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Conserved domains on  [gi|332801011|ref|NP_001131146|]
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zinc finger protein 860 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-64 1.95e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.44  E-value: 1.95e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 332801011   24 LTFRDVAIEFSLEEWKCLDPTQRALYRAMMLENYRNLHSVD 64
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-617 9.69e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 9.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 284 KPYKCNECGKVFNQQSNLASHHRLHTGEKPYKC--EECDKVFSRKSNLERHRRIHTGEKPYKCKVCE------KAFRRDS 355
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 356 HLTQHTRIHTGEKPYKCNE----------------------------------------------CGKAFSGQSTLIHHQ 389
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 390 AIHGIGKLYKCNDCHKvfsnATTIANHWRIHNEERSYKCNKCGKFFRRRSYLVVHWRTHTGEKPYKCNECGKTFHHN--- 466
Cdd:COG5048  192 VSTSIPSSSENSPLSS----SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpt 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 467 SALVIHKAIHTGE-------KPYKCNECGKTFRHNSALVIHK--AIHTGE--KPYKCNE--CGKVFNQQATLARHHRLHT 533
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 534 GEKPYKC--EECDTVFSRKSHHETHKRIH-----TGEKPYKCDDFD--EAFSQASSYAKQRRIHMGEKHH--KCDDCGKA 602
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSciRNFKRDSNLSLHIITHLSFRPYncKNPPCSKS 427

                        410
                 ....*....|....*
gi 332801011 603 FTSHSHRIRHQRIHT 617
Cdd:COG5048  428 FNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-64 1.95e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.44  E-value: 1.95e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 332801011   24 LTFRDVAIEFSLEEWKCLDPTQRALYRAMMLENYRNLHSVD 64
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
24-64 1.34e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.94  E-value: 1.34e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 332801011    24 LTFRDVAIEFSLEEWKCLDPTQRALYRAMMLENYRNLHSVD 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-62 1.53e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.53e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 332801011  24 LTFRDVAIEFSLEEWKCLDPTQRALYRAMMLENYRNLHS 62
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-617 9.69e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 9.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 284 KPYKCNECGKVFNQQSNLASHHRLHTGEKPYKC--EECDKVFSRKSNLERHRRIHTGEKPYKCKVCE------KAFRRDS 355
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 356 HLTQHTRIHTGEKPYKCNE----------------------------------------------CGKAFSGQSTLIHHQ 389
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 390 AIHGIGKLYKCNDCHKvfsnATTIANHWRIHNEERSYKCNKCGKFFRRRSYLVVHWRTHTGEKPYKCNECGKTFHHN--- 466
Cdd:COG5048  192 VSTSIPSSSENSPLSS----SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpt 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 467 SALVIHKAIHTGE-------KPYKCNECGKTFRHNSALVIHK--AIHTGE--KPYKCNE--CGKVFNQQATLARHHRLHT 533
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 534 GEKPYKC--EECDTVFSRKSHHETHKRIH-----TGEKPYKCDDFD--EAFSQASSYAKQRRIHMGEKHH--KCDDCGKA 602
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSciRNFKRDSNLSLHIITHLSFRPYncKNPPCSKS 427

                        410
                 ....*....|....*
gi 332801011 603 FTSHSHRIRHQRIHT 617
Cdd:COG5048  428 FNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-388 3.67e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 179 VEKSINDASSVLTSQRISSRPKI--HISNNYENNFFHSSLLTLKQEVHIR-EKSFQCNESGKAFNCSSLLRKHQIIYL-- 253
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhs 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 254 --GGKQYKCDV--CGKVFNQKRYLACHHRCHTGEKPYKC--NECGKVFNQQSN--LASHHRLHTGEKPYKCEECD----- 320
Cdd:COG5048  316 geSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNnePPQSLQQYKDLKNDKKSETLsnsci 395

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 321 KVFSRKSNLERHRRIHTGEKPY--KCKVCEKAFRRDSHLTQHTRIHTgEKPYKCNECGKAFSGQSTLIHH 388
Cdd:COG5048  396 RNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 1.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 332801011  328 NLERHRRIHTGEKPYKCKVCEKAFRR 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 368-422 5.52e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.52e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 332801011 368 KPYkCNECGKAFSGQSTLIHHQ-AIHgigklYKCNDCHKVFSNATTIANH-WRIHNE 422
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQkAKH-----FKCHICHKKLYTAGGLAVHcLQVHKE 51
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-64 1.95e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.44  E-value: 1.95e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 332801011   24 LTFRDVAIEFSLEEWKCLDPTQRALYRAMMLENYRNLHSVD 64
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
24-64 1.34e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.94  E-value: 1.34e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 332801011    24 LTFRDVAIEFSLEEWKCLDPTQRALYRAMMLENYRNLHSVD 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-62 1.53e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.53e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 332801011  24 LTFRDVAIEFSLEEWKCLDPTQRALYRAMMLENYRNLHS 62
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-617 9.69e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 9.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 284 KPYKCNECGKVFNQQSNLASHHRLHTGEKPYKC--EECDKVFSRKSNLERHRRIHTGEKPYKCKVCE------KAFRRDS 355
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 356 HLTQHTRIHTGEKPYKCNE----------------------------------------------CGKAFSGQSTLIHHQ 389
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 390 AIHGIGKLYKCNDCHKvfsnATTIANHWRIHNEERSYKCNKCGKFFRRRSYLVVHWRTHTGEKPYKCNECGKTFHHN--- 466
Cdd:COG5048  192 VSTSIPSSSENSPLSS----SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpt 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 467 SALVIHKAIHTGE-------KPYKCNECGKTFRHNSALVIHK--AIHTGE--KPYKCNE--CGKVFNQQATLARHHRLHT 533
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 534 GEKPYKC--EECDTVFSRKSHHETHKRIH-----TGEKPYKCDDFD--EAFSQASSYAKQRRIHMGEKHH--KCDDCGKA 602
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSciRNFKRDSNLSLHIITHLSFRPYncKNPPCSKS 427

                        410
                 ....*....|....*
gi 332801011 603 FTSHSHRIRHQRIHT 617
Cdd:COG5048  428 FNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
312-625 6.59e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 6.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 312 KPYKCEECDKVFSRKSNLERHRRIHTGEKPYKCKV--CEKAFRRDSHLTQHTRIHTGEKPYKCNecGKAFSGQSTLIHHQ 389
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 390 AIHGIGKLYKCNDCHKV-----FSNATTIANHWRIHNEERSYK-CNKCGKFFRRRSYLVVhwrthtgekPYKCNECGKTF 463
Cdd:COG5048  110 LSSSSSNSNDNNLLSSHslppsSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHP---------PLPANSLSKDP 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 464 HHNSALVIHKAIHTGEKPYKCNECGKTFRHNSALVIHKAIHTGEKPYKCNECGKVFNQQATLARH------HRLHTGEKP 537
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 538 YKCEECDTVFSRKSHHETHKRIHTG-EKPYKCDDFDEAFSQASSYAKQRR--IHMGE--KHHKCD--DCGKAFTSHSHRI 610
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALK 340

                        330
                 ....*....|....*
gi 332801011 611 RHQRIHTGQKSYKCH 625
Cdd:COG5048  341 RHILLHTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-440 3.82e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 284 KPYKCNECGKVFNQQSNLASH--HRLHTGE--KPYKCEE--CDKVFSRKSNLERHRRIHTGEKPYKCK--VCEKAFRRDS 355
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 356 H--LTQHTRIHTGEKPYKCNE-----CGKAFSGQSTLIHH--QAIHGIGKLYKCNDCHKVFSNATTIANHWRIHNEERSY 426
Cdd:COG5048  368 NnePPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....
gi 332801011 427 KCNKCGKFFRRRSY 440
Cdd:COG5048  448 LCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-388 3.67e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 179 VEKSINDASSVLTSQRISSRPKI--HISNNYENNFFHSSLLTLKQEVHIR-EKSFQCNESGKAFNCSSLLRKHQIIYL-- 253
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhs 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 254 --GGKQYKCDV--CGKVFNQKRYLACHHRCHTGEKPYKC--NECGKVFNQQSN--LASHHRLHTGEKPYKCEECD----- 320
Cdd:COG5048  316 geSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNnePPQSLQQYKDLKNDKKSETLsnsci 395

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 321 KVFSRKSNLERHRRIHTGEKPY--KCKVCEKAFRRDSHLTQHTRIHTgEKPYKCNECGKAFSGQSTLIHH 388
Cdd:COG5048  396 RNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 1.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 332801011  328 NLERHRRIHTGEKPYKCKVCEKAFRR 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 282-360 5.01e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 5.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 282 GEKPYKCN--ECGKVFNQQSNLaSHHRLHTGEKPYKCEECDKvfsrksnlERHRRIHTGEKPYKCKVCEKAFRRDSHLTQ 359
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 332801011 360 H 360
Cdd:COG5189  417 H 417
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 368-422 5.52e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.52e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 332801011 368 KPYkCNECGKAFSGQSTLIHHQ-AIHgigklYKCNDCHKVFSNATTIANH-WRIHNE 422
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQkAKH-----FKCHICHKKLYTAGGLAVHcLQVHKE 51
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-380 7.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.67e-04
                          10        20
                  ....*....|....*....|....*
gi 332801011  356 HLTQHTRIHTGEKPYKCNECGKAFS 380
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
312-530 1.56e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 312 KPYKCEECDKVFSRKSNLERHRR--IHTGE--KPYKCKV--CEKAFRRDSHLTQHTRIHTGEKPYKCnecgkaFSGQSTL 385
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE------KLLNSSS 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332801011 386 IHHQAIHGigklykcndCHKVFSNATTIANHwrIHNEERSYkcNKCGKFFRRRSYLVVHWRTHTGEKPYKCnecgktfhh 465
Cdd:COG5048  362 KFSPLLNN---------EPPQSLQQYKDLKN--DKKSETLS--NSCIRNFKRDSNLSLHIITHLSFRPYNC--------- 419

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332801011 466 nsalvihkaihtgekpyKCNECGKTFRHNSALVIHKAIHTgEKPYKCNECGKVFNQQATLARHHR 530
Cdd:COG5048  420 -----------------KNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 314-336 1.60e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.60e-03
                          10        20
                  ....*....|....*....|...
gi 332801011  314 YKCEECDKVFSRKSNLERHRRIH 336
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-325 2.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 332801011  300 NLASHHRLHTGEKPYKCEECDKVFSR 325
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
314-338 5.59e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.45  E-value: 5.59e-03
                          10        20
                  ....*....|....*....|....*
gi 332801011  314 YKCEECDKVFSRKSNLERHRRIHTG 338
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
468-493 6.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 332801011  468 ALVIHKAIHTGEKPYKCNECGKTFRH 493
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
496-521 6.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 332801011  496 ALVIHKAIHTGEKPYKCNECGKVFNQ 521
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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