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Conserved domains on  [gi|224589129|ref|NP_001139187|]
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importin subunit alpha-8 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
7-507 2.77e-155

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 453.19  E-value: 2.77e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129   7 PEERRRKFKYRGK-DVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSLTLGEIIKGVNSSDPV 85
Cdd:COG5064    7 PEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  86 LCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELL 165
Cdd:COG5064   87 QQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 166 SSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILP 244
Cdd:COG5064  167 SSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALP 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 245 ALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 324
Cdd:COG5064  247 ILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINC 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 325 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQ 402
Cdd:COG5064  327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDI 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 403 LIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQS 477
Cdd:COG5064  407 IRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDK 486

                        490       500       510
                 ....*....|....*....|....*....|
gi 224589129 478 ALNIIEKHFGeEEDESQTLLSQVIDQDYEF 507
Cdd:COG5064  487 AYSIIEKFFG-EEDAVDELAPETAGNTFTF 515
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
7-507 2.77e-155

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 453.19  E-value: 2.77e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129   7 PEERRRKFKYRGK-DVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSLTLGEIIKGVNSSDPV 85
Cdd:COG5064    7 PEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  86 LCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELL 165
Cdd:COG5064   87 QQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 166 SSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILP 244
Cdd:COG5064  167 SSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALP 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 245 ALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 324
Cdd:COG5064  247 ILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINC 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 325 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQ 402
Cdd:COG5064  327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDI 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 403 LIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQS 477
Cdd:COG5064  407 IRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDK 486

                        490       500       510
                 ....*....|....*....|....*....|
gi 224589129 478 ALNIIEKHFGeEEDESQTLLSQVIDQDYEF 507
Cdd:COG5064  487 AYSIIEKFFG-EEDAVDELAPETAGNTFTF 515
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 10-92 7.99e-25

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 97.61  E-value: 7.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129   10 RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNIT-SFCPDTPSEKTakgvaVSLTLGEIIKGVNSSDPVLCF 88
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGaPSSSSSSAESQ-----LLESLPEMVQGVNSDDPELQL 75


                  ....
gi 224589129   89 QATQ 92
Cdd:pfam01749  76 EATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 314-354 6.51e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.58  E-value: 6.51e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 224589129   314 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 354
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 131-393 2.21e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.32  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  131 QFEAAWALTNIASGTSEQTR-AVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALIsp 209
Cdd:PLN03200  462 QQEYAVALLAILTDEVDESKwAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLL-- 539

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  210 tlpitflrnitwtlsnlcRNKNPYPCDTAVKqilpALLHLLQHQDSEVLSDacwALSYLTDGSNKRIGQVVNtgVLPRlv 289
Cdd:PLN03200  540 ------------------KNGGPKGQEIAAK----TLTKLVRTADAATISQ---LTALLLGDLPESKVHVLD--VLGH-- 590

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  290 VLMTSSELNVLTP------SLRTVGNIVTGTDEQTQ--------------------MAIDAgMLNVLPQLLQHNKPSIQK 343
Cdd:PLN03200  591 VLSVASLEDLVREgsaandALRTLIQLLSSSKEETQekaasvladifssrqdlcesLATDE-IINPCIKLLTNNTEAVAT 669

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 224589129  344 EAAWALSNVaAGPCHHIQQL--LAYDVLPPLVALLKNGEFKVQKEAVWMVAN 393
Cdd:PLN03200  670 QSARALAAL-SRSIKENRKVsyAAEDAIKPLIKLAKSSSIEVAEQAVCALAN 720
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
7-507 2.77e-155

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 453.19  E-value: 2.77e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129   7 PEERRRKFKYRGK-DVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSLTLGEIIKGVNSSDPV 85
Cdd:COG5064    7 PEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  86 LCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELL 165
Cdd:COG5064   87 QQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 166 SSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILP 244
Cdd:COG5064  167 SSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALP 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 245 ALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 324
Cdd:COG5064  247 ILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINC 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 325 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQ 402
Cdd:COG5064  327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDI 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 403 LIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQS 477
Cdd:COG5064  407 IRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDK 486

                        490       500       510
                 ....*....|....*....|....*....|
gi 224589129 478 ALNIIEKHFGeEEDESQTLLSQVIDQDYEF 507
Cdd:COG5064  487 AYSIIEKFFG-EEDAVDELAPETAGNTFTF 515
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 10-92 7.99e-25

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 97.61  E-value: 7.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129   10 RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNIT-SFCPDTPSEKTakgvaVSLTLGEIIKGVNSSDPVLCF 88
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGaPSSSSSSAESQ-----LLESLPEMVQGVNSDDPELQL 75


                  ....
gi 224589129   89 QATQ 92
Cdd:pfam01749  76 EATQ 79
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 452-497 2.38e-16

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 73.01  E-value: 2.38e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 224589129  452 LLIEELGGIDRIEALQLHENRQIGQSALNIIEKHFGEEEDESQTLL 497
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEEDDENL 46
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 314-354 1.61e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 53.23  E-value: 1.61e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 224589129  314 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 354
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 145-184 2.71e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.46  E-value: 2.71e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 224589129  145 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIA 184
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 314-354 6.51e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.58  E-value: 6.51e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 224589129   314 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 354
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 145-184 9.26e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 9.26e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 224589129   145 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIA 184
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 130-183 5.94e-07

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 46.21  E-value: 5.94e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 224589129  130 LQFEAAWALTNIASGTSEQTRAVVEGgAIQPLIELLSSSNVAVCEQAVWALGNI 183
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
115-265 1.22e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 47.70  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 115 IPRMVEFLKSSlYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAgdgpefrdnv 194
Cdd:COG1413   18 VPALIAALADE-DPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPEVRAAAAEALGRIG---------- 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 224589129 195 iTSNAIPHLL-ALISPTLPITflRNITWTLSNLcrnknpypcdtAVKQILPALLHLLQHQDSEVLSDACWAL 265
Cdd:COG1413   76 -DPEAVPALIaALKDEDPEVR--RAAAEALGRL-----------GDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
134-270 1.64e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 47.32  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 134 AAWALTNIasGTSEqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAGDGpefrdnvitsnAIPHLLALISPTLPI 213
Cdd:COG1413    5 AARALGRL--GDPA---------AVPALIAALADEDPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPE 62

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 224589129 214 TfLRNITWTLSNLcrnknpypcdtAVKQILPALLHLLQHQDSEVLSDACWALSYLTD 270
Cdd:COG1413   63 V-RAAAAEALGRI-----------GDPEAVPALIAALKDEDPEVRRAAAEALGRLGD 107
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 242-270 1.83e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 44.75  E-value: 1.83e-06
                          10        20
                  ....*....|....*....|....*....
gi 224589129  242 ILPALLHLLQHQDSEVLSDACWALSYLTD 270
Cdd:pfam00514  13 AVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 231-270 1.74e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.65  E-value: 1.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 224589129   231 NPYPCDTAVKQ-ILPALLHLLQHQDSEVLSDACWALSYLTD 270
Cdd:smart00185   1 DDENKQAVVDAgGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
240-389 3.28e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.85  E-value: 3.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 240 KQILPALLHLLQHQDSEVLSDACWALSYLTDgsnkrigqvvnTGVLPRLVVLMTSSELNVLTPSLRTVGNIvtGTDEqtq 319
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALGRI--GDPE--- 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 320 mAIDAgmlnvLPQLLQHNKPSIQKEAAWALSNVAAGpchhiqqllayDVLPPLVALLKNGEFKVQKEAVW 389
Cdd:COG1413   79 -AVPA-----LIAALKDEDPEVRRAAAEALGRLGDP-----------AAVPALLEALKDPDWEVRRAAAR 131
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 103-143 1.96e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.97  E-value: 1.96e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 224589129  103 NPPLKLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIAS 143
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 131-393 2.21e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.32  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  131 QFEAAWALTNIASGTSEQTR-AVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALIsp 209
Cdd:PLN03200  462 QQEYAVALLAILTDEVDESKwAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLL-- 539

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  210 tlpitflrnitwtlsnlcRNKNPYPCDTAVKqilpALLHLLQHQDSEVLSDacwALSYLTDGSNKRIGQVVNtgVLPRlv 289
Cdd:PLN03200  540 ------------------KNGGPKGQEIAAK----TLTKLVRTADAATISQ---LTALLLGDLPESKVHVLD--VLGH-- 590

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  290 VLMTSSELNVLTP------SLRTVGNIVTGTDEQTQ--------------------MAIDAgMLNVLPQLLQHNKPSIQK 343
Cdd:PLN03200  591 VLSVASLEDLVREgsaandALRTLIQLLSSSKEETQekaasvladifssrqdlcesLATDE-IINPCIKLLTNNTEAVAT 669

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 224589129  344 EAAWALSNVaAGPCHHIQQL--LAYDVLPPLVALLKNGEFKVQKEAVWMVAN 393
Cdd:PLN03200  670 QSARALAAL-SRSIKENRKVsyAAEDAIKPLIKLAKSSSIEVAEQAVCALAN 720
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 102-143 2.50e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 2.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224589129   102 KNPPLKLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIAS 143
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 358-396 3.27e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.20  E-value: 3.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 224589129  358 HHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFAT 396
Cdd:pfam00514   3 ENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 339-394 6.36e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 37.73  E-value: 6.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 224589129  339 PSIQKEAAWALSNVAaGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANF 394
Cdd:pfam13513   1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 197-388 1.01e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.01  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  197 SNAIPHLLALI-SPTLPITFlrNITWTLSNLCRNKnpypcDTAVKQIL----PALLHLLQHQDSEVLSDACWALSYLTDG 271
Cdd:PLN03200   57 SQAMPLLVSLLrSGTLGAKV--NAAAVLGVLCKEE-----DLRVKVLLggciPPLLSLLKSGSAEAQKAAAEAIYAVSSG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  272 SNK-RIGQ--VVNTGVLPRLVVLMTS------SELNVLTPSLRtvgNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQ 342
Cdd:PLN03200  130 GLSdHVGSkiFSTEGVVPSLWDQLQPgnkqdkVVEGLLTGALR---NLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQ 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 224589129  343 KEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNG-EFKVQKEAV 388
Cdd:PLN03200  207 ANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQGnEVSVRAEAA 253
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 188-228 1.28e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.66  E-value: 1.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 224589129  188 PEFRDNVITSNAIPHLLALISPTlPITFLRNITWTLSNLCR 228
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 217-268 1.32e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.96  E-value: 1.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 224589129  217 RNITWTLSNLCrNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYL 268
Cdd:pfam13513   5 EAAALALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 272-312 1.79e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 1.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 224589129  272 SNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVT 312
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 115-207 5.48e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.16  E-value: 5.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  115 IPRMVEFLKSSLYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAgdgpefrdnv 194
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGDPE-----------AVPALLELLKDEDPAVRRAAAEALGKIG---------- 59

                          90
                  ....*....|...
gi 224589129  195 iTSNAIPHLLALI 207
Cdd:pfam13646  60 -DPEALPALLELL 71
HEAT COG1413
HEAT repeat [General function prediction only];
115-184 5.72e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.30  E-value: 5.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 115 IPRMVEFLKSSlYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIA 184
Cdd:COG1413   80 VPALIAALKDE-DPEVRRAAAEALGRLGDPA-----------AVPALLEALKDPDWEVRRAAARALGRLG 137
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 94-210 5.87e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.70  E-value: 5.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129   94 ARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSN-VAV 172
Cdd:PLN03200  170 ALRNLCGSTDGFWSATLEAGGVDILVKLLSSG-NSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQGNeVSV 248

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 224589129  173 CEQAVWALGNIAGDGPEFRDNVITSNAIPHLL-ALISPT 210
Cdd:PLN03200  249 RAEAAGALEALSSQSKEAKQAIADAGGIPALInATVAPS 287
HEAT COG1413
HEAT repeat [General function prediction only];
323-409 7.19e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 36.92  E-value: 7.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129 323 DAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGpchhiqqllayDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQ 402
Cdd:COG1413   14 DPAAVPALIAALADEDPDVRAAAARALGRLGDP-----------RAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPA 82


                 ....*..
gi 224589129 403 LIQLVHS 409
Cdd:COG1413   83 LIAALKD 89
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 310-441 7.32e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.32  E-value: 7.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589129  310 IVTGTDEQTQMAID-AGMLNVLPQLLQHNKPSIQKEAAWALSNVaagpCHHIQQLLA----YDVLPPLVALLKNGEFKVQ 384
Cdd:PLN03200  472 ILTDEVDESKWAITaAGGIPPLVQLLETGSQKAKEDSATVLWNL----CCHSEDIRAcvesAGAVPALLWLLKNGGPKGQ 547

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 224589129  385 KEAVwmvanfatgATMDQLIQLVHSGVLEPLVNLLT--APDVKIVliILDVISCILQAA 441
Cdd:PLN03200  548 EIAA---------KTLTKLVRTADAATISQLTALLLgdLPESKVH--VLDVLGHVLSVA 595
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 358-395 8.33e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 34.33  E-value: 8.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 224589129   358 HHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFA 395
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 133-187 9.71e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 38.93  E-value: 9.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 224589129  133 EAAWALTNIASGTSE-QTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDG 187
Cdd:PLN03200  670 QSARALAALSRSIKEnRKVSYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDP 725
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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