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Conserved domains on  [gi|332078479|ref|NP_001193668|]
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centromere protein R isoform 1 [Homo sapiens]

Protein Classification

CENP-R domain-containing protein( domain architecture ID 10535532)

CENP-R domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CENP-R pfam06729
Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex ...
 64-200 5.96e-77

Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis.


:

Pssm-ID: 429086  Cd Length: 138  Bit Score: 227.75  E-value: 5.96e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332078479   64 RKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDnDEFMMLLSKVEKLSEEIMEIM 143
Cdd:pfam06729   1 RKKSITSYSPTTGTCQMSPFSSPTSSKEQEHRNGPSNGKRKKLNHLSLSRRGQSTTKD-DEFMVLLSKVEKSLEEIMEIM 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 332078479  144 QNLSSIQALEGSRELENLIGISCASHFLKREMQKTKELMTKVNKQKLFEK-STGLPHK 200
Cdd:pfam06729  80 QNLSSLQALEGSRELENLIGVSCTSCFLKREMQKTKELMTKAEKQKLLEKkSSGLPAK 137
 
Name Accession Description Interval E-value
CENP-R pfam06729
Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex ...
 64-200 5.96e-77

Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis.


Pssm-ID: 429086  Cd Length: 138  Bit Score: 227.75  E-value: 5.96e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332078479   64 RKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDnDEFMMLLSKVEKLSEEIMEIM 143
Cdd:pfam06729   1 RKKSITSYSPTTGTCQMSPFSSPTSSKEQEHRNGPSNGKRKKLNHLSLSRRGQSTTKD-DEFMVLLSKVEKSLEEIMEIM 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 332078479  144 QNLSSIQALEGSRELENLIGISCASHFLKREMQKTKELMTKVNKQKLFEK-STGLPHK 200
Cdd:pfam06729  80 QNLSSLQALEGSRELENLIGVSCTSCFLKREMQKTKELMTKAEKQKLLEKkSSGLPAK 137
 
Name Accession Description Interval E-value
CENP-R pfam06729
Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex ...
 64-200 5.96e-77

Kinetochore component, CENP-R; This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis.


Pssm-ID: 429086  Cd Length: 138  Bit Score: 227.75  E-value: 5.96e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332078479   64 RKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDnDEFMMLLSKVEKLSEEIMEIM 143
Cdd:pfam06729   1 RKKSITSYSPTTGTCQMSPFSSPTSSKEQEHRNGPSNGKRKKLNHLSLSRRGQSTTKD-DEFMVLLSKVEKSLEEIMEIM 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 332078479  144 QNLSSIQALEGSRELENLIGISCASHFLKREMQKTKELMTKVNKQKLFEK-STGLPHK 200
Cdd:pfam06729  80 QNLSSLQALEGSRELENLIGVSCTSCFLKREMQKTKELMTKAEKQKLLEKkSSGLPAK 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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