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Conserved domains on  [gi|157823613|ref|NP_001099907|]
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FH2 domain-containing protein 1 [Rattus norvegicus]

Protein Classification

FH2 domain-containing protein( domain architecture ID 13671889)

FH2 domain-containing protein; FH2 domain-containing protein similar to formin homology proteins that control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarization; FH2 domain-containing protein; FH2 domain-containing protein similar to formin homology proteins that control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarization

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
93-457 1.72e-114

Formin Homology 2 Domain;


:

Pssm-ID: 396655  Cd Length: 372  Bit Score: 360.43  E-value: 1.72e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613    93 KKKRMRSFFWKTIPEEQVRGktNIWTLAAKQQHHYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSfrdaREEIAVLDA 172
Cdd:pfam02181    7 PKKKLKPLHWDKVRPSQDRG--TVWDKLDDESFELDGDLSELEELFSAKAKTKKNKKSEDKSSSKKK----PKEVSLLDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   173 KRSMNIGIFLKQFKKSPQSIVEDIHQGRSEHYGSETLREILKLLPESEEVKKLKTFNGDVSKLSLADSFLYCLIQVPNYS 252
Cdd:pfam02181   81 KRAQNIAILLRKLKLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPRLE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   253 LRIEAMVLKKEFLPFCTSLYKDITTLRAAMKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANK 332
Cdd:pfam02181  161 ARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGTRRGQAKGFKLSSLLKLSDTKSTD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   333 PGMNLLHFVAQEAQKHNTILLNFSEKLQQVQETSRLSLDIIEAELHSLFVRTKSLRENIQR-------DQELRQQMEDFL 405
Cdd:pfam02181  241 NKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELsaldehpDDKFREVLKEFL 320

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 157823613   406 QFAVEKLAELELWKRELQVEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFN 457
Cdd:pfam02181  321 KSAEEKLDKLESLLREALELFKELVEYFGEDPKETSPEEFFKILRDFLKEFK 372
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 733-1128 1.83e-12

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 72.13  E-value: 1.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  733 GEDDRAISDEPSSEALVSVVVTDTEDKDPGSLLYVSDTTDCSLTLDCSEGTDsRPGGDKHrEEKEGDGSVSSGAGEAGSS 812
Cdd:PHA03307   44 VSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTL-APASPAR-EGSPTPPGPSSPDPPPPTP 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  813 QVSSNPASSPPGEVPAPKSTKSEPSCQGGLQKDRPSRGKDAMAPKRNSfKEASVGASKPVSARRSQGVAPKPVrtlnsse 892
Cdd:PHA03307  122 PPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASS-RQAALPLSSPEETARAPSSPPAEP------- 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  893 nehmrkvvPISKSSRGAGPWKRPELTSRATPRETPSSTDTQLSRRSSVRGTSDTSPRRPQVSGSGTEEP---------RL 963
Cdd:PHA03307  194 --------PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENEcplprpapiTL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  964 PRS--SGSIGGRPGKDPTLQ-PRASFRKPSAKPLRNIPRQKPEENKVSSPNSRDPESPKEEPKAPQAPGASRALPPTPSf 1040
Cdd:PHA03307  266 PTRiwEASGWNGPSSRPGPAsSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPG- 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613 1041 arntvASSSRSMRADAPPAARATGITRtvsQRQLRVKSGSEDSASKDSGTLKRASSARASKKCPESAGGSSANVETPLKG 1120
Cdd:PHA03307  345 -----PSPSRSPSPSRPPPPADPSSPR---KRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSP 416


                  ....*...
gi 157823613 1121 RGTTERSS 1128
Cdd:PHA03307  417 LDAGAASG 424
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 559-760 8.51e-04

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.52  E-value: 8.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  559 PEDPNKFNSlPRSSPRQTRPTiawmEPREqethgpvfthdPQASKNQEQTPHPAwqnhlppswlgEPVSPSPPAGRSRPS 638
Cdd:PTZ00449  591 PEEPKKPKR-PRSAQRPTRPK----SPKL-----------PELLDIPKSPKRPE-----------SPKSPKRPPPPQRPS 643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  639 LRKRSSEPVGLGTAQSP--PLLPLDLGIRE-------------HELVTGLTQFDLQSPKSLEETSQLTLNDF-CPTKLPP 702
Cdd:PTZ00449  644 SPERPEGPKIIKSPKPPksPKPPFDPKFKEkfyddyldaaaksKETKTTVVLDESFESILKETLPETPGTPFtTPRPLPP 723

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157823613  703 -LGDKSSQPFDAGGDSRAPKdTDPREALSPAGEDDRAISDEPSSEALVSVVVTDTEDKD 760
Cdd:PTZ00449  724 kLPRDEEFPFEPIGDPDAEQ-PDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEED 781
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
93-457 1.72e-114

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 360.43  E-value: 1.72e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613    93 KKKRMRSFFWKTIPEEQVRGktNIWTLAAKQQHHYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSfrdaREEIAVLDA 172
Cdd:pfam02181    7 PKKKLKPLHWDKVRPSQDRG--TVWDKLDDESFELDGDLSELEELFSAKAKTKKNKKSEDKSSSKKK----PKEVSLLDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   173 KRSMNIGIFLKQFKKSPQSIVEDIHQGRSEHYGSETLREILKLLPESEEVKKLKTFNGDVSKLSLADSFLYCLIQVPNYS 252
Cdd:pfam02181   81 KRAQNIAILLRKLKLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPRLE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   253 LRIEAMVLKKEFLPFCTSLYKDITTLRAAMKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANK 332
Cdd:pfam02181  161 ARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGTRRGQAKGFKLSSLLKLSDTKSTD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   333 PGMNLLHFVAQEAQKHNTILLNFSEKLQQVQETSRLSLDIIEAELHSLFVRTKSLRENIQR-------DQELRQQMEDFL 405
Cdd:pfam02181  241 NKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELsaldehpDDKFREVLKEFL 320

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 157823613   406 QFAVEKLAELELWKRELQVEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFN 457
Cdd:pfam02181  321 KSAEEKLDKLESLLREALELFKELVEYFGEDPKETSPEEFFKILRDFLKEFK 372
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
 94-486 1.52e-60

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 212.98  E-value: 1.52e-60
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613     94 KKRMRSFFWKTIPEEQVRGktniwTLAAKQQHHYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSfRDAREEIAVLDAK 173
Cdd:smart00498    7 KKKLKPLHWDKLNPSDLSG-----TVWDKIDEESEGDLDELEELFSAKEKTKSASKDVSEKKSILK-KKASQEFKILDPK 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613    174 RSMNIGIFLKQFKKSPQSIVEDIHQGRSEHYGSETLREILKLLPESEEVKKLKTFNG-DVSKLSLADSFLYCLIQVPNYS 252
Cdd:smart00498   81 RSQNLAILLRKLHMSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEeDPEELARAEQFLLLISNIPYLE 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613    253 LRIEAMVLKKEFLPFCTSLYKDITTLRAAMKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANK 332
Cdd:smart00498  161 ERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGGSRRGQAYGFKLSSLLKLSDVKSAD 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613    333 PGMNLLHFVAQEaqkhntILLNFSEKLQQVQetsrlsldiieaelhslfvrtkslreniQRDQELRQQMEDFLQFAVEKL 412
Cdd:smart00498  241 NKTTLLHFLVKI------IRKKYLGGLSDPE----------------------------NLDDKFIEVMKPFLKAAKEKY 286

                           330       340       350       360       370       380       390
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157823613    413 AELELWKRELQVEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDR-EEQERKQLQRLKELEQKRHS 486
Cdd:smart00498  287 DKLQKDLSDLKTRFEKLVEYYGEDPKDTSPEEFFKDFNEFLKEFSKAAEENIKKeEEEEERRKKLVKETTEYEQS 361
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 733-1128 1.83e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 72.13  E-value: 1.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  733 GEDDRAISDEPSSEALVSVVVTDTEDKDPGSLLYVSDTTDCSLTLDCSEGTDsRPGGDKHrEEKEGDGSVSSGAGEAGSS 812
Cdd:PHA03307   44 VSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTL-APASPAR-EGSPTPPGPSSPDPPPPTP 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  813 QVSSNPASSPPGEVPAPKSTKSEPSCQGGLQKDRPSRGKDAMAPKRNSfKEASVGASKPVSARRSQGVAPKPVrtlnsse 892
Cdd:PHA03307  122 PPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASS-RQAALPLSSPEETARAPSSPPAEP------- 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  893 nehmrkvvPISKSSRGAGPWKRPELTSRATPRETPSSTDTQLSRRSSVRGTSDTSPRRPQVSGSGTEEP---------RL 963
Cdd:PHA03307  194 --------PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENEcplprpapiTL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  964 PRS--SGSIGGRPGKDPTLQ-PRASFRKPSAKPLRNIPRQKPEENKVSSPNSRDPESPKEEPKAPQAPGASRALPPTPSf 1040
Cdd:PHA03307  266 PTRiwEASGWNGPSSRPGPAsSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPG- 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613 1041 arntvASSSRSMRADAPPAARATGITRtvsQRQLRVKSGSEDSASKDSGTLKRASSARASKKCPESAGGSSANVETPLKG 1120
Cdd:PHA03307  345 -----PSPSRSPSPSRPPPPADPSSPR---KRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSP 416


                  ....*...
gi 157823613 1121 RGTTERSS 1128
Cdd:PHA03307  417 LDAGAASG 424
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 559-760 8.51e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.52  E-value: 8.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  559 PEDPNKFNSlPRSSPRQTRPTiawmEPREqethgpvfthdPQASKNQEQTPHPAwqnhlppswlgEPVSPSPPAGRSRPS 638
Cdd:PTZ00449  591 PEEPKKPKR-PRSAQRPTRPK----SPKL-----------PELLDIPKSPKRPE-----------SPKSPKRPPPPQRPS 643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  639 LRKRSSEPVGLGTAQSP--PLLPLDLGIRE-------------HELVTGLTQFDLQSPKSLEETSQLTLNDF-CPTKLPP 702
Cdd:PTZ00449  644 SPERPEGPKIIKSPKPPksPKPPFDPKFKEkfyddyldaaaksKETKTTVVLDESFESILKETLPETPGTPFtTPRPLPP 723

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157823613  703 -LGDKSSQPFDAGGDSRAPKdTDPREALSPAGEDDRAISDEPSSEALVSVVVTDTEDKD 760
Cdd:PTZ00449  724 kLPRDEEFPFEPIGDPDAEQ-PDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEED 781
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 809-1047 5.48e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.13  E-value: 5.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   809 AGSSQVSSNPASSPPGEVPAPKSTKSE-------PSCQGGLQKDRP--SRGKDAM-APKRNSFKEASVGASKPVSARRSQ 878
Cdd:TIGR00927  135 AGTERVKEDTPATPSRALNHYISTSGRqrvksytPKPRGEVKSSSPtqTREKVRKyTPSPLGRMVNSYAPSTFMTMPRSH 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   879 GVAPKPvrTLNSSENEHMRKVVPISKSSRGAGPwKRPELTSRATPrETPS------STDTQLSRRSSVRGTSDTSPRRPQ 952
Cdd:TIGR00927  215 GITPRT--TVKDSEITATYKMLETNPSKRTAGK-TTPTPLKGMTD-NTPTfltrevETDLLTSPRSVVEKNTLTTPRRVE 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   953 VSgsgteeprlprSSGSIGGRPGKDPTLQPRASFRKPSAK------PLRNIPRQKPEENKVSSP--NSRDPESPKEEPKA 1024
Cdd:TIGR00927  291 SN-----------SSTNHWGLVGKNNLTTPQGTVLEHTPAtsegqvTISIMTGSSPAETKASTAawKIRNPLSRTSAPAV 359

                          250       260
                   ....*....|....*....|...
gi 157823613  1025 PQAPGASRALPPTPSFARNTVAS 1047
Cdd:TIGR00927  360 RIASATFRGLEKNPSTAPSTPAT 382
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
93-457 1.72e-114

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 360.43  E-value: 1.72e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613    93 KKKRMRSFFWKTIPEEQVRGktNIWTLAAKQQHHYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSfrdaREEIAVLDA 172
Cdd:pfam02181    7 PKKKLKPLHWDKVRPSQDRG--TVWDKLDDESFELDGDLSELEELFSAKAKTKKNKKSEDKSSSKKK----PKEVSLLDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   173 KRSMNIGIFLKQFKKSPQSIVEDIHQGRSEHYGSETLREILKLLPESEEVKKLKTFNGDVSKLSLADSFLYCLIQVPNYS 252
Cdd:pfam02181   81 KRAQNIAILLRKLKLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPRLE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   253 LRIEAMVLKKEFLPFCTSLYKDITTLRAAMKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANK 332
Cdd:pfam02181  161 ARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGTRRGQAKGFKLSSLLKLSDTKSTD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   333 PGMNLLHFVAQEAQKHNTILLNFSEKLQQVQETSRLSLDIIEAELHSLFVRTKSLRENIQR-------DQELRQQMEDFL 405
Cdd:pfam02181  241 NKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELsaldehpDDKFREVLKEFL 320

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 157823613   406 QFAVEKLAELELWKRELQVEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFN 457
Cdd:pfam02181  321 KSAEEKLDKLESLLREALELFKELVEYFGEDPKETSPEEFFKILRDFLKEFK 372
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
 94-486 1.52e-60

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 212.98  E-value: 1.52e-60
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613     94 KKRMRSFFWKTIPEEQVRGktniwTLAAKQQHHYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSfRDAREEIAVLDAK 173
Cdd:smart00498    7 KKKLKPLHWDKLNPSDLSG-----TVWDKIDEESEGDLDELEELFSAKEKTKSASKDVSEKKSILK-KKASQEFKILDPK 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613    174 RSMNIGIFLKQFKKSPQSIVEDIHQGRSEHYGSETLREILKLLPESEEVKKLKTFNG-DVSKLSLADSFLYCLIQVPNYS 252
Cdd:smart00498   81 RSQNLAILLRKLHMSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEeDPEELARAEQFLLLISNIPYLE 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613    253 LRIEAMVLKKEFLPFCTSLYKDITTLRAAMKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANK 332
Cdd:smart00498  161 ERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGGSRRGQAYGFKLSSLLKLSDVKSAD 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613    333 PGMNLLHFVAQEaqkhntILLNFSEKLQQVQetsrlsldiieaelhslfvrtkslreniQRDQELRQQMEDFLQFAVEKL 412
Cdd:smart00498  241 NKTTLLHFLVKI------IRKKYLGGLSDPE----------------------------NLDDKFIEVMKPFLKAAKEKY 286

                           330       340       350       360       370       380       390
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157823613    413 AELELWKRELQVEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDR-EEQERKQLQRLKELEQKRHS 486
Cdd:smart00498  287 DKLQKDLSDLKTRFEKLVEYYGEDPKDTSPEEFFKDFNEFLKEFSKAAEENIKKeEEEEERRKKLVKETTEYEQS 361
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 733-1128 1.83e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 72.13  E-value: 1.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  733 GEDDRAISDEPSSEALVSVVVTDTEDKDPGSLLYVSDTTDCSLTLDCSEGTDsRPGGDKHrEEKEGDGSVSSGAGEAGSS 812
Cdd:PHA03307   44 VSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTL-APASPAR-EGSPTPPGPSSPDPPPPTP 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  813 QVSSNPASSPPGEVPAPKSTKSEPSCQGGLQKDRPSRGKDAMAPKRNSfKEASVGASKPVSARRSQGVAPKPVrtlnsse 892
Cdd:PHA03307  122 PPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASS-RQAALPLSSPEETARAPSSPPAEP------- 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  893 nehmrkvvPISKSSRGAGPWKRPELTSRATPRETPSSTDTQLSRRSSVRGTSDTSPRRPQVSGSGTEEP---------RL 963
Cdd:PHA03307  194 --------PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENEcplprpapiTL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  964 PRS--SGSIGGRPGKDPTLQ-PRASFRKPSAKPLRNIPRQKPEENKVSSPNSRDPESPKEEPKAPQAPGASRALPPTPSf 1040
Cdd:PHA03307  266 PTRiwEASGWNGPSSRPGPAsSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPG- 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613 1041 arntvASSSRSMRADAPPAARATGITRtvsQRQLRVKSGSEDSASKDSGTLKRASSARASKKCPESAGGSSANVETPLKG 1120
Cdd:PHA03307  345 -----PSPSRSPSPSRPPPPADPSSPR---KRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSP 416


                  ....*...
gi 157823613 1121 RGTTERSS 1128
Cdd:PHA03307  417 LDAGAASG 424
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 523-978 3.09e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 58.26  E-value: 3.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  523 PNSPSYRPPNTRRSRLSLGISADRELLTFLESATSSPEDPNKFNSLPRSSP------RQTRPTIAWMEPREQETHGPVFT 596
Cdd:PHA03307   25 PATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPgteapaNESRSTPTWSLSTLAPASPAREG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  597 HDPQASKNQEQTPHPAWQNHLPPSWLGEPVSPSPPAGRSRPSLRKRSSEPVGLGTAQSPpllpldlgirEHELVTGLTQF 676
Cdd:PHA03307  105 SPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA----------SDAASSRQAAL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  677 DLQSPKSLEETSqltlndfcPTKLPPLGdKSSQPFDAGGDSRAPKDTDPREALSPAGEDDRAISDEPSSEALVSVVVTDT 756
Cdd:PHA03307  175 PLSSPEETARAP--------SSPPAEPP-PSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESS 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  757 EDKDPGSllyvSDTTDCSLTLDCSEGTDSRPGGDKHREEKEGDGSVSSGAGEAGSSQVSSNPaSSPPGEVPAPKSTKSEP 836
Cdd:PHA03307  246 GCGWGPE----NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSP-GSGPAPSSPRASSSSSS 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  837 SCQGGLQKDRPSRGKDAMAPkrnsfkeASVGASKPVSARRSQGVAPKPVRTLNSSENEHMRKVVPISKSSRGAGPWKRPE 916
Cdd:PHA03307  321 SRESSSSSTSSSSESSRGAA-------VSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAA 393

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157823613  917 LTSRATPRETPSSTDTQLSRRSsvrgtsdtSPRRPQVSGSGTEEPRLPRSSGSIGgrPGKDP 978
Cdd:PHA03307  394 VAGRARRRDATGRFPAGRPRPS--------PLDAGAASGAFYARYPLLTPSGEPW--PGSPP 445
PHA03247 PHA03247
large tegument protein UL36; Provisional
 523-1039 2.78e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 2.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  523 PNSPSYRPPNTRRSRLSLGISADrelltfleSATSSPEDPNKfnslPRSSPRQTrPTIAWMEPREQETHGPVFTH----D 598
Cdd:PHA03247 2475 PGAPVYRRPAEARFPFAAGAAPD--------PGGGGPPDPDA----PPAPSRLA-PAILPDEPVGEPVHPRMLTWirglE 2541

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  599 PQASKNQEQTPHPAwQNHLPPSWLGEPVSPSPPAGR-SRPSLRKRSSEPvGLGTAQSPPLLPLDlgirehelvtgltqfD 677
Cdd:PHA03247 2542 ELASDDAGDPPPPL-PPAAPPAAPDRSVPPPRPAPRpSEPAVTSRARRP-DAPPQSARPRAPVD---------------D 2604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  678 LQSPKSLEETSQLTLNDFCPTklPPLGDKSSQPFDAGGDSRAPKDTDPREALSPAGEDDRaisdePSSEALvsvvvtdte 757
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPD--PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS-----RPRRAR--------- 2668

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  758 dkdpgsllyvsdttdcslTLDCSEGTDSRPGGDKHREEKEGDGSVSSGAgeagssqvssNPASSPPGEVPAPKSTKSEPS 837
Cdd:PHA03247 2669 ------------------RLGRAAQASSPPQRPRRRAARPTVGSLTSLA----------DPPPPPPTPEPAPHALVSATP 2720

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  838 CQGGLQKDRPSRGKDAMAPKRNSFKEASVGASKPVSARRSQGVAPKPvrtlnSSENEHMRKVVPISKSSRGAGPWKRPEL 917
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP-----APAPPAAPAAGPPRRLTRPAVASLSESR 2795

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  918 TSRATPRETPSSTDTQLSRRSSVRGTSDTSPRRPQVSGSGTEEPRLPR----SSGSIGGR--PGKD-----PTLQPRASF 986
Cdd:PHA03247 2796 ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPgpppPSLPLGGSvaPGGDvrrrpPSRSPAAKP 2875

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157823613  987 RKPSAKPLRNIPRQKPEENKVSSPNSRDPESPKEEPKAPQAPGASRALPPTPS 1039
Cdd:PHA03247 2876 AAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 790-1144 1.04e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  790 DKHREEKEGDGSVSSGAGEAGSSQvSSNPASSPPGEVPAPKSTKSEPSCQGGLQKDRPSRGKDAMAPKRNSFKEASVGAS 869
Cdd:PTZ00449  505 DKHDEPPEGPEASGLPPKAPGDKE-GEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPK 583

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  870 KPVSARRsqgvaPKPVRTLnssenehmrkvvpiskssrgagpwKRPELTSRATPRETPSSTDTQLSRRSSVRGTSDTSPR 949
Cdd:PTZ00449  584 DPKHPKD-----PEEPKKP------------------------KRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPK 634

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  950 RP-----QVSGSGTEEPRLPRSSGS-IGGRPGKDPTLQPR----------------------ASFRKPSAKPLRNIPRQK 1001
Cdd:PTZ00449  635 RPpppqrPSSPERPEGPKIIKSPKPpKSPKPPFDPKFKEKfyddyldaaaksketkttvvldESFESILKETLPETPGTP 714

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613 1002 PEENKVSSPN-SRDPESPKEEPKAPQAPGASRALPPTPsfarntvASSSRSMRADAPPAARATGI-TRTVSQRQLRVKSG 1079
Cdd:PTZ00449  715 FTTPRPLPPKlPRDEEFPFEPIGDPDAEQPDDIEFFTP-------PEEERTFFHETPADTPLPDIlAEEFKEEDIHAETG 787

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157823613 1080 SEDSAskdsgtLKRASSarASKKCPESAGGSSAnveTPLKgRGTTERSSLRLKDSgQATLGRILR 1144
Cdd:PTZ00449  788 EPDEA------MKRPDS--PSEHEDKPPGDHPS---LPKK-RHRLDGLALSTTDL-ESDAGRIAK 839
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 701-995 5.75e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.94  E-value: 5.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  701 PPLGDKSSQPFDAGGDSRAPKDTDPREALSPAgedDRAISDEPSSEALVSVVVTDTEDKDPGSLLYVSDTTDCSLTLDCS 780
Cdd:PHA03307  142 GSPGPPPAASPPAAGASPAAVASDAASSRQAA---LPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASAS 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  781 EGTDSRPGGDKHREEKEGDGSVSSGAGEAGSSQVSSNPASSP-PGEVPAPKSTKSEPscqgglqkDRPSRGKDAmAPKRN 859
Cdd:PHA03307  219 SPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPaPITLPTRIWEASGW--------NGPSSRPGP-ASSSS 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  860 SFKEASVGASKPVSARRSQGVAPKPVRTLNSSENEHMRKVVPISKSSRGAGPWKRPELTSRATPRETPSSTDTQLSRR-- 937
Cdd:PHA03307  290 SPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKrp 369

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  938 --SSVRGTSDTSPRRPQVSGSGTEEPRLPRSSGSIGGRPGKDPTLQPRASFRKPSAKPLR 995
Cdd:PHA03307  370 rpSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYAR 429
PHA03247 PHA03247
large tegument protein UL36; Provisional
 521-1039 2.63e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  521 PRPNSPSYRPPNTRRSR--LSLGISADRELLTFLESATSSPEDPNKFNSLPRSSP-----RQTRPTIA------WMEPRE 587
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDppPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRprrarRLGRAAQAssppqrPRRRAA 2688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  588 QETHGPVFT-HDPQAsknQEQTPHPAwqnhlPPSWLgePVSPSPPAGRSrpslrkrssepvGLGTAQSPPLLPldlgire 666
Cdd:PHA03247 2689 RPTVGSLTSlADPPP---PPPTPEPA-----PHALV--SATPLPPGPAA------------ARQASPALPAAP------- 2739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  667 helvtgltqfdlqSPKSLEETSQLTLNDFCPTKlPPLGDKSSQPFDAGGDSRAPKDTDPREALSPAGEDdRAISDEPSSE 746
Cdd:PHA03247 2740 -------------APPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSES-RESLPSPWDP 2804

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  747 ALVSVVVTDTEDKDPGSLLYVSDTTDCSLTLDCSEGTDSRPGGDkhreekegdgSVSSGAGEAGSSQVSSNPASSPPGEV 826
Cdd:PHA03247 2805 ADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPP----------SLPLGGSVAPGGDVRRRPPSRSPAAK 2874

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  827 PA---------------PKSTKSEPscqggLQKDRPSRGKDAMAPKRNSFKEASVGASKPVSARRSQGVAPKPV----RT 887
Cdd:PHA03247 2875 PAaparppvrrlarpavSRSTESFA-----LPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLapttDP 2949

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  888 LNSSENEHMRKVVPISKSSRGAGPWKRPELTSRATPRETPSSTDTQLSRRSSVRGTSDTSprrpqvSGSGTEEPRLPRSS 967
Cdd:PHA03247 2950 AGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWAS------SLALHEETDPPPVS 3023

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157823613  968 gsiggrpgKDPTLQPRASFRKPSAKPLRNiprqkpeenkvSSPNSRDPESPKEEPKAPQAPGASRALPPTPS 1039
Cdd:PHA03247 3024 --------LKQTLWPPDDTEDSDADSLFD-----------SDSERSDLEALDPLPPEPHDPFAHEPDPATPE 3076
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 559-760 8.51e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.52  E-value: 8.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  559 PEDPNKFNSlPRSSPRQTRPTiawmEPREqethgpvfthdPQASKNQEQTPHPAwqnhlppswlgEPVSPSPPAGRSRPS 638
Cdd:PTZ00449  591 PEEPKKPKR-PRSAQRPTRPK----SPKL-----------PELLDIPKSPKRPE-----------SPKSPKRPPPPQRPS 643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  639 LRKRSSEPVGLGTAQSP--PLLPLDLGIRE-------------HELVTGLTQFDLQSPKSLEETSQLTLNDF-CPTKLPP 702
Cdd:PTZ00449  644 SPERPEGPKIIKSPKPPksPKPPFDPKFKEkfyddyldaaaksKETKTTVVLDESFESILKETLPETPGTPFtTPRPLPP 723

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157823613  703 -LGDKSSQPFDAGGDSRAPKdTDPREALSPAGEDDRAISDEPSSEALVSVVVTDTEDKD 760
Cdd:PTZ00449  724 kLPRDEEFPFEPIGDPDAEQ-PDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEED 781
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
804-1039 9.58e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 9.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  804 SGAGEAGSSQVSSNPASSPPGEVPAPKSTKSEPSCQGGLQKDRPSRGKDAMAPKRNSFKEASVGASKPVSARRSQGVAPk 883
Cdd:PRK07003  387 AAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDE- 465

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613  884 pvrtlnssenehmRKVVPISKSSRGAGPWKRPELTSRATPrETPSSTDTQLSRRSSVRGTSDTSPRRPQVSGSGTEEPRL 963
Cdd:PRK07003  466 -------------RDAQPPADSGSASAPASDAPPDAAFEP-APRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPE 531

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157823613  964 PRSSGSIGGRPGKdptlqpRASFRKPSAKPLRNIPRqkpeenKVSSPNSRDPES---PKEEPKAPQAPGASRALPPTPS 1039
Cdd:PRK07003  532 ARPPTPAAAAPAA------RAGGAAAALDVLRNAGM------RVSSDRGARAAAaakPAAAPAAAPKPAAPRVAVQVPT 598
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 809-1047 5.48e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.13  E-value: 5.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   809 AGSSQVSSNPASSPPGEVPAPKSTKSE-------PSCQGGLQKDRP--SRGKDAM-APKRNSFKEASVGASKPVSARRSQ 878
Cdd:TIGR00927  135 AGTERVKEDTPATPSRALNHYISTSGRqrvksytPKPRGEVKSSSPtqTREKVRKyTPSPLGRMVNSYAPSTFMTMPRSH 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   879 GVAPKPvrTLNSSENEHMRKVVPISKSSRGAGPwKRPELTSRATPrETPS------STDTQLSRRSSVRGTSDTSPRRPQ 952
Cdd:TIGR00927  215 GITPRT--TVKDSEITATYKMLETNPSKRTAGK-TTPTPLKGMTD-NTPTfltrevETDLLTSPRSVVEKNTLTTPRRVE 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823613   953 VSgsgteeprlprSSGSIGGRPGKDPTLQPRASFRKPSAK------PLRNIPRQKPEENKVSSP--NSRDPESPKEEPKA 1024
Cdd:TIGR00927  291 SN-----------SSTNHWGLVGKNNLTTPQGTVLEHTPAtsegqvTISIMTGSSPAETKASTAawKIRNPLSRTSAPAV 359

                          250       260
                   ....*....|....*....|...
gi 157823613  1025 PQAPGASRALPPTPSFARNTVAS 1047
Cdd:TIGR00927  360 RIASATFRGLEKNPSTAPSTPAT 382
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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