NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|67189069|ref|NP_001018017|]
View 

mucin-1 isoform 3 precursor [Homo sapiens]

Protein Classification

SEA domain-containing protein( domain architecture ID 10640846)

SEA domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 36-152 1.46e-35

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


:

Pssm-ID: 214554  Cd Length: 121  Bit Score: 122.91  E-value: 1.46e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67189069     36 ETSATQRSSVPSST--EKNAFNSSLEDPSTDYYQELQRDISEMFLQIYKQG----GFLGLSNIKFRPGSVVVQLTLAFRE 109
Cdd:smart00200   1 PTQSFGVSLSVLSVegENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTdlkpDFVGTEVIEFRNGSVVVDLGLLFNE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 67189069    110 GTINVHDVETQFNQYKTEAAsrYNLTISDVSVSDVPFPFSAQS 152
Cdd:smart00200  81 GVTNGQDVEEDLLQVIKQAA--YSLKITNVNVVDVLDPDSADS 121
 
Name Accession Description Interval E-value
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 36-152 1.46e-35

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 122.91  E-value: 1.46e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67189069     36 ETSATQRSSVPSST--EKNAFNSSLEDPSTDYYQELQRDISEMFLQIYKQG----GFLGLSNIKFRPGSVVVQLTLAFRE 109
Cdd:smart00200   1 PTQSFGVSLSVLSVegENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTdlkpDFVGTEVIEFRNGSVVVDLGLLFNE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 67189069    110 GTINVHDVETQFNQYKTEAAsrYNLTISDVSVSDVPFPFSAQS 152
Cdd:smart00200  81 GVTNGQDVEEDLLQVIKQAA--YSLKITNVNVVDVLDPDSADS 121
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 54-108 2.20e-04

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 39.53  E-value: 2.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67189069    54 FNSSLEDPSTDYYQELQRDISEMFLQIYKQ----GGFLGLSNIKFRP--GSVVVQLTLAFR 108
Cdd:pfam01390  14 YTPDLGNPSSQEFKSLSRRIESLLNELFRNsslrKQYIKSHVLRLRPdgGSVVVDVVLVFR 74
 
Name Accession Description Interval E-value
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 36-152 1.46e-35

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 122.91  E-value: 1.46e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67189069     36 ETSATQRSSVPSST--EKNAFNSSLEDPSTDYYQELQRDISEMFLQIYKQG----GFLGLSNIKFRPGSVVVQLTLAFRE 109
Cdd:smart00200   1 PTQSFGVSLSVLSVegENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTdlkpDFVGTEVIEFRNGSVVVDLGLLFNE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 67189069    110 GTINVHDVETQFNQYKTEAAsrYNLTISDVSVSDVPFPFSAQS 152
Cdd:smart00200  81 GVTNGQDVEEDLLQVIKQAA--YSLKITNVNVVDVLDPDSADS 121
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 54-108 2.20e-04

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 39.53  E-value: 2.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67189069    54 FNSSLEDPSTDYYQELQRDISEMFLQIYKQ----GGFLGLSNIKFRP--GSVVVQLTLAFR 108
Cdd:pfam01390  14 YTPDLGNPSSQEFKSLSRRIESLLNELFRNsslrKQYIKSHVLRLRPdgGSVVVDVVLVFR 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH