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Conserved domains on  [gi|307775416|ref|NP_001182729|]
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low-density lipoprotein receptor isoform 4 precursor [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 11081348)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 361-401 3.10e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 66.80  E-value: 3.10e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775416  361 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 401
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 5.60e-12

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.34  E-value: 5.60e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 307775416   25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 319-358 3.25e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.33  E-value: 3.25e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775416  319 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVDP 358
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 4.11e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 4.11e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 307775416   66 VTCKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDEQGC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 271-315 7.90e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.17  E-value: 7.90e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 307775416  271 NRIYWSDLSQRmiCSTQLDRAHGvSSYDTVISRDIQAPDGLAVDW 315
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 385-427 1.14e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.14e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 307775416   385 YSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNR 427
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
110-140 3.12e-08

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 3.12e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 307775416  110 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 140
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
186-220 4.32e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 4.32e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 307775416   186 DIDECQDPDTCSQ--LCVNLEGGYKCQCEEGFQLDPH 220
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 448-488 5.45e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 5.45e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 307775416  448 DKVFWTDIINEAIFSANRLTGSDV-NLLAENLLSPEDMVLFH 488
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 150-178 6.78e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.08  E-value: 6.78e-07
                          10        20
                  ....*....|....*....|....*....
gi 307775416  150 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 178
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 503-543 9.49e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 9.49e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775416  503 TLSNGGCQYLCLPAPQinphspKFTCACPDGMLLARDMRSC 543
Cdd:pfam14670   2 SVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 251-289 5.16e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.27  E-value: 5.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 307775416   251 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLD 289
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 361-401 3.10e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 66.80  E-value: 3.10e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775416  361 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 401
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 5.60e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.34  E-value: 5.60e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 307775416   25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 319-358 3.25e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.33  E-value: 3.25e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775416  319 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVDP 358
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 4.11e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 4.11e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 307775416   66 VTCKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDEQGC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 271-315 7.90e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.17  E-value: 7.90e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 307775416  271 NRIYWSDLSQRmiCSTQLDRAHGvSSYDTVISRDIQAPDGLAVDW 315
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 385-427 1.14e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.14e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 307775416   385 YSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNR 427
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 405-447 1.03e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.09  E-value: 1.03e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 307775416  405 GRLYWVDSKLH-SISSIDVNGGNRKTILEDEkrLAHPFSLAVFE 447
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-58 1.06e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.06e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 307775416  27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-58 1.78e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.78e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775416    26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 68-104 1.81e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.81e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 307775416  68 CKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDEQGC 104
Cdd:cd00112    1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 299-340 3.10e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 3.10e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 307775416   299 TVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKR 340
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-101 5.27e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 5.27e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 307775416    67 TCKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDE 101
Cdd:smart00192   1 TCPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
110-140 3.12e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 3.12e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 307775416  110 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 140
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
186-220 4.32e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 4.32e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 307775416   186 DIDECQDPDTCSQ--LCVNLEGGYKCQCEEGFQLDPH 220
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 448-488 5.45e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 5.45e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 307775416  448 DKVFWTDIINEAIFSANRLTGSDV-NLLAENLLSPEDMVLFH 488
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 150-178 6.78e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.08  E-value: 6.78e-07
                          10        20
                  ....*....|....*....|....*....
gi 307775416  150 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 178
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 341-381 8.26e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 8.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 307775416   341 KTLFRENGSKPRAIVVDPVHGFMYWTDWGTPaKIKKGGLNG 381
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDG 40
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 110-140 8.38e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 8.38e-07
                         10        20        30
                 ....*....|....*....|....*....|.
gi 307775416 110 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 140
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 186-218 2.02e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.02e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775416 186 DIDECQDPDTCS--QLCVNLEGGYKCQCEEGFQLD 218
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
261-425 2.80e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 2.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 261 VVALDTEVASNRIYWSDlsqrmicstqlDRAHGVSSYDTV---ISRDIQA---PDGLAVDWIHSNIYWTDSVLGTVSVAD 334
Cdd:COG3391   70 ADGADAGADGRRLYVAN-----------SGSGRVSVIDLAtgkVVATIPVgggPRGLAVDPDGGRLYVADSGNGRVSVID 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 335 TK-GVKRKTLfrENGSKPRAIVVDPVHGFMYWTDWGTP--AKIkkgglngVDIYSLVTENI-------QWPNGITLDLLS 404
Cdd:COG3391  139 TAtGKVVATI--PVGAGPHGIAVDPDGKRLYVANSGSNtvSVI-------VSVIDTATGKVvatipvgGGPVGVAVSPDG 209

                        170       180
                 ....*....|....*....|....*...
gi 307775416 405 GRLY-------WVDSKLHSISSIDVNGG 425
Cdd:COG3391  210 RRLYvanrgsnTSNGGSNTVSVIDLATL 237
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 110-140 6.65e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 6.65e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 307775416   110 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 140
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 503-543 9.49e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 9.49e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775416  503 TLSNGGCQYLCLPAPQinphspKFTCACPDGMLLARDMRSC 543
Cdd:pfam14670   2 SVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 298-460 2.52e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 298 DTVISRDIQAPDGLAVDwiHSNIYWTDSVLGTVSVADTKGVKRKTlFRENGSK------PRAIVVDPvHGFMYWTDWGTp 371
Cdd:cd14963   94 EKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPGSEpgelsyPNGIAVDE-DGNIYVADSGN- 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 372 akikkgglNGVDIYSLVTENIQWPNGITLDLLS------------GRLYWVDSKLHSISSIDVNGGNRKTIL---EDEKR 436
Cdd:cd14963  169 --------GRIQVFDKNGKFIKELNGSPDGKSGfvnprgiavdpdGNLYVVDNLSHRVYVFDEQGKELFTFGgrgKDDGQ 240

                        170       180
                 ....*....|....*....|....*
gi 307775416 437 LAHPFSLAVFEDKVFW-TDIINEAI 460
Cdd:cd14963  241 FNLPNGLFIDDDGRLYvTDRENNRV 265
EGF_CA pfam07645
Calcium-binding EGF domain;
186-214 2.25e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 2.25e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 307775416  186 DIDECQDP-DTCSQ--LCVNLEGGYKCQCEEG 214
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 251-289 5.16e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.27  E-value: 5.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 307775416   251 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLD 289
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
148-185 7.62e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.53  E-value: 7.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 307775416   148 NECLDNNGgCSH--VCNDLKIGYECLCPDGFQlvAQRRCE 185
Cdd:smart00179   3 DECASGNP-CQNggTCVNTVGSYRCECPPGYT--DGRNCE 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 361-401 3.10e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 66.80  E-value: 3.10e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775416  361 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 401
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 5.60e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.34  E-value: 5.60e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 307775416   25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 319-358 3.25e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 58.33  E-value: 3.25e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775416  319 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVDP 358
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 4.11e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 4.11e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 307775416   66 VTCKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDEQGC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 271-315 7.90e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.17  E-value: 7.90e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 307775416  271 NRIYWSDLSQRmiCSTQLDRAHGvSSYDTVISRDIQAPDGLAVDW 315
Cdd:pfam00058   1 GRLYWTDSSLR--ASISSADLNG-SDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 385-427 1.14e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.14e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 307775416   385 YSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNR 427
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 405-447 1.03e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.09  E-value: 1.03e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 307775416  405 GRLYWVDSKLH-SISSIDVNGGNRKTILEDEkrLAHPFSLAVFE 447
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-58 1.06e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.06e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 307775416  27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 26-58 1.78e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.78e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775416    26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 68-104 1.81e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.81e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 307775416  68 CKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDEQGC 104
Cdd:cd00112    1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 299-340 3.10e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 3.10e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 307775416   299 TVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKR 340
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-101 5.27e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 5.27e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 307775416    67 TCKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDE 101
Cdd:smart00192   1 TCPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
110-140 3.12e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 3.12e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 307775416  110 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 140
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
186-220 4.32e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 4.32e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 307775416   186 DIDECQDPDTCSQ--LCVNLEGGYKCQCEEGFQLDPH 220
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 448-488 5.45e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 5.45e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 307775416  448 DKVFWTDIINEAIFSANRLTGSDV-NLLAENLLSPEDMVLFH 488
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 150-178 6.78e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.08  E-value: 6.78e-07
                          10        20
                  ....*....|....*....|....*....
gi 307775416  150 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 178
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYEL 29
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 341-381 8.26e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 8.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 307775416   341 KTLFRENGSKPRAIVVDPVHGFMYWTDWGTPaKIKKGGLNG 381
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDG 40
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 110-140 8.38e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 8.38e-07
                         10        20        30
                 ....*....|....*....|....*....|.
gi 307775416 110 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 140
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 186-218 2.02e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.02e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775416 186 DIDECQDPDTCS--QLCVNLEGGYKCQCEEGFQLD 218
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
261-425 2.80e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 2.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 261 VVALDTEVASNRIYWSDlsqrmicstqlDRAHGVSSYDTV---ISRDIQA---PDGLAVDWIHSNIYWTDSVLGTVSVAD 334
Cdd:COG3391   70 ADGADAGADGRRLYVAN-----------SGSGRVSVIDLAtgkVVATIPVgggPRGLAVDPDGGRLYVADSGNGRVSVID 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 335 TK-GVKRKTLfrENGSKPRAIVVDPVHGFMYWTDWGTP--AKIkkgglngVDIYSLVTENI-------QWPNGITLDLLS 404
Cdd:COG3391  139 TAtGKVVATI--PVGAGPHGIAVDPDGKRLYVANSGSNtvSVI-------VSVIDTATGKVvatipvgGGPVGVAVSPDG 209

                        170       180
                 ....*....|....*....|....*...
gi 307775416 405 GRLY-------WVDSKLHSISSIDVNGG 425
Cdd:COG3391  210 RRLYvanrgsnTSNGGSNTVSVIDLATL 237
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 110-140 6.65e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 6.65e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 307775416   110 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 140
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 503-543 9.49e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 9.49e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775416  503 TLSNGGCQYLCLPAPQinphspKFTCACPDGMLLARDMRSC 543
Cdd:pfam14670   2 SVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 298-460 2.52e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 298 DTVISRDIQAPDGLAVDwiHSNIYWTDSVLGTVSVADTKGVKRKTlFRENGSK------PRAIVVDPvHGFMYWTDWGTp 371
Cdd:cd14963   94 EKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPGSEpgelsyPNGIAVDE-DGNIYVADSGN- 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 372 akikkgglNGVDIYSLVTENIQWPNGITLDLLS------------GRLYWVDSKLHSISSIDVNGGNRKTIL---EDEKR 436
Cdd:cd14963  169 --------GRIQVFDKNGKFIKELNGSPDGKSGfvnprgiavdpdGNLYVVDNLSHRVYVFDEQGKELFTFGgrgKDDGQ 240

                        170       180
                 ....*....|....*....|....*
gi 307775416 437 LAHPFSLAVFEDKVFW-TDIINEAI 460
Cdd:cd14963  241 FNLPNGLFIDDDGRLYvTDRENNRV 265
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 305-445 3.42e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 46.04  E-value: 3.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 305 IQAPDGLAVDWiHSNIYWTDSVLGTVSVADTKGVKRKTLFRENG---SKPRAIVVDPvHGFMYWTDwGTPAKIKKGGLNG 381
Cdd:cd14962   11 LTRPYGVAADG-RGRIYVADTGRGAVFVFDLPNGKVFVIGNAGPnrfVSPIGVAIDA-NGNLYVSD-AELGKVFVFDRDG 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 307775416 382 VDIYSLVTENIQW-PNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILED---EKRLAHPFSLAV 445
Cdd:cd14962   88 KFLRAIGAGALFKrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRgsgPGEFNLPTDLAV 155
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 308-457 6.57e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.39  E-value: 6.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 308 PDGLAVDwIHSNIYWTDSVLGTVSVADTKGvKRKTLFRENGSK------PRAIVVDPvHGFMYWTDWGTpAKIKK----- 376
Cdd:cd05819   10 PQGIAVD-SSGNIYVADTGNNRIQVFDPDG-NFITSFGSFGSGdgqfnePAGVAVDS-DGNLYVADTGN-HRIQKfdpdg 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 377 GGLNGVDIYSLVTENIQWPNGITLDLlSGRLYWVDSKLHSISSIDVNGGNRKTI---LEDEKRLAHPFSLAVF-EDKVFW 452
Cdd:cd05819   86 NFLASFGGSGDGDGEFNGPRGIAVDS-SGNIYVADTGNHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVAVDsDGNIYV 164


                 ....*
gi 307775416 453 TDIIN 457
Cdd:cd05819  165 ADTGN 169
EGF_CA pfam07645
Calcium-binding EGF domain;
186-214 2.25e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 2.25e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 307775416  186 DIDECQDP-DTCSQ--LCVNLEGGYKCQCEEG 214
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 189-220 4.62e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 4.62e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 307775416 189 ECQDPDTCS--QLCVNLEGGYKCQCEEGFQLDPH 220
Cdd:cd00053    1 ECAASNPCSngGTCVNTPGSYRCVCPPGYTGDRS 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 196-224 5.99e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 5.99e-04
                          10        20
                  ....*....|....*....|....*....
gi 307775416  196 CSQLCVNLEGGYKCQCEEGFQLDPHTKAC 224
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF smart00181
Epidermal growth factor-like domain;
189-220 9.47e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.11  E-value: 9.47e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775416   189 ECQDPDTCSQ-LCVNLEGGYKCQCEEGFQLDPH 220
Cdd:smart00181   1 ECASGGPCSNgTCINTPGSYTCSCPPGYTGDKR 33
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 306-449 1.41e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775416 306 QAPDGLAVDWiHSNIYWTDSVLGTVSVADTKGVKRKTL----FRENGSKPRAIVVDpvHGFMYWTDWGtPAKIKKGGLNG 381
Cdd:cd14963   56 KYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKYFpekkDRVKLISPAGLAID--DGKLYVSDVK-KHKVIVFDLEG 131

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 307775416 382 VDIYSLVTE-----NIQWPNGITLDlLSGRLYWVDSKLHSISSIDVNGGNRKTI---LEDEKRLAHPFSLAVFEDK 449
Cdd:cd14963  132 KLLLEFGKPgsepgELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELngsPDGKSGFVNPRGIAVDPDG 206
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 184-223 3.53e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 39.68  E-value: 3.53e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 307775416 184 CEDIDECQD-PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA 223
Cdd:cd01475  184 CVVPDLCATlSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 251-289 5.16e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.27  E-value: 5.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 307775416   251 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLD 289
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
148-185 7.62e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.53  E-value: 7.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 307775416   148 NECLDNNGgCSH--VCNDLKIGYECLCPDGFQlvAQRRCE 185
Cdd:smart00179   3 DECASGNP-CQNggTCVNTVGSYRCECPPGYT--DGRNCE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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