NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|291621657|ref|NP_001167587|]
View 

dmX-like protein 2 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Rav1p_C super family cl13644
RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between ...
 1171-1902 1.36e-75

RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.


The actual alignment was detected with superfamily member pfam12234:

Pssm-ID: 432413  Cd Length: 637  Bit Score: 266.36  E-value: 1.36e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1171 LDWVSKEDGSHILTVGVGANIFMYGRLSgivTEQTNSkdgvavitLPlggsikqgvksRWVLLRSIDLVssvDGTPSLPV 1250
Cdd:pfam12234   76 LDWTSTPDSQSILAVGFPHHVLLLTQLR---YDYTNK--------GP-----------SWAPIRKIDIR---DLTPHPIG 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1251 SLSWVRDGILVVGMDCEMHVYAQWkhavkfgdteadssnAEEAAMQDHSTfksnmlaRKSVVEGTAISDDvfcsptviqd 1330
Cdd:pfam12234  131 DSIWLDDGTLVVAAGNQLFIYDKW---------------LDLRLPDDPFT-------LRSIGSRKILSND---------- 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1331 ggLFEAAHVLSPTLPQYHPTQLLELMDLGKVRRAKAILSHLVKCIagevaivrdpdagegtkrhlsrtisvsgstaketv 1410
Cdd:pfam12234  179 --LFHLVSVLNGPLPVYHPQFLIQCLLAGKLELVKEILLRLFKEL----------------------------------- 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1411 tvgKDGTRDYTEIDSIPPLPLYALLAaDQDTSYRISEESTkipqsyedqtvSQPEDQYSELFQiqdiptddidlepekre 1490
Cdd:pfam12234  222 ---KFYSEDLEDLDSFLGIDLEKFLK-DDDKAYSKNKAFT-----------SSSDDDDPDPYE----------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1491 nkskvinlsqygpaYFGQEHARVLSSHLMHSSLPGLTRLEQMFLVALADTVATTSTEldesrdkscsgRDTLDECGLRYL 1570
Cdd:pfam12234  270 --------------TFNEEVASSLNEKLTKISLPQLTRHEQITLINVIEAVGEVEKH-----------RRSLDENGARFL 324

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1571 LAMRLHTclltslppLYRVQLLHQGVSTCHFAWAFHSEAEEELINMIPAIQRGDPQWSELRAMGIGWWVRNINTLRRCIE 1650
Cdd:pfam12234  325 LGFKLHL--------LHKKRTSQSSLSWRDISWALHSDNQEILLDLVSRHYGNKLLWEAARESGIFMWLKDIEALRAQFE 396

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1651 KVAKASFQRNN--DALDAALFYLSMKKKAVVWGLFR--SQHDE--KMTTFFSHNFNEDRWRKAALKNAFSLLGKQRFEQS 1724
Cdd:pfam12234  397 VIARNEYTKSDerDPVDCSLFYLALKKKQVLQGLWRmaSWHPEqaKTLKFLSNDFSEPRWRTAALKNAFALLSKHRYEYA 476

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1725 AAFFLLAGSLKDAIEVCLEKMEDIQLAMVIARLYESefETSSTYISILNQKIL-GCQKDGsgfsckrlhpDPFLRSLAYW 1803
Cdd:pfam12234  477 AAFFLLADSLKDAVNVLLRQLKDLQLAIAVARVYEG--DDGPVLRELLEERVLpLAIKEG----------DRWLASWAFW 544

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1804 VMK---DYTRAL----DTLLEQTPKEDDEHQVII-KSC---NPVAFSFYNYLRTHPL-LIRRNLASPEgtlatlglKTEK 1871
Cdd:pfam12234  545 MLKrrdLAVRALvtppYDLLENTDLKKSDPASPVsKSFltdDPALVLLYQQLRKKTLqTLKGALKVTP--------KEEY 616

                          730       740       750
                   ....*....|....*....|....*....|.
gi 291621657  1872 NFVdkinlierklfFTTANAHFKVGCPVLAL 1902
Cdd:pfam12234  617 DFV-----------LRVARIYDRMGCDLLAL 636
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2767-3019 1.01e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 1.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2767 VKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAGNArVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPY 2846
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP-VRDVAASADGTYLASGSSDKTIRLWDLE----TGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2847 MSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVC 2926
Cdd:cd00200    87 RTLTGHTSYVSSVAFSPDGRILSSSS---RDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2927 IFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSeHakqsifrniGAGVMQIDIIQG 3006
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-H---------ENGVNSVAFSPD 230

                         250
                  ....*....|....
gi 291621657 3007 NRLF-SCGADGTLK 3019
Cdd:cd00200   231 GYLLaSGSEDGTIR 244
WD40 super family cl43672
WD40 repeat [General function prediction only];
45-268 3.98e-03

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657   45 ECVQIIPGakHGNiQVSCVECSNQQGRIA-ASYGNAVCIFEPLGinshkrncqlkCQWLKTGQFFLSSVtYNLAWDPQDN 123
Cdd:COG2319   195 KLLRTLTG--HTG-AVRSVAFSPDGKLLAsGSADGTVRLWDLAT-----------GKLLRTLTGHSGSV-RSVAFSPDGR 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  124 RLLTATD--SIQLWAPPGDDILEEEEEIDNTVppvlndwkcvwqckTSVSvhlmeWSPDGEYFATAGkDDCLLKVWYPMT 201
Cdd:COG2319   260 LLASGSAdgTVRLWDLATGELLRTLTGHSGGV--------------NSVA-----FSPDGKLLASGS-DDGTVRLWDLAT 319

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 291621657  202 GWKSSIIPqdhhevkrrqsstqfsfvylAHPRAVTGFSWRktskymPRGsvcNVLLTSCHDGVCRLW 268
Cdd:COG2319   320 GKLLRTLT--------------------GHTGAVRSVAFS------PDG---KTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
Rav1p_C pfam12234
RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between ...
 1171-1902 1.36e-75

RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.


Pssm-ID: 432413  Cd Length: 637  Bit Score: 266.36  E-value: 1.36e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1171 LDWVSKEDGSHILTVGVGANIFMYGRLSgivTEQTNSkdgvavitLPlggsikqgvksRWVLLRSIDLVssvDGTPSLPV 1250
Cdd:pfam12234   76 LDWTSTPDSQSILAVGFPHHVLLLTQLR---YDYTNK--------GP-----------SWAPIRKIDIR---DLTPHPIG 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1251 SLSWVRDGILVVGMDCEMHVYAQWkhavkfgdteadssnAEEAAMQDHSTfksnmlaRKSVVEGTAISDDvfcsptviqd 1330
Cdd:pfam12234  131 DSIWLDDGTLVVAAGNQLFIYDKW---------------LDLRLPDDPFT-------LRSIGSRKILSND---------- 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1331 ggLFEAAHVLSPTLPQYHPTQLLELMDLGKVRRAKAILSHLVKCIagevaivrdpdagegtkrhlsrtisvsgstaketv 1410
Cdd:pfam12234  179 --LFHLVSVLNGPLPVYHPQFLIQCLLAGKLELVKEILLRLFKEL----------------------------------- 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1411 tvgKDGTRDYTEIDSIPPLPLYALLAaDQDTSYRISEESTkipqsyedqtvSQPEDQYSELFQiqdiptddidlepekre 1490
Cdd:pfam12234  222 ---KFYSEDLEDLDSFLGIDLEKFLK-DDDKAYSKNKAFT-----------SSSDDDDPDPYE----------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1491 nkskvinlsqygpaYFGQEHARVLSSHLMHSSLPGLTRLEQMFLVALADTVATTSTEldesrdkscsgRDTLDECGLRYL 1570
Cdd:pfam12234  270 --------------TFNEEVASSLNEKLTKISLPQLTRHEQITLINVIEAVGEVEKH-----------RRSLDENGARFL 324

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1571 LAMRLHTclltslppLYRVQLLHQGVSTCHFAWAFHSEAEEELINMIPAIQRGDPQWSELRAMGIGWWVRNINTLRRCIE 1650
Cdd:pfam12234  325 LGFKLHL--------LHKKRTSQSSLSWRDISWALHSDNQEILLDLVSRHYGNKLLWEAARESGIFMWLKDIEALRAQFE 396

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1651 KVAKASFQRNN--DALDAALFYLSMKKKAVVWGLFR--SQHDE--KMTTFFSHNFNEDRWRKAALKNAFSLLGKQRFEQS 1724
Cdd:pfam12234  397 VIARNEYTKSDerDPVDCSLFYLALKKKQVLQGLWRmaSWHPEqaKTLKFLSNDFSEPRWRTAALKNAFALLSKHRYEYA 476

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1725 AAFFLLAGSLKDAIEVCLEKMEDIQLAMVIARLYESefETSSTYISILNQKIL-GCQKDGsgfsckrlhpDPFLRSLAYW 1803
Cdd:pfam12234  477 AAFFLLADSLKDAVNVLLRQLKDLQLAIAVARVYEG--DDGPVLRELLEERVLpLAIKEG----------DRWLASWAFW 544

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1804 VMK---DYTRAL----DTLLEQTPKEDDEHQVII-KSC---NPVAFSFYNYLRTHPL-LIRRNLASPEgtlatlglKTEK 1871
Cdd:pfam12234  545 MLKrrdLAVRALvtppYDLLENTDLKKSDPASPVsKSFltdDPALVLLYQQLRKKTLqTLKGALKVTP--------KEEY 616

                          730       740       750
                   ....*....|....*....|....*....|.
gi 291621657  1872 NFVdkinlierklfFTTANAHFKVGCPVLAL 1902
Cdd:pfam12234  617 DFV-----------LRVARIYDRMGCDLLAL 636
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2767-3019 1.01e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 1.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2767 VKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAGNArVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPY 2846
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP-VRDVAASADGTYLASGSSDKTIRLWDLE----TGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2847 MSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVC 2926
Cdd:cd00200    87 RTLTGHTSYVSSVAFSPDGRILSSSS---RDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2927 IFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSeHakqsifrniGAGVMQIDIIQG 3006
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-H---------ENGVNSVAFSPD 230

                         250
                  ....*....|....
gi 291621657 3007 NRLF-SCGADGTLK 3019
Cdd:cd00200   231 GYLLaSGSEDGTIR 244
WD40 COG2319
WD40 repeat [General function prediction only];
2767-3019 1.79e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.79e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2767 VKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFrQAGNARVTRLYFNSQGNKCGVADGEGFLSIWQVnqtaSNPKPY 2846
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2847 MSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTLispGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVC 2926
Cdd:COG2319   156 RTLTGHSGAVTSVAFSPDGKLLASGS---DDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2927 IFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSEhakqsifrniGAGVMQIDII-Q 3005
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----------SGGVNSVAFSpD 299

                         250
                  ....*....|....
gi 291621657 3006 GNRLFSCGADGTLK 3019
Cdd:COG2319   300 GKLLASGSDDGTVR 313
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 2932-2970 4.43e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.43e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 291621657   2932 QRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVW 2970
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
2933-2970 1.19e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 291621657  2933 RQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVW 2970
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
45-268 3.98e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657   45 ECVQIIPGakHGNiQVSCVECSNQQGRIA-ASYGNAVCIFEPLGinshkrncqlkCQWLKTGQFFLSSVtYNLAWDPQDN 123
Cdd:COG2319   195 KLLRTLTG--HTG-AVRSVAFSPDGKLLAsGSADGTVRLWDLAT-----------GKLLRTLTGHSGSV-RSVAFSPDGR 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  124 RLLTATD--SIQLWAPPGDDILEEEEEIDNTVppvlndwkcvwqckTSVSvhlmeWSPDGEYFATAGkDDCLLKVWYPMT 201
Cdd:COG2319   260 LLASGSAdgTVRLWDLATGELLRTLTGHSGGV--------------NSVA-----FSPDGKLLASGS-DDGTVRLWDLAT 319

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 291621657  202 GWKSSIIPqdhhevkrrqsstqfsfvylAHPRAVTGFSWRktskymPRGsvcNVLLTSCHDGVCRLW 268
Cdd:COG2319   320 GKLLRTLT--------------------GHTGAVRSVAFS------PDG---KTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
Rav1p_C pfam12234
RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between ...
 1171-1902 1.36e-75

RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.


Pssm-ID: 432413  Cd Length: 637  Bit Score: 266.36  E-value: 1.36e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1171 LDWVSKEDGSHILTVGVGANIFMYGRLSgivTEQTNSkdgvavitLPlggsikqgvksRWVLLRSIDLVssvDGTPSLPV 1250
Cdd:pfam12234   76 LDWTSTPDSQSILAVGFPHHVLLLTQLR---YDYTNK--------GP-----------SWAPIRKIDIR---DLTPHPIG 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1251 SLSWVRDGILVVGMDCEMHVYAQWkhavkfgdteadssnAEEAAMQDHSTfksnmlaRKSVVEGTAISDDvfcsptviqd 1330
Cdd:pfam12234  131 DSIWLDDGTLVVAAGNQLFIYDKW---------------LDLRLPDDPFT-------LRSIGSRKILSND---------- 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1331 ggLFEAAHVLSPTLPQYHPTQLLELMDLGKVRRAKAILSHLVKCIagevaivrdpdagegtkrhlsrtisvsgstaketv 1410
Cdd:pfam12234  179 --LFHLVSVLNGPLPVYHPQFLIQCLLAGKLELVKEILLRLFKEL----------------------------------- 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1411 tvgKDGTRDYTEIDSIPPLPLYALLAaDQDTSYRISEESTkipqsyedqtvSQPEDQYSELFQiqdiptddidlepekre 1490
Cdd:pfam12234  222 ---KFYSEDLEDLDSFLGIDLEKFLK-DDDKAYSKNKAFT-----------SSSDDDDPDPYE----------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1491 nkskvinlsqygpaYFGQEHARVLSSHLMHSSLPGLTRLEQMFLVALADTVATTSTEldesrdkscsgRDTLDECGLRYL 1570
Cdd:pfam12234  270 --------------TFNEEVASSLNEKLTKISLPQLTRHEQITLINVIEAVGEVEKH-----------RRSLDENGARFL 324

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1571 LAMRLHTclltslppLYRVQLLHQGVSTCHFAWAFHSEAEEELINMIPAIQRGDPQWSELRAMGIGWWVRNINTLRRCIE 1650
Cdd:pfam12234  325 LGFKLHL--------LHKKRTSQSSLSWRDISWALHSDNQEILLDLVSRHYGNKLLWEAARESGIFMWLKDIEALRAQFE 396

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1651 KVAKASFQRNN--DALDAALFYLSMKKKAVVWGLFR--SQHDE--KMTTFFSHNFNEDRWRKAALKNAFSLLGKQRFEQS 1724
Cdd:pfam12234  397 VIARNEYTKSDerDPVDCSLFYLALKKKQVLQGLWRmaSWHPEqaKTLKFLSNDFSEPRWRTAALKNAFALLSKHRYEYA 476

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1725 AAFFLLAGSLKDAIEVCLEKMEDIQLAMVIARLYESefETSSTYISILNQKIL-GCQKDGsgfsckrlhpDPFLRSLAYW 1803
Cdd:pfam12234  477 AAFFLLADSLKDAVNVLLRQLKDLQLAIAVARVYEG--DDGPVLRELLEERVLpLAIKEG----------DRWLASWAFW 544

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  1804 VMK---DYTRAL----DTLLEQTPKEDDEHQVII-KSC---NPVAFSFYNYLRTHPL-LIRRNLASPEgtlatlglKTEK 1871
Cdd:pfam12234  545 MLKrrdLAVRALvtppYDLLENTDLKKSDPASPVsKSFltdDPALVLLYQQLRKKTLqTLKGALKVTP--------KEEY 616

                          730       740       750
                   ....*....|....*....|....*....|.
gi 291621657  1872 NFVdkinlierklfFTTANAHFKVGCPVLAL 1902
Cdd:pfam12234  617 DFV-----------LRVARIYDRMGCDLLAL 636
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2767-3019 1.01e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 1.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2767 VKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAGNArVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPY 2846
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP-VRDVAASADGTYLASGSSDKTIRLWDLE----TGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2847 MSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVC 2926
Cdd:cd00200    87 RTLTGHTSYVSSVAFSPDGRILSSSS---RDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2927 IFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSeHakqsifrniGAGVMQIDIIQG 3006
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-H---------ENGVNSVAFSPD 230

                         250
                  ....*....|....
gi 291621657 3007 NRLF-SCGADGTLK 3019
Cdd:cd00200   231 GYLLaSGSEDGTIR 244
WD40 COG2319
WD40 repeat [General function prediction only];
2767-3019 1.79e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.79e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2767 VKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFrQAGNARVTRLYFNSQGNKCGVADGEGFLSIWQVnqtaSNPKPY 2846
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2847 MSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTLispGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVC 2926
Cdd:COG2319   156 RTLTGHSGAVTSVAFSPDGKLLASGS---DDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2927 IFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSEhakqsifrniGAGVMQIDII-Q 3005
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----------SGGVNSVAFSpD 299

                         250
                  ....*....|....
gi 291621657 3006 GNRLFSCGADGTLK 3019
Cdd:COG2319   300 GKLLASGSDDGTVR 313
WD40 COG2319
WD40 repeat [General function prediction only];
2777-3019 5.50e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 5.50e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2777 QYYLTGAQDGSVRMFEWTRPQQLVCFRqAGNARVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPYMSWQCHSKAT 2856
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA----TGKLLRTLTGHSGSV 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2857 SDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQRQLI 2936
Cdd:COG2319   250 RSVAFSPDGRLLASGS---ADGTVRLWDL---ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2937 HTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKsEHakqsifrniGAGVMQIDI-IQGNRLFSCGAD 3015
Cdd:COG2319   324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GH---------TGAVTSVAFsPDGRTLASGSAD 393


                  ....
gi 291621657 3016 GTLK 3019
Cdd:COG2319   394 GTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2765-3020 5.46e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 5.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2765 HNVKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAgNARVTRLYFNSQGN--KCGVADGEgfLSIWQVNqtasN 2842
Cdd:cd00200    52 GPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH-TSYVSSVAFSPDGRilSSSSRDKT--IKVWDVE----T 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2843 PKPYMSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRK 2922
Cdd:cd00200   125 GKCLTTLRGHTDWVNSVAFSPDGTFVASSS---QDGTIKLWDL---RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2923 GHVCIFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFkSEHAKqsifrnigaGVMQID 3002
Cdd:cd00200   199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHTN---------SVTSLA 268

                         250
                  ....*....|....*....
gi 291621657 3003 IIQ-GNRLFSCGADGTLKT 3020
Cdd:cd00200   269 WSPdGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2807-3019 1.88e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 1.88e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2807 NARVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPYMSWQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTl 2886
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLE----TGELLRTLKGHTGPVRDVAASADGTYLASGS---SDKTIRLWDL- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2887 isPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGN 2966
Cdd:cd00200    81 --ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 291621657 2967 IKVWRLTGHGLIHSFKSeHAKQsifrnigagVMQIDII-QGNRLFSCGADGTLK 3019
Cdd:cd00200   159 IKLWDLRTGKCVATLTG-HTGE---------VNSVAFSpDGEKLLSSSSDGTIK 202
WD40 COG2319
WD40 repeat [General function prediction only];
2777-2974 9.26e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 9.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2777 QYYLTGAQDGSVRMFEWTRPQQLVCFRqAGNARVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPYMSWQCHSKAT 2856
Cdd:COG2319   217 KLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA----TGELLRTLTGHSGGV 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2857 SDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQRQLI 2936
Cdd:COG2319   292 NSVAFSPDGKLLASGS---DDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 291621657 2937 HTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTG 2974
Cdd:COG2319   366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2773-2971 2.97e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.00  E-value: 2.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2773 HPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAgNARVTRLYFNSQGNKCGVADGEGFLSIWQVNqtasNPKPYMSWQCH 2852
Cdd:cd00200   102 SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTIKLWDLR----TGKCVATLTGH 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2853 SKATSDFAFITSSSLVATSGhsnDNRNVCLWDTLISpgnSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQ 2932
Cdd:cd00200   177 TGEVNSVAFSPDGEKLLSSS---SDGTIKLWDLSTG---KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 291621657 2933 RQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWR 2971
Cdd:cd00200   251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2849-3019 4.77e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 4.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2849 WQCHSKATSDFAFITSSSLVATSGhsnDNRNVCLWDTlisPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIF 2928
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGS---GDGTIKVWDL---ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2929 DIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTghglihSFKSEHAkqsiFRNIGAGVMQIDIIQGNR 3008
Cdd:cd00200    79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE------TGKCLTT----LRGHTDWVNSVAFSPDGT 148

                         170
                  ....*....|..
gi 291621657 3009 -LFSCGADGTLK 3019
Cdd:cd00200   149 fVASSSQDGTIK 160
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2893-3019 1.75e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.75  E-value: 1.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2893 LIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRL 2972
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 291621657 2973 TGHGLIHSFKSeHAKqsifrnigaGVMQIDIIQGNR-LFSCGADGTLK 3019
Cdd:cd00200    81 ETGECVRTLTG-HTS---------YVSSVAFSPDGRiLSSSSRDKTIK 118
WD40 COG2319
WD40 repeat [General function prediction only];
2852-3019 8.26e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 8.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2852 HSKATSDFAFITSSSLVATSGHSNDNRnvcLWDTLispGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIR 2931
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLL---LLDAA---AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657 2932 QRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKsEHAkqsifrnigAGVMQIDII-QGNRLF 3010
Cdd:COG2319   109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-GHS---------GAVTSVAFSpDGKLLA 178


                  ....*....
gi 291621657 3011 SCGADGTLK 3019
Cdd:COG2319   179 SGSDDGTVR 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 2932-2970 4.43e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.43e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 291621657   2932 QRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVW 2970
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
2933-2970 1.19e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 291621657  2933 RQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVW 2970
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
45-268 3.98e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657   45 ECVQIIPGakHGNiQVSCVECSNQQGRIA-ASYGNAVCIFEPLGinshkrncqlkCQWLKTGQFFLSSVtYNLAWDPQDN 123
Cdd:COG2319   195 KLLRTLTG--HTG-AVRSVAFSPDGKLLAsGSADGTVRLWDLAT-----------GKLLRTLTGHSGSV-RSVAFSPDGR 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291621657  124 RLLTATD--SIQLWAPPGDDILEEEEEIDNTVppvlndwkcvwqckTSVSvhlmeWSPDGEYFATAGkDDCLLKVWYPMT 201
Cdd:COG2319   260 LLASGSAdgTVRLWDLATGELLRTLTGHSGGV--------------NSVA-----FSPDGKLLASGS-DDGTVRLWDLAT 319

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 291621657  202 GWKSSIIPqdhhevkrrqsstqfsfvylAHPRAVTGFSWRktskymPRGsvcNVLLTSCHDGVCRLW 268
Cdd:COG2319   320 GKLLRTLT--------------------GHTGAVRSVAFS------PDG---KTLASGSDDGTVRLW 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH