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Conserved domains on  [gi|218563732|ref|NP_001007433|]
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N-acetylgalactosamine kinase [Danio rerio]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 16-453 2.63e-155

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 449.54  E-value: 2.63e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  16 ERLQKLKAAFRDKYGQMPLFYACAPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVSVSD-TKTIQLTNTDPKYKDFAVSA 94
Cdd:PLN02521  30 LRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEgSKKLRIANVNDKYTTCTFPA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  95 D-AISIDRENPQWHYYFLCGVKGLQEHLSLSSLA-----GMCCVVDGTIPASSGLSSSSALVCCAGLLAMEANHRSLSKV 168
Cdd:PLN02521 110 DpDQEVDLANHKWGNYFICGYKGVFEFLKSKGVDvgppvGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKK 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 169 TLAEMCAKCERYIGTEGGGMDQSISFLAEEGTAKLIEFNPLRATDVKLPDGAVFVIANCCVEMNKA--ASSHFNMRVVEC 246
Cdd:PLN02521 190 EVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAvtAATNYNNRVVEC 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 247 RLATKMLAKARGLDWRRLLK----LGDLQKeLRVSLEEM------LELLEELLHPEPYSREEICRSLGitdQQLGEDILS 316
Cdd:PLN02521 270 RLAAIVLAVKLGMSAEEAISkvktLSDVEG-LCVSFAGShgssdpAVAVKELLHEGPYTAEEIEEILG---ESLTSIFKN 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 317 ANT-----QHATHFKLYQRARHVYGEAARVLQFKAVCDS--SPASAITQLGDLMKQSHGSCRDLYECSCPELDQLVDICL 389
Cdd:PLN02521 346 SPTslavlKAAKHFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCR 425

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218563732 390 QAGAVGSRLTGAGWGGCTVSMVPGERIDSFLQTVRERYYMPDARRAALEKQSL----FVTRPGGGAAI 453
Cdd:PLN02521 426 DNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKSRIEKGVIKEEDLglyvFASKPSSGAAI 493
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 16-453 2.63e-155

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 449.54  E-value: 2.63e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  16 ERLQKLKAAFRDKYGQMPLFYACAPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVSVSD-TKTIQLTNTDPKYKDFAVSA 94
Cdd:PLN02521  30 LRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEgSKKLRIANVNDKYTTCTFPA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  95 D-AISIDRENPQWHYYFLCGVKGLQEHLSLSSLA-----GMCCVVDGTIPASSGLSSSSALVCCAGLLAMEANHRSLSKV 168
Cdd:PLN02521 110 DpDQEVDLANHKWGNYFICGYKGVFEFLKSKGVDvgppvGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKK 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 169 TLAEMCAKCERYIGTEGGGMDQSISFLAEEGTAKLIEFNPLRATDVKLPDGAVFVIANCCVEMNKA--ASSHFNMRVVEC 246
Cdd:PLN02521 190 EVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAvtAATNYNNRVVEC 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 247 RLATKMLAKARGLDWRRLLK----LGDLQKeLRVSLEEM------LELLEELLHPEPYSREEICRSLGitdQQLGEDILS 316
Cdd:PLN02521 270 RLAAIVLAVKLGMSAEEAISkvktLSDVEG-LCVSFAGShgssdpAVAVKELLHEGPYTAEEIEEILG---ESLTSIFKN 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 317 ANT-----QHATHFKLYQRARHVYGEAARVLQFKAVCDS--SPASAITQLGDLMKQSHGSCRDLYECSCPELDQLVDICL 389
Cdd:PLN02521 346 SPTslavlKAAKHFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCR 425

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218563732 390 QAGAVGSRLTGAGWGGCTVSMVPGERIDSFLQTVRERYYMPDARRAALEKQSL----FVTRPGGGAAI 453
Cdd:PLN02521 426 DNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKSRIEKGVIKEEDLglyvFASKPSSGAAI 493
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 19-427 4.39e-80

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 253.21  E-value: 4.39e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732   19 QKLKAAFRDKYGQMPLFYACAPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVSVSDTK--TIQLTNTDPKYKDFavSADA 96
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKnvRIYLANADNKFAER--SLDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732   97 ISIDRENPQWHYYFLCGVKGLQEHLSlSSLAGMCCVVDGTIPASSGLSSSSALVCCAGLLAMEANHRSLSKVTLAEMCAK 176
Cdd:TIGR00131  80 PLDGSEVSDWANYFKGVLHVAQERFN-SFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  177 CE-RYIGTEGGGMDQSISFLAEEGTAKLIEFNPLRATDVKLP-DGAVFVIANCCVEMNKAASShFNMRVVECRLATKMLA 254
Cdd:TIGR00131 159 AEnHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRTLAPSN-YNTRRQECTTAANFLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  255 KargldwRRLLKLGDLQkelrvsleemlelleellhPEPYSREEiCRSLGItdQQLGEdilsantqhathfklyQRARHV 334
Cdd:TIGR00131 238 A------TDKGALRDFM-------------------NEYFARYI-ARLTKM--LPLVE----------------ERAKHV 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  335 YGEAARVLQ-FKAVCDSSpasaITQLGDLMKQSHGSCRDLYECSCPELDQLVD-ICLQAGAVGSRLTGAGWGGCTVSMVP 412
Cdd:TIGR00131 274 VSENLRVLKaVKAMKDND----FKQFGALMNESHASCDDDYECTCPEIDELVCsAALVNGSGGSRMTGAGFGGCTVHLVP 349

                         410
                  ....*....|....*
gi 218563732  413 GERIDSFLQTVRERY 427
Cdd:TIGR00131 350 NENVDKVRQAVADKY 364
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
17-451 5.76e-79

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 250.07  E-value: 5.76e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  17 RLQKLKAAFRDKYGQMPLFYACAPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVSVSDTKTIQLTNTDPKyKDFAVSADA 96
Cdd:COG0153    1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFD-EEVEFDLDD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  97 ISIDREnPQWHYYFLcGV-KGLQEH-LSLSslaGMCCVVDGTIPAssglssssalvcCAGL-----------LAM-EANH 162
Cdd:COG0153   80 LEPGEE-DGWANYVR-GVaWALQERgYKLG---GFDLVIDGDVPL------------GAGLsssaalevavaLALnDLFG 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 163 RSLSKVTLAEMCAKCE-RYIGTEGGGMDQSISFLAEEGTAKLIEFNPLRATDVKLP-DGAVFVIANCCVEMNkAASSHFN 240
Cdd:COG0153  143 LGLDPVELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYN 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 241 MRVVECRLATKMLAKARgldwrrllkLGDLQKELrvsleemlelleellhpepysreeicrsLGITDQQLGEDIlsantq 320
Cdd:COG0153  222 ERRAECEAAAAILGVKS---------LRDVTLED----------------------------LEAARARLGDEV------ 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 321 hathfkLYQRARHVYGEAARVLQFKAVCDsspASAITQLGDLMKQSHGSCRDLYECSCPELDQLVDICL-QAGAVGSRLT 399
Cdd:COG0153  259 ------LRRRARHVVTENQRVLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALaEAGVLGARMT 329

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 218563732 400 GAGWGGCTVSMVPGERIDSFLQTVRERYYmpdarRAALEKQSLFVTRPGGGA 451
Cdd:COG0153  330 GGGFGGCTIALVPKDAVDEFIEAVAEAYA-----EKTGLEPDFYVVKPSDGA 376
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 23-71 2.87e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 89.43  E-value: 2.87e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 218563732   23 AAFRDKYGQMPLFYACAPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVS 71
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVS 49
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 16-453 2.63e-155

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 449.54  E-value: 2.63e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  16 ERLQKLKAAFRDKYGQMPLFYACAPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVSVSD-TKTIQLTNTDPKYKDFAVSA 94
Cdd:PLN02521  30 LRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEgSKKLRIANVNDKYTTCTFPA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  95 D-AISIDRENPQWHYYFLCGVKGLQEHLSLSSLA-----GMCCVVDGTIPASSGLSSSSALVCCAGLLAMEANHRSLSKV 168
Cdd:PLN02521 110 DpDQEVDLANHKWGNYFICGYKGVFEFLKSKGVDvgppvGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKK 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 169 TLAEMCAKCERYIGTEGGGMDQSISFLAEEGTAKLIEFNPLRATDVKLPDGAVFVIANCCVEMNKA--ASSHFNMRVVEC 246
Cdd:PLN02521 190 EVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAvtAATNYNNRVVEC 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 247 RLATKMLAKARGLDWRRLLK----LGDLQKeLRVSLEEM------LELLEELLHPEPYSREEICRSLGitdQQLGEDILS 316
Cdd:PLN02521 270 RLAAIVLAVKLGMSAEEAISkvktLSDVEG-LCVSFAGShgssdpAVAVKELLHEGPYTAEEIEEILG---ESLTSIFKN 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 317 ANT-----QHATHFKLYQRARHVYGEAARVLQFKAVCDS--SPASAITQLGDLMKQSHGSCRDLYECSCPELDQLVDICL 389
Cdd:PLN02521 346 SPTslavlKAAKHFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCR 425

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218563732 390 QAGAVGSRLTGAGWGGCTVSMVPGERIDSFLQTVRERYYMPDARRAALEKQSL----FVTRPGGGAAI 453
Cdd:PLN02521 426 DNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKSRIEKGVIKEEDLglyvFASKPSSGAAI 493
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 19-427 4.39e-80

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 253.21  E-value: 4.39e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732   19 QKLKAAFRDKYGQMPLFYACAPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVSVSDTK--TIQLTNTDPKYKDFavSADA 96
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKnvRIYLANADNKFAER--SLDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732   97 ISIDRENPQWHYYFLCGVKGLQEHLSlSSLAGMCCVVDGTIPASSGLSSSSALVCCAGLLAMEANHRSLSKVTLAEMCAK 176
Cdd:TIGR00131  80 PLDGSEVSDWANYFKGVLHVAQERFN-SFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  177 CE-RYIGTEGGGMDQSISFLAEEGTAKLIEFNPLRATDVKLP-DGAVFVIANCCVEMNKAASShFNMRVVECRLATKMLA 254
Cdd:TIGR00131 159 AEnHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRTLAPSN-YNTRRQECTTAANFLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  255 KargldwRRLLKLGDLQkelrvsleemlelleellhPEPYSREEiCRSLGItdQQLGEdilsantqhathfklyQRARHV 334
Cdd:TIGR00131 238 A------TDKGALRDFM-------------------NEYFARYI-ARLTKM--LPLVE----------------ERAKHV 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  335 YGEAARVLQ-FKAVCDSSpasaITQLGDLMKQSHGSCRDLYECSCPELDQLVD-ICLQAGAVGSRLTGAGWGGCTVSMVP 412
Cdd:TIGR00131 274 VSENLRVLKaVKAMKDND----FKQFGALMNESHASCDDDYECTCPEIDELVCsAALVNGSGGSRMTGAGFGGCTVHLVP 349

                         410
                  ....*....|....*
gi 218563732  413 GERIDSFLQTVRERY 427
Cdd:TIGR00131 350 NENVDKVRQAVADKY 364
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
17-451 5.76e-79

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 250.07  E-value: 5.76e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  17 RLQKLKAAFRDKYGQMPLFYACAPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVSVSDTKTIQLTNTDPKyKDFAVSADA 96
Cdd:COG0153    1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFD-EEVEFDLDD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  97 ISIDREnPQWHYYFLcGV-KGLQEH-LSLSslaGMCCVVDGTIPAssglssssalvcCAGL-----------LAM-EANH 162
Cdd:COG0153   80 LEPGEE-DGWANYVR-GVaWALQERgYKLG---GFDLVIDGDVPL------------GAGLsssaalevavaLALnDLFG 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 163 RSLSKVTLAEMCAKCE-RYIGTEGGGMDQSISFLAEEGTAKLIEFNPLRATDVKLP-DGAVFVIANCCVEMNkAASSHFN 240
Cdd:COG0153  143 LGLDPVELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYN 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 241 MRVVECRLATKMLAKARgldwrrllkLGDLQKELrvsleemlelleellhpepysreeicrsLGITDQQLGEDIlsantq 320
Cdd:COG0153  222 ERRAECEAAAAILGVKS---------LRDVTLED----------------------------LEAARARLGDEV------ 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 321 hathfkLYQRARHVYGEAARVLQFKAVCDsspASAITQLGDLMKQSHGSCRDLYECSCPELDQLVDICL-QAGAVGSRLT 399
Cdd:COG0153  259 ------LRRRARHVVTENQRVLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALaEAGVLGARMT 329

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 218563732 400 GAGWGGCTVSMVPGERIDSFLQTVRERYYmpdarRAALEKQSLFVTRPGGGA 451
Cdd:COG0153  330 GGGFGGCTIALVPKDAVDEFIEAVAEAYA-----EKTGLEPDFYVVKPSDGA 376
PRK05322 PRK05322
galactokinase; Provisional
 18-427 2.72e-46

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 164.65  E-value: 2.72e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  18 LQKLKAAFRDKYGQMP--LFYAcaPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVSVSDTKTIQL--TNTDPKYKdFAVS 93
Cdd:PRK05322   3 KEELKKKFAEVFGEEAedVFFS--PGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLysANFEDLGI-IEFD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  94 ADAISIDRENpQWHYYFLCGVKGLQEH-LSLSSlaGMCCVVDGTIPASSGLSSSSALVCCAGLLAMEANHRSLSKVTLAE 172
Cdd:PRK05322  80 LDDLSFDKED-DWANYPKGVLKFLQEAgYKIDH--GFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 173 MCAKCE-RYIGTEGGGMDQSISFLAEEGTAKLIEFNPLRATDVKLP-DGAVFVIANccveMNKA---ASSHFNMRVVECR 247
Cdd:PRK05322 157 LGQKTEnEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDlGDYVIVIMN----TNKRrelADSKYNERRAECE 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 248 LAtkmlakargldwrrllkLGDLQKELRVSleemlelleellhpepysreeicrSLG-ITDQQLGE--DILSANTqhath 324
Cdd:PRK05322 233 KA-----------------LEELQKKLDIK------------------------SLGeLTEEEFDEysYLIKDET----- 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 325 fkLYQRARHVYGEAARVLQ-FKAVCDSSpasaITQLGDLMKQSHGSCRDLYECSCPELDQLVDICL-QAGAVGSRLTGAG 402
Cdd:PRK05322 267 --LLKRARHAVTENQRTLKaVKALKAGD----LEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWkQEGVLGARMTGAG 340

                        410       420
                 ....*....|....*....|....*
gi 218563732 403 WGGCTVSMVPGERIDSFLQTVRERY 427
Cdd:PRK05322 341 FGGCAIAIVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 19-453 3.76e-40

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 148.15  E-value: 3.76e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  19 QKLKAAFRDKYGQMPLFYACAPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVSVSDTKTIQLTNTdpkykDFAVSADAIS 98
Cdd:PRK05101   5 QKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAA-----DYDNQQDEFS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  99 IDRE-----NPQWHYYFLCGVKGLQEHlsLSSLAGMCCVVDGTIPASsglssssalvccAGL---LAME---------AN 161
Cdd:PRK05101  80 LDAPivphpEQQWANYVRGVVKHLQER--NPDFGGADLVISGNVPQG------------AGLsssASLEvavgqtfqqLY 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 162 HRSLSKVTLAEMCAKCE-RYIGTEGGGMDQSISFLAEEGTAKLIEFNPLRATDVKLPDGAVFVIANCCVEMNkAASSHFN 240
Cdd:PRK05101 146 HLPLSGAEIALNGQEAEnQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYN 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 241 MRVVECRLATKMLAkargldwrrllklgdlQKELRvsleemlelleellhpepysreeicrslGITDQQLGEdilsanTQ 320
Cdd:PRK05101 225 TRRQQCETAARFFG----------------VKALR----------------------------DVTLEQFNA------VA 254

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 321 HATHFKLYQRARHVYGEAARVLQfkAVcDSSPASAITQLGDLMKQSHGSCRDLYECSCPELDQLVDIclqAGAV-----G 395
Cdd:PRK05101 255 AELDPVVAKRARHVITENARTLE--AA-SALAAGDLKRMGELMAESHASMRDDFEITVPQIDTLVEI---VKAVigdqgG 328

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 218563732 396 SRLTGAGWGGCTVSMVPGERIDSFLQTVRERYYmpdaRRAALeKQSLFVTRPGGGAAI 453
Cdd:PRK05101 329 VRMTGGGFGGCIVALVPEELVEAVRQAVAEQYE----AKTGL-KETFYVCKASQGAGQ 381
PRK03817 PRK03817
galactokinase; Provisional
 39-428 2.95e-32

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 125.88  E-value: 2.95e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  39 APGRVNLIGEHIDYC-GYaVLPMAIEQSILAAVSVSDtKTIQLTNTDPKYKDFAVSadaiSIDRENpQWHYYflcgVKGL 117
Cdd:PRK03817   5 SPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSE-KFIFYSENFNEEKTFELD----KLEKLN-SWADY----IKGV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 118 -----QEHLSLSSLAGMccvVDGTIPASsglssssalvccAGL-------LAM-----EANHRSLSKVTLAEMCAKCER- 179
Cdd:PRK03817  74 iwvleKRGYEVGGVKGK---VSSNLPIG------------AGLsssasleVAVayalnEAYNLNLSKLELALLAREAENe 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 180 YIGTEGGGMDQSISFLAEEGTAKLIEFNPLRATDVKLPDGAVFVIANCCVEmNKAASSHFNMRVVECRLATKMLAKARgl 259
Cdd:PRK03817 139 FVGVPCGIMDQFAVAFGKKDHAIFLDTMTLEYEYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKKS-- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 260 dwrrllklgdlqkelrvsleemlelleellhpepySREeicrslgITDQQLgedilsaNTQHATHFKlyqRARHVYGEAA 339
Cdd:PRK03817 216 -----------------------------------SKE-------VTEEDL-------SKLPPLLRK---RAGYVLRENE 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 340 RVLQFKavcDSSPASAITQLGDLMKQSHGSCRDLYECSCPELDQLVDICLQAGAVGSRLTGAGWGGCTVSMVPGERIDSF 419
Cdd:PRK03817 244 RVLKVR---DALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESI 320


                 ....*....
gi 218563732 420 LQTVRERYY 428
Cdd:PRK03817 321 GEELLEEYK 329
PRK00555 PRK00555
galactokinase; Provisional
 32-453 5.69e-32

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 125.36  E-value: 5.69e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  32 MPLFYAcAPGRVNLIGEHIDY-CGYAvLPMAIEQSILAAVSVSDTKTIQLTNtdpkykDFAVSADAISIDRENPQ---WH 107
Cdd:PRK00555   1 MTVRYA-APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLDTTPGQvtgWA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 108 YYFLCGVKGLQEHLSLSSLAGMCCVVDGTIpasSGLSSSSALVCCAGLLAMEANHRS-LSKVTLAEMCAKCER-YIGTEG 185
Cdd:PRK00555  73 AYAAGVIWALRGAGHPVPGGAMSITSDVEI---GSGLSSSAALECAVLGAVGAATGTrIDRLEQARLAQRAENeYVGAPT 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 186 GGMDQSISFLAEEGTAKLIEFNPLRATDVKL-PDGA-VFVIANCCVEMNKAASSHFNMRVVECRLAtkmlAKARGLDwrr 263
Cdd:PRK00555 150 GLLDQLAALFGAPKTALLIDFRDLTVRPVAFdPDAAgVVLLLMDSRARHRHAGGEYAARRASCERA----AADLGVS--- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 264 llKLGDLQkelrvsleemlelleellhpepysrEEICRSLGITDqqlgeDILSAntqhathfklyQRARHVYGEAARVLQ 343
Cdd:PRK00555 223 --SLRAVQ-------------------------DRGLAALGAIA-----DPIDA-----------RRARHVLTENQRVLD 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 344 FKAVCDSSPasaITQLGDLMKQSHGSCRDLYECSCPELDQLVDICLQAGAVGSRLTGAGWGGCTVSMVPGERIDSFLQTV 423
Cdd:PRK00555 260 FAAALADSD---FTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTV 336

                        410       420       430
                 ....*....|....*....|....*....|
gi 218563732 424 REryympDARRAALEKQSLFVTRPGGGAAI 453
Cdd:PRK00555 337 RR-----AAVTAGYPEPAVSRTYAAPGAGE 361
PLN02865 PLN02865
galactokinase
 37-453 4.30e-23

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 101.03  E-value: 4.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  37 ACAPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVSVSDTKTIQL-TNTDPKYKDFAVSADAISID------RENPQWHYY 109
Cdd:PLN02865  33 VVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLrSAQFEGEVRFRVDEIQHPIAnvssdsKEESNWGDY 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 110 FLCGVKGLQE---HLSlsslAGMCCVVDGTIPASSGLSSSSALVCCAGLLAME-ANHRSLSKVTLAEMCAKCE-RYIGTE 184
Cdd:PLN02865 113 ARGAVYALQSrghALS----QGITGYISGSEGLDSSGLSSSAAVGVAYLLALEnANNLTVSPEDNIELDRLIEnEYLGLR 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 185 GGGMDQSISFLAEEGTAKLIEFNPLRATDVKLPDGAV-------FVIANCCVEMNKAASSHFNMRVVECRLATKMLAKAR 257
Cdd:PLN02865 189 NGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPggekpfkILLAFSGLRHALTNKPGYNLRVSECQEAARFLLEAS 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 258 GLDwrrllklgDLQKELRvsleemlelleeLLHPEPYSREEIcrslgitdqqlgedILSANtqhathfkLYQRARHVYGE 337
Cdd:PLN02865 269 GND--------ELEPLLC------------NVEPEVYEAHKC--------------KLEAV--------LARRAEHYFSE 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 338 AARVLQ-FKAVCDSSpasaITQLGDLMKQSHGSCRDLYECSCPELDQLVDICLQA-GAVGSRLTGAGWGGCTVSMVPGER 415
Cdd:PLN02865 307 NMRVIKgVEAWASGN----LEEFGKLISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRGCCVAFVDAEM 382

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 218563732 416 IDSFLQTVRERYY--MPDARRAALEKQSLFVTRPGGGAAI 453
Cdd:PLN02865 383 AEEAASFVRDEYEkaQPELASNINGDKPVLICEAGDCARV 422
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 23-71 2.87e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 89.43  E-value: 2.87e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 218563732   23 AAFRDKYGQMPLFYACAPGRVNLIGEHIDYCGYAVLPMAIEQSILAAVS 71
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVS 49
PTZ00290 PTZ00290
galactokinase; Provisional
 18-427 1.29e-16

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 81.79  E-value: 1.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  18 LQKLKAAFRDKYGQMP------LFYACAPGRVNLIGEHIDYCGYAVLPMAIEQS--ILaavsVSDTKTIQltntDPKYKd 89
Cdd:PTZ00290  15 LSTLKPIFLETFKVENdadvewLLFTFAPGRVNFIGEHVDYMGGYVCPAAVLEGchIL----VGRVKHFC----DHKLR- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  90 FAVSADA-ISIDR-----ENPQWHYyFLCGVKGLQ-EHLSLS----SLAGMCCVVDGTIPASSGLSSSSA-LVCCAGLLA 157
Cdd:PTZ00290  86 FATETDEhFVLDHlggakHNKAWTT-FVRGAATLRlNRLGVAidapSLQGVCMVVHGTLPMGAGMSASASfGVALLNAIN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 158 MEANHR----------------SLSKVTLAEMCAKCER----YIGTEGGGMDQSISFLAEEG----------TAKLIEFN 207
Cdd:PTZ00290 165 TVVTRRykgcptspgrrysilpPMSKEELIELAKQARRieteFCGVNVGIMDQFISAFAEEDkfmfldckslTFESHDMT 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 208 PLratdvkLPDGAVFVIANCCV--EMNKAASSHFNMRVVECRLATKMLAKARgldwrrllklgdlqkelrvsleemlell 285
Cdd:PTZ00290 245 PL------LGDGACFLLIDSMIkhDLLGGTAGMYNTVRSDQEGAQKKIGKHR---------------------------- 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 286 eelLHPEPYSREEICRSlgitDQQLGED-----ILSANTQHATHFKlYQRARHVYGEAARVLQFKAVCDssPASAITQ-- 358
Cdd:PTZ00290 291 ---YRGKPFTFSDLVRN----PKKYTFDgdvvaFMESCKPLMTPGE-FERGTYNIMEQIRTLEFIKLND--PELPLSRee 360

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 218563732 359 ----LGDLMKQSHGSCRDLYECSCPELDQLVD-ICLQAGAVGSRLTGAGWGGCTVSMVPGERIDSFLQTVRERY 427
Cdd:PTZ00290 361 rfrkAGEILNAGHQGMRDLMKITTPELDFIHElINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKF 434
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 39-406 3.88e-09

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 57.54  E-value: 3.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732  39 APGRVNLIGEHIDYCGYAVLPMAIEQSILAAVSVSDTKTIQLtntDPKYKDFAVSADAIsidrENPQWHYyFLCGVKGLQ 118
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRI---ESPDLGGTLDLDPL----ADAALRY-IKAAIEAAL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 119 EHLSLSsLAGMCCVVDGTIPASsglssssalvccAGL-----LA-------MEANHRSLSKVTLAEMCAKCERYIGTEGG 186
Cdd:COG1577   73 EYLGLP-LKGFDIEIDSEIPRK------------RGLgssaaVAvaviralAAFYGVELSKEELFKLALEAEKIVHGNPS 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 187 GMDQSISFLaeEGtakLIEF-NPLRATDVKLPDGAVFVIANCCVemnkAASSHfnmrvvecrlatKMLAKARGLdWRRll 265
Cdd:COG1577  140 GLDTAASTY--GG---PIYYqRGDRAEPLELPKNLPLVVGDTGV----PASTK------------ELVAKVRKL-KER-- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 266 klgdlqkelrvsleemlelleellhpEPYSREEICRSLG-ITDQqlGEDILSANTqhathfklyqrarhvygeaarvlqf 344
Cdd:COG1577  196 --------------------------NPELYEAFLEEIGdLVEE--AIEALEEGD------------------------- 222

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 218563732 345 kavcdsspasaITQLGDLMKQSHGSCRDLYeCSCPELDQLVDICLQAGAVGSRLTGAGWGGC 406
Cdd:COG1577  223 -----------LEALGELMNENHGLLRALG-VSTPELDRLVEAARKAGALGAKLTGAGGGGC 272
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 313-426 4.90e-09

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 57.56  E-value: 4.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563732 313 DILSANTQHATHFK-LYQRARHVYGEAARVLQfkavcdsspASAITQLGDLMKQSHGSCRDLyECSCPELDQLVDICLQA 391
Cdd:PTZ00298 204 DVRKLKENQPTWFNrLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTY 273

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 218563732 392 GAVGSRLTGAGWGGCTVSMVPGE-RIDSFLQTVRER 426
Cdd:PTZ00298 274 GALGAKMSGTGRGGLVVALAASEdQRDAIAKAVRAR 309
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 358-408 8.89e-09

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 56.15  E-value: 8.89e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 218563732  358 QLGDLMKQSHGSCRDLyECSCPELDQLVDICLQAGAVGSRLTGAGWGGCTV 408
Cdd:TIGR00549 222 SLGELMNINQGLLKAL-GVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMI 271
PRK03926 PRK03926
mevalonate kinase; Provisional
 357-418 4.59e-08

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 54.29  E-value: 4.59e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 218563732 357 TQLGDLMKQSHGsCRDLYECSCPELDQLVDICLQAGAVGSRLTGAGWGGCTVSMVPGERIDS 418
Cdd:PRK03926 214 VSLGELMNINQG-LLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEKQSE 274
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 356-428 9.22e-08

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 49.39  E-value: 9.22e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218563732  356 ITQLGDLMKQSHGSC--RDLYECSCPELDQLVDICLQAGaVGSRLTGAGWGGCTVSMVPGE-RIDSFLQTVRERYY 428
Cdd:pfam08544  10 LEELGKLLTESAESLepLLVVGILPPELDELLEALLELG-LGAKLSGSGGGPTVFALFKDEdDAEEVARALREAGK 84
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 379-447 9.59e-05

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 44.40  E-value: 9.59e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218563732 379 PELDQLVDICLQAGAVGSRLTGAGWGGCTVSMVPGERIdsflqtvreryympDARRAALEKQSLFVTRP 447
Cdd:COG2605  263 PAIDEIYELARKAGALGGKLLGAGGGGFLLFYAPPERR--------------EAVREALSKAGLRVVPF 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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