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Conserved domains on  [gi|215490039|ref|NP_001135899|]
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mortality factor 4-like protein 2 [Homo sapiens]

Protein Classification

MRG family protein( domain architecture ID 10529714)

MRG family protein may be involved in transcriptional regulation via histone acetylation; contains a chromo (chromatin organization modifier) domain

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MRG pfam05712
MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4 ...
102-276 7.07e-77

MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation. It contains 2 chromo domains and a leucine zipper motif.


:

Pssm-ID: 461721  Cd Length: 185  Bit Score: 231.72  E-value: 7.07e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490039  102 RARADPtveSEEAFKNRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEY----ANCKKSQGNVDNKEY 177
Cdd:pfam05712   1 RARDSE---SEDEFSKRPEIKLDIPDELKKILVDDWENITKNNQLVPLPAKPPVDEILEDYveheKVKRANGSNKTRDED 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490039  178 AVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEIL-------LAHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLA 250
Cdd:pfam05712  78 LLEEVVAGLREYFDKALGRILLYRFERPQYAELRkkwasgpNDDQGKEPSDIYGAEHLLRLFVKLPELLAQTNMDEQSLN 157
                         170       180
                  ....*....|....*....|....*.
gi 215490039  251 LLLGYLHDFLKYLAKNSASLFTASDY 276
Cdd:pfam05712 158 RLREHLEDFLEFLAKNHERYFSKQEY 183
 
Name Accession Description Interval E-value
MRG pfam05712
MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4 ...
102-276 7.07e-77

MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation. It contains 2 chromo domains and a leucine zipper motif.


Pssm-ID: 461721  Cd Length: 185  Bit Score: 231.72  E-value: 7.07e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490039  102 RARADPtveSEEAFKNRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEY----ANCKKSQGNVDNKEY 177
Cdd:pfam05712   1 RARDSE---SEDEFSKRPEIKLDIPDELKKILVDDWENITKNNQLVPLPAKPPVDEILEDYveheKVKRANGSNKTRDED 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490039  178 AVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEIL-------LAHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLA 250
Cdd:pfam05712  78 LLEEVVAGLREYFDKALGRILLYRFERPQYAELRkkwasgpNDDQGKEPSDIYGAEHLLRLFVKLPELLAQTNMDEQSLN 157
                         170       180
                  ....*....|....*....|....*.
gi 215490039  251 LLLGYLHDFLKYLAKNSASLFTASDY 276
Cdd:pfam05712 158 RLREHLEDFLEFLAKNHERYFSKQEY 183
 
Name Accession Description Interval E-value
MRG pfam05712
MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4 ...
102-276 7.07e-77

MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation. It contains 2 chromo domains and a leucine zipper motif.


Pssm-ID: 461721  Cd Length: 185  Bit Score: 231.72  E-value: 7.07e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490039  102 RARADPtveSEEAFKNRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEY----ANCKKSQGNVDNKEY 177
Cdd:pfam05712   1 RARDSE---SEDEFSKRPEIKLDIPDELKKILVDDWENITKNNQLVPLPAKPPVDEILEDYveheKVKRANGSNKTRDED 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490039  178 AVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEIL-------LAHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLA 250
Cdd:pfam05712  78 LLEEVVAGLREYFDKALGRILLYRFERPQYAELRkkwasgpNDDQGKEPSDIYGAEHLLRLFVKLPELLAQTNMDEQSLN 157
                         170       180
                  ....*....|....*....|....*.
gi 215490039  251 LLLGYLHDFLKYLAKNSASLFTASDY 276
Cdd:pfam05712 158 RLREHLEDFLEFLAKNHERYFSKQEY 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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