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Conserved domains on  [gi|256773178|ref|NP_001157739|]
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WD repeat-containing protein 46 isoform 2 [Homo sapiens]

Protein Classification

WDR46/Utp7 family WD40 repeat domain-containing protein( domain architecture ID 11456818)

WDR46/Utp7 family WD40 repeat domain-containing protein similar to Saccharomyces cerevisiae U3 small nucleolar RNA-associated protein 7 that is involved in nucleolar processing of pre-18S ribosomal RNA, and Canis lupus familiaris WD repeat-containing protein 46, a scaffold component of the nucleolar structure

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042274|GO:0030490|GO:0003723
PubMed:  10322433|30069656|21468892

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 386-463 1.14e-48

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


:

Pssm-ID: 462375  Cd Length: 79  Bit Score: 163.01  E-value: 1.14e-48
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256773178  386 PYLTHRLSG-PVHGLQFCPFEDVLGVGHTGGITSMLVPGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLD 463
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 COG2319
WD40 repeat [General function prediction only];
127-336 1.81e-15

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 127 DIASAAKHFDLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAALDWVTKKLMCEINV-MEAVRDIRFLHSEALLAVA-QNRW 204
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGsADGT 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 205 LHIYD-NQGIELHCIR-RCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGH 282
Cdd:COG2319  270 VRLWDlATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 256773178 283 SNGTVSLWSPAMKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRG 336
Cdd:COG2319  350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 386-463 1.14e-48

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 163.01  E-value: 1.14e-48
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256773178  386 PYLTHRLSG-PVHGLQFCPFEDVLGVGHTGGITSMLVPGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLD 463
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 386-464 1.14e-48

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 163.17  E-value: 1.14e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178   386 PYLTHRLSGP-VHGLQFCPFEDVLGVGHTGGITSMLVPGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLDP 464
Cdd:smart01033   1 PYMTHGLPGSrVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
WD40 COG2319
WD40 repeat [General function prediction only];
127-336 1.81e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 127 DIASAAKHFDLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAALDWVTKKLMCEINV-MEAVRDIRFLHSEALLAVA-QNRW 204
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGsADGT 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 205 LHIYD-NQGIELHCIR-RCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGH 282
Cdd:COG2319  270 VRLWDlATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 256773178 283 SNGTVSLWSPAMKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRG 336
Cdd:COG2319  350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 154-333 2.08e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 2.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 154 RHLAFGGRRGHVAALdWVTKKLMCEINV---MEAVRDIRFLHSEALLAVA-QNRWLHIYDNQGIElhCIRRC----DRVT 225
Cdd:cd00200  105 GRILSSSSRDKTIKV-WDVETGKCLTTLrghTDWVNSVAFSPDGTFVASSsQDGTIKLWDLRTGK--CVATLtghtGEVN 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 226 RLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHR 305
Cdd:cd00200  182 SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT 261

                        170       180
                 ....*....|....*....|....*...
gi 256773178 306 GGVRAVAVDSTGTYMATSGLDHQLKIFD 333
Cdd:cd00200  262 NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 301-419 3.00e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 3.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 301 ILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRgTYQPLSTRTLP-HGAGHLAFSQRG--LLVAGMGDVVNIWagqgk 377
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-TGELLRTLKGHtGPVRDVAASADGtyLASGSSDKTIRLW----- 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 256773178 378 asppSLEQPYLTHRLsgpvhglqfcpfedvlgVGHTGGITSM 419
Cdd:cd00200   79 ----DLETGECVRTL-----------------TGHTSYVSSV 99
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 295-333 3.38e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 3.38e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 256773178   295 KEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFD 333
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
295-333 3.57e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 256773178  295 KEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFD 333
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 386-463 1.14e-48

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 163.01  E-value: 1.14e-48
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256773178  386 PYLTHRLSG-PVHGLQFCPFEDVLGVGHTGGITSMLVPGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLD 463
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 386-464 1.14e-48

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 163.17  E-value: 1.14e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178   386 PYLTHRLSGP-VHGLQFCPFEDVLGVGHTGGITSMLVPGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLDP 464
Cdd:smart01033   1 PYMTHGLPGSrVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
WD40 COG2319
WD40 repeat [General function prediction only];
127-336 1.81e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 127 DIASAAKHFDLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAALDWVTKKLMCEINV-MEAVRDIRFLHSEALLAVA-QNRW 204
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGsADGT 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 205 LHIYD-NQGIELHCIR-RCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGH 282
Cdd:COG2319  270 VRLWDlATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 256773178 283 SNGTVSLWSPAMKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRG 336
Cdd:COG2319  350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
74-415 5.31e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 5.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178  74 TRSRLEVAEAEEEETSIKAARSELLLAEEPGFLEGEDGEDTAKICQADIVEAVDIASAAKHFDLNLRQFGPYRLNYSRTG 153
Cdd:COG2319   11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 154 RHLAFGGRRGHVAALDWVTKKLMCEIN-VMEAVRDIRFLHSEALLAVA-QNRWLHIYD-NQGIELHCIRR-CDRVTRLEF 229
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGsADGTVRLWDlATGKLLRTLTGhSGAVTSVAF 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 230 LPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHRGGVR 309
Cdd:COG2319  171 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 310 AVAVDSTGTYMATSGLDHQLKIFDLRgTYQPLstRTLPHGAG---HLAFSQRG--LLVAGMGDVVNIWagqgkasppSLE 384
Cdd:COG2319  251 SVAFSPDGRLLASGSADGTVRLWDLA-TGELL--RTLTGHSGgvnSVAFSPDGklLASGSDDGTVRLW---------DLA 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 256773178 385 QPYLTHRLSG---PVHGLQFCPFEDVLGVGHTGG 415
Cdd:COG2319  319 TGKLLRTLTGhtgAVRSVAFSPDGKTLASGSDDG 352
WD40 COG2319
WD40 repeat [General function prediction only];
195-403 7.51e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 7.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 195 ALLAVAQNRWLHIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPY 274
Cdd:COG2319   10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 275 NAVIHLGHSNGTVSLWSPAMKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRgTYQPLstRTLPHGAG--- 351
Cdd:COG2319   90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TGKLL--RTLTGHSGavt 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 256773178 352 HLAFSQRG--LLVAGMGDVVNIWagqgkasppSLEQPYLTHRLSG---PVHGLQFCP 403
Cdd:COG2319  167 SVAFSPDGklLASGSDDGTVRLW---------DLATGKLLRTLTGhtgAVRSVAFSP 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 154-333 2.08e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 2.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 154 RHLAFGGRRGHVAALdWVTKKLMCEINV---MEAVRDIRFLHSEALLAVA-QNRWLHIYDNQGIElhCIRRC----DRVT 225
Cdd:cd00200  105 GRILSSSSRDKTIKV-WDVETGKCLTTLrghTDWVNSVAFSPDGTFVASSsQDGTIKLWDLRTGK--CVATLtghtGEVN 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 226 RLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHR 305
Cdd:cd00200  182 SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT 261

                        170       180
                 ....*....|....*....|....*...
gi 256773178 306 GGVRAVAVDSTGTYMATSGLDHQLKIFD 333
Cdd:cd00200  262 NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 222-403 2.30e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 2.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 222 DRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKI 301
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 302 LCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRgTYQPLSTRTlPHGAG--HLAFSQRGLLVA-GMGD-VVNIWagqgk 377
Cdd:cd00200   90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-TGKCLTTLR-GHTDWvnSVAFSPDGTFVAsSSQDgTIKLW----- 162

                        170       180
                 ....*....|....*....|....*....
gi 256773178 378 asppSLEQPYLTHRLSG---PVHGLQFCP 403
Cdd:cd00200  163 ----DLRTGKCVATLTGhtgEVNSVAFSP 187
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 185-403 9.21e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 9.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 185 VRDIRFL-HSEALLAVAQNRWLHIYDNQGIEL--------HCIRRCDrvtrleFLPFHFLLATASETGFLTYLDVSVGKI 255
Cdd:cd00200   12 VTCVAFSpDGKLLATGSGDGTIKVWDLETGELlrtlkghtGPVRDVA------ASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 256 VAALNARAGrlDVMS--QNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFD 333
Cdd:cd00200   86 VRTLTGHTS--YVSSvaFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256773178 334 LRGTYqplSTRTLPhgaGH------LAFSQRG--LLVAGMGDVVNIWagqgKASPPSLEQPYLTHRlsGPVHGLQFCP 403
Cdd:cd00200  164 LRTGK---CVATLT---GHtgevnsVAFSPDGekLLSSSSDGTIKLW----DLSTGKCLGTLRGHE--NGVNSVAFSP 229
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 222-373 7.44e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 7.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 222 DRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKI 301
Cdd:cd00200  136 DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 302 LCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRgTYQPLstRTLPhgaGH------LAFSQRGLLVAGMGD--VVNIWA 373
Cdd:cd00200  216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR-TGECV--QTLS---GHtnsvtsLAWSPDGKRLASGSAdgTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
229-403 8.21e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 8.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 229 FLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHRGGV 308
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 309 RAVAVDSTGTYMATSGLDHQLKIFDLRGTYQPLSTRTLPHGAGHLAFSQRG--LLVAGMGDVVNIW-AGQGKasppsLEQ 385
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGktLASGSADGTVRLWdLATGK-----LLR 156

                        170
                 ....*....|....*...
gi 256773178 386 PYLTHrlSGPVHGLQFCP 403
Cdd:COG2319  157 TLTGH--SGAVTSVAFSP 172
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 301-419 3.00e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 3.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773178 301 ILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRgTYQPLSTRTLP-HGAGHLAFSQRG--LLVAGMGDVVNIWagqgk 377
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-TGELLRTLKGHtGPVRDVAASADGtyLASGSSDKTIRLW----- 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 256773178 378 asppSLEQPYLTHRLsgpvhglqfcpfedvlgVGHTGGITSM 419
Cdd:cd00200   79 ----DLETGECVRTL-----------------TGHTSYVSSV 99
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 295-333 3.38e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 3.38e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 256773178   295 KEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFD 333
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
295-333 3.57e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 256773178  295 KEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFD 333
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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