|
Name |
Accession |
Description |
Interval |
E-value |
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
1-641 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 1001.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 1 MTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPaGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS 80
Cdd:TIGR01787 6 VEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTVLAYVA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 81 LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM 160
Cdd:TIGR01787 85 LKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRMVYLPM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 161 SYCYAVRLSAAEDPlvqslRQELYVEDfASIDwlAQRNNVAPDELYTPHSWLLRVVYALLNL-YEHHHSAHLRQRAVQKL 239
Cdd:TIGR01787 165 SYCYGERLSAPIDP-----REELYVED-DSIR--AQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKRALQWL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 240 YEHIVADDrftksiSIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTnGSQIWDTAFAIQALLEA 319
Cdd:TIGR01787 237 YEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQALRES 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 320 GGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRK-GGFSFSTLDCGW-IVSDCTAEALKAVLLLQEkcphvTEH 397
Cdd:TIGR01787 310 GDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE-----DEH 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 398 IPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFhkrfpEHRAAEIR 477
Cdd:TIGR01787 385 VKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHRADEIR 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 478 ETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESCE 557
Cdd:TIGR01787 460 NVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGEDCFSYE 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 558 ERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFN-KSCAISYTSYRNIFPIWAL 636
Cdd:TIGR01787 537 DPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIFPLWAL 616
|
....*
gi 224177558 637 GRFSQ 641
Cdd:TIGR01787 617 GRYRQ 621
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
1-639 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 934.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 1 MTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS 80
Cdd:cd02892 5 LEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFGTVLNYVA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 81 LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM 160
Cdd:cd02892 85 LRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTVYVPM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 161 SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPdeLYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLY 240
Cdd:cd02892 165 SYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDLYD--YRPPWQRLFDALDRLLHWYEPLPPKPLRRKALRKAY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 241 EHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAG 320
Cdd:cd02892 243 EWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQALLEAG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 321 GHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHvTEHIPR 400
Cdd:cd02892 323 LA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQELPPF-GEKVSR 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 401 ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRaAEIRETL 480
Cdd:cd02892 400 ERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REIDPAI 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 481 TQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESCEERR 560
Cdd:cd02892 479 RRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSYEDKS 555
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224177558 561 YLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRF 639
Cdd:cd02892 556 YAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWALGRY 634
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
3-644 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 589.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 3 FYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNY 78
Cdd:PLN03012 105 FFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYCHQKEDGGWGLHIEGHSTMFCTTLNY 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 79 VSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 155
Cdd:PLN03012 184 ICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPIHPAKMWCYCRL 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 156 VYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH----- 230
Cdd:PLN03012 264 VYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIFAEPFLACwpfnk 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 231 -LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQIWDT 309
Cdd:PLN03012 344 lLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMKMQ-SFGSQLWDS 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 310 AFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQ 388
Cdd:PLN03012 422 GFALQALLAS--NLSNEIPDVLRRGHDFIKNSQVGENPSgDFKNMYRHISKGAWTFSDRDHGWQASDCTAEGFKCCLLFS 499
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 389 EKCPH-VTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKR 467
Cdd:PLN03012 500 MIAPDiVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQL 579
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 468 FPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADG 547
Cdd:PLN03012 580 YPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIRKGVHFLLAAQKDNG 656
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 548 GWGEDFESCEERRYLQSA--QSQIHNTCWAMMGLM----AVRHPdiEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCA 621
Cdd:PLN03012 657 GWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDFPQQEATGAFLKNCL 734
|
650 660
....*....|....*....|...
gi 224177558 622 ISYTSYRNIFPIWALGRFSQLYP 644
Cdd:PLN03012 735 LHYAAYRNIFPLWALAEYRARVP 757
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
4-643 |
0e+00 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 562.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 4 YVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRI 83
Cdd:COG1657 31 LLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDLSTTVKAYFALKL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 84 LGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYC 163
Cdd:COG1657 111 LGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFSYWARTVIVPLLIL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 164 YAVRLSAAEDPLVqsLRQELYVEDFASIDWLAQRNNVApdelyTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHI 243
Cdd:COG1657 191 YARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPRDR-----SPWSRFFLALDRLLRAYERLPPKPLRRRALRKAEDWI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 244 vaDDRFTKS---ISIGP-ISKTINMLvRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGtNGSQIWDTAFAIQALLEA 319
Cdd:COG1657 264 --LERLEGDgglGGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CVSPVWDTALAVQALQEA 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 320 GghhRPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQekcpHVTEHIP 399
Cdd:COG1657 340 G---LPEDHPALERAADWLLSKQILV-KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMALLRLR----LPDEPRY 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 400 RERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEvFGdIMIDYTYVECTSAVMQALKyfhkrfpEHRAAEIRET 479
Cdd:COG1657 412 REAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLG-------QLGLTEDHPA 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 480 LTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGGWGEDFESCEER 559
Cdd:COG1657 483 IRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDD----PAIRRAVAWLLSIQNADGGWGEDCRSYEDP 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 560 RYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYTSYRNIFPIWALGR 638
Cdd:COG1657 559 RYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYHLYRQYFPLWALAR 638
|
....*
gi 224177558 639 FSQLY 643
Cdd:COG1657 639 YRNLR 643
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
304-639 |
3.20e-51 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 179.84 E-value: 3.20e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 304 SQIWDTAFAIQALLEAGGhhrPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 383
Cdd:pfam13243 2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLV-KGDWAVKRPDLEPGGWAFQFANDHYPDVDDTAVVVLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 384 vlLLQEKCPHVTEhiPRERLCDAVAVLLNMRNPDGGFATYETKrggHLLELLN--PsevFGDI--MIDYTYVECTSAVMQ 459
Cdd:pfam13243 78 --LDRVRLPDERR--RDDAIARGIEWILGMQSKNGGWGAFDKD---NTKYYLNkiP---FADHgaLLDPPTADVTARVLE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 460 ALKYFHkrFPEHRAAEIRetltqGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFL 539
Cdd:pfam13243 148 MLGQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNR----PYIRKAVDWL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 540 LSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNK 618
Cdd:pfam13243 217 KSRQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAAGEVDSPAVRRGIQYLLETQKPDGTWDEPYFTGTgFPR 296
|
330 340
....*....|....*....|.
gi 224177558 619 SCAISYTSYRNIFPIWALGRF 639
Cdd:pfam13243 297 VFYLKYHGYRNYFPLWALARY 317
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
1-641 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 1001.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 1 MTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPaGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS 80
Cdd:TIGR01787 6 VEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTVLAYVA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 81 LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM 160
Cdd:TIGR01787 85 LKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRMVYLPM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 161 SYCYAVRLSAAEDPlvqslRQELYVEDfASIDwlAQRNNVAPDELYTPHSWLLRVVYALLNL-YEHHHSAHLRQRAVQKL 239
Cdd:TIGR01787 165 SYCYGERLSAPIDP-----REELYVED-DSIR--AQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKRALQWL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 240 YEHIVADDrftksiSIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTnGSQIWDTAFAIQALLEA 319
Cdd:TIGR01787 237 YEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQALRES 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 320 GGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRK-GGFSFSTLDCGW-IVSDCTAEALKAVLLLQEkcphvTEH 397
Cdd:TIGR01787 310 GDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE-----DEH 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 398 IPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFhkrfpEHRAAEIR 477
Cdd:TIGR01787 385 VKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHRADEIR 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 478 ETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESCE 557
Cdd:TIGR01787 460 NVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGEDCFSYE 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 558 ERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFN-KSCAISYTSYRNIFPIWAL 636
Cdd:TIGR01787 537 DPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIFPLWAL 616
|
....*
gi 224177558 637 GRFSQ 641
Cdd:TIGR01787 617 GRYRQ 621
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
1-639 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 934.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 1 MTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS 80
Cdd:cd02892 5 LEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFGTVLNYVA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 81 LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM 160
Cdd:cd02892 85 LRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTVYVPM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 161 SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPdeLYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLY 240
Cdd:cd02892 165 SYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDLYD--YRPPWQRLFDALDRLLHWYEPLPPKPLRRKALRKAY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 241 EHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAG 320
Cdd:cd02892 243 EWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQALLEAG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 321 GHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHvTEHIPR 400
Cdd:cd02892 323 LA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQELPPF-GEKVSR 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 401 ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRaAEIRETL 480
Cdd:cd02892 400 ERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REIDPAI 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 481 TQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESCEERR 560
Cdd:cd02892 479 RRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSYEDKS 555
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224177558 561 YLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRF 639
Cdd:cd02892 556 YAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWALGRY 634
|
|
| osq_cycl |
TIGR03463 |
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ... |
7-639 |
0e+00 |
|
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.
Pssm-ID: 274591 [Multi-domain] Cd Length: 634 Bit Score: 617.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 7 LQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGV 86
Cdd:TIGR03463 4 LQDSAGDWEGDMGGCQFIIAIAVAGLHVMGRPPDAEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVALRLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 87 GPDDPDLVRARNILH-KKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYA 165
Cdd:TIGR03463 84 GKDDAGLARARAWFHaQPEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLIYLGIAWLSG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 166 VRLSAAE-DPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIV 244
Cdd:TIGR03463 164 RGARAPEsDPLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGYERLAGKALRARALDFAFEQIL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 245 ADDRFTKSISIGPISKTINMLVrWYVDGPASTAFQEHVSRIPDYLWMGLD-GMKMQGTNGSQIWDTAFAIQALLEAG--- 320
Cdd:TIGR03463 244 AEDEATHYICIGPINGLLNCLA-IFAHDPDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSNALWDTAFAVQALAALGeld 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 321 GHHRpefsSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEK-CPHVTEHIP 399
Cdd:TIGR03463 323 EEAK----HALEEAAAFIDAAQMLADLADPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEELgDNRISEALG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 400 RERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRET 479
Cdd:TIGR03463 399 AARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYVECTAACLGALAAWLKHHPDLPDAKIDAA 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 480 LTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGGWGEDFESCEER 559
Cdd:TIGR03463 479 IRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAEPAD----MALQAAAAFLLEKQRADGAWGEHVESCLEA 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 560 RYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRF 639
Cdd:TIGR03463 555 RWVEGKHGHAVMTAWALLALAAAGEAAHDAAERGIAWLCEQQGEDGGWPPEGIAGIFFGAAAIDYDAYLRIFPTWALARC 634
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
3-644 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 589.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 3 FYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNY 78
Cdd:PLN03012 105 FFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYCHQKEDGGWGLHIEGHSTMFCTTLNY 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 79 VSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 155
Cdd:PLN03012 184 ICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPIHPAKMWCYCRL 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 156 VYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH----- 230
Cdd:PLN03012 264 VYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIFAEPFLACwpfnk 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 231 -LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQIWDT 309
Cdd:PLN03012 344 lLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMKMQ-SFGSQLWDS 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 310 AFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQ 388
Cdd:PLN03012 422 GFALQALLAS--NLSNEIPDVLRRGHDFIKNSQVGENPSgDFKNMYRHISKGAWTFSDRDHGWQASDCTAEGFKCCLLFS 499
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 389 EKCPH-VTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKR 467
Cdd:PLN03012 500 MIAPDiVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQL 579
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 468 FPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADG 547
Cdd:PLN03012 580 YPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIRKGVHFLLAAQKDNG 656
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 548 GWGEDFESCEERRYLQSA--QSQIHNTCWAMMGLM----AVRHPdiEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCA 621
Cdd:PLN03012 657 GWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDFPQQEATGAFLKNCL 734
|
650 660
....*....|....*....|...
gi 224177558 622 ISYTSYRNIFPIWALGRFSQLYP 644
Cdd:PLN03012 735 LHYAAYRNIFPLWALAEYRARVP 757
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
4-643 |
0e+00 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 562.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 4 YVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRI 83
Cdd:COG1657 31 LLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDLSTTVKAYFALKL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 84 LGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYC 163
Cdd:COG1657 111 LGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFSYWARTVIVPLLIL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 164 YAVRLSAAEDPLVqsLRQELYVEDFASIDWLAQRNNVApdelyTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHI 243
Cdd:COG1657 191 YARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPRDR-----SPWSRFFLALDRLLRAYERLPPKPLRRRALRKAEDWI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 244 vaDDRFTKS---ISIGP-ISKTINMLvRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGtNGSQIWDTAFAIQALLEA 319
Cdd:COG1657 264 --LERLEGDgglGGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CVSPVWDTALAVQALQEA 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 320 GghhRPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQekcpHVTEHIP 399
Cdd:COG1657 340 G---LPEDHPALERAADWLLSKQILV-KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMALLRLR----LPDEPRY 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 400 RERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEvFGdIMIDYTYVECTSAVMQALKyfhkrfpEHRAAEIRET 479
Cdd:COG1657 412 REAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLG-------QLGLTEDHPA 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 480 LTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGGWGEDFESCEER 559
Cdd:COG1657 483 IRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDD----PAIRRAVAWLLSIQNADGGWGEDCRSYEDP 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 560 RYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYTSYRNIFPIWALGR 638
Cdd:COG1657 559 RYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYHLYRQYFPLWALAR 638
|
....*
gi 224177558 639 FSQLY 643
Cdd:COG1657 639 YRNLR 643
|
|
| PLN02993 |
PLN02993 |
lupeol synthase |
1-639 |
0e+00 |
|
lupeol synthase
Pssm-ID: 215537 [Multi-domain] Cd Length: 763 Bit Score: 559.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 1 MTFYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTAL 76
Cdd:PLN02993 103 VSFFSALQASDGHWpgeiTGPLFFLPPLVFCLYITGHLEEV-FDAEHRKEMLRHIYCHQNEDGGWGLHIESKSVMFCTVL 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 77 NYVSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHC 153
Cdd:PLN02993 182 NYICLRMLGEGPNggrENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPMPPEIWLLPSFLPIHLGKTLCYT 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 154 RQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH--- 230
Cdd:PLN02993 262 RMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLVQDLIWDTLHNFVEPFLTRwpl 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 231 ---LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQIW 307
Cdd:PLN02993 342 nklVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACW-IENPNGDHFKKHLARIPDYMWVAEDGMKMQ-SFGSQLW 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 308 DTAFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLL 386
Cdd:PLN02993 420 DTGFAIQALLAS--DLSDETDDVLRRGHNYIKKSQVRENPSgDFKSMYRHISKGAWTLSDRDHGWQVSDCTAEALKCCML 497
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 387 LQEKCPHVT-EHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFH 465
Cdd:PLN02993 498 LSMMPADVVgQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANTMVEREYVECTSAVIQALVLFK 577
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 466 KRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMA 545
Cdd:PLN02993 578 QLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYND---CLAMRKGVHFLLTIQRD 654
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 546 DGGWGEDFESCEERRY--LQSAQSQIHNTCWAMMGLMAVRHP--DIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCA 621
Cdd:PLN02993 655 DGGWGESYLSCPEQRYipLEGNRSNLVQTAWAMMGLIHAGQAerDLIPLHRAAKLIITSQLENGDFPQQEILGAFMNTCM 734
|
650
....*....|....*...
gi 224177558 622 ISYTSYRNIFPIWALGRF 639
Cdd:PLN02993 735 LHYATYRNTFPLWALAEY 752
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
304-639 |
1.87e-175 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 502.52 E-value: 1.87e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 304 SQIWDTAFAIQALLEAGGHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 383
Cdd:cd02889 23 SQVWDTALALQALLEAGLA--PEFDPALKKALEWLLKSQIRDNPDDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 384 VLLLQEKCPHvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELlnPSEVFGDIMIDYTYVECTSAVMQALKY 463
Cdd:cd02889 101 LLRLQKKPPD-GKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEALGL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 464 FHKRFPEHRAaEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRdgtaCAEVSRACDFLLSRQ 543
Cdd:cd02889 178 FGKLYPEHRR-EIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGEDEN----SPYVRKACDWLLSKQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 544 MADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAIS 623
Cdd:cd02889 253 NPDGGWGESYESYEDPSYAGGGRSTVVQTAWALLALMAAGEPDSEAVKRGVKYLLNTQQEDGDWPQEEITGVFFKNFYIR 332
|
330
....*....|....*.
gi 224177558 624 YTSYRNIFPIWALGRF 639
Cdd:cd02889 333 YHNYRNYFPLWALGRY 348
|
|
| hopene_cyclase |
TIGR01507 |
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ... |
3-642 |
3.74e-63 |
|
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]
Pssm-ID: 273661 [Multi-domain] Cd Length: 635 Bit Score: 220.92 E-value: 3.74e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 3 FYVGLQAEDGHWTGDYGGPLFLLPGLLITCH----VARIPLpagyrEEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNY 78
Cdd:TIGR01507 24 YLLSCQKDEGYWWGELESNVTIEAEYVLLCHildrVDRDRM-----EKIRNYLLHEQREDGTWALYPGGPGDLSTTVEAY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 79 VSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYL 158
Cdd:TIGR01507 99 VALKYIGMSRDEPPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFPFNIYEFSSWARATVV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 159 PMSYCYAVRLSAaedPLVQSLR-QELYVEDfasidwlaqrnnVAPDELYTPHS---W-LLRVVYALLNLYEHHHSAHLRQ 233
Cdd:TIGR01507 179 PLSIVCSRKPVF---PLPERARvPELYETD------------VPKPRRRGAKGgtgWgIFDALDRALHGYEKLSVHPFRR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 234 RAVQKLYEHIVAddRFTKSISIGPISKT-INMLVRWYVDG-PASTAF-QEHVSRIPDYLWMGLDGMKMQGTNgSQIWDTA 310
Cdd:TIGR01507 244 AAEIRALDWLLE--RQAGDGSWGGIQPAmFNALIALKILGmTQHDAFiKLGWEGIDLYGVELDDSWMFQACV-SPVWDTA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 311 FAIQALLEAGghhRPEFSSCLQKAHEFLRLSQVpDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEK 390
Cdd:TIGR01507 321 LAVLALREAG---LPADHDALVKAGEWLLDKQI-TVPGDWAVKRPNLEPGGWAFQFDNVYYPDVDDTAVVVWALNGLRLP 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 391 cphvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNpsevFGDI--MIDYTYVECTSAVMQALKYFHKRF 468
Cdd:TIGR01507 397 ----DERRRRDAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADVTARVLECLGSFGYDD 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 469 PehraaeiRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGG 548
Cdd:TIGR01507 469 A-------WPVIERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALKAVGIDTRE----PYIQKALAWLESHQNPDGG 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 549 WGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYTSY 627
Cdd:TIGR01507 538 WGEDCRSYEDPAYAGKGASTASQTAWALIALIAAGRAESEAARRGVQYLVETQRPDGGWDEPYYTGTgFPGDFYLGYHMY 617
|
650
....*....|....*
gi 224177558 628 RNIFPIWALGRFSQL 642
Cdd:TIGR01507 618 RHVFPLLALARYKQA 632
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
294-639 |
1.20e-56 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 193.92 E-value: 1.20e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 294 DGMKMQGTNGSQIWDTAFAIQALLEAGGH--HRPEFSSCLQKAHEFLRLSQVPDnppdyqkyyrqmrkGGFSFSTLDcGW 371
Cdd:cd00688 15 DGHWYQSLCGEQTWSTAWPLLALLLLLAAtgIRDKADENIEKGIQRLLSYQLSD--------------GGFSGWGGN-DY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 372 IVSDCTAEALKAVLLLQEkcphvTEHIPRERLCDAVAVLLNMRNPDGGFATYEtkrgghllellnpsEVFGDIMIDYTYV 451
Cdd:cd00688 80 PSLWLTAYALKALLLAGD-----YIAVDRIDLARALNWLLSLQNEDGGFREDG--------------PGNHRIGGDESDV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 452 ECTSAVMQALKYFHKRFPehraaeiRETLTQGLEFCRRQQRADGSWeGSWGVCFTYGTWFGLEAFACMGQTYRDgtacaE 531
Cdd:cd00688 141 RLTAYALIALALLGKLDP-------DPLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAALALLGDLDSP-----D 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 532 VSRACDFLLSRQMADGGWGedfesceERRYLQSAQSQIHNTCWAMMGLMA-VRHPDIEAQERGVRCLLEKQLPNGDWPQE 610
Cdd:cd00688 208 AKKALRWLLSRQRPDGGWG-------EGRDRTNKLSDSCYTEWAAYALLAlGKLGDLEDAEKLVKWLLSQQNEDGGFSSK 280
|
330 340
....*....|....*....|....*....
gi 224177558 611 NIagvfnkscaISYTSYRNIFPIWALGRF 639
Cdd:cd00688 281 PG---------KSYDTQHTVFALLALSLY 300
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
304-639 |
3.20e-51 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 179.84 E-value: 3.20e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 304 SQIWDTAFAIQALLEAGGhhrPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 383
Cdd:pfam13243 2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLV-KGDWAVKRPDLEPGGWAFQFANDHYPDVDDTAVVVLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 384 vlLLQEKCPHVTEhiPRERLCDAVAVLLNMRNPDGGFATYETKrggHLLELLN--PsevFGDI--MIDYTYVECTSAVMQ 459
Cdd:pfam13243 78 --LDRVRLPDERR--RDDAIARGIEWILGMQSKNGGWGAFDKD---NTKYYLNkiP---FADHgaLLDPPTADVTARVLE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 460 ALKYFHkrFPEHRAAEIRetltqGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFL 539
Cdd:pfam13243 148 MLGQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNR----PYIRKAVDWL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 540 LSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNK 618
Cdd:pfam13243 217 KSRQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAAGEVDSPAVRRGIQYLLETQKPDGTWDEPYFTGTgFPR 296
|
330 340
....*....|....*....|.
gi 224177558 619 SCAISYTSYRNIFPIWALGRF 639
Cdd:pfam13243 297 VFYLKYHGYRNYFPLWALARY 317
|
|
| SQHop_cyclase_N |
pfam13249 |
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
6-245 |
4.07e-41 |
|
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Pssm-ID: 433061 [Multi-domain] Cd Length: 290 Bit Score: 151.10 E-value: 4.07e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 6 GLQAEDGHWTGD----------YggplfllpgllITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTA 75
Cdd:pfam13249 10 SLQHPDGHWVGEleanvtitaeY-----------ILLRHFLGPDDPELEAKIARYLRSQQREDGGWPLFHGGPGDLSTTV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 76 LNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 155
Cdd:pfam13249 79 EAYFALKLLGDSPDAPHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPRWFPFNIYKFSSWART 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 156 VYLPMSYCYAVRLSAAEDPlvQSLRQELYVEDFASIDWlaqrnnvaPDELYTPHSW--LLRVVYALLNLYEHHHSAHLRQ 233
Cdd:pfam13249 159 TIVPLLILSALKPVAPLPP--GIGLDELFVEPPENVRY--------YPRPHRLFSWtnLFLGLDRVLKLYERLPPKPLRR 228
|
250
....*....|..
gi 224177558 234 RAVQKLYEHIVA 245
Cdd:pfam13249 229 RALRKAEEWILE 240
|
|
| squa_tetra_cyc |
TIGR04277 |
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ... |
51-639 |
4.56e-19 |
|
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.
Pssm-ID: 212000 [Multi-domain] Cd Length: 624 Bit Score: 91.23 E-value: 4.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 51 LRSVQLPDGGWgLHIEDKSTVFG----TALNYVSLRILGVGPD-DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSW 125
Cdd:TIGR04277 77 LLGSQFEDGSW-EQVEDANIETGqldaTIFNYWYLKAIGIDIHiDAALKKAQEWIKANGGIEAAQTMTKFKLAAFGQYPW 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 126 EGLntLFPEMWLFPDWAPAHPSTLWCHCRQ-VYLPMSYCYAVRLSAAEDPLVQSLRQELYvedfasIDWLAQRNNVAPDE 204
Cdd:TIGR04277 156 EDL--FKIPLFIFKKKGIFKPLYIKDITAQwVYPHLTALAYLQNQRIIFNVAVADIRELW------INKAKKGIKHQKKE 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 205 LYT--PHSWLLRVVYALLNLYEHHHSahLRQRAVQKLYEHIVADDrFTksisigpiSKTINMlvrwyvdgpastafqeHV 282
Cdd:TIGR04277 228 RPSffIDNDLLILMDEIFKLKQPLGS--FGAYTISTLLSLLAFKD-FQ--------GKHPHK----------------HK 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 283 SRIPDYLWMGLDGMKM------QGTNGS----QIWDTAFAIQALLEAGGHH---RPEFSSCLQKAHEflrlsqvPDNPPD 349
Cdd:TIGR04277 281 NEIQDALEDGLDFVEFnyfnfrEAYHGSlddgRWWDTILISWAMLESGEDKekiFPIVENMLKEGLQ-------PKGGIE 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 350 YQKYYrqmrkgGFSFSTLDCGwivsdctaealkavLLLQEKCPHVTEHipRERLCDAVAVLLNMRNPDGGFATYET-KRG 428
Cdd:TIGR04277 354 YGYDF------EYAPDADDTG--------------LLLQVLSYYGEAF--ADAIDEGAEFLFSMQNDDGGFPAFDKgKME 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 429 GHLL--------ELLNPSEVFgdimiDYTYVECTSAVMQALKYFHKRfPEHraaeirETLTQGLEFCRRQQRADGSWEGS 500
Cdd:TIGR04277 412 DNLLfkfafkiaGIADSAEIF-----DPSCPDITAHILEGLGEFGDQ-ANH------DQIQKMIKYFMDTQEKFGSWEAR 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 501 WGVCFTYGTWFGLEAFACMGQTYRDGTacaeVSRACDFLLSRQMADGGWGEDFESCEE-RRYLQSAQSQIHNTCWAMMGL 579
Cdd:TIGR04277 480 WGINYIMAAGAVLPALAKMNYDLNEGW----AKNAINWLLNKQNADGGFGECTLSYNDpEKWNGIGKSTVTQTSWGLLAL 555
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224177558 580 MAVR-HPDI--EAQERGVRCLLEK-QLPNGDWPQENIAGVFNKSCA-ISYTSYRNIFPIWALGRF 639
Cdd:TIGR04277 556 LAVEdHNDQikEAADKAAQYLLDQfKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQSFPLIALGRF 620
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
44-85 |
5.86e-10 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 54.82 E-value: 5.86e-10
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 224177558 44 REEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILG 85
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALLG 44
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
410-605 |
2.85e-08 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 55.48 E-value: 2.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 410 LLNMRNPDGGFATYETkrgghllellnPSEVFgdimidYTYVECTSAVMQALKYFHkrfpEHRAAEIRETLtqglefcrr 489
Cdd:COG5029 28 LRASQNPDGGFAGRSG-----------PSDLY------STYYAVRTLALLGESPKW----RDRVADLLSSL--------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 490 qQRADGSW----EGSWGvcFTYGTWFGLEAFACMGQTYRDgtacaeVSRACDFLLSRQMADGGWGEDFesceerrylqSA 565
Cdd:COG5029 78 -RVEDGGFakapEGGAG--STYHTYLATLLAELLGRPPPD------PDRLVRFLISQQNDDGGFEISP----------GR 138
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 224177558 566 QSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNG 605
Cdd:COG5029 139 RSDTNPTAAAIGALRALGALDDPIETKVIRFLRDVQSPEG 178
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
484-520 |
3.15e-07 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 47.12 E-value: 3.15e-07
10 20 30
....*....|....*....|....*....|....*...
gi 224177558 484 LEFCRRQQRADGSWEGSWGVC-FTYGTWFGLEAFACMG 520
Cdd:pfam00432 7 VDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
40-100 |
2.86e-06 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 49.32 E-value: 2.86e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224177558 40 PAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGpDDPDLVRARNIL 100
Cdd:COG5029 111 PPPDPDRLVRFLISQQNDDGGFEISPGRRSDTNPTAAAIGALRALGAL-DDPIETKVIRFL 170
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
532-578 |
1.50e-05 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 42.50 E-value: 1.50e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 224177558 532 VSRACDFLLSRQMADGGWGEDFESCeerryLQSAQSQIHNTCWAMMG 578
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGE-----SDTYYTYCALAALALLG 44
|
|
| AF1543 |
COG1689 |
Class II terpene cyclase family protein AF1543 [General function prediction only]; |
331-580 |
1.78e-03 |
|
Class II terpene cyclase family protein AF1543 [General function prediction only];
Pssm-ID: 441295 [Multi-domain] Cd Length: 272 Bit Score: 40.86 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 331 LQKAHEFLRLSQVPDnppdyqkyyrqmrkGGFSF-----STLdcgwivSDcTAEALKAVLLLQEKCPHVTEHIprerlcd 405
Cdd:COG1689 8 LARTIEYVLKRQNED--------------GGFCAypglpSTL------AD-TYYAVRILKLLGEEVPNRDKTI------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 406 avAVLLNMRNPDGG-FATYETKRGGHLLELLnpsevfGDIMIDYtyvectsavMQALKYFHKRFPEHRAAE---IRET-- 479
Cdd:COG1689 60 --EFLESCQDEEGGgFALYTTSYGLMALALL------GIDPPDE---------QEALEYLSDALPTKFAGGasdLEETyl 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 480 LTQGLE--------------FCRRQQRADGSWEGSWGVcfTYGTWFGLEAFACMGQTYRDGtacaevSRACDFLLSRQMA 545
Cdd:COG1689 123 AVALLEalgaseperekireFLLSLRRPDGGFGGKKPN--LEDTYWALAALRRLGRDLPPA------DRVIAFILACQNE 194
|
250 260 270
....*....|....*....|....*....|....*
gi 224177558 546 DGGWGedfesceerrYLQSAQSQIHNTCWAMMGLM 580
Cdd:COG1689 195 DGGFS----------KTPGSYSDLEATYYALRALK 219
|
|
| AF1543 |
COG1689 |
Class II terpene cyclase family protein AF1543 [General function prediction only]; |
308-496 |
3.20e-03 |
|
Class II terpene cyclase family protein AF1543 [General function prediction only];
Pssm-ID: 441295 [Multi-domain] Cd Length: 272 Bit Score: 40.09 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 308 DTAFAIQALLEAGG-------------HHRPEFSSCLQKAHEFLR---LSQVPDNPPDYQK---YYR-----QMRKGGFS 363
Cdd:COG1689 37 DTYYAVRILKLLGEevpnrdktiefleSCQDEEGGGFALYTTSYGlmaLALLGIDPPDEQEaleYLSdalptKFAGGASD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177558 364 FSTLDCgwivsdcTAEALKAVLLLQEKCPhvtehiprerlcDAVAVLLNMRNPDGGFA-----TYETkrgGHLLELL--- 435
Cdd:COG1689 117 LEETYL-------AVALLEALGASEPERE------------KIREFLLSLRRPDGGFGgkkpnLEDT---YWALAALrrl 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224177558 436 -----NPSEV-------------FGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAeiretltqgLEFCRRQQRADGS 496
Cdd:COG1689 175 grdlpPADRViafilacqnedggFSKTPGSYSDLEATYYALRALKLLGEPPKNVDKL---------LEFIASCQNSDGG 244
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
534-607 |
6.71e-03 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 39.13 E-value: 6.71e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224177558 534 RACDFLLSRQMADGGWGEDFesceerrylqsaqSQIHNTCWAMMGLMA--VRHPDIEAQERGVRCLLEKQLP-NGDW 607
Cdd:cd02889 3 RALDFLLSLQAPDGHWPGEY-------------SQVWDTALALQALLEagLAPEFDPALKKALEWLLKSQIRdNPDD 66
|
|
| |
