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Conserved domains on  [gi|339895886|ref|NP_001073877|]
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prospero homeobox protein 2 isoform 2 [Homo sapiens]

Protein Classification

homeo-prospero domain-containing protein( domain architecture ID 141796)

homeo-prospero domain (HPD)-containing protein similar to Drosophila melanogaster homeobox protein prospero, a homeodomain protein that controls neuronal identity

CATH:  1.10.10.500
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  12429095|15837198

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HPD super family cl20287
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
 244-365 1.84e-80

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


The actual alignment was detected with superfamily member pfam05044:

Pssm-ID: 461534  Cd Length: 154  Bit Score: 242.72  E-value: 1.84e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895886  244 KFNRCITSQMIKWFSNFREFYYIQMEKSARQAISDGVTNPKMLVVLRNSELFQALNMHYNKGNDFEVPDCFLEIASLTLQ 323
Cdd:pfam05044  33 KFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRDSELFRVLNLHYNKNNDFEVPDRFLEVVQLTLR 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 339895886  324 EFFRAVSAGRDSDPSWKKPIYKIISKLDSDIPEIFKSSSYPQ 365
Cdd:pfam05044 113 EFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
 
Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
 244-365 1.84e-80

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


Pssm-ID: 461534  Cd Length: 154  Bit Score: 242.72  E-value: 1.84e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895886  244 KFNRCITSQMIKWFSNFREFYYIQMEKSARQAISDGVTNPKMLVVLRNSELFQALNMHYNKGNDFEVPDCFLEIASLTLQ 323
Cdd:pfam05044  33 KFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRDSELFRVLNLHYNKNNDFEVPDRFLEVVQLTLR 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 339895886  324 EFFRAVSAGRDSDPSWKKPIYKIISKLDSDIPEIFKSSSYPQ 365
Cdd:pfam05044 113 EFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
 
Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
 244-365 1.84e-80

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


Pssm-ID: 461534  Cd Length: 154  Bit Score: 242.72  E-value: 1.84e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895886  244 KFNRCITSQMIKWFSNFREFYYIQMEKSARQAISDGVTNPKMLVVLRNSELFQALNMHYNKGNDFEVPDCFLEIASLTLQ 323
Cdd:pfam05044  33 KFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRDSELFRVLNLHYNKNNDFEVPDRFLEVVQLTLR 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 339895886  324 EFFRAVSAGRDSDPSWKKPIYKIISKLDSDIPEIFKSSSYPQ 365
Cdd:pfam05044 113 EFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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