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Conserved domains on  [gi|55956786|ref|NP_001007468|]
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protein SFI1 homolog isoform a [Homo sapiens]

Protein Classification

Sfi1 domain-containing protein( domain architecture ID 713344)

Sfi1 domain-containing protein similar to Homo sapiens coiled-coil domain-containing protein 191

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sfi1 super family cl25835
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 417-841 8.13e-11

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


The actual alignment was detected with superfamily member pfam08457:

Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 66.16  E-value: 8.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    417 LLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELWLQYTQKRRykqLLQARADGHFQQRALPAAFHTWn 494
Cdd:pfam08457   57 LRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAWRRRTLQIR---VREEVAVQVYQENLLKRSFWKW- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    495 rlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQ---- 570
Cdd:pfam08457  119 ---FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLREREQEAEAKRKRLLLSSALQIWSERTEAVQAAEqead 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    571 -------------EWQTVA---------CAHHRHGRLKKAFCLWRESAQGLRtertgrvRAAEFHMAQLLRWAWSQWR-- 626
Cdd:pfam08457  189 sfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKLRARMSR-------QAREVDRARILRNAWTTWNde 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    627 -ECLALRG----------------AERQKLMRAdlHHQHSVLHRALQAWVTyqgRVRSILREVAARESQH----NRQLLR 685
Cdd:pfam08457  262 lRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVLSTWVT---NTRDTRTRLLRHEEEFeehrNRKLLR 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    686 GALRRWKENTMAR---------VDEAKKTFQASTHYR------------------RTICSKVLVQWREAVSVQMYYRQQE 738
Cdd:pfam08457  337 SKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRerhqhvqklekwardarfYFLATRTLKKWRAATEESRRERRQD 416

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    739 DCA-IWEAQKV-LDRGCLRTWFQRwwdcSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLA 816
Cdd:pfam08457  417 AYAqVRRKVKInLARRALSKWRSK----AAEVADLEQQADQLRQNRLLEDAIELFDRWRERTAKRKQR---AEDADQFYA 489

                          490       500
                   ....*....|....*....|....*.
gi 55956786    817 QRLSRTCFRQWRQQLAA-RRQEQRAT 841
Cdd:pfam08457  490 EQLLRSYLARWRERLRElRELEQDAD 515
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 936-1129 6.02e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 6.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   936 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 1015
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1016 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1095
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 55956786  1096 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1129
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
 
Name Accession Description Interval E-value
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 417-841 8.13e-11

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 66.16  E-value: 8.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    417 LLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELWLQYTQKRRykqLLQARADGHFQQRALPAAFHTWn 494
Cdd:pfam08457   57 LRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAWRRRTLQIR---VREEVAVQVYQENLLKRSFWKW- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    495 rlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQ---- 570
Cdd:pfam08457  119 ---FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLREREQEAEAKRKRLLLSSALQIWSERTEAVQAAEqead 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    571 -------------EWQTVA---------CAHHRHGRLKKAFCLWRESAQGLRtertgrvRAAEFHMAQLLRWAWSQWR-- 626
Cdd:pfam08457  189 sfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKLRARMSR-------QAREVDRARILRNAWTTWNde 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    627 -ECLALRG----------------AERQKLMRAdlHHQHSVLHRALQAWVTyqgRVRSILREVAARESQH----NRQLLR 685
Cdd:pfam08457  262 lRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVLSTWVT---NTRDTRTRLLRHEEEFeehrNRKLLR 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    686 GALRRWKENTMAR---------VDEAKKTFQASTHYR------------------RTICSKVLVQWREAVSVQMYYRQQE 738
Cdd:pfam08457  337 SKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRerhqhvqklekwardarfYFLATRTLKKWRAATEESRRERRQD 416

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    739 DCA-IWEAQKV-LDRGCLRTWFQRwwdcSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLA 816
Cdd:pfam08457  417 AYAqVRRKVKInLARRALSKWRSK----AAEVADLEQQADQLRQNRLLEDAIELFDRWRERTAKRKQR---AEDADQFYA 489

                          490       500
                   ....*....|....*....|....*.
gi 55956786    817 QRLSRTCFRQWRQQLAA-RRQEQRAT 841
Cdd:pfam08457  490 EQLLRSYLARWRERLRElRELEQDAD 515
PHA03247 PHA03247
large tegument protein UL36; Provisional
 936-1129 6.02e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 6.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   936 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 1015
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1016 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1095
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 55956786  1096 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1129
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 920-1146 1.48e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 1.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    920 HRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEgPLLNRIAAGAG--------DGTLETKRPQASRPLGALGRLA- 990
Cdd:pfam03154  228 HTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQ-PLPQPSLHGQMppmphslqTGPSHMQHPVPPQPFPLTPQSSq 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    991 AEEPHALELNTAHSARKQPRRPhfllePAQSQ--RPQKPQEHGLgmaqPAAPsLTRPFLAEAPTALVPHSPLPGALS--- 1065
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTP-----PSQSQlqSQQPPREQPL----PPAP-LSMPHIKPPPTTPIPQLPNPQSHKhpp 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   1066 --SAPGPKQ---------------------PPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPR-DKPPVPSSLASV 1121
Cdd:pfam03154  377 hlSGPSPFQmnsnlppppalkplsslsthhPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPaASHPPTSGLHQV 456

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 55956786   1122 PD-----PHLLLPGD-----------FSATRAGPGLSTAGS 1146
Cdd:pfam03154  457 PSqspfpQHPFVPGGpppitppsgppTSTSSAMPGIQPPSS 497
COG3899 COG3899
Predicted ATPase [General function prediction only];
450-976 7.61e-04

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 44.08  E-value: 7.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  450 IALLCKCIELWLQYTQKRRYKQLLQARADGHFQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQK 529
Cdd:COG3899  725 LRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLLLG 804

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  530 MFQhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQEWQTVacahhrHGRLKKAFCLWRESAQGLRTERTGRVRA 609
Cdd:COG3899  805 DYE-EAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREA------LELLREALEAGLETGDAALALLALAAAA 877

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  610 AEFHMAQLLRWAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALR 689
Cdd:COG3899  878 AAAAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAA 957

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  690 RWKENTMARVDEAKKTFQASTHYRRTICSKVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSA 769
Cdd:COG3899  958 LALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALL 1037

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  770 QQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWA 849
Cdd:COG3899 1038 AAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALA 1117

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  850 FSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLLRFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATL 929
Cdd:COG3899 1118 AALAALALAAAARAAAALLLLAAALALALAALLLLAALLLALALLLLALAALALAAALAALAAALLAAAAAAAAAAALLA 1197

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 55956786  930 WKQKVLGRGGKPQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKR 976
Cdd:COG3899 1198 ALLALAARLAALLALALLALEAAALLLLLLLAALALAAALLALRLLA 1244
 
Name Accession Description Interval E-value
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 417-841 8.13e-11

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 66.16  E-value: 8.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    417 LLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELWLQYTQKRRykqLLQARADGHFQQRALPAAFHTWn 494
Cdd:pfam08457   57 LRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAWRRRTLQIR---VREEVAVQVYQENLLKRSFWKW- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    495 rlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQ---- 570
Cdd:pfam08457  119 ---FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLREREQEAEAKRKRLLLSSALQIWSERTEAVQAAEqead 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    571 -------------EWQTVA---------CAHHRHGRLKKAFCLWRESAQGLRtertgrvRAAEFHMAQLLRWAWSQWR-- 626
Cdd:pfam08457  189 sfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKLRARMSR-------QAREVDRARILRNAWTTWNde 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    627 -ECLALRG----------------AERQKLMRAdlHHQHSVLHRALQAWVTyqgRVRSILREVAARESQH----NRQLLR 685
Cdd:pfam08457  262 lRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVLSTWVT---NTRDTRTRLLRHEEEFeehrNRKLLR 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    686 GALRRWKENTMAR---------VDEAKKTFQASTHYR------------------RTICSKVLVQWREAVSVQMYYRQQE 738
Cdd:pfam08457  337 SKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRerhqhvqklekwardarfYFLATRTLKKWRAATEESRRERRQD 416

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    739 DCA-IWEAQKV-LDRGCLRTWFQRwwdcSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLA 816
Cdd:pfam08457  417 AYAqVRRKVKInLARRALSKWRSK----AAEVADLEQQADQLRQNRLLEDAIELFDRWRERTAKRKQR---AEDADQFYA 489

                          490       500
                   ....*....|....*....|....*.
gi 55956786    817 QRLSRTCFRQWRQQLAA-RRQEQRAT 841
Cdd:pfam08457  490 EQLLRSYLARWRERLRElRELEQDAD 515
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 340-830 2.80e-07

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 54.99  E-value: 2.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    340 HAQVEKLARKMALRRAFTHWKhymLLCAEEAAQFEMAEEHHRHSQLYFCFRALKDNvthahlQQIRRnlAHQQHGVTLLH 419
Cdd:pfam08457   69 TAVNELKAQRFALKRPLGAWR---RRTLQIRVREEVAVQVYQENLLKRSFWKWFWE------FCERR--APQWYDFRLKR 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    420 RFWNLWRSQIEQKKEREllpllHAAWDHYRIALLCKCIELWLQytqKRRYKQLLQARADGHFQQRALPAAFHTWnrlwRW 499
Cdd:pfam08457  138 RSLLTWLRKFRTLRERE-----QEAEAKRKRLLLSSALQIWSE---RTEAVQAAEQEADSFRRRKLLRRALDEW----RI 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    500 RHQENVLSARATRFHRETLEKQVFSLWRQKMFQHRENRLAERMAILH---------------AER-------QLLYRsWF 557
Cdd:pfam08457  206 QARLEPALRQVSAKVDRRILRSALSVWKLRARMSRQAREVDRARILRnawttwndelrckalRERiderlklEALYK-WV 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    558 MWHQQAAARHqeqewqtvacaHHRHGRLKKAFCLWRESAQGLRTERTGRVRAAEFHMAQ-LLRWAWSQWRECLALRgaeR 636
Cdd:pfam08457  285 LEERLRLFQR-----------IREQRLKREVLSTWVTNTRDTRTRLLRHEEEFEEHRNRkLLRSKLLKWRDQLAEQ---R 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    637 QKLMRADLHHQHSVLHRALQAWvtyqgrvRSILREVAARESQHNRQ----LLRGALRRWKENTmarVDEAKKTFQASTH- 711
Cdd:pfam08457  351 EREIAANEFYAPRLLQEALDAW-------RERHQHVQKLEKWARDArfyfLATRTLKKWRAAT---EESRRERRQDAYAq 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    712 YRRTI----CSKVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWfqrwwdcSRRSAQQRLQLERAVQHHHRQLL 787
Cdd:pfam08457  421 VRRKVkinlARRALSKWRSKAAEVADLEQQADQLRQNRLLEDAIELFDRW-------RERTAKRKQRAEDADQFYAEQLL 493

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55956786    788 LEGLARW-------KTHHLQCVRKRLLHrQSTQLLAQ---------------------------RLSRTCFRQWRQQ 830
Cdd:pfam08457  494 RSYLARWrerlrelRELEQDADAYRREH-TLGQAAAAlrkwslrlfqirsreetadalrernlrKHLRNMLRHWLQK 569
PHA03247 PHA03247
large tegument protein UL36; Provisional
 936-1129 6.02e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 6.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   936 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 1015
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1016 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1095
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 55956786  1096 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1129
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
PHA03247 PHA03247
large tegument protein UL36; Provisional
 976-1146 8.79e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 8.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   976 RPQASRPLGAlGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQ-SQRPQKPQEHGLGMAQPAAPSLTRPFLAE----- 1049
Cdd:PHA03247 2632 SPAANEPDPH-PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQaSSPPQRPRRRAARPTVGSLTSLADPPPPPptpep 2710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1050 APTALVPHSPLP----------GALSSAPGPKQPPTASTGPELLLLPLSSFMPCGA------AAPARVSAQRATPRDKPP 1113
Cdd:PHA03247 2711 APHALVSATPLPpgpaaarqasPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPpapappAAPAAGPPRRLTRPAVAS 2790

                         170       180       190
                  ....*....|....*....|....*....|...
gi 55956786  1114 VPSSLASVPDPHLLLPGDFSATRAGPGLSTAGS 1146
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
PHA03247 PHA03247
large tegument protein UL36; Provisional
 941-1172 1.12e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   941 PQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKRPQASRPLgalgrlAAEEPHALELntahsARKQPRRPH--FLLEP 1018
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA------APARPPVRRL-----ARPAVSRSTesFALPP 2902

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1019 AQSQRPQKPQehglgmaqPAAPSLTRPfLAEAPTALVPHSPLPGAlssaPGPKQPPTASTGPELLLLPLSSFMPCGAAAP 1098
Cdd:PHA03247 2903 DQPERPPQPQ--------APPPPQPQP-QPPPPPQPQPPPPPPPR----PQPPLAPTTDPAGAGEPSGAVPQPWLGALVP 2969

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55956786  1099 ARVSAQRA-TPRDKPPVPSSLASVPDPHlllpgdfsaTRAGPGLST-AGSLDLEAELEEIQQQLlhyqttKQNLWS 1172
Cdd:PHA03247 2970 GRVAVPRFrVPQPAPSREAPASSTPPLT---------GHSLSRVSSwASSLALHEETDPPPVSL------KQTLWP 3030
PHA03247 PHA03247
large tegument protein UL36; Provisional
 938-1125 3.03e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   938 GGKPQPLAAIAPSrkvtfegpllnriaaGAGDGTLETKRPqASRPLGAlgrlaaeephalelntahSARKQPRRPHFLLE 1017
Cdd:PHA03247 2549 GDPPPPLPPAAPP---------------AAPDRSVPPPRP-APRPSEP------------------AVTSRARRPDAPPQ 2594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1018 PAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPH--SPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMpcGA 1095
Cdd:PHA03247 2595 SARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAanEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL--GR 2672

                         170       180       190
                  ....*....|....*....|....*....|
gi 55956786  1096 AAPARVSAQRATPRDKPPVPSSLASVPDPH 1125
Cdd:PHA03247 2673 AAQASSPPQRPRRRAARPTVGSLTSLADPP 2702
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1001-1224 3.41e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.53  E-value: 3.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1001 TAHSARKQPRRPHFLLEPAQSQRPQKPQEH--GLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGAlSSAPGPKQPPTAST 1078
Cdd:PRK07764  598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPapAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA-SDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1079 GPELLLLPLSSFMPCGAAAPARvSAQRATPRDKPPVPSSLASVPDPhlllPGDfSATRAGPGLSTAGSLDLEAELEEIQQ 1158
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAGAAP-AQPAPAPAATPPAGQADDPAAQP----PQA-AQGASAPSPAADDPVPLPPEPDDPPD 750

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55956786  1159 QLLHYQTTKQNLWSCRRQASSLR-RWLELNREEPGPEDQEVEQQVQKELEQVEMQIQLLAEELQAQR 1224
Cdd:PRK07764  751 PAGAPAQPPPPPAPAPAAAPAAApPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEEELGAKK 817
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
940-1124 8.82e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.23  E-value: 8.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   940 KPQPLAAIAPSRKVTfegPLLNRIAAGAGDGTletkrpQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPA 1019
Cdd:PRK07003  411 APKAAAAAAATRAEA---PPAAPAPPATADRG------DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPA 481

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1020 QSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTAL-------VPHSPLPGALSSAPGPKQPPTASTGPELLL-------L 1085
Cdd:PRK07003  482 SDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAsredapaAAAPPAPEARPPTPAAAAPAARAGGAAAALdvlrnagM 561

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 55956786  1086 PLSSFMPCGAAAPARVSAQRATPrDKPPVPSSLASVPDP 1124
Cdd:PRK07003  562 RVSSDRGARAAAAAKPAAAPAAA-PKPAAPRVAVQVPTP 599
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
936-1149 9.36e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.23  E-value: 9.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   936 GRGGKPQPLAAIAPSRKVTFEGPllnRIAAGAGDGTLETKRPQASRPLGALgRLAAEEPHALELNTAhsarkqprrphfl 1015
Cdd:PRK07003  363 TGGGAPGGGVPARVAGAVPAPGA---RAAAAVGASAVPAVTAVTGAAGAAL-APKAAAAAAATRAEA------------- 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1016 lEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLP---GALSSAPGPKQPPTASTGPELLLLPLSSFMP 1092
Cdd:PRK07003  426 -PPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPpadSGSASAPASDAPPDAAFEPAPRAAAPSAATP 504

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 55956786  1093 CGAAAPARVSAQRATPRDKPP-VPSSLASVPDPhlllPGDFSATRAGpglSTAGSLDL 1149
Cdd:PRK07003  505 AAVPDARAPAAASREDAPAAAaPPAPEARPPTP----AAAAPAARAG---GAAAALDV 555
PHA03378 PHA03378
EBNA-3B; Provisional
 968-1143 1.06e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 50.07  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   968 GDGTLETKRPQASRPLGALGRLAAEEPHALELNTA---HSARKQPRR-PHFLLEPAQSQRPQKPqeHGLGMAQPAAPSLT 1043
Cdd:PHA03378  607 EPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPItfnVLVFPTPHQpPQVEITPYKPTWTQIG--HIPYQPSPTGANTM 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1044 RPFLAeAPTALVPHSPLPGALS---SAPGPKQPPTASTGPellllplssfMPCGAAAPARVSAQRATPRDKPPvPSSLAS 1120
Cdd:PHA03378  685 LPIQW-APGTMQPPPRAPTPMRppaAPPGRAQRPAAATGR----------ARPPAAAPGRARPPAAAPGRARP-PAAAPG 752

                         170       180
                  ....*....|....*....|...
gi 55956786  1121 VPDPHLLLPGDFSATRAGPGLST 1143
Cdd:PHA03378  753 RARPPAAAPGRARPPAAAPGAPT 775
PHA03247 PHA03247
large tegument protein UL36; Provisional
 940-1147 2.21e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   940 KPQPLAAIAPSRkVTFEGPLLNRIAAGAGDGTLETKRPQASRP-LGALGRLA---------AEEPHALELNTAHSARKQP 1009
Cdd:PHA03247 2649 PERPRDDPAPGR-VSRPRRARRLGRAAQASSPPQRPRRRAARPtVGSLTSLAdpppppptpEPAPHALVSATPLPPGPAA 2727

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1010 RRPHFLLEPAQSQRPQKPQehglGMAQPAAPS--LTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPL 1087
Cdd:PHA03247 2728 ARQASPALPAAPAPPAVPA----GPATPGGPArpARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1088 SSFMPcgAAAPARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSatragPGLSTAGSL 1147
Cdd:PHA03247 2804 PADPP--AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP-----PSLPLGGSV 2856
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 920-1146 1.48e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 1.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    920 HRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEgPLLNRIAAGAG--------DGTLETKRPQASRPLGALGRLA- 990
Cdd:pfam03154  228 HTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQ-PLPQPSLHGQMppmphslqTGPSHMQHPVPPQPFPLTPQSSq 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786    991 AEEPHALELNTAHSARKQPRRPhfllePAQSQ--RPQKPQEHGLgmaqPAAPsLTRPFLAEAPTALVPHSPLPGALS--- 1065
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTP-----PSQSQlqSQQPPREQPL----PPAP-LSMPHIKPPPTTPIPQLPNPQSHKhpp 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   1066 --SAPGPKQ---------------------PPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPR-DKPPVPSSLASV 1121
Cdd:pfam03154  377 hlSGPSPFQmnsnlppppalkplsslsthhPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPaASHPPTSGLHQV 456

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 55956786   1122 PD-----PHLLLPGD-----------FSATRAGPGLSTAGS 1146
Cdd:pfam03154  457 PSqspfpQHPFVPGGpppitppsgppTSTSSAMPGIQPPSS 497
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
946-1137 5.95e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 5.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   946 AIAPSRKVTFEGPLLNRIA---AGAGDGTleTKRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQSQ 1022
Cdd:PRK12323  344 ALAPDEYAGFTMTLLRMLAfrpGQSGGGA--GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAA 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1023 RPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMPCGAA------ 1096
Cdd:PRK12323  422 APARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDpppwee 501

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 55956786  1097 APARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSATRA 1137
Cdd:PRK12323  502 LPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLA 542
COG3899 COG3899
Predicted ATPase [General function prediction only];
450-976 7.61e-04

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 44.08  E-value: 7.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  450 IALLCKCIELWLQYTQKRRYKQLLQARADGHFQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQK 529
Cdd:COG3899  725 LRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLLLG 804

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  530 MFQhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQEWQTVacahhrHGRLKKAFCLWRESAQGLRTERTGRVRA 609
Cdd:COG3899  805 DYE-EAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREA------LELLREALEAGLETGDAALALLALAAAA 877

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  610 AEFHMAQLLRWAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALR 689
Cdd:COG3899  878 AAAAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAA 957

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  690 RWKENTMARVDEAKKTFQASTHYRRTICSKVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSA 769
Cdd:COG3899  958 LALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALL 1037

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  770 QQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWA 849
Cdd:COG3899 1038 AAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALA 1117

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  850 FSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLLRFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATL 929
Cdd:COG3899 1118 AALAALALAAAARAAAALLLLAAALALALAALLLLAALLLALALLLLALAALALAAALAALAAALLAAAAAAAAAAALLA 1197

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 55956786  930 WKQKVLGRGGKPQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKR 976
Cdd:COG3899 1198 ALLALAARLAALLALALLALEAAALLLLLLLAALALAAALLALRLLA 1244
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
941-1162 2.68e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   941 PQPLAAIAPSRKVTfEGPLLNRIAAGAGDGTLETKRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRrPHFLLEPAQ 1020
Cdd:PRK12323  383 AQPAPAAAAPAAAA-PAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA-PAPAAAPAA 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1021 SQRPQKPQEHGLGMA--------QPAAPSltrpflAEAPTALVPHSPLPGALSSaPGPKQPPTASTGPEllllpLSSFMP 1092
Cdd:PRK12323  461 AARPAAAGPRPVAAAaaaaparaAPAAAP------APADDDPPPWEELPPEFAS-PAPAQPDAAPAGWV-----AESIPD 528

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55956786  1093 CGAAAPARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSATRAGPgLSTAGSLDLEAEL--EEIQQQLLH 1162
Cdd:PRK12323  529 PATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD-MFDGDWPALAARLpvRGLAQQLAR 599
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 985-1122 5.47e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 5.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786   985 ALGRLAAEEPHALELNTAHSARKQPRRPHfLLEPAQSQRPQKpqehglgmAQPAAPSLTRPFLAEAPTALVPHSPlPGAL 1064
Cdd:PRK14951  357 VLLRLLAFKPAAAAEAAAPAEKKTPARPE-AAAPAAAPVAQA--------AAAPAPAAAPAAAASAPAAPPAAAP-PAPV 426

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55956786  1065 SSAPGPKQPPTASTGPELLLLPLSSFM---PCGAAAPARVSAQRATPRDKPPVPSSLASVP 1122
Cdd:PRK14951  427 AAPAAAAPAAAPAAAPAAVALAPAPPAqaaPETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1035-1147 6.77e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 6.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55956786  1035 AQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPRDKPPV 1114
Cdd:PRK14951  379 KTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPE 458

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 55956786  1115 PSSLA--SVPDPHLLLPGDFSATRAGPGLSTAGSL 1147
Cdd:PRK14951  459 TVAIPvrVAPEPAVASAAPAPAAAPAAARLTPTEE 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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