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Conserved domains on  [gi|255759955|ref|NP_001157283|]
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WD repeat-containing protein 81 isoform 4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
413-712 1.92e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 1.92e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 413 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLynyGDGTsetaPRLVYTQHRKSVFFV-----GQLEApqhVVS 487
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL---ATGK----LLRTLTGHSGAVTSVafspdGKLLA---SGS 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 488 CDGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTsITMASSDSTLRFVDCRKPGLQHEFRLGGGLnpglVRALAI 567
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTGHTGAV--RSVAFSPDGKL-LASGSADGTVRLWDLATGKLLRTLTGHSGS----VRSVAF 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 568 SPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIkAV--EGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPI 645
Cdd:COG2319  255 SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV-AFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 255759955 646 H--TFDLYGSEVVTGTVSNKIGVCSLleppSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIRL 712
Cdd:COG2319  334 RsvAFSPDGKTLASGSDDGTVRLWDL----ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
413-712 1.92e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 1.92e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 413 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLynyGDGTsetaPRLVYTQHRKSVFFV-----GQLEApqhVVS 487
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL---ATGK----LLRTLTGHSGAVTSVafspdGKLLA---SGS 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 488 CDGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTsITMASSDSTLRFVDCRKPGLQHEFRLGGGLnpglVRALAI 567
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTGHTGAV--RSVAFSPDGKL-LASGSADGTVRLWDLATGKLLRTLTGHSGS----VRSVAF 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 568 SPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIkAV--EGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPI 645
Cdd:COG2319  255 SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV-AFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 255759955 646 H--TFDLYGSEVVTGTVSNKIGVCSLleppSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIRL 712
Cdd:COG2319  334 RsvAFSPDGKTLASGSDDGTVRLWDL----ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 414-628 1.87e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 1.87e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 414 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGdgtsetaPRLVYTQHRKSVFFVGQLEAPQHVVSC--DGA 491
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK-------CLTTLRGHTDWVNSVAFSPDGTFVASSsqDGT 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 492 VHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTSITmASSDSTLRFVDCRKPGLQHEFRlgGGLNPglVRALAISPSG 571
Cdd:cd00200  159 IKLWDLRTGKCVATLTGHTGEV--NSVAFSPDGEKLLS-SSSDGTIKLWDLSTGKCLGTLR--GHENG--VNSVAFSPDG 231

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 255759955 572 RSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAV-EGSVLVSSSSDHSLTVWK 628
Cdd:cd00200  232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
414-448 1.90e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.90e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 255759955  414 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLW 448
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 414-448 9.81e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 9.81e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 255759955   414 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLW 448
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 489-666 2.96e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 489 DGAVHVWDPFTGKTLRTVEPLDSRVpltavavmpaphTSITMASSDSTLrFVDCRKPGLQHEFRLGGGLNPGLVRALA-- 566
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRV------------WSIDYSSADPTL-LASGSDDGSVKLWSINQGVSIGTIKTKAni 620

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 567 -----ISPSGRSVVAGFSSGFMVLLDTRT-GLVLRGWPAHEGDILQIKAVEGSVLVSSSSDHSLTVW------KELEQKP 634
Cdd:PLN00181 621 ccvqfPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsiSGINETP 700

                        170       180       190
                 ....*....|....*....|....*....|....
gi 255759955 635 THHYKSASDPIHTFDLYGSE--VVTGTVSNKIGV 666
Cdd:PLN00181 701 LHSFMGHTNVKNFVGLSVSDgyIATGSETNEVFV 734
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
413-712 1.92e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 1.92e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 413 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLynyGDGTsetaPRLVYTQHRKSVFFV-----GQLEApqhVVS 487
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL---ATGK----LLRTLTGHSGAVTSVafspdGKLLA---SGS 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 488 CDGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTsITMASSDSTLRFVDCRKPGLQHEFRLGGGLnpglVRALAI 567
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTGHTGAV--RSVAFSPDGKL-LASGSADGTVRLWDLATGKLLRTLTGHSGS----VRSVAF 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 568 SPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIkAV--EGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPI 645
Cdd:COG2319  255 SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV-AFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 255759955 646 H--TFDLYGSEVVTGTVSNKIGVCSLleppSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIRL 712
Cdd:COG2319  334 RsvAFSPDGKTLASGSDDGTVRLWDL----ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
413-712 4.85e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.07  E-value: 4.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 413 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLynygdgtSETAPRLVYTQHRKSVFFV-----GQLEApqhVVS 487
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-------ATGLLLRTLTGHTGAVRSVafspdGKTLA---SGS 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 488 CDGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTSITmASSDSTLRFVDCRKPGLQHEFRLGgglnPGLVRALAI 567
Cdd:COG2319  140 ADGTVRLWDLATGKLLRTLTGHSGAV--TSVAFSPDGKLLAS-GSDDGTVRLWDLATGKLLRTLTGH----TGAVRSVAF 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 568 SPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIkAV--EGSVLVSSSSDHSLTVW----KELEQKPTHHyksa 641
Cdd:COG2319  213 SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-AFspDGRLLASGSADGTVRLWdlatGELLRTLTGH---- 287

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 255759955 642 SDPIHT--FDLYGSEVVTGTVSNKIGVCSLLEPPSQATtklsSENFRGTLTSLALLPTKRHLLLGSDNGVIRL 712
Cdd:COG2319  288 SGGVNSvaFSPDGKLLASGSDDGTVRLWDLATGKLLRT----LTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 414-628 1.87e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 1.87e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 414 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGdgtsetaPRLVYTQHRKSVFFVGQLEAPQHVVSC--DGA 491
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK-------CLTTLRGHTDWVNSVAFSPDGTFVASSsqDGT 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 492 VHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTSITmASSDSTLRFVDCRKPGLQHEFRlgGGLNPglVRALAISPSG 571
Cdd:cd00200  159 IKLWDLRTGKCVATLTGHTGEV--NSVAFSPDGEKLLS-SSSDGTIKLWDLSTGKCLGTLR--GHENG--VNSVAFSPDG 231

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 255759955 572 RSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAV-EGSVLVSSSSDHSLTVWK 628
Cdd:cd00200  232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
413-627 1.98e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 1.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 413 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLynygdgtSETAPRLVYTQHRKSVFFV-----GQLEApqhVVS 487
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL-------ATGKLLRTLTGHSGSVRSVafspdGRLLA---SGS 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 488 CDGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTsITMASSDSTLRFVDCRKPGLQHEFRLggglNPGLVRALAI 567
Cdd:COG2319  266 ADGTVRLWDLATGELLRTLTGHSGGV--NSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTG----HTGAVRSVAF 338

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 255759955 568 SPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIK-AVEGSVLVSSSSDHSLTVW 627
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAfSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 414-712 4.88e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 4.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 414 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWplyNYGDGTSETaprlVYTQHRKSVFFVGQLEAPQHVVSC--DGA 491
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELLR----TLKGHTGPVRDVAASADGTYLASGssDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 492 VHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTsITMASSDSTLRFVDCRKPGLQHEFRlgggLNPGLVRALAISPSG 571
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYV--SSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLR----GHTDWVNSVAFSPDG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 572 RSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVE-GSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIHT--F 648
Cdd:cd00200  148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSvaF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 255759955 649 DLYGSEVVTGTVSNKIGVCSLLEPpsQATTKLSSENfrGTLTSLALLPTKRHLLLGSDNGVIRL 712
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTG--ECVQTLSGHT--NSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
489-712 2.69e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 2.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 489 DGAVHVWDPFTGKTLRTVEPLDSRVplTAVAVMPAPHTSITmASSDSTLRFVDCRKPGLQHEFRLggglNPGLVRALAIS 568
Cdd:COG2319   57 DLTLLLLDAAAGALLATLLGHTAAV--LSVAFSPDGRLLAS-ASADGTVRLWDLATGLLLRTLTG----HTGAVRSVAFS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 569 PSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIkAV--EGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIH 646
Cdd:COG2319  130 PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV-AFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 208

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255759955 647 --TFDLYGSEVVTGTVSNKIGVCSLLEPPSQATTKLSSenfrGTLTSLALLPTKRHLLLGSDNGVIRL 712
Cdd:COG2319  209 svAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS----GSVRSVAFSPDGRLLASGSADGTVRL 272
WD40 pfam00400
WD domain, G-beta repeat;
414-448 1.90e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.90e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 255759955  414 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLW 448
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 414-448 9.81e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 9.81e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 255759955   414 LQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLW 448
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
413-499 9.41e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 9.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 413 RLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLynygdgtSETAPRLVYTQHRKSVFFVGQLEAPQHVVSC--DG 490
Cdd:COG2319  322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-------ATGELLRTLTGHTGAVTSVAFSPDGRTLASGsaDG 394


                 ....*....
gi 255759955 491 AVHVWDPFT 499
Cdd:COG2319  395 TVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 489-666 2.96e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 489 DGAVHVWDPFTGKTLRTVEPLDSRVpltavavmpaphTSITMASSDSTLrFVDCRKPGLQHEFRLGGGLNPGLVRALA-- 566
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRV------------WSIDYSSADPTL-LASGSDDGSVKLWSINQGVSIGTIKTKAni 620

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 567 -----ISPSGRSVVAGFSSGFMVLLDTRT-GLVLRGWPAHEGDILQIKAVEGSVLVSSSSDHSLTVW------KELEQKP 634
Cdd:PLN00181 621 ccvqfPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsiSGINETP 700

                        170       180       190
                 ....*....|....*....|....*....|....
gi 255759955 635 THHYKSASDPIHTFDLYGSE--VVTGTVSNKIGV 666
Cdd:PLN00181 701 LHSFMGHTNVKNFVGLSVSDgyIATGSETNEVFV 734
WD40 COG2319
WD40 repeat [General function prediction only];
559-712 9.44e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 9.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 559 PGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKA-VEGSVLVSSSSDHSLTVWKELEQKPTHH 637
Cdd:COG2319   36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFsPDGRLLASASADGTVRLWDLATGLLLRT 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255759955 638 YKSASDPIHTFDLY--GSEVVTGTVSNKIGVCSLLEPPSQATTKLSSenfrGTLTSLALLPTKRHLLLGSDNGVIRL 712
Cdd:COG2319  116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHS----GAVTSVAFSPDGKLLASGSDDGTVRL 188
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
489-602 1.30e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255759955 489 DGAVHVWDPFTGKTLRTVEPLDSrvpLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGlnpglVRALAIS 568
Cdd:COG3391   89 SGRVSVIDLATGKVVATIPVGGG---PRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAG-----PHGIAVD 160

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 255759955 569 PSGRSV-VAGFSSG----FMVLLDTRTGLVLRGWPAHEG 602
Cdd:COG3391  161 PDGKRLyVANSGSNtvsvIVSVIDTATGKVVATIPVGGG 199
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 551-604 6.07e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 6.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 255759955  551 FRLGG----GLNP----GLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDI 604
Cdd:pfam12894  22 HRLNWqrvwTLSPdkedLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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