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Conserved domains on  [gi|110347437|ref|NP_001036010|]
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latent-transforming growth factor beta-binding protein 4 isoform c precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 351-392 4.66e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 4.66e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 110347437   351 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREIC 392
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1293-1335 2.13e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.13e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 110347437  1293 VCSHPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1335
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1126-1168 6.14e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.27  E-value: 6.14e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 110347437  1126 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1168
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
811-847 1.19e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.19e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 110347437    811 DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPR 847
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
767-800 1.55e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.55e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 110347437    767 DVDECSSGaPPCGPHGHCTNTEGSFRCSCAPGYR 800
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
982-1023 1.87e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.87e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 110347437    982 DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEgarDGRHCV 1023
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
853-888 8.89e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.89e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 110347437    853 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 888
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 604-641 2.71e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 110347437  604 DVDECtQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE 641
Cdd:cd00054     1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
290-320 3.69e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 3.69e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 110347437    290 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 320
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
685-726 1.80e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.80e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110347437    685 DVDECArSPPPCTYG-RCENTEGSFQCVCPMGFqpnTAGSECE 726
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
520-556 3.21e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.21e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 110347437    520 DVDECRRvPPPCAPG-RCENSPGSFRCVCGPGFRAGPR 556
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
562-603 6.39e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.39e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 110347437    562 DVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAaphGASCQ 603
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
643-677 1.32e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.32e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 110347437    643 DVDECAqEPPPCGPG-RCDNTAGSFHCACPAGFRSR 677
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1229-1258 2.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.33e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 110347437 1229 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1258
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
1507-1541 2.94e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.94e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 110347437   1507 DINECDEaeaaSPLCVN-ARCLNTDGSFRCICRPGF 1541
Cdd:smart00179    1 DIDECAS----GNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
894-932 4.02e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.02e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 110347437    894 DVDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHAGP 932
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
938-981 4.67e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.67e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 110347437    938 DVDECQEYGPEICGAqRCENTPGSYRCTpaCDPGYqpTPGGGCQ 981
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRCE--CPPGY--TDGRNCE 39
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 351-392 4.66e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 4.66e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 110347437   351 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREIC 392
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1293-1335 2.13e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.13e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 110347437  1293 VCSHPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1335
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1126-1168 6.14e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.27  E-value: 6.14e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 110347437  1126 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1168
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
811-847 1.19e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.19e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 110347437    811 DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPR 847
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
767-800 1.55e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.55e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 110347437    767 DVDECSSGaPPCGPHGHCTNTEGSFRCSCAPGYR 800
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
982-1023 1.87e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.87e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 110347437    982 DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEgarDGRHCV 1023
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 767-800 2.59e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.59e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 110347437  767 DVDECSSGaPPCGPHGHCTNTEGSFRCSCAPGYR 800
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 982-1017 6.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.92e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110347437  982 DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR 1017
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
853-888 8.89e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.89e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 110347437    853 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 888
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 811-843 1.96e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.96e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 110347437  811 DVNECLEGDFCFPHGECLNTDGSFACTCAPGYR 843
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 604-641 2.71e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 110347437  604 DVDECtQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE 641
Cdd:cd00054     1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
767-798 3.66e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 3.66e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 110347437   767 DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPG 798
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
290-320 3.69e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 3.69e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 110347437    290 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 320
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 853-884 8.22e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 8.22e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 110347437  853 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 884
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
604-641 1.19e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.19e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 110347437    604 DVDECtQSPGLCGRGA-CKNLPGSFRCVCPAGFR-GSACE 641
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 290-324 1.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110347437  290 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 324
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
685-726 1.80e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.80e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110347437    685 DVDECArSPPPCTYG-RCENTEGSFQCVCPMGFqpnTAGSECE 726
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
520-556 3.21e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.21e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 110347437    520 DVDECRRvPPPCAPG-RCENSPGSFRCVCGPGFRAGPR 556
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
562-603 6.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.39e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 110347437    562 DVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAaphGASCQ 603
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
853-882 1.04e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.04e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 110347437   853 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 882
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 992-1022 1.31e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.58  E-value: 1.31e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 110347437   992 CGAHAVCQNLPGSFQCLCDQGYEGarDGRHC 1022
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
643-677 1.32e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.32e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 110347437    643 DVDECAqEPPPCGPG-RCDNTAGSFHCACPAGFRSR 677
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 685-720 1.41e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110347437  685 DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNT 720
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 643-677 1.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110347437  643 DVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSR 677
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1229-1258 2.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.33e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 110347437 1229 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1258
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
1229-1258 2.44e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.44e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 110347437   1229 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1258
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
290-319 2.81e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 2.81e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 110347437   290 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 319
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1507-1541 2.94e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.94e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 110347437   1507 DINECDEaeaaSPLCVN-ARCLNTDGSFRCICRPGF 1541
Cdd:smart00179    1 DIDECAS----GNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 520-552 3.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.92e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 110347437  520 DVDECRRVPPPCAPGRCENSPGSFRCVCGPGFR 552
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
894-932 4.02e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.02e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 110347437    894 DVDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHAGP 932
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 562-603 4.04e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 4.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 110347437  562 DVDECHRVPPPCDLGRCENTPGSFLCVCPAGYqaapHGASCQ 603
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
938-981 4.67e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.67e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 110347437    938 DVDECQEYGPEICGAqRCENTPGSYRCTpaCDPGYqpTPGGGCQ 981
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRCE--CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1507-1545 6.42e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 110347437 1507 DINECDEAeaaSPLCVNARCLNTDGSFRCICRPGFAPTH 1545
Cdd:cd00054     1 DIDECASG---NPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
685-715 8.73e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 8.73e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 110347437   685 DVDECARSPPPCTY-GRCENTEGSFQCVCPMG 715
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 351-392 4.66e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 4.66e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 110347437   351 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREIC 392
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1293-1335 2.13e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.13e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 110347437  1293 VCSHPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1335
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1126-1168 6.14e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.27  E-value: 6.14e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 110347437  1126 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1168
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
811-847 1.19e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.19e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 110347437    811 DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPR 847
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
767-800 1.55e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.55e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 110347437    767 DVDECSSGaPPCGPHGHCTNTEGSFRCSCAPGYR 800
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
982-1023 1.87e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.87e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 110347437    982 DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEgarDGRHCV 1023
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 767-800 2.59e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.59e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 110347437  767 DVDECSSGaPPCGPHGHCTNTEGSFRCSCAPGYR 800
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 982-1017 6.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.92e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110347437  982 DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR 1017
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
853-888 8.89e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.89e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 110347437    853 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 888
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 811-843 1.96e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.96e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 110347437  811 DVNECLEGDFCFPHGECLNTDGSFACTCAPGYR 843
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 604-641 2.71e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 110347437  604 DVDECtQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACE 641
Cdd:cd00054     1 DIDEC-ASGNPCQNGGtCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
767-798 3.66e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 3.66e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 110347437   767 DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPG 798
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
290-320 3.69e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 3.69e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 110347437    290 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 320
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 853-884 8.22e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 8.22e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 110347437  853 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 884
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
604-641 1.19e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.19e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 110347437    604 DVDECtQSPGLCGRGA-CKNLPGSFRCVCPAGFR-GSACE 641
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 290-324 1.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110347437  290 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 324
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
685-726 1.80e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.80e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 110347437    685 DVDECArSPPPCTYG-RCENTEGSFQCVCPMGFqpnTAGSECE 726
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
520-556 3.21e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.21e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 110347437    520 DVDECRRvPPPCAPG-RCENSPGSFRCVCGPGFRAGPR 556
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 771-800 3.49e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.50  E-value: 3.49e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 110347437   771 CSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 800
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYT 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
562-603 6.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.39e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 110347437    562 DVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAaphGASCQ 603
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
853-882 1.04e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.04e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 110347437   853 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 882
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 992-1022 1.31e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.58  E-value: 1.31e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 110347437   992 CGAHAVCQNLPGSFQCLCDQGYEGarDGRHC 1022
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
643-677 1.32e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.32e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 110347437    643 DVDECAqEPPPCGPG-RCDNTAGSFHCACPAGFRSR 677
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 685-720 1.41e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110347437  685 DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNT 720
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 643-677 1.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 110347437  643 DVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSR 677
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF smart00181
Epidermal growth factor-like domain;
293-325 1.93e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.11  E-value: 1.93e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 110347437    293 ECATGGRCQHGECANTRGGYTCVCPDGFLLDSS 325
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1229-1258 2.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.33e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 110347437 1229 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1258
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
1229-1258 2.44e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.44e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 110347437   1229 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1258
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
290-319 2.81e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 2.81e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 110347437   290 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 319
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1507-1541 2.94e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.94e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 110347437   1507 DINECDEaeaaSPLCVN-ARCLNTDGSFRCICRPGF 1541
Cdd:smart00179    1 DIDECAS----GNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 520-552 3.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.92e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 110347437  520 DVDECRRVPPPCAPGRCENSPGSFRCVCGPGFR 552
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
894-932 4.02e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.02e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 110347437    894 DVDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHAGP 932
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 562-603 4.04e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 4.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 110347437  562 DVDECHRVPPPCDLGRCENTPGSFLCVCPAGYqaapHGASCQ 603
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
938-981 4.67e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.67e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 110347437    938 DVDECQEYGPEICGAqRCENTPGSYRCTpaCDPGYqpTPGGGCQ 981
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRCE--CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1507-1545 6.42e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 110347437 1507 DINECDEAeaaSPLCVNARCLNTDGSFRCICRPGFAPTH 1545
Cdd:cd00054     1 DIDECASG---NPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
685-715 8.73e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 8.73e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 110347437   685 DVDECARSPPPCTY-GRCENTEGSFQCVCPMG 715
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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