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Conserved domains on  [gi|332634996|ref|NP_001073873|]
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zinc finger protein 878 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.89e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 1.89e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 332634996    3 SVAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
122-521 1.86e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 1.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 122 RAFSYSSSLAIHGRTHTGEKPYEC--KECGKAFRFPSSVRRHERIHSAKKPYEC-KQCGKAFSFPSSVRRHERIHSAKKP 198
Cdd:COG5048   41 DSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDN 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 199 YECKQCGKALSYLVSFQTHMRMHTGERPHKCNICGKAFF-SPSSLKRHEKSHTGEKRykckqcdKAFNCPSSFQYHERTH 277
Cdd:COG5048  121 NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 278 SGEKPYECTQCRKAFRSVKYLRVHERKHTGEKPYECKLCGKGF-ISSTSFRYHEKTHTGEKPYECKKCVKAFSFV----- 351
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpKSLLSQSPSSLSSSDSSSSASESPRSSLPTAssqss 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 352 KDLRIHERTHTG-EKPFECKQCGKTFTSSNSFHYHERT--HTGE--KPYEC--KQCGKAFRSASVLQKHIRTHTGEKPYG 424
Cdd:COG5048  274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 425 CK--QCGKVFRVAS-----QLKMHERTHTGEKPYEC--KQCGKAFISSNSIRYHKRTHTGEKP--YKCKQCGKAFISSNS 493
Cdd:COG5048  354 EKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                        410       420
                 ....*....|....*....|....*...
gi 332634996 494 FLYHERIHTGEKPYECKQCGKAFRSASI 521
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRDLDL 461
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.89e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 1.89e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 332634996    3 SVAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 1.18e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.34  E-value: 1.18e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 332634996     4 VAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIGKK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.87e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.06  E-value: 2.87e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 332634996   4 VAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSI 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
122-521 1.86e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 1.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 122 RAFSYSSSLAIHGRTHTGEKPYEC--KECGKAFRFPSSVRRHERIHSAKKPYEC-KQCGKAFSFPSSVRRHERIHSAKKP 198
Cdd:COG5048   41 DSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDN 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 199 YECKQCGKALSYLVSFQTHMRMHTGERPHKCNICGKAFF-SPSSLKRHEKSHTGEKRykckqcdKAFNCPSSFQYHERTH 277
Cdd:COG5048  121 NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 278 SGEKPYECTQCRKAFRSVKYLRVHERKHTGEKPYECKLCGKGF-ISSTSFRYHEKTHTGEKPYECKKCVKAFSFV----- 351
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpKSLLSQSPSSLSSSDSSSSASESPRSSLPTAssqss 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 352 KDLRIHERTHTG-EKPFECKQCGKTFTSSNSFHYHERT--HTGE--KPYEC--KQCGKAFRSASVLQKHIRTHTGEKPYG 424
Cdd:COG5048  274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 425 CK--QCGKVFRVAS-----QLKMHERTHTGEKPYEC--KQCGKAFISSNSIRYHKRTHTGEKP--YKCKQCGKAFISSNS 493
Cdd:COG5048  354 EKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                        410       420
                 ....*....|....*....|....*...
gi 332634996 494 FLYHERIHTGEKPYECKQCGKAFRSASI 521
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-266 1.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 332634996  241 SLKRHEKSHTGEKRYKCKQCDKAFNC 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PRK04860 PRK04860
SprT family zinc-dependent metalloprotease;
170-210 5.25e-03

SprT family zinc-dependent metalloprotease;


Pssm-ID: 179886  Cd Length: 160  Bit Score: 37.97  E-value: 5.25e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 332634996 170 PYECkQCGkafSFPSSVRRHERIHSAKKPYECKQCGKALSY 210
Cdd:PRK04860 119 PYRC-KCQ---EHQLTVRRHNRVVRGEAVYRCRRCGETLVF 155
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.89e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 1.89e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 332634996    3 SVAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 1.18e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.34  E-value: 1.18e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 332634996     4 VAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIGKK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.87e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.06  E-value: 2.87e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 332634996   4 VAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSI 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
122-521 1.86e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 1.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 122 RAFSYSSSLAIHGRTHTGEKPYEC--KECGKAFRFPSSVRRHERIHSAKKPYEC-KQCGKAFSFPSSVRRHERIHSAKKP 198
Cdd:COG5048   41 DSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDN 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 199 YECKQCGKALSYLVSFQTHMRMHTGERPHKCNICGKAFF-SPSSLKRHEKSHTGEKRykckqcdKAFNCPSSFQYHERTH 277
Cdd:COG5048  121 NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 278 SGEKPYECTQCRKAFRSVKYLRVHERKHTGEKPYECKLCGKGF-ISSTSFRYHEKTHTGEKPYECKKCVKAFSFV----- 351
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpKSLLSQSPSSLSSSDSSSSASESPRSSLPTAssqss 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 352 KDLRIHERTHTG-EKPFECKQCGKTFTSSNSFHYHERT--HTGE--KPYEC--KQCGKAFRSASVLQKHIRTHTGEKPYG 424
Cdd:COG5048  274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 425 CK--QCGKVFRVAS-----QLKMHERTHTGEKPYEC--KQCGKAFISSNSIRYHKRTHTGEKP--YKCKQCGKAFISSNS 493
Cdd:COG5048  354 EKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                        410       420
                 ....*....|....*....|....*...
gi 332634996 494 FLYHERIHTGEKPYECKQCGKAFRSASI 521
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-531 9.52e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 9.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 225 RPHKCNICGKAFFSPSSLKRHEKSHTGEKRYKC--KQCDKAFNCPSSFQYHERTHSGEKPYECTQCRKAFRSVKYLRVHE 302
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 303 RKHTGE-KPYECKLCGKGFISSTSFRYHEKTHTgeKPYECKKCVKAFSFVKDLRIHERTHTGEKPFECKqcgkTFTSSNS 381
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSK----DPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 382 FHYHERTHTGEKPYECKQCGKAFRSASVLQKHIRTHTGEKPYGCKQCGKVF-------RVASQLKMHERTHTGEKPYECK 454
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 455 QcGKAFISSNSIRYHKRTHTG-EKPYKCKQCGKAFISSNSFLYHER--IHTGE--KPYEC--KQCGKAFRSASILQKHVR 527
Cdd:COG5048  266 P-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344


                 ....
gi 332634996 528 THAG 531
Cdd:COG5048  345 LHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-529 1.94e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 166 SAKKPYECKQCGKAFSFPSSVRRHERIHSAKKPYECKQCGKALSY--LVSFQTHMRMHTGERPHKCNI-CGKAFFSPSSL 242
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 243 KRHEKSHTGEKRYKCKQCDKAFNCPSSFQYHERTHSGEKPYECTQC-RKAFRSVKY---------------------LRV 300
Cdd:COG5048  109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSnslhpplpanslskdpssnlsLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 301 HERKHTGEKPYECKLCGKGFISSTSFRYHEKTHTGEKPYECKKCVKAFSFVKDLRIHERTHTGEKPFECKQCG------K 374
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 375 TFTSSNSFHYHERTHTG-EKPYECKQCGKAFRSASVLQKHIRT--HTGE--KPYGC--KQCGKVFRVASQLKMHERTHTG 447
Cdd:COG5048  269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 448 EKPYECK--QCGKAFISSNSIRYHKRT--HTGEKPYKCK-----QCGKAFISSNSFLYHERIHTGEKPYECK--QCGKAF 516
Cdd:COG5048  349 ISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                        410
                 ....*....|...
gi 332634996 517 RSASILQKHVRTH 529
Cdd:COG5048  429 NRHYNLIPHKKIH 441
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 447-529 5.24e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 5.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 447 GEKPYECK--QCGKAFISSNSIRYHKRT-HTGEKPYKckqcGKAFISSNSFLyherihTGEKPYECKQCGKAFRSASILQ 523
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----NPSPEKMNIFS------AKDKPYRCEVCDKRYKNLNGLK 415


                 ....*.
gi 332634996 524 KHvRTH 529
Cdd:COG5189  416 YH-RKH 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 307-390 6.81e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 6.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 307 GEKPYECKL--CGKGFISSTSFRYHEKT-HTGEKPYECKKCVKAFSFVKDlriherthtgEKPFECKQCGKTFTSSNSFH 383
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAK----------DKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 332634996 384 YHeRTHT 390
Cdd:COG5189  416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-266 1.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 332634996  241 SLKRHEKSHTGEKRYKCKQCDKAFNC 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
438-462 2.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.84e-04
                          10        20
                  ....*....|....*....|....*
gi 332634996  438 LKMHERTHTGEKPYECKQCGKAFIS 462
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
353-378 5.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 332634996  353 DLRIHERTHTGEKPFECKQCGKTFTS 378
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-490 7.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.07e-04
                          10        20
                  ....*....|....*....|....
gi 332634996  467 RYHKRTHTGEKPYKCKQCGKAFIS 490
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 363-418 1.00e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.00e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 332634996 363 GEKPFECK--QCGKTFTSSNSFHYH---------------ERTHTG----EKPYECKQCGKAFRSASVLQKHiRTHT 418
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-322 1.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 332634996  297 YLRVHERKHTGEKPYECKLCGKGFIS 322
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
213-236 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....
gi 332634996  213 SFQTHMRMHTGERPHKCNICGKAF 236
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 391-474 2.64e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332634996 391 GEKPYECK--QCGKAFRSASVLQKHiRTHTGEKPygckqcgKVFRVASQLKmHERTHTGEKPYECKQCGKAFISSNSIRY 468
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 332634996 469 HkRTHT 474
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-406 2.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.66e-03
                          10        20
                  ....*....|....*....|..
gi 332634996  385 HERTHTGEKPYECKQCGKAFRS 406
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
497-518 2.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.99e-03
                          10        20
                  ....*....|....*....|..
gi 332634996  497 HERIHTGEKPYECKQCGKAFRS 518
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-294 4.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.99e-03
                          10        20
                  ....*....|....*....|....*.
gi 332634996  269 SFQYHERTHSGEKPYECTQCRKAFRS 294
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PRK04860 PRK04860
SprT family zinc-dependent metalloprotease;
170-210 5.25e-03

SprT family zinc-dependent metalloprotease;


Pssm-ID: 179886  Cd Length: 160  Bit Score: 37.97  E-value: 5.25e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 332634996 170 PYECkQCGkafSFPSSVRRHERIHSAKKPYECKQCGKALSY 210
Cdd:PRK04860 119 PYRC-KCQ---EHQLTVRRHNRVVRGEAVYRCRRCGETLVF 155
zf-H2C2_2 pfam13465
Zinc-finger double domain;
157-181 6.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.26e-03
                          10        20
                  ....*....|....*....|....*
gi 332634996  157 SVRRHERIHSAKKPYECKQCGKAFS 181
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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