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Conserved domains on  [gi|131887972|ref|NP_001076497|]
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protein PAT1 homolog 1 [Danio rerio]

Protein Classification

PAT1 family protein( domain architecture ID 1001013)

PAT1 family protein similar to Saccharomyces cerevisiae DNA topoisomerase 2-associated protein PAT1, an activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation

Gene Ontology:  GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 230-628 2.63e-12

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 70.45  E-value: 2.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  230 PPPRSSSPVIGSPPVRAVPIGTPPKQPMSQILNQQNNHPSAIHVRASVPM----RfpPPFPERLSPNNLLSIAKSPLSHS 305
Cdd:pfam09770 214 PAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVtilqR--PQSPQPDPAQPSIQPQAQQFHQQ 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  306 PFPAGVNPvlSQIqraqLLNSQVGQFQRGPAPPLLQGGVGGFRPFFGQSGPRIGPHGPPLghapirhnttHLHPQHRRML 385
Cdd:pfam09770 292 PPPVPVQP--TQI----LQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI----------ITHPQQLAQL 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  386 SQRMQ-------------NRGDHVGGRGVGerknrdpysnLMTQREKEWVAKIQMMQL---------QSTDPYL-DDYYY 442
Cdd:pfam09770 356 SEEEKaayldeeakrakrNHKIFLLSKDNG----------LMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYY 425

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  443 QNY-----------------------------YEKMeKRQERDRDN---RKEHttklitpQV------AKLEHTYRPVQF 484
Cdd:pfam09770 426 QVYsqirggprqhpsqplsnfaqtylfqtgsrQGGM-RRQGRGAENhmqRMEQ-------QVqraveaAKNKPKNKQLVI 497

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  485 AGSLGKLTVSSVNNPRKMI---------DAVVTSRSDDEEKREKQVWNKRRQILYTVEKMYSLLLEVQDFEKKFLQTPEH 555
Cdd:pfam09770 498 EGSLGKISFSNAKTPKPLLnikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTE 577

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  556 QRDV-LLEQHKT--HTLQLYNslrEKEWDD-RVSDE-------QCLMIMSVRKGKRLISRLLPFLPQPQAAAVVMGIARN 624
Cdd:pfam09770 578 DSDPeLIEKHMEwrSTLQALN---AKLWQElKVHEPigsttphPFIAFLSHPKGKKAIPRIFRHLSQEQRTTILTMIVVH 654


                  ....
gi 131887972  625 LPAL 628
Cdd:pfam09770 655 LDQL 658
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 230-628 2.63e-12

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 70.45  E-value: 2.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  230 PPPRSSSPVIGSPPVRAVPIGTPPKQPMSQILNQQNNHPSAIHVRASVPM----RfpPPFPERLSPNNLLSIAKSPLSHS 305
Cdd:pfam09770 214 PAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVtilqR--PQSPQPDPAQPSIQPQAQQFHQQ 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  306 PFPAGVNPvlSQIqraqLLNSQVGQFQRGPAPPLLQGGVGGFRPFFGQSGPRIGPHGPPLghapirhnttHLHPQHRRML 385
Cdd:pfam09770 292 PPPVPVQP--TQI----LQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI----------ITHPQQLAQL 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  386 SQRMQ-------------NRGDHVGGRGVGerknrdpysnLMTQREKEWVAKIQMMQL---------QSTDPYL-DDYYY 442
Cdd:pfam09770 356 SEEEKaayldeeakrakrNHKIFLLSKDNG----------LMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYY 425

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  443 QNY-----------------------------YEKMeKRQERDRDN---RKEHttklitpQV------AKLEHTYRPVQF 484
Cdd:pfam09770 426 QVYsqirggprqhpsqplsnfaqtylfqtgsrQGGM-RRQGRGAENhmqRMEQ-------QVqraveaAKNKPKNKQLVI 497

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  485 AGSLGKLTVSSVNNPRKMI---------DAVVTSRSDDEEKREKQVWNKRRQILYTVEKMYSLLLEVQDFEKKFLQTPEH 555
Cdd:pfam09770 498 EGSLGKISFSNAKTPKPLLnikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTE 577

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  556 QRDV-LLEQHKT--HTLQLYNslrEKEWDD-RVSDE-------QCLMIMSVRKGKRLISRLLPFLPQPQAAAVVMGIARN 624
Cdd:pfam09770 578 DSDPeLIEKHMEwrSTLQALN---AKLWQElKVHEPigsttphPFIAFLSHPKGKKAIPRIFRHLSQEQRTTILTMIVVH 654


                  ....
gi 131887972  625 LPAL 628
Cdd:pfam09770 655 LDQL 658
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 230-628 2.63e-12

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 70.45  E-value: 2.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  230 PPPRSSSPVIGSPPVRAVPIGTPPKQPMSQILNQQNNHPSAIHVRASVPM----RfpPPFPERLSPNNLLSIAKSPLSHS 305
Cdd:pfam09770 214 PAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVtilqR--PQSPQPDPAQPSIQPQAQQFHQQ 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  306 PFPAGVNPvlSQIqraqLLNSQVGQFQRGPAPPLLQGGVGGFRPFFGQSGPRIGPHGPPLghapirhnttHLHPQHRRML 385
Cdd:pfam09770 292 PPPVPVQP--TQI----LQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI----------ITHPQQLAQL 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  386 SQRMQ-------------NRGDHVGGRGVGerknrdpysnLMTQREKEWVAKIQMMQL---------QSTDPYL-DDYYY 442
Cdd:pfam09770 356 SEEEKaayldeeakrakrNHKIFLLSKDNG----------LMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYY 425

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  443 QNY-----------------------------YEKMeKRQERDRDN---RKEHttklitpQV------AKLEHTYRPVQF 484
Cdd:pfam09770 426 QVYsqirggprqhpsqplsnfaqtylfqtgsrQGGM-RRQGRGAENhmqRMEQ-------QVqraveaAKNKPKNKQLVI 497

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  485 AGSLGKLTVSSVNNPRKMI---------DAVVTSRSDDEEKREKQVWNKRRQILYTVEKMYSLLLEVQDFEKKFLQTPEH 555
Cdd:pfam09770 498 EGSLGKISFSNAKTPKPLLnikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTE 577

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 131887972  556 QRDV-LLEQHKT--HTLQLYNslrEKEWDD-RVSDE-------QCLMIMSVRKGKRLISRLLPFLPQPQAAAVVMGIARN 624
Cdd:pfam09770 578 DSDPeLIEKHMEwrSTLQALN---AKLWQElKVHEPigsttphPFIAFLSHPKGKKAIPRIFRHLSQEQRTTILTMIVVH 654


                  ....
gi 131887972  625 LPAL 628
Cdd:pfam09770 655 LDQL 658
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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