deoxyribonuclease gamma isoform 2 precursor [Homo sapiens]
exonuclease/endonuclease/phosphatase family protein( domain architecture ID 662)
exonuclease/endonuclease/phosphatase (EEP) family protein may cleave phosphodiester bonds
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
EEP super family | cl00490 | Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes ... |
15-252 | 1.30e-144 | |||||
Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes the catalytic domain (exonuclease/endonuclease/phosphatase or EEP domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps proteins. The actual alignment was detected with superfamily member smart00476: Pssm-ID: 469791 Cd Length: 276 Bit Score: 406.44 E-value: 1.30e-144
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Name | Accession | Description | Interval | E-value | |||||
DNaseIc | smart00476 | deoxyribonuclease I; Deoxyribonuclease I catalyzes the endonucleolytic cleavage of ... |
15-252 | 1.30e-144 | |||||
deoxyribonuclease I; Deoxyribonuclease I catalyzes the endonucleolytic cleavage of double-stranded DNA. The enzyme is secreted outside the cell and also involved in apoptosis in the nucleus. Pssm-ID: 128752 Cd Length: 276 Bit Score: 406.44 E-value: 1.30e-144
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DNase1 | cd10282 | Deoxyribonuclease 1; Deoxyribonuclease 1 (DNase1, EC 3.1.21.1), also known as DNase I, is a ... |
22-251 | 1.60e-135 | |||||
Deoxyribonuclease 1; Deoxyribonuclease 1 (DNase1, EC 3.1.21.1), also known as DNase I, is a Ca2+, Mg2+/Mn2+-dependent secretory endonuclease, first isolated from bovine pancreas extracts. It cleaves DNA preferentially at phosphodiester linkages next to a pyrimidine nucleotide, producing 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3'. It generally produces tetranucleotides. DNase1 substrates include single-stranded DNA, double-stranded DNA, and chromatin. This enzyme may be responsible for apoptotic DNA fragmentation. Other deoxyribonucleases in this subfamily include human DNL1L (human DNase I lysosomal-like, also known as DNASE1L1, Xib, and DNase X ), human DNASE1L2 (also known as DNAS1L2), and DNASE1L3 (also known as DNAS1L3, nhDNase, LS-DNase, DNase Y, and DNase gamma) . DNASE1L3 is implicated in apoptotic DNA fragmentation. DNase I is also a cytoskeletal protein which binds actin. A recombinant form of human DNase1 is used as a mucoactive therapy in patients with cystic fibrosis; it hydrolyzes the extracellular DNA in sputum and reduces its viscosity. Mutations in the gene encoding DNase1 have been associated with Systemic Lupus Erythematosus, a multifactorial autoimmune disease. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. Pssm-ID: 197337 [Multi-domain] Cd Length: 256 Bit Score: 382.74 E-value: 1.60e-135
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Exo_endo_phos | pfam03372 | Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium ... |
24-162 | 3.93e-11 | |||||
Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin. Pssm-ID: 460902 [Multi-domain] Cd Length: 183 Bit Score: 60.70 E-value: 3.93e-11
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YafD | COG3021 | Uncharacterized conserved protein YafD, endonuclease/exonuclease/phosphatase (EEP) superfamily ... |
21-162 | 3.21e-05 | |||||
Uncharacterized conserved protein YafD, endonuclease/exonuclease/phosphatase (EEP) superfamily [General function prediction only]; Pssm-ID: 442257 [Multi-domain] Cd Length: 310 Bit Score: 44.60 E-value: 3.21e-05
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Name | Accession | Description | Interval | E-value | |||||
DNaseIc | smart00476 | deoxyribonuclease I; Deoxyribonuclease I catalyzes the endonucleolytic cleavage of ... |
15-252 | 1.30e-144 | |||||
deoxyribonuclease I; Deoxyribonuclease I catalyzes the endonucleolytic cleavage of double-stranded DNA. The enzyme is secreted outside the cell and also involved in apoptosis in the nucleus. Pssm-ID: 128752 Cd Length: 276 Bit Score: 406.44 E-value: 1.30e-144
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DNase1 | cd10282 | Deoxyribonuclease 1; Deoxyribonuclease 1 (DNase1, EC 3.1.21.1), also known as DNase I, is a ... |
22-251 | 1.60e-135 | |||||
Deoxyribonuclease 1; Deoxyribonuclease 1 (DNase1, EC 3.1.21.1), also known as DNase I, is a Ca2+, Mg2+/Mn2+-dependent secretory endonuclease, first isolated from bovine pancreas extracts. It cleaves DNA preferentially at phosphodiester linkages next to a pyrimidine nucleotide, producing 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3'. It generally produces tetranucleotides. DNase1 substrates include single-stranded DNA, double-stranded DNA, and chromatin. This enzyme may be responsible for apoptotic DNA fragmentation. Other deoxyribonucleases in this subfamily include human DNL1L (human DNase I lysosomal-like, also known as DNASE1L1, Xib, and DNase X ), human DNASE1L2 (also known as DNAS1L2), and DNASE1L3 (also known as DNAS1L3, nhDNase, LS-DNase, DNase Y, and DNase gamma) . DNASE1L3 is implicated in apoptotic DNA fragmentation. DNase I is also a cytoskeletal protein which binds actin. A recombinant form of human DNase1 is used as a mucoactive therapy in patients with cystic fibrosis; it hydrolyzes the extracellular DNA in sputum and reduces its viscosity. Mutations in the gene encoding DNase1 have been associated with Systemic Lupus Erythematosus, a multifactorial autoimmune disease. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. Pssm-ID: 197337 [Multi-domain] Cd Length: 256 Bit Score: 382.74 E-value: 1.60e-135
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DNase1-like | cd09075 | Deoxyribonuclease 1 and related proteins; This family includes Deoxyribonuclease 1 (DNase1, EC ... |
22-251 | 3.48e-57 | |||||
Deoxyribonuclease 1 and related proteins; This family includes Deoxyribonuclease 1 (DNase1, EC 3.1.21.1) and related proteins. DNase1, also known as DNase I, is a Ca2+, Mg2+/Mn2+-dependent secretory endonuclease, first isolated from bovine pancreas extracts. It cleaves DNA preferentially at phosphodiester linkages next to a pyrimidine nucleotide, producing 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3'. It generally produces tetranucleotides. DNase1 substrates include single-stranded DNA, double-stranded DNA, and chromatin. This enzyme may be responsible for apoptotic DNA fragmentation. Other deoxyribonucleases in this subfamily include human DNL1L (human DNase I lysosomal-like, also known as DNASE1L1, Xib and DNase X ), human DNASE1L2 (also known as DNAS1L2), and DNASE1L3 (also known as DNAS1L3, nhDNase, LS-DNase, DNase Y, and DNase gamma). DNASE1L3 is also implicated in apoptotic DNA fragmentation. DNase1 is also a cytoskeletal protein which binds actin. A recombinant form of human DNase1 is used as a mucoactive therapy in patients with cystic fibrosis; it hydrolyzes the extracellular DNA in sputum and reduces its viscosity. Mutations in the gene encoding DNase1 have been associated with Systemic Lupus Erythematosus, a multifactorial autoimmune disease. This family also includes a subfamily of mostly uncharacterized proteins, which includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease. The in vivo role of MnuA is as yet undetermined. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. Pssm-ID: 197309 [Multi-domain] Cd Length: 258 Bit Score: 183.75 E-value: 3.48e-57
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MnuA_DNase1-like | cd10283 | Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a ... |
22-251 | 7.08e-21 | |||||
Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease related to Deoxyribonuclease 1 (DNase1 or DNase I, EC 3.1.21.1). The in vivo role of MnuA is as yet undetermined. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. Pssm-ID: 197338 [Multi-domain] Cd Length: 266 Bit Score: 88.99 E-value: 7.08e-21
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EEP | cd08372 | Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes ... |
23-251 | 1.30e-15 | |||||
Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes the catalytic domain (exonuclease/endonuclease/phosphatase or EEP domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps proteins. Pssm-ID: 197306 [Multi-domain] Cd Length: 241 Bit Score: 74.05 E-value: 1.30e-15
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Exo_endo_phos | pfam03372 | Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium ... |
24-162 | 3.93e-11 | |||||
Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin. Pssm-ID: 460902 [Multi-domain] Cd Length: 183 Bit Score: 60.70 E-value: 3.93e-11
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YafD | COG3021 | Uncharacterized conserved protein YafD, endonuclease/exonuclease/phosphatase (EEP) superfamily ... |
21-162 | 3.21e-05 | |||||
Uncharacterized conserved protein YafD, endonuclease/exonuclease/phosphatase (EEP) superfamily [General function prediction only]; Pssm-ID: 442257 [Multi-domain] Cd Length: 310 Bit Score: 44.60 E-value: 3.21e-05
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ElsH | COG3568 | Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function ... |
20-251 | 9.45e-05 | |||||
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only]; Pssm-ID: 442789 [Multi-domain] Cd Length: 167 Bit Score: 41.82 E-value: 9.45e-05
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TDP2 | cd09080 | Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related ... |
146-245 | 2.06e-03 | |||||
Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Human TDP2, also known as TTRAP (TRAF/TNFR-associated factors, and tumor necrosis factor receptor/TNFR-associated protein), is a 5'-tyrosyl DNA phosphodiesterase. It is required for the efficient repair of topoisomerase II-induced DNA double strand breaks. The topoisomerase is covalently linked by a phosphotyrosyl bond to the 5'-terminus of the break. TDP2 cleaves the DNA 5'-phosphodiester bond and restores 5'-phosphate termini, needed for subsequent DNA ligation, and hence repair of the break. TDP2 and 3'-tyrosyl DNA phosphodiesterase (TDP1) are complementary activities; together, they allow cells to remove trapped topoisomerase from both 3'- and 5'-DNA termini. TTRAP has been reported as being involved in apoptosis, embryonic development, and transcriptional regulation, and it may inhibit the activation of nuclear factor-kB. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. Pssm-ID: 197314 [Multi-domain] Cd Length: 248 Bit Score: 38.86 E-value: 2.06e-03
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Blast search parameters | ||||
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