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Conserved domains on  [gi|374671768|ref|NP_001243437|]
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carabin isoform 2 [Homo sapiens]

Protein Classification

TBC domain-containing protein( domain architecture ID 771)

TBC (Tre-2, BUB2p, Cdc16p) domain-containing protein may perform a GTP-activator activity on Rab-like GTPases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TBC super family cl47029
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 89-157 3.06e-09

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


The actual alignment was detected with superfamily member smart00164:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 56.16  E-value: 3.06e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 374671768    89 CRKGIPSALRARCWPLLCGAHV-CQKNSPGTYQELAE--APGDPQWMETIGRDLHRQFPLHEMFVSPQGHGR 157
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPmDTSADKDLYSRLLKetAPDDKSIVHQIEKDLRRTFPEHSFFQDKEGPGQ 72
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 89-157 3.06e-09

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 56.16  E-value: 3.06e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 374671768    89 CRKGIPSALRARCWPLLCGAHV-CQKNSPGTYQELAE--APGDPQWMETIGRDLHRQFPLHEMFVSPQGHGR 157
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPmDTSADKDLYSRLLKetAPDDKSIVHQIEKDLRRTFPEHSFFQDKEGPGQ 72
COG5210 COG5210
GTPase-activating protein [General function prediction only];
90-157 2.73e-03

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 39.01  E-value: 2.73e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 374671768  90 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEA------PGDPQWMEtIGRDLHRQFPLHEMFVSPQGHGR 157
Cdd:COG5210  210 RKGIPNELRGDVWEFLLGIGFDLDKNPGLYERLLNLhreakiPTQEIISQ-IEKDLSRTFPDNSLFQTEISIRA 282
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 89-157 3.06e-09

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 56.16  E-value: 3.06e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 374671768    89 CRKGIPSALRARCWPLLCGAHV-CQKNSPGTYQELAE--APGDPQWMETIGRDLHRQFPLHEMFVSPQGHGR 157
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPmDTSADKDLYSRLLKetAPDDKSIVHQIEKDLRRTFPEHSFFQDKEGPGQ 72
COG5210 COG5210
GTPase-activating protein [General function prediction only];
90-157 2.73e-03

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 39.01  E-value: 2.73e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 374671768  90 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEA------PGDPQWMEtIGRDLHRQFPLHEMFVSPQGHGR 157
Cdd:COG5210  210 RKGIPNELRGDVWEFLLGIGFDLDKNPGLYERLLNLhreakiPTQEIISQ-IEKDLSRTFPDNSLFQTEISIRA 282
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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