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Conserved domains on  [gi|197100900|ref|NP_001127694|]
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iroquois-class homeodomain protein IRX-2 [Homo sapiens]

Protein Classification

iroquois-class homeodomain protein( domain architecture ID 11160563)

iroquois-class homeodomain protein plays numerous roles in early embryo patterning

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 133-171 2.24e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 75.24  E-value: 2.24e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 197100900  133 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 171
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
322-339 2.72e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


:

Pssm-ID: 214716  Cd Length: 18  Bit Score: 35.25  E-value: 2.72e-03
                           10
                   ....*....|....*...
gi 197100900   322 PPASKPKLWSLAEIATSD 339
Cdd:smart00548   1 SPAAKPKIWSLADTATSS 18
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 133-171 2.24e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 75.24  E-value: 2.24e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 197100900  133 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 171
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 118-176 5.14e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 63.42  E-value: 5.14e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 197100900 118 RKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 176
Cdd:cd00086    4 RTRFTPEQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 117-173 9.31e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 59.96  E-value: 9.31e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 197100900   117 YRKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK 173
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQ---KNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
114-177 1.23e-05

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 45.12  E-value: 1.23e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197100900 114 DPAYRKNATRDATATLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK 177
Cdd:COG5576   51 PKSKRRRTTDEQLMVLER---EFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
322-339 2.72e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 35.25  E-value: 2.72e-03
                           10
                   ....*....|....*...
gi 197100900   322 PPASKPKLWSLAEIATSD 339
Cdd:smart00548   1 SPAAKPKIWSLADTATSS 18
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 133-171 2.24e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 75.24  E-value: 2.24e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 197100900  133 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 171
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 118-176 5.14e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 63.42  E-value: 5.14e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 197100900 118 RKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 176
Cdd:cd00086    4 RTRFTPEQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 117-173 9.31e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 59.96  E-value: 9.31e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 197100900   117 YRKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK 173
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQ---KNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
118-174 1.64e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 45.18  E-value: 1.64e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 197100900  118 RKNATRDATATLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK 174
Cdd:pfam00046   4 RTTFTPEQLEELEK---EFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
114-177 1.23e-05

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 45.12  E-value: 1.23e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197100900 114 DPAYRKNATRDATATLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK 177
Cdd:COG5576   51 PKSKRRRTTDEQLMVLER---EFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
322-339 2.72e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 35.25  E-value: 2.72e-03
                           10
                   ....*....|....*...
gi 197100900   322 PPASKPKLWSLAEIATSD 339
Cdd:smart00548   1 SPAAKPKIWSLADTATSS 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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