10-52 2.22e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 36.80  E-value: 2.22e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 998177827  10 RILLLLKENSRmTTKEMSKELEIPQTTIHNRIKNLAQRGIIKR 52
Cdd:COG4742   20 NILLLLAEGPK-TRSELAESLDVSRSTILRQLKELEERGLIER 61
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-62 2.46e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.10  E-value: 2.46e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 998177827  10 RILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRFTIDIDGKKI 62
Cdd:COG1846   42 RVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAV 94
YrhO COG1378
Sugar-specific transcriptional regulator TrmB [Transcription];
4-52 3.38e-03

Sugar-specific transcriptional regulator TrmB [Transcription];


Pssm-ID: 440988 [Multi-domain]  Cd Length: 238  Bit Score: 36.15  E-value: 3.38e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 998177827   4 LDDKDNRILLLLKENSRMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKR 52
Cdd:COG1378   11 LSEYEAKVYLALLELGPATASELAKASGVPRSRVYDVLESLEEKGLVEV 59
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
10-62 6.08e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 33.72  E-value: 6.08e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 998177827    10 RILLLLKENSrMTTKEMSKELEIPQTTIHNRIKNLAQRGIIKRftiDIDGKKI 62
Cdd:smart00418   1 KILKLLAEGE-LCVCELAEILGLSQSTVSHHLKKLREAGLVES---RREGKRV 49
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 1-52 8.04e-03

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 34.89  E-value: 8.04e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 998177827   1 MNELDDKDNRILLLLKENSRM-----TTKEMSKELEIPQTTIHNRIKNLAQRGIIKR 52
Cdd:COG1974    1 MKKLTKRQREILDFIKEYIRErgyppSQREIAEALGLSSSAVHRHLKALEKKGYLRR 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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