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Conserved domains on  [gi|54400716|ref|NP_001005875|]
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26S proteasome non-ATPase regulatory subunit 12 [Rattus norvegicus]

Protein Classification

26S proteasome non-ATPase regulatory subunit 12( domain architecture ID 231523)

26S proteasome non-ATPase regulatory subunit 12 (PSMD12), also known as RPN7, is a non-ATPase subunit of the 19S regulatory complex of the 26S proteasome which is involved in the recognition of ubiquitinated protein substrates, and it plays a role in the degradation of these substrates by the proteasome

Gene Ontology:  GO:0005838|GO:0043161
PubMed:  24706844

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RPN5 super family cl21585
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
14-456 3.30e-133

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG5071:

Pssm-ID: 227403 [Multi-domain]  Cd Length: 439  Bit Score: 391.23  E-value: 3.30e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716  14 VKMEVDYSATVDQRLPECEKLAKEGrLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKR 93
Cdd:COG5071   3 QKPEVDYSEKFAELQKSLNNLNTID-IDANLEKLLIFEKKVRQASDTSTNTKVLIYIADLLFSAGDFQGLNEQLVSLFKK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716  94 RSQLKQAVAKMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVET 173
Cdd:COG5071  82 HGQLKQSITSMIQHVMEYLKGIDDLKTKINLIETLRTVTEGKIFVEVERARLTQLLSQIKEEQGDIKSAQDILCNEPVET 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716 174 YGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDT 253
Cdd:COG5071 162 YGSFDLSEKVAFILEQVRLFLLRSDYYMASTYTKKINKKFFEKEDVQSLKLKYYELKVRIGLHDRAYLDVCKYYRAVYDT 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716 254 PCIQAESDKWQQALKSVVLYVILAPFDNEQSDLVHRISSDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGVELRKgss 333
Cdd:COG5071 242 AVVQEDPAKWKEVLSNVVCFALLTPYDNEQADLLHKINADHKLNSLPLLQQLVKCFIVNELMRWPKVAEIYGSALRS--- 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716 334 etpatDVFS-STEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGV 412
Cdd:COG5071 319 -----NVFAfNDEKGEKRWSDLRKRVIEHNIRVIANYYSRIHCSRLGVLLDMSPSETEQFISDLVNKGHFYAKINRPAQI 393
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 54400716 413 INFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ 456
Cdd:COG5071 394 ISFEKSQNVQEQLNEWGSNVTELLGKLEKVRHLIIKEEMMNSIQ 437
 
Name Accession Description Interval E-value
RPN5 COG5071
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
14-456 3.30e-133

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227403 [Multi-domain]  Cd Length: 439  Bit Score: 391.23  E-value: 3.30e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716  14 VKMEVDYSATVDQRLPECEKLAKEGrLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKR 93
Cdd:COG5071   3 QKPEVDYSEKFAELQKSLNNLNTID-IDANLEKLLIFEKKVRQASDTSTNTKVLIYIADLLFSAGDFQGLNEQLVSLFKK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716  94 RSQLKQAVAKMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVET 173
Cdd:COG5071  82 HGQLKQSITSMIQHVMEYLKGIDDLKTKINLIETLRTVTEGKIFVEVERARLTQLLSQIKEEQGDIKSAQDILCNEPVET 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716 174 YGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDT 253
Cdd:COG5071 162 YGSFDLSEKVAFILEQVRLFLLRSDYYMASTYTKKINKKFFEKEDVQSLKLKYYELKVRIGLHDRAYLDVCKYYRAVYDT 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716 254 PCIQAESDKWQQALKSVVLYVILAPFDNEQSDLVHRISSDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGVELRKgss 333
Cdd:COG5071 242 AVVQEDPAKWKEVLSNVVCFALLTPYDNEQADLLHKINADHKLNSLPLLQQLVKCFIVNELMRWPKVAEIYGSALRS--- 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716 334 etpatDVFS-STEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGV 412
Cdd:COG5071 319 -----NVFAfNDEKGEKRWSDLRKRVIEHNIRVIANYYSRIHCSRLGVLLDMSPSETEQFISDLVNKGHFYAKINRPAQI 393
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 54400716 413 INFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ 456
Cdd:COG5071 394 ISFEKSQNVQEQLNEWGSNVTELLGKLEKVRHLIIKEEMMNSIQ 437
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
300-417 1.13e-18

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 81.11  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716   300 PKYKDLLKLFTTMELMRWSTLVEDYGVELRKgssetpatDVFSSTeegekRWKDLKNRVVEHNIRIMAKYYTRITMKRMA 379
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLL--------DDGLAE-----HLEDLRRKIREHNLRQLSKPYSSISLSDLA 67
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 54400716   380 QLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGVINFQR 417
Cdd:pfam01399  68 KLLGLSVDEVEKILAKLIRDGRIRAKIDQVNGIVVFSK 105
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
349-435 4.26e-16

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 73.05  E-value: 4.26e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716    349 KRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGVINFQRPKDPN-NLLND 427
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRsEPLAQ 80

                   ....*...
gi 54400716    428 WSQKLNSL 435
Cdd:smart00088  81 FAETLKKL 88
 
Name Accession Description Interval E-value
RPN5 COG5071
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
14-456 3.30e-133

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227403 [Multi-domain]  Cd Length: 439  Bit Score: 391.23  E-value: 3.30e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716  14 VKMEVDYSATVDQRLPECEKLAKEGrLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKR 93
Cdd:COG5071   3 QKPEVDYSEKFAELQKSLNNLNTID-IDANLEKLLIFEKKVRQASDTSTNTKVLIYIADLLFSAGDFQGLNEQLVSLFKK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716  94 RSQLKQAVAKMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVET 173
Cdd:COG5071  82 HGQLKQSITSMIQHVMEYLKGIDDLKTKINLIETLRTVTEGKIFVEVERARLTQLLSQIKEEQGDIKSAQDILCNEPVET 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716 174 YGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDT 253
Cdd:COG5071 162 YGSFDLSEKVAFILEQVRLFLLRSDYYMASTYTKKINKKFFEKEDVQSLKLKYYELKVRIGLHDRAYLDVCKYYRAVYDT 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716 254 PCIQAESDKWQQALKSVVLYVILAPFDNEQSDLVHRISSDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGVELRKgss 333
Cdd:COG5071 242 AVVQEDPAKWKEVLSNVVCFALLTPYDNEQADLLHKINADHKLNSLPLLQQLVKCFIVNELMRWPKVAEIYGSALRS--- 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716 334 etpatDVFS-STEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGV 412
Cdd:COG5071 319 -----NVFAfNDEKGEKRWSDLRKRVIEHNIRVIANYYSRIHCSRLGVLLDMSPSETEQFISDLVNKGHFYAKINRPAQI 393
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 54400716 413 INFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ 456
Cdd:COG5071 394 ISFEKSQNVQEQLNEWGSNVTELLGKLEKVRHLIIKEEMMNSIQ 437
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
300-417 1.13e-18

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 81.11  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716   300 PKYKDLLKLFTTMELMRWSTLVEDYGVELRKgssetpatDVFSSTeegekRWKDLKNRVVEHNIRIMAKYYTRITMKRMA 379
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLL--------DDGLAE-----HLEDLRRKIREHNLRQLSKPYSSISLSDLA 67
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 54400716   380 QLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGVINFQR 417
Cdd:pfam01399  68 KLLGLSVDEVEKILAKLIRDGRIRAKIDQVNGIVVFSK 105
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
349-435 4.26e-16

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 73.05  E-value: 4.26e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400716    349 KRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGVINFQRPKDPN-NLLND 427
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRsEPLAQ 80

                   ....*...
gi 54400716    428 WSQKLNSL 435
Cdd:smart00088  81 FAETLKKL 88
RPN5_C pfam18098
26S proteasome regulatory subunit RPN5 C-terminal domain; This is the C-terminal domain of the ...
422-453 1.18e-12

26S proteasome regulatory subunit RPN5 C-terminal domain; This is the C-terminal domain of the 26S proteasome regulatory subunit RPN5 proteins.This helical domain can be found adjacent to pfam01399. The 26S proteasome is the major ATP-dependent protease in eukaryotes. Three subcomplexes form this degradation machine: the lid, the base, and the core. The helices found at the C terminus of each lid subunit form a helical bundle that directs the ordered self-assembly of the lid subcomplex. This domain which comprises the tail of RPN5 along with the tail of Rpn9, are important for Rpn12 binding to the lid.


Pssm-ID: 436272  Cd Length: 32  Bit Score: 61.86  E-value: 1.18e-12
                          10        20        30
                  ....*....|....*....|....*....|..
gi 54400716   422 NNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIH 453
Cdd:pfam18098   1 NEVLNEWSHNVNSLLELVEKTTHLINKEEMVH 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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