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Conserved domains on  [gi|159110962|ref|NP_001103740|]
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urea transporter 2 isoform 3 [Rattus norvegicus]

Protein Classification

urea transporter( domain architecture ID 10505473)

urea transporter is an integral membrane protein that facilitates the rapid and passive diffusion of urea down its concentration gradient

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
58-353 5.18e-126

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


:

Pssm-ID: 460863  Cd Length: 292  Bit Score: 364.94  E-value: 5.18e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962   58 LDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSD 137
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  138 KGnyyWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNITWSDvQ 217
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  218 VPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIG 297
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 159110962  298 GMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTT 353
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFVLVTWLFLLLTT 292
 
Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
58-353 5.18e-126

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


Pssm-ID: 460863  Cd Length: 292  Bit Score: 364.94  E-value: 5.18e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962   58 LDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSD 137
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  138 KGnyyWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNITWSDvQ 217
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  218 VPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIG 297
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 159110962  298 GMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTT 353
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFVLVTWLFLLLTT 292
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
52-351 2.34e-73

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 230.91  E-value: 2.34e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  52 SPVFQFLDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLVGLL 131
Cdd:COG4413    1 NPLLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962 132 MAVFSdKGNYYWWLLlpVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNI 211
Cdd:COG4413   81 LGFFF-GPSPASWVL--LVLGAALSALVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPLLPPALPAPAS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962 212 TWSDVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTL 291
Cdd:COG4413  158 ATNGLTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVL 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962 292 ACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLL 351
Cdd:COG4413  238 TAIALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFVLATWLFLLA 297
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
56-350 2.58e-43

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 152.47  E-value: 2.58e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962   56 QFLDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVF 135
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALPLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  136 SDKGNYYWWLLLPVIVMSMtcpILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNITwSD 215
Cdd:TIGR03441  82 LAPSPQLWAIIVIGSILST---VVMAAVSEILKPWKVPALTMPFVLTTWIFLLASYAFKGLHTDAPVLPHDIEPVAF-GG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  216 VQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIA 295
Cdd:TIGR03441 158 PARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLTAIA 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 159110962  296 IGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLL 350
Cdd:TIGR03441 238 LGVVFLRPSIRSAAYAVLGVVLTVFVQGALDTLLTPLGLPTLTFPFVLVTWLFLF 292
 
Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
58-353 5.18e-126

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


Pssm-ID: 460863  Cd Length: 292  Bit Score: 364.94  E-value: 5.18e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962   58 LDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSD 137
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVFLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  138 KGnyyWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNITWSDvQ 217
Cdd:pfam03253  81 PS---PLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  218 VPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIG 297
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 159110962  298 GMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTT 353
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFVLVTWLFLLLTT 292
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
52-351 2.34e-73

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 230.91  E-value: 2.34e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  52 SPVFQFLDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLVGLL 131
Cdd:COG4413    1 NPLLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962 132 MAVFSdKGNYYWWLLlpVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNI 211
Cdd:COG4413   81 LGFFF-GPSPASWVL--LVLGAALSALVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPLLPPALPAPAS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962 212 TWSDVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTL 291
Cdd:COG4413  158 ATNGLTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVL 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962 292 ACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLL 351
Cdd:COG4413  238 TAIALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFVLATWLFLLA 297
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
56-350 2.58e-43

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 152.47  E-value: 2.58e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962   56 QFLDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVF 135
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALPLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  136 SDKGNYYWWLLLPVIVMSMtcpILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNITwSD 215
Cdd:TIGR03441  82 LAPSPQLWAIIVIGSILST---VVMAAVSEILKPWKVPALTMPFVLTTWIFLLASYAFKGLHTDAPVLPHDIEPVAF-GG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  216 VQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIA 295
Cdd:TIGR03441 158 PARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLTAIA 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 159110962  296 IGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLL 350
Cdd:TIGR03441 238 LGVVFLRPSIRSAAYAVLGVVLTVFVQGALDTLLTPLGLPTLTFPFVLVTWLFLF 292
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
221-352 3.94e-20

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 89.93  E-value: 3.94e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962 221 LLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGgMF 300
Cdd:COG4413    6 FIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLALG-FF 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 159110962 301 YVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLT 352
Cdd:COG4413   85 FGPSPASWVLLVLGAALSALVTAALSRLLIPWGLPALTLPFVLVTWLLLLAA 136
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
221-351 1.42e-14

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 73.51  E-value: 1.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962  221 LLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGgMF 300
Cdd:TIGR03441   3 LIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALP-LF 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 159110962  301 YVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLL 351
Cdd:TIGR03441  82 LAPSPQLWAIIVIGSILSTVVMAAVSEILKPWKVPALTMPFVLTTWIFLLA 132
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
54-188 8.33e-13

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 68.50  E-value: 8.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110962   54 VFQFLDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVL--VGLL 131
Cdd:TIGR03441 160 RENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLtaIALG 239
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 159110962  132 MAVFSDKGNYYWWLLLPVIVMSmtcpILSSALSTVFSKWDLPVFTLPFNIAVTLYLA 188
Cdd:TIGR03441 240 VVFLRPSIRSAAYAVLGVVLTV----FVQGALDTLLTPLGLPTLTFPFVLVTWLFLF 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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