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Conserved domains on  [gi|60279265|ref|NP_001012474|]
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protein transport protein Sec61 subunit gamma [Homo sapiens]

Protein Classification

preprotein translocase subunit SecE( domain architecture ID 1575)

preprotein translocase subunit SecE is an essential subunit of the Sec protein translocation channel SecYEG and it clamps together the 2 halves of SecY; may contact the channel plug during translocation

CATH:  1.20.5.1030
Gene Ontology:  GO:0043952|GO:0065002|GO:0006605
SCOP:  4005885
TCDB:  3.A.5

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
secE super family cl00481
preprotein translocase subunit SecE; Reviewed
 12-68 4.35e-25

preprotein translocase subunit SecE; Reviewed


The actual alignment was detected with superfamily member PTZ00478:

Pssm-ID: 469787  Cd Length: 81  Bit Score: 88.23  E-value: 4.35e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 60279265  12 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG 68
Cdd:PTZ00478 24 QEFANDSRRLIRKCTKPDAKEYTNIAYACSVGFFIMGFIGYSIKLVFIPINNIIVGS 80
 
Name Accession Description Interval E-value
PTZ00478 PTZ00478
Sec superfamily; Provisional
 12-68 4.35e-25

Sec superfamily; Provisional


Pssm-ID: 185656  Cd Length: 81  Bit Score: 88.23  E-value: 4.35e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 60279265  12 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG 68
Cdd:PTZ00478 24 QEFANDSRRLIRKCTKPDAKEYTNIAYACSVGFFIMGFIGYSIKLVFIPINNIIVGS 80
secE_euk_arch TIGR00327
protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic; This model describes ...
 6-66 1.14e-12

protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic; This model describes archaeal SEC61-like and eukaryotic SEC61 but not bacterial secE proteins, for which a Pfam pfam00584 (SecE) has been created. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273016  Cd Length: 61  Bit Score: 56.31  E-value: 1.14e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 60279265    6 QFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIV 66
Cdd:TIGR00327  1 KLIEAPVEFIKEGTRVLAVCKKPDLEEYLKVAKVTGIGIIIVGIIGYIIKIIAIPIRGVLK 61
SecE pfam00584
SecE/Sec61-gamma subunits of protein translocation complex; SecE is part of the SecYEG complex ...
 12-65 1.36e-10

SecE/Sec61-gamma subunits of protein translocation complex; SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates protein from the cytoplasm to the ER. Archaea have a similar complex.


Pssm-ID: 459858  Cd Length: 55  Bit Score: 50.50  E-value: 1.36e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 60279265   12 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIH-IPINNII 65
Cdd:pfam00584  1 KKFFKEVKAELKKVTWPTRKELLKYTVVVLVFVVIMGLFLFLVDLGFsILINLLL 55
Sss1 COG2443
Preprotein translocase subunit Sss1 [Intracellular trafficking, secretion, and vesicular ...
 12-57 2.98e-08

Preprotein translocase subunit Sss1 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441984  Cd Length: 63  Bit Score: 44.82  E-value: 2.98e-08
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*.
gi 60279265 12 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLI 57
Cdd:COG2443 10 KELLKDYKRVLKLARKPDKEEFLQIAKITGLGILLIGLIGFIIYLI 55
 
Name Accession Description Interval E-value
PTZ00478 PTZ00478
Sec superfamily; Provisional
 12-68 4.35e-25

Sec superfamily; Provisional


Pssm-ID: 185656  Cd Length: 81  Bit Score: 88.23  E-value: 4.35e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 60279265  12 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG 68
Cdd:PTZ00478 24 QEFANDSRRLIRKCTKPDAKEYTNIAYACSVGFFIMGFIGYSIKLVFIPINNIIVGS 80
secE_euk_arch TIGR00327
protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic; This model describes ...
 6-66 1.14e-12

protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic; This model describes archaeal SEC61-like and eukaryotic SEC61 but not bacterial secE proteins, for which a Pfam pfam00584 (SecE) has been created. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273016  Cd Length: 61  Bit Score: 56.31  E-value: 1.14e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 60279265    6 QFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIV 66
Cdd:TIGR00327  1 KLIEAPVEFIKEGTRVLAVCKKPDLEEYLKVAKVTGIGIIIVGIIGYIIKIIAIPIRGVLK 61
SecE pfam00584
SecE/Sec61-gamma subunits of protein translocation complex; SecE is part of the SecYEG complex ...
 12-65 1.36e-10

SecE/Sec61-gamma subunits of protein translocation complex; SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates protein from the cytoplasm to the ER. Archaea have a similar complex.


Pssm-ID: 459858  Cd Length: 55  Bit Score: 50.50  E-value: 1.36e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 60279265   12 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIH-IPINNII 65
Cdd:pfam00584  1 KKFFKEVKAELKKVTWPTRKELLKYTVVVLVFVVIMGLFLFLVDLGFsILINLLL 55
Sss1 COG2443
Preprotein translocase subunit Sss1 [Intracellular trafficking, secretion, and vesicular ...
 12-57 2.98e-08

Preprotein translocase subunit Sss1 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441984  Cd Length: 63  Bit Score: 44.82  E-value: 2.98e-08
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*.
gi 60279265 12 RQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLI 57
Cdd:COG2443 10 KELLKDYKRVLKLARKPDKEEFLQIAKITGLGILLIGLIGFIIYLI 55
secE PRK09400
preprotein translocase subunit SecE; Reviewed
 5-57 7.02e-08

preprotein translocase subunit SecE; Reviewed


Pssm-ID: 236497  Cd Length: 61  Bit Score: 44.07  E-value: 7.02e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 60279265   5 MQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLI 57
Cdd:PRK09400  4 NKLQENVKNFLEDYKRVLKVARKPTREEFLLVAKVTGLGILLIGLIGFIIYLI 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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