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Conserved domains on  [gi|380254499|ref|NP_001244063|]
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cytochrome c oxidase assembly protein COX14 [Homo sapiens]

Protein Classification

cytochrome c oxidase assembly protein COX14( domain architecture ID 10632820)

cytochrome c oxidase assembly protein COX14 is the core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COX14 pfam14880
Cytochrome oxidase c assembly; COX14 plays an essential role in cytochrome oxidase assembly. ...
 1-57 4.19e-12

Cytochrome oxidase c assembly; COX14 plays an essential role in cytochrome oxidase assembly. The COX14 product is a low-molecular weight membrane protein of mitochondria, but it is not a subunit of cytochrome oxidase. Orthology-prediction methods have identified the vertebrate C12orf62 orthologues to be orthologues of the yeast COX14.


:

Pssm-ID: 434280  Cd Length: 59  Bit Score: 54.22  E-value: 4.19e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 380254499   1 MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM 57
Cdd:pfam14880  3 RPRGRRIADKAHRGTVLGLIGVTVYGGGLTGYTVYSYFKYNRRQRQEFIEREKLKEE 59
 
Name Accession Description Interval E-value
COX14 pfam14880
Cytochrome oxidase c assembly; COX14 plays an essential role in cytochrome oxidase assembly. ...
 1-57 4.19e-12

Cytochrome oxidase c assembly; COX14 plays an essential role in cytochrome oxidase assembly. The COX14 product is a low-molecular weight membrane protein of mitochondria, but it is not a subunit of cytochrome oxidase. Orthology-prediction methods have identified the vertebrate C12orf62 orthologues to be orthologues of the yeast COX14.


Pssm-ID: 434280  Cd Length: 59  Bit Score: 54.22  E-value: 4.19e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 380254499   1 MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM 57
Cdd:pfam14880  3 RPRGRRIADKAHRGTVLGLIGVTVYGGGLTGYTVYSYFKYNRRQRQEFIEREKLKEE 59
 
Name Accession Description Interval E-value
COX14 pfam14880
Cytochrome oxidase c assembly; COX14 plays an essential role in cytochrome oxidase assembly. ...
 1-57 4.19e-12

Cytochrome oxidase c assembly; COX14 plays an essential role in cytochrome oxidase assembly. The COX14 product is a low-molecular weight membrane protein of mitochondria, but it is not a subunit of cytochrome oxidase. Orthology-prediction methods have identified the vertebrate C12orf62 orthologues to be orthologues of the yeast COX14.


Pssm-ID: 434280  Cd Length: 59  Bit Score: 54.22  E-value: 4.19e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 380254499   1 MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM 57
Cdd:pfam14880  3 RPRGRRIADKAHRGTVLGLIGVTVYGGGLTGYTVYSYFKYNRRQRQEFIEREKLKEE 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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