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Conserved domains on  [gi|339275847|ref|NP_001229856|]
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zinc finger protein 410 isoform d [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
252-277 1.92e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.92e-05
                          10        20
                  ....*....|....*....|....*.
gi 339275847  252 SLRKHLVVHSGEKPHQCQVCGKTFSQ 277
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-294 4.65e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 4.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275847  75 SGNDFLSSESTDSSIPwFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQSKDSGP--LPQVEKKLKCTV-- 150
Cdd:COG5048  213 SSSSDQNLENSSSSLP-LTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPneSDSSSEKGFSLPik 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275847 151 -----EGCDRTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKN 225
Cdd:COG5048  292 skqcnISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEP 371

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 339275847 226 H-----RRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCqvcgKTFSQSGSRNVHMRKHHLQLGA 294
Cdd:COG5048  372 PqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNC----KNPPCSKSFNRHYNLIPHKKIH 441
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
252-277 1.92e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.92e-05
                          10        20
                  ....*....|....*....|....*.
gi 339275847  252 SLRKHLVVHSGEKPHQCQVCGKTFSQ 277
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-294 4.65e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 4.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275847  75 SGNDFLSSESTDSSIPwFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQSKDSGP--LPQVEKKLKCTV-- 150
Cdd:COG5048  213 SSSSDQNLENSSSSLP-LTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPneSDSSSEKGFSLPik 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275847 151 -----EGCDRTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKN 225
Cdd:COG5048  292 skqcnISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEP 371

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 339275847 226 H-----RRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCqvcgKTFSQSGSRNVHMRKHHLQLGA 294
Cdd:COG5048  372 PqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNC----KNPPCSKSFNRHYNLIPHKKIH 441
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 206-230 2.93e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.93e-03
                          10        20
                  ....*....|....*....|....*
gi 339275847  206 FMCHEsgCGKQFTTAGNLKNHRRIH 230
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
252-277 1.92e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.92e-05
                          10        20
                  ....*....|....*....|....*.
gi 339275847  252 SLRKHLVVHSGEKPHQCQVCGKTFSQ 277
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-294 4.65e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 4.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275847  75 SGNDFLSSESTDSSIPwFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQSKDSGP--LPQVEKKLKCTV-- 150
Cdd:COG5048  213 SSSSDQNLENSSSSLP-LTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPneSDSSSEKGFSLPik 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275847 151 -----EGCDRTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKN 225
Cdd:COG5048  292 skqcnISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEP 371

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 339275847 226 H-----RRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCqvcgKTFSQSGSRNVHMRKHHLQLGA 294
Cdd:COG5048  372 PqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNC----KNPPCSKSFNRHYNLIPHKKIH 441
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 116-227 7.67e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 7.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275847 116 KTSSNGENVHlgSGDGQSKDSGPLPQV--EKKLKCTVEGCDRTFVWPAHFKYH-LKTHRNDRSFICPAEGCGKSFYVlqr 192
Cdd:COG5189  320 NSSSNGKLAH--GGERNIDTPSRMLKVkdGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSA--- 394

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 339275847 193 lkvhmrthnGEKPFMCHEsgCGKQFTTAGNLKNHR 227
Cdd:COG5189  395 ---------KDKPYRCEV--CDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-253 2.54e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275847 172 NDRSFICPaeGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGCGRSFAEYS 251
Cdd:COG5048   30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107


                 ..
gi 339275847 252 SL 253
Cdd:COG5048  108 SS 109
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 202-290 3.89e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 3.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275847 202 GEKPFMCHESGCGKQFTTAGNLKNHRRihtgekpflceaQG-CGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGS 280
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHML------------HGhQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNG 413

                         90
                 ....*....|
gi 339275847 281 RNVHMRKHHL 290
Cdd:COG5189  414 LKYHRKHSHD 423
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 266-288 6.10e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.10e-04
                          10        20
                  ....*....|....*....|...
gi 339275847  266 HQCQVCGKTFSQSGSRNVHMRKH 288
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 206-230 2.93e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.93e-03
                          10        20
                  ....*....|....*....|....*
gi 339275847  206 FMCHEsgCGKQFTTAGNLKNHRRIH 230
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 178-259 4.84e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.24  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275847  178 CPAEGCGKSFYVLQRLKVHMRTHNGE------KPFMCHESGCGKQFTTAGNLKNHRRIH-TGEKPFLCEaqGCGRSFAEY 250
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKCE--NCLLRFRTH 79


                  ....*....
gi 339275847  251 SSLRKHLVV 259
Cdd:pfam15909  80 RSLFKHLHV 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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