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Conserved domains on  [gi|375331901|ref|NP_001243582|]
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zinc finger protein 43 isoform 3 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-72 2.67e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 2.67e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901    13 LTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPW 72
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
295-763 2.21e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.82  E-value: 2.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 295 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 372
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 373 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 451
Cdd:COG5048  114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 452 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 531
Cdd:COG5048  189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 532 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 607
Cdd:COG5048  268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 608 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 685
Cdd:COG5048  327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 686 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 762
Cdd:COG5048  387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 375331901 763 R 763
Cdd:COG5048  466 K 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
742-803 7.71e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 7.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 375331901 742 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 803
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-72 2.67e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 2.67e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901    13 LTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPW 72
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 8.18e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 8.18e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 375331901   12 PLTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLG 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 8.30e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 8.30e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 375331901  13 LTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFL 52
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
295-763 2.21e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.82  E-value: 2.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 295 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 372
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 373 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 451
Cdd:COG5048  114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 452 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 531
Cdd:COG5048  189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 532 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 607
Cdd:COG5048  268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 608 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 685
Cdd:COG5048  327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 686 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 762
Cdd:COG5048  387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 375331901 763 R 763
Cdd:COG5048  466 K 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
562-586 4.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.60e-04
                          10        20
                  ....*....|....*....|....*
gi 375331901  562 LTKHKRIHTGEKPYKCEECGKAFTQ 586
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
742-803 7.71e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 7.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 375331901 742 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 803
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
757-782 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331901  757 HLNTHKRIHTKEQPYKCKECGKAFNQ 782
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-72 2.67e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 2.67e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901    13 LTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPW 72
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 8.18e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 8.18e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 375331901   12 PLTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLG 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 8.30e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 8.30e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 375331901  13 LTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFL 52
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
295-763 2.21e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.82  E-value: 2.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 295 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 372
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 373 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 451
Cdd:COG5048  114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 452 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 531
Cdd:COG5048  189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 532 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 607
Cdd:COG5048  268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 608 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 685
Cdd:COG5048  327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 686 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 762
Cdd:COG5048  387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 375331901 763 R 763
Cdd:COG5048  466 K 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
389-791 2.98e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 2.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 389 SRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEKPYKC--EECGKAFNWPSTLTKHNRIHTGEKPYKCE 466
Cdd:COG5048   16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 467 VCGKAFNQFSNLTTHKRIHTAE-KPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEEC--------------------- 524
Cdd:COG5048   96 KSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpans 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 525 --GKAFKWSSKLTEHKITHTGEKPYKCEECGKaFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKF 602
Cdd:COG5048  176 lsKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 603 YKCEECGKAFTQSSNLTTHKKIHTG-------GKPYKCEECGKAFNQFSTLTKHK--IIHTEE--KPYKCEE--CGKAFK 669
Cdd:COG5048  255 SSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFS 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 670 WSSTLTKHKIIHTGEKPYKC--EECGKAF------KLSSTLSTHKIIHTGEKPYKCE-KCGKAFNRSSNLIEHKKIHTGE 740
Cdd:COG5048  335 RNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSF 414

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 375331901 741 QP--YKCEECGKAFNYSSHLNTHKRIHTKEQPYKCkECGKAFNQYSNLTTHNK 791
Cdd:COG5048  415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-582 2.70e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 2.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 212 KCEKCGKAFNCPSIITKHKRINTGEKPYTCEECGKVFNWS----------------SRLTTHKKNYTRYKLYKCE----- 270
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelsrhlrthhnnpSDLNSKSLPLSNSKASSSSlssss 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 271 --------ECGKAFNKSSILTTHKIIRTGEKFYKCKECAKAFNQSSNLTEHKKIHPGEKPYKCEECGKAFNWPStltkHK 342
Cdd:COG5048  115 snsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI----SS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 343 RIHTGEKPYTCEECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKL 422
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 423 TEHKLTHTGE-------KPYKCEECGKAFNWPSTLTKHNR--IHTGE--KPYKC--EVCGKAFNQFSNLTTHKRIHTAEK 489
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 490 PYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCE---------ECGKAFKWSSKLTEHKITHTGEKP--YKCEECGKAFNH 558
Cdd:COG5048  351 PAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNdkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                        410       420
                 ....*....|....*....|....
gi 375331901 559 FSILTKHKRIHTGEKPYKCEECGK 582
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
461-793 2.58e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 2.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 461 KPYKCEVCGKAFNQFSNLTTHKRIHTAEKPYKC--EECGKAFSRSSNLTKHKKIHIEKKPYKCE-ECGKAFKWSSKLTEH 537
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 538 KITHTGEKPYKCEECGKAFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFykceeCGKAFTQSSN 617
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL-----SKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 618 LTTHKKIHTGGKPYKCEECGKA------------FNQFSTLTKHKIIHTEEKPYKCE---------------ECGKAFKW 670
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 671 SSTLTKHKIIHTGE-------KPYKCEECGKAFKLSSTLSTHK--IIHTGE--KPYKC--EKCGKAFNRSSNLIEHKKIH 737
Cdd:COG5048  267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 375331901 738 TGEQPYKCEEC------GKAFNYSSHLNTHKRIHTKEQPYKC---KECGKAFNQYSNLTTHNKIH 793
Cdd:COG5048  347 TSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITH 411
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
545-800 9.88e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 9.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 545 KPYKCEECGKAFNHFSILTKHKRIHTGEKPYKC--EECGKAFTQSSNLTTHKKIHTGEK-FYKCEECGKAFTQSSNLTTH 621
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPsDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 622 KKIHTGGKPYKCEECGKAFNQFSTLTKHKIIHTEEKPYKCEEC-----------------------GKAFKWSSTLTKHK 678
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 679 IIHTGEKPYKCEECGKA------------FKLSSTLSTHKIIHTGEKPYKCEK-----------CGKAFNRSSNLIEHKK 735
Cdd:COG5048  192 VSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQSpsslsssdsssSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 736 IHTGEQ-----------PYKCEECGKAFNYSSHLNTHKR--IHTKE--QPYKCKE--CGKAFNQYSNLTTHNKIHTGEKL 798
Cdd:COG5048  272 SSSPNEsdsssekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351


                 ..
gi 375331901 799 YK 800
Cdd:COG5048  352 AK 353
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 405-482 6.54e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 6.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 405 KPYKCE--ECGKAFKWSSKLTEHKLtHTGEKPYKCEEcgkafnwPSTLtKHNRIHTGEKPYKCEVCGKAFNQFSNLTTHK 482
Cdd:COG5189  348 KPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHEN-------PSPE-KMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 585-678 1.22e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 585 TQSSNLTThkkihTGEKFYKCE--ECGKAFTQSSNLTTHKKiHTggkpykceECGKAFNQFSTLTKHKIIHTEEKPYKCE 662
Cdd:COG5189  337 TPSRMLKV-----KDGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCE 402

                         90
                 ....*....|....*.
gi 375331901 663 ECGKAFKWSSTLTKHK 678
Cdd:COG5189  403 VCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
562-586 4.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.60e-04
                          10        20
                  ....*....|....*....|....*
gi 375331901  562 LTKHKRIHTGEKPYKCEECGKAFTQ 586
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 613-706 7.51e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 7.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 613 TQSSNLTThkkihTGGKPYKCE--ECGKAFNQFSTLTKHKIiHTEEKPYKCEecgkafkwSSTLTKHKIIHTGEKPYKCE 690
Cdd:COG5189  337 TPSRMLKV-----KDGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCE 402

                         90
                 ....*....|....*.
gi 375331901 691 ECGKAFKLSSTLSTHK 706
Cdd:COG5189  403 VCDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
742-803 7.71e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 7.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 375331901 742 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 803
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
338-362 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*
gi 375331901  338 LTKHKRIHTGEKPYTCEECGKAFNQ 362
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
477-502 1.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331901  477 NLTTHKRIHTAEKPYKCEECGKAFSR 502
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 655-735 1.35e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 655 EEKPYKCE--ECGKAFKWSSTLTKHKiihtgekpyKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSNLIE 732
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 375331901 733 HKK 735
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
757-782 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331901  757 HLNTHKRIHTKEQPYKCKECGKAFNQ 782
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
534-558 1.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.91e-03
                          10        20
                  ....*....|....*....|....*
gi 375331901  534 LTEHKITHTGEKPYKCEECGKAFNH 558
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
617-642 1.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.91e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331901  617 NLTTHKKIHTGGKPYKCEECGKAFNQ 642
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
450-474 1.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|....*
gi 375331901  450 LTKHNRIHTGEKPYKCEVCGKAFNQ 474
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
393-417 1.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.99e-03
                          10        20
                  ....*....|....*....|....*
gi 375331901  393 NLTKHKKIHTEKKPYKCEECGKAFK 417
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
729-754 2.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331901  729 NLIEHKKIHTGEQPYKCEECGKAFNY 754
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-333 2.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.23e-03
                          10        20
                  ....*....|....*....|....*
gi 375331901  309 NLTEHKKIHPGEKPYKCEECGKAFN 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
589-614 2.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331901  589 NLTTHKKIHTGEKFYKCEECGKAFTQ 614
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
674-697 2.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.59e-03
                          10        20
                  ....*....|....*....|....
gi 375331901  674 LTKHKIIHTGEKPYKCEECGKAFK 697
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 347-430 2.92e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 347 GEKPYTCE--ECGKAFNQFSNLTTHKrihtaekfyKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTE 424
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 375331901 425 HKlTHT 430
Cdd:COG5189  417 HR-KHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
702-726 3.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.95e-03
                          10        20
                  ....*....|....*....|....*
gi 375331901  702 LSTHKIIHTGEKPYKCEKCGKAFNR 726
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
422-445 4.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.44e-03
                          10        20
                  ....*....|....*....|....
gi 375331901  422 LTEHKLTHTGEKPYKCEECGKAFN 445
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 459-542 8.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 8.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331901 459 GEKPYKCEV--CGKAFNQFSNLTTHKRI-HTAEK--PYKCEECGKAFSrssnltkhkkihIEKKPYKCEECGKAFKWSSK 533
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKlhENPSPEKMNIFS------------AKDKPYRCEVCDKRYKNLNG 413


                 ....*....
gi 375331901 534 LTEHkITHT 542
Cdd:COG5189  414 LKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
646-669 9.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.11e-03
                          10        20
                  ....*....|....*....|....
gi 375331901  646 LTKHKIIHTEEKPYKCEECGKAFK 669
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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