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Conserved domains on  [gi|68508967|ref|NP_001020366|]
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liver carboxylesterase 1 isoform a precursor [Homo sapiens]

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate, and lipase, which hydrolyzes triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids

CATH:  3.40.50.1820
EC:  3.1.1.-
PubMed:  8453375|3163407|8280778|9704093|11099800
SCOP:  3000102

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
23-548 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 630.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967    23 SPPVVDTVHGKVLGKFVSLEGFaQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQllself 102
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   103 tnrKENIPLKLSEDCLYLNIYTPADLTK-KNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST 181
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKEnKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   182 GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD 261
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   262 VKpLAEQIAITAGCKTTTSAVMVHCLRQKTEeellettlkMKFLSLDLQGDPRESQPLL--GTVIDGMLLLKTPEELQAE 339
Cdd:pfam00135 231 RQ-RAKELAKLVGCPTSDSAELVECLRSKPA---------EELLDAQLKLLVYGSVPFVpfGPVVDGDFLPEHPEELLKS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   340 RNFHTVPYMVGINKQEFGWLIPMqLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAK--ELIPEATEKYL--GGTDDTVKKK 415
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAY-ILDNVDILKALEEKLLRSLLIDLLYLLLVDLpeEISAALREEYLdwGDRDDPETSR 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   416 DLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSsdMKPKTVIGDHGDELFSVFGAPFL-KEGASEEEIRLS 494
Cdd:pfam00135 380 RALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLS 457

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 68508967   495 KMVMKFWANFARNGNPNG-EGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKEVAFW 548
Cdd:pfam00135 458 RKMMTYWTNFAKTGNPNGpEGLPKWPPYTDENGqYLSIDLEPRVKQGLKAERCAFW 513
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
23-548 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 630.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967    23 SPPVVDTVHGKVLGKFVSLEGFaQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQllself 102
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   103 tnrKENIPLKLSEDCLYLNIYTPADLTK-KNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST 181
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKEnKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   182 GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD 261
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   262 VKpLAEQIAITAGCKTTTSAVMVHCLRQKTEeellettlkMKFLSLDLQGDPRESQPLL--GTVIDGMLLLKTPEELQAE 339
Cdd:pfam00135 231 RQ-RAKELAKLVGCPTSDSAELVECLRSKPA---------EELLDAQLKLLVYGSVPFVpfGPVVDGDFLPEHPEELLKS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   340 RNFHTVPYMVGINKQEFGWLIPMqLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAK--ELIPEATEKYL--GGTDDTVKKK 415
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAY-ILDNVDILKALEEKLLRSLLIDLLYLLLVDLpeEISAALREEYLdwGDRDDPETSR 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   416 DLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSsdMKPKTVIGDHGDELFSVFGAPFL-KEGASEEEIRLS 494
Cdd:pfam00135 380 RALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLS 457

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 68508967   495 KMVMKFWANFARNGNPNG-EGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKEVAFW 548
Cdd:pfam00135 458 RKMMTYWTNFAKTGNPNGpEGLPKWPPYTDENGqYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 26-539 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 593.15  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967  26 VVDTVHGKVLGKFVSlegfaqPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLselftnr 105
Cdd:cd00312   1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 106 kENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAA-HENVVVVTIQYRLGIWGFFSTGDE 184
Cdd:cd00312  68 -WNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAReGDNVIVVSINYRLGVLGFLSTGDI 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 185 HSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGdVKP 264
Cdd:cd00312 147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQEN-ARG 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 265 LAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGdpresqpLLGTVIDGMLLLKTPEELQAERNFHT 344
Cdd:cd00312 226 RAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSPFL-------PFGPVVDGDFIPDDPEELIKEGKFAK 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 345 VPYMVGINKQEFGWLIPMQLMSYPLsegqLDQKTAMSLLWKSYPLVCIA-KELIPEATEKYLGGTDDTVKKKDLFLDLIA 423
Cdd:cd00312 299 VPLIIGVTKDEGGYFAAMLLNFDAK----LIIETNDRWLELLPYLLFYAdDALADKVLEKYPGDVDDSVESRKNLSDMLT 374

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 424 DVMFGVPSVIVARNHRDA-GAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWA 502
Cdd:cd00312 375 DLLFKCPARYFLAQHRKAgGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWA 454

                       490       500       510
                ....*....|....*....|....*....|....*....
gi 68508967 503 NFARNGNPNGEG-LPHWPEYN-QKEGYLQIGANTQAAQK 539
Cdd:cd00312 455 NFAKTGNPNTEGnLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
14-552 1.78e-156

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 457.04  E-value: 1.78e-156
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967  14 SAAWAGHPSSPPVVDTVHGKVLGkfVSLEGfaqpVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPK 93
Cdd:COG2272   2 KRLLAAAAAAAPVVRTEAGRVRG--VVEGG----VRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967  94 AGQLLSelftnrkeniPLKLSEDCLYLNIYTPADLTKKnRLPVMVWIHGGGLMVGAAST--YDGLALAAhENVVVVTIQY 171
Cdd:COG2272  76 PGDPGG----------PAPGSEDCLYLNVWTPALAAGA-KLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINY 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 172 RLGIWGFF-----STGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIS 246
Cdd:COG2272 144 RLGALGFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIA 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 247 ESGVALTsvLVKKGDVKPLAEQIAITAGCKTTTSAvmvhCLRQKTEEellettlkmKFLSLDLQGDPRESQPL-LGTVID 325
Cdd:COG2272 224 QSGAGLS--VLTLAEAEAVGAAFAAALGVAPATLA----ALRALPAE---------ELLAAQAALAAEGPGGLpFGPVVD 288

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 326 GMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQktamsLLWKSYPlvciakELIPEATEKYL 405
Cdd:COG2272 289 GDVLPEDPLEAFAAGRAADVPLLIGTNRDEGRLFAALLGDLGPLTAADYRA-----ALRRRFG------DDADEVLAAYP 357

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 406 GGTDdtvkkKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVigdHGDELFSVFG--APFLK 483
Cdd:COG2272 358 AASP-----AEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGnlDAPAL 429

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68508967 484 EGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKE-VAFWTNLF 552
Cdd:COG2272 430 TGLTPADRALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLWDGVV 500
PRK10162 PRK10162
acetyl esterase;
136-224 1.18e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 44.32  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967  136 VMVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLGIWGFFSTGDEHSrgnwghldqVAALRWVQDNIASFGGNP 213
Cdd:PRK10162  83 TLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVCCYFHQHAEDYGINM 153

                         90
                 ....*....|.
gi 68508967  214 GSVTIFGESAG 224
Cdd:PRK10162 154 SRIGFAGDSAG 164
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
23-548 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 630.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967    23 SPPVVDTVHGKVLGKFVSLEGFaQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQllself 102
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   103 tnrKENIPLKLSEDCLYLNIYTPADLTK-KNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST 181
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKEnKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   182 GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD 261
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   262 VKpLAEQIAITAGCKTTTSAVMVHCLRQKTEeellettlkMKFLSLDLQGDPRESQPLL--GTVIDGMLLLKTPEELQAE 339
Cdd:pfam00135 231 RQ-RAKELAKLVGCPTSDSAELVECLRSKPA---------EELLDAQLKLLVYGSVPFVpfGPVVDGDFLPEHPEELLKS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   340 RNFHTVPYMVGINKQEFGWLIPMqLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAK--ELIPEATEKYL--GGTDDTVKKK 415
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAY-ILDNVDILKALEEKLLRSLLIDLLYLLLVDLpeEISAALREEYLdwGDRDDPETSR 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   416 DLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSsdMKPKTVIGDHGDELFSVFGAPFL-KEGASEEEIRLS 494
Cdd:pfam00135 380 RALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLS 457

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 68508967   495 KMVMKFWANFARNGNPNG-EGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKEVAFW 548
Cdd:pfam00135 458 RKMMTYWTNFAKTGNPNGpEGLPKWPPYTDENGqYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 26-539 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 593.15  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967  26 VVDTVHGKVLGKFVSlegfaqPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLselftnr 105
Cdd:cd00312   1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 106 kENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAA-HENVVVVTIQYRLGIWGFFSTGDE 184
Cdd:cd00312  68 -WNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAReGDNVIVVSINYRLGVLGFLSTGDI 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 185 HSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGdVKP 264
Cdd:cd00312 147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQEN-ARG 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 265 LAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGdpresqpLLGTVIDGMLLLKTPEELQAERNFHT 344
Cdd:cd00312 226 RAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSPFL-------PFGPVVDGDFIPDDPEELIKEGKFAK 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 345 VPYMVGINKQEFGWLIPMQLMSYPLsegqLDQKTAMSLLWKSYPLVCIA-KELIPEATEKYLGGTDDTVKKKDLFLDLIA 423
Cdd:cd00312 299 VPLIIGVTKDEGGYFAAMLLNFDAK----LIIETNDRWLELLPYLLFYAdDALADKVLEKYPGDVDDSVESRKNLSDMLT 374

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 424 DVMFGVPSVIVARNHRDA-GAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWA 502
Cdd:cd00312 375 DLLFKCPARYFLAQHRKAgGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWA 454

                       490       500       510
                ....*....|....*....|....*....|....*....
gi 68508967 503 NFARNGNPNGEG-LPHWPEYN-QKEGYLQIGANTQAAQK 539
Cdd:cd00312 455 NFAKTGNPNTEGnLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
14-552 1.78e-156

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 457.04  E-value: 1.78e-156
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967  14 SAAWAGHPSSPPVVDTVHGKVLGkfVSLEGfaqpVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPK 93
Cdd:COG2272   2 KRLLAAAAAAAPVVRTEAGRVRG--VVEGG----VRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967  94 AGQLLSelftnrkeniPLKLSEDCLYLNIYTPADLTKKnRLPVMVWIHGGGLMVGAAST--YDGLALAAhENVVVVTIQY 171
Cdd:COG2272  76 PGDPGG----------PAPGSEDCLYLNVWTPALAAGA-KLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINY 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 172 RLGIWGFF-----STGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIS 246
Cdd:COG2272 144 RLGALGFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIA 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 247 ESGVALTsvLVKKGDVKPLAEQIAITAGCKTTTSAvmvhCLRQKTEEellettlkmKFLSLDLQGDPRESQPL-LGTVID 325
Cdd:COG2272 224 QSGAGLS--VLTLAEAEAVGAAFAAALGVAPATLA----ALRALPAE---------ELLAAQAALAAEGPGGLpFGPVVD 288

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 326 GMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQktamsLLWKSYPlvciakELIPEATEKYL 405
Cdd:COG2272 289 GDVLPEDPLEAFAAGRAADVPLLIGTNRDEGRLFAALLGDLGPLTAADYRA-----ALRRRFG------DDADEVLAAYP 357

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 406 GGTDdtvkkKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVigdHGDELFSVFG--APFLK 483
Cdd:COG2272 358 AASP-----AEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGnlDAPAL 429

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68508967 484 EGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKE-VAFWTNLF 552
Cdd:COG2272 430 TGLTPADRALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLWDGVV 500
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
122-225 2.10e-20

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 89.55  E-value: 2.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 122 IYTPADLTKKnrLPVMVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLGiwgffstgDEHSrgnW-GHLDQV-A 197
Cdd:COG0657   3 VYRPAGAKGP--LPVVVYFHGGGWVSGSKDTHDPLArrLAARAGAAVVSVDYRLA--------PEHP---FpAALEDAyA 69

                        90       100
                ....*....|....*....|....*...
gi 68508967 198 ALRWVQDNIASFGGNPGSVTIFGESAGG 225
Cdd:COG0657  70 ALRWLRANAAELGIDPDRIAVAGDSAGG 97
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 137-225 2.23e-14

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 72.24  E-value: 2.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   137 MVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLgiwgffstGDEHSrgnW--GHLDQVAALRWVQDNIASFGGN 212
Cdd:pfam07859   1 LVYFHGGGFVLGSADTHDRLCrrLAAEAGAVVVSVDYRL--------APEHP---FpaAYDDAYAALRWLAEQAAELGAD 69

                          90
                  ....*....|...
gi 68508967   213 PGSVTIFGESAGG 225
Cdd:pfam07859  70 PSRIAVAGDSAGG 82
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
122-251 3.18e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 60.42  E-value: 3.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 122 IYTPADltkKNRLPVMVWIHGGGlmVGAASTYDGLALAAHEN-VVVVTIQYRlgiwgffstGDEHSRGNWGHL---DQVA 197
Cdd:COG1506  14 LYLPAD---GKKYPVVVYVHGGP--GSRDDSFLPLAQALASRgYAVLAPDYR---------GYGESAGDWGGDevdDVLA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 68508967 198 ALRWVqdnIASFGGNPGSVTIFGESAGGesVSVLVLSPLAKNLFHRAISESGVA 251
Cdd:COG1506  80 AIDYL---AARPYVDPDRIGIYGHSYGG--YMALLAAARHPDRFKAAVALAGVS 128
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 120-225 5.02e-09

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 56.80  E-value: 5.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   120 LNIYTPAdlTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENV-----VVVTIQYRLgiwgffsTGDEHSRgnwghlD 194
Cdd:pfam20434   1 LDIYLPK--NAKGPYPVVIWIHGGGWNSGDKEADMGFMTNTVKALlkagyAVASINYRL-------STDAKFP------A 65

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 68508967   195 QV----AALRWVQDNIASFGGNPGSVTIFGESAGG 225
Cdd:pfam20434  66 QIqdvkAAIRFLRANAAKYGIDTNKIALMGFSAGG 100
PRK10162 PRK10162
acetyl esterase;
136-224 1.18e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 44.32  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967  136 VMVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLGIWGFFSTGDEHSrgnwghldqVAALRWVQDNIASFGGNP 213
Cdd:PRK10162  83 TLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVCCYFHQHAEDYGINM 153

                         90
                 ....*....|.
gi 68508967  214 GSVTIFGESAG 224
Cdd:PRK10162 154 SRIGFAGDSAG 164
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 122-225 4.28e-04

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 42.30  E-value: 4.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 122 IYTPADLTKKNRLPVMVWIHGGGlmvGAASTYD---GL-ALAAHENVVVV----TIQYRLGIWGFFSTGDEHSRGnwGHL 193
Cdd:COG3509  41 LYVPAGYDGGAPLPLVVALHGCG---GSAADFAagtGLnALADREGFIVVypegTGRAPGRCWNWFDGRDQRRGR--DDV 115

                        90       100       110
                ....*....|....*....|....*....|..
gi 68508967 194 DQVAALrwVQDNIASFGGNPGSVTIFGESAGG 225
Cdd:COG3509 116 AFIAAL--VDDLAARYGIDPKRVYVTGLSAGG 145
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 120-254 7.63e-04

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 41.29  E-value: 7.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967   120 LNIYTPADLTKKNRLPVMVWIHGGGL--MVGAASTYDGLALAAH-ENVVVVTIQY-----RLGIWGFfstGDEHSRGNWG 191
Cdd:pfam00756  10 VQVYLPEDYPPGRKYPVLYLLDGTGWfqNGPAKEGLDRLAASGEiPPVIIVGSPRggevsFYSDWDR---GLNATEGPGA 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 68508967   192 H--LDQVAA--LRWVQDNiasFGGNPGSVTIFGESAGGesVSVLVLSPLAKNLFHRAISESGVALTS 254
Cdd:pfam00756  87 YayETFLTQelPPLLDAN---FPTAPDGRALAGQSMGG--LGALYLALKYPDLFGSVSSFSPILNPS 148
COG4099 COG4099
Predicted peptidase [General function prediction only];
94-225 9.99e-04

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 41.11  E-value: 9.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967  94 AGQLLSELFTNRKENIPLKlsedclYlNIYTPADLTKKNRLPVMVWIHGGG---------LMVGAAStYDGLALAAHENV 164
Cdd:COG4099  16 QDGFEARTFTDPSDGDTLP------Y-RLYLPKGYDPGKKYPLVLFLHGAGergtdnekqLTHGAPK-FINPENQAKFPA 87

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68508967 165 VVVTIQYRLGIWgffstgdehsrgnWGHLDQVAAL-RWVQDNIASFGGNPGSVTIFGESAGG 225
Cdd:COG4099  88 IVLAPQCPEDDY-------------WSDTKALDAVlALLDDLIAEYRIDPDRIYLTGLSMGG 136
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
120-249 2.15e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 40.61  E-value: 2.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68508967 120 LNIYTPADLTKKN-RLPVMVWIHGGGL-------MVGAASTYDGLAlAAHE--NVVVVTIQYRLGiwgffSTGDEHSRGN 189
Cdd:COG2382  97 VWVYLPPGYDNPGkKYPVLYLLDGGGGdeqdwfdQGRLPTILDNLI-AAGKipPMIVVMPDGGDG-----GDRGTEGPGN 170

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68508967 190 WGHLDQVAA--LRWVQDNiASFGGNPGSVTIFGESAGG-ESVSVLVLSPlakNLFHRAISESG 249
Cdd:COG2382 171 DAFERFLAEelIPFVEKN-YRVSADPEHRAIAGLSMGGlAALYAALRHP---DLFGYVGSFSG 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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