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Conserved domains on  [gi|261399884|ref|NP_001159762|]
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ATP-sensitive inward rectifier potassium channel 11 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IRK_C pfam17655
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
94-264 3.42e-98

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


:

Pssm-ID: 465439  Cd Length: 174  Bit Score: 286.02  E-value: 3.42e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261399884   94 LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHV 173
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLKTRVTKEGEVIPLYQVDLDLGVDTGSDRIFLVWPLTVYHV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261399884  174 IDANSPLYDLAPSDLhHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEED-GRYSVDYSKFGNTVKV 252
Cdd:pfam17655  81 IDEDSPLYDLSAKDL-LEEDFELVVILEGTVESTGMTTQARTSYLPEEILWGHRFEPVISYSKeGRYVVDYSNFDKTVEV 159
                         170
                  ....*....|..
gi 261399884  253 PTPLCTARQLDE 264
Cdd:pfam17655 160 PTPHCSAKELDE 171
IRK super family cl47618
Inward rectifier potassium channel transmembrane domain;
1-87 2.39e-45

Inward rectifier potassium channel transmembrane domain;


The actual alignment was detected with superfamily member pfam01007:

Pssm-ID: 460023  Cd Length: 141  Bit Score: 150.41  E-value: 2.39e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261399884    1 MAWWLIAFAHGDLAPSEGT-AEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGC 79
Cdd:pfam01007  54 LIWYLIAYSHGDLDQRPDDgHTPCVYNVHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGI 133

                  ....*...
gi 261399884   80 IFMKTAQA 87
Cdd:pfam01007 134 VFAKMARP 141
 
Name Accession Description Interval E-value
IRK_C pfam17655
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
94-264 3.42e-98

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


Pssm-ID: 465439  Cd Length: 174  Bit Score: 286.02  E-value: 3.42e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261399884   94 LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHV 173
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLKTRVTKEGEVIPLYQVDLDLGVDTGSDRIFLVWPLTVYHV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261399884  174 IDANSPLYDLAPSDLhHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEED-GRYSVDYSKFGNTVKV 252
Cdd:pfam17655  81 IDEDSPLYDLSAKDL-LEEDFELVVILEGTVESTGMTTQARTSYLPEEILWGHRFEPVISYSKeGRYVVDYSNFDKTVEV 159
                         170
                  ....*....|..
gi 261399884  253 PTPLCTARQLDE 264
Cdd:pfam17655 160 PTPHCSAKELDE 171
IRK pfam01007
Inward rectifier potassium channel transmembrane domain;
1-87 2.39e-45

Inward rectifier potassium channel transmembrane domain;


Pssm-ID: 460023  Cd Length: 141  Bit Score: 150.41  E-value: 2.39e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261399884    1 MAWWLIAFAHGDLAPSEGT-AEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGC 79
Cdd:pfam01007  54 LIWYLIAYSHGDLDQRPDDgHTPCVYNVHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGI 133

                  ....*...
gi 261399884   80 IFMKTAQA 87
Cdd:pfam01007 134 VFAKMARP 141
 
Name Accession Description Interval E-value
IRK_C pfam17655
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
94-264 3.42e-98

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


Pssm-ID: 465439  Cd Length: 174  Bit Score: 286.02  E-value: 3.42e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261399884   94 LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHV 173
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLKTRVTKEGEVIPLYQVDLDLGVDTGSDRIFLVWPLTVYHV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261399884  174 IDANSPLYDLAPSDLhHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEED-GRYSVDYSKFGNTVKV 252
Cdd:pfam17655  81 IDEDSPLYDLSAKDL-LEEDFELVVILEGTVESTGMTTQARTSYLPEEILWGHRFEPVISYSKeGRYVVDYSNFDKTVEV 159
                         170
                  ....*....|..
gi 261399884  253 PTPLCTARQLDE 264
Cdd:pfam17655 160 PTPHCSAKELDE 171
IRK pfam01007
Inward rectifier potassium channel transmembrane domain;
1-87 2.39e-45

Inward rectifier potassium channel transmembrane domain;


Pssm-ID: 460023  Cd Length: 141  Bit Score: 150.41  E-value: 2.39e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261399884    1 MAWWLIAFAHGDLAPSEGT-AEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGC 79
Cdd:pfam01007  54 LIWYLIAYSHGDLDQRPDDgHTPCVYNVHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGI 133

                  ....*...
gi 261399884   80 IFMKTAQA 87
Cdd:pfam01007 134 VFAKMARP 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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