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Conserved domains on  [gi|336285191|ref|NP_001229556|]
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zinc finger protein ZFPM1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_ZFPM1 cd19215
PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed ...
 101-209 7.64e-55

PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.


:

Pssm-ID: 380992  Cd Length: 110  Bit Score: 185.37  E-value: 7.64e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285191 101 WSGPEELELALQDGQRCVRARLSLTEGLSWGPFYGSIQTRALSPE-REEPGPALTLMVDESCWLRMLPQALTEEEANSEI 179
Cdd:cd19215    1 WNGPDELELVGSSGQRRVRARQSLSEGLSWGPYHGSIQSSASSPGqAEESPAVTLLLVDEDCWLRRLPLVSTEAEANCTI 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 336285191 180 YRKDDALWCRVTKAVPSGGLLHVLLVAEPH 209
Cdd:cd19215   81 YRKGDAIWCKTTKPVPEGELLSAILVTEPQ 110
PHA00733 super family cl26169
hypothetical protein
 332-387 5.65e-03

hypothetical protein


The actual alignment was detected with superfamily member PHA00733:

Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 5.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 336285191 332 PFVCLICLSAFTTKANCERHLKVHTDTLsgVCHNCGFISTTRDILYSHLVTNHMVC 387
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHVCKKHNIC 126
 
Name Accession Description Interval E-value
PR-SET_ZFPM1 cd19215
PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed ...
 101-209 7.64e-55

PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.


Pssm-ID: 380992  Cd Length: 110  Bit Score: 185.37  E-value: 7.64e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285191 101 WSGPEELELALQDGQRCVRARLSLTEGLSWGPFYGSIQTRALSPE-REEPGPALTLMVDESCWLRMLPQALTEEEANSEI 179
Cdd:cd19215    1 WNGPDELELVGSSGQRRVRARQSLSEGLSWGPYHGSIQSSASSPGqAEESPAVTLLLVDEDCWLRRLPLVSTEAEANCTI 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 336285191 180 YRKDDALWCRVTKAVPSGGLLHVLLVAEPH 209
Cdd:cd19215   81 YRKGDAIWCKTTKPVPEGELLSAILVTEPQ 110
PHA00733 PHA00733
hypothetical protein
 332-387 5.65e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 5.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 336285191 332 PFVCLICLSAFTTKANCERHLKVHTDTLsgVCHNCGFISTTRDILYSHLVTNHMVC 387
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHVCKKHNIC 126
 
Name Accession Description Interval E-value
PR-SET_ZFPM1 cd19215
PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed ...
 101-209 7.64e-55

PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.


Pssm-ID: 380992  Cd Length: 110  Bit Score: 185.37  E-value: 7.64e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285191 101 WSGPEELELALQDGQRCVRARLSLTEGLSWGPFYGSIQTRALSPE-REEPGPALTLMVDESCWLRMLPQALTEEEANSEI 179
Cdd:cd19215    1 WNGPDELELVGSSGQRRVRARQSLSEGLSWGPYHGSIQSSASSPGqAEESPAVTLLLVDEDCWLRRLPLVSTEAEANCTI 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 336285191 180 YRKDDALWCRVTKAVPSGGLLHVLLVAEPH 209
Cdd:cd19215   81 YRKGDAIWCKTTKPVPEGELLSAILVTEPQ 110
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 101-209 2.01e-29

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 113.59  E-value: 2.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285191 101 WSGPEELELALQDG----QRCVRARLSLTEGLSWGPFYGSIQTRALSPEREEP---------GPALTLMVDESCWLRMLP 167
Cdd:cd19201    1 LSLPGELELRKPSQdagrSGGVWAKQPLPEGTRFGPYPGKLVKEPLDPSYEWKveaqgskggEGLLLLTEDSGTWLKLVR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 336285191 168 QALTEEEANSEIYRKDDALWCRVTKAVPSGGLLHVLLVAEPH 209
Cdd:cd19201   81 SADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREPLL 122
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 104-202 3.05e-13

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 66.07  E-value: 3.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285191 104 PEELELALQD---GQRCVRARLSLTEGLSWGPFYGSIqtralspereepgpaltlmvdesCWLRMLPQALTEEEANSEIY 180
Cdd:cd10534    2 PAGLELVLSSipeGGLGVFARRTIPAGTRFGPLEGVV-----------------------NWMRFVRPARNEEEQNLVAY 58

                         90       100
                 ....*....|....*....|..
gi 336285191 181 RKDDALWCRVTKAVPSGGLLHV 202
Cdd:cd10534   59 QHGGQIYFRTTRDIPPGEELLV 80
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 101-197 1.47e-10

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380993  Cd Length: 111  Bit Score: 59.13  E-value: 1.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285191 101 WSGPEELELALQDGQRCVRARLSLTEGLSWGPFYGSIQTRALSPEREEPGPaLTLMVDESCWLRMLPQALTEEEANSEIY 180
Cdd:cd19216    1 WDGPGELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVP-LVLTAGPKWLLDVTWQGTEDNKNNCIVY 79

                         90
                 ....*....|....*..
gi 336285191 181 RKDDALWCRVTKAVPSG 197
Cdd:cd19216   80 SKGGQLWCTTTKNISEG 96
PHA00733 PHA00733
hypothetical protein
 332-387 5.65e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 5.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 336285191 332 PFVCLICLSAFTTKANCERHLKVHTDTLsgVCHNCGFISTTRDILYSHLVTNHMVC 387
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHVCKKHNIC 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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