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Conserved domains on  [gi|540344560|ref|NP_001269389|]
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leucine-rich repeat-containing protein 63 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
306-469 1.25e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.42  E-value: 1.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 306 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 383
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 384 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 462
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                 ....*..
gi 540344560 463 KIQFENN 469
Cdd:COG4886  232 TLDLSNN 238
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
306-469 1.25e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.42  E-value: 1.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 306 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 383
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 384 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 462
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                 ....*..
gi 540344560 463 KIQFENN 469
Cdd:COG4886  232 TLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
393-449 2.12e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 2.12e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 540344560  393 LRIFTIAFNLITVLPIGLFS-LSYLEELDVSYNELTFI-PNEIQKLRSLEKLTVDGNEL 449
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 373-450 1.95e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.58  E-value: 1.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 373 LKLRNNPIK-EIPSEIQQLEFLRIFTIAFNLIT-VLPIGLFSLSYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 449
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                 .
gi 540344560 450 S 450
Cdd:PLN03150 503 S 503
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-514 1.47e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 352 LSFNDLH--YFPTEILClKNLQILKLRNNPIKEIP------------------SEIQQLEFLRIFT---IAFNLITVLpI 408
Cdd:cd21340    7 LYLNDKNitKIDNLSLC-KNLKVLYLYDNKITKIEnlefltnlthlylqnnqiEKIENLENLVNLKklyLGGNRISVV-E 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 409 GLFSLSYLEELDVSY------NELTFIPNEIQKL-RSLEKLTVDGNELSfFPHGILKL-NLTKIQFENnfthpcfwrdNY 480
Cdd:cd21340   85 GLENLTNLEELHIENqrlppgEKLTFDPRSLAALsNSLRVLNISGNNID-SLEPLAPLrNLEQLDASN----------NQ 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 540344560 481 LNNPQQLTQIIS-------LFIVQN---KLHKFYDKIPVEVQKL 514
Cdd:cd21340  154 ISDLEELLDLLSswpslreLDLTGNpvcKKPKYRDKIILASKSL 197
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
306-469 1.25e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.42  E-value: 1.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 306 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 383
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 384 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 462
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                 ....*..
gi 540344560 463 KIQFENN 469
Cdd:COG4886  232 TLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
343-469 3.14e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 3.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 343 LAFQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPikeipsEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVS 422
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLS 144

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 540344560 423 YNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLTKIQFENN 469
Cdd:COG4886  145 NNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLtNLKELDLSNN 192
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
306-515 2.74e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 2.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 306 ETITAMTNLAIVNCqvyGRNALNLKGFFILNCPdltplafQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEIPS 385
Cdd:COG4886  153 EPLGNLTNLKSLDL---SNNQLTDLPEELGNLT-------NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 386 EIQQLEFLRIFTIAFNLITVLPI---------------------GLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTV 444
Cdd:COG4886  223 PLANLTNLETLDLSNNQLTDLPElgnltnleeldlsnnqltdlpPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 540344560 445 DGNELSFFPHGILKLNLTKIQFENNFTHPCFWRDNYLNNPQQLTQIISLFIVQNKLHKFYDKIPVEVQKLL 515
Cdd:COG4886  303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
299-469 5.16e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 5.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 299 TVAATRYETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAFQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNN 378
Cdd:COG4886    4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 379 PIKEIPSEIQQLEFLRIFTIAFNLitvlpiGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILK 458
Cdd:COG4886   84 LLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGN 157

                        170
                 ....*....|..
gi 540344560 459 L-NLTKIQFENN 469
Cdd:COG4886  158 LtNLKSLDLSNN 169
LRR_8 pfam13855
Leucine rich repeat;
393-449 2.12e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 2.12e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 540344560  393 LRIFTIAFNLITVLPIGLFS-LSYLEELDVSYNELTFI-PNEIQKLRSLEKLTVDGNEL 449
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 373-450 1.95e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.58  E-value: 1.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 373 LKLRNNPIK-EIPSEIQQLEFLRIFTIAFNLIT-VLPIGLFSLSYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 449
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                 .
gi 540344560 450 S 450
Cdd:PLN03150 503 S 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 345-514 4.99e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 4.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 345 FQLIYLNLSFNDL-HYFPTEILCLKNLQILKLRNNP-IKEIPSEIQQLEFLRIFTIAFN-LITVLPIGLFSLSYLEELDV 421
Cdd:PLN00113 164 SSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNnLSGEIPYEIGGLTSLNHLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 422 SYNELTF-IPNEIQKLRSLEKLTVDGNELSF-FPHGILKL-NLTKIQFEnnfthpcfwrDNYLNN--PQQLTQIISLFIV 496
Cdd:PLN00113 244 VYNNLTGpIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLqKLISLDLS----------DNSLSGeiPELVIQLQNLEIL 313

                        170
                 ....*....|....*...
gi 540344560 497 QNKLHKFYDKIPVEVQKL 514
Cdd:PLN00113 314 HLFSNNFTGKIPVALTSL 331
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
301-471 2.92e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.00  E-value: 2.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 301 AATRYETITAMTNlaivnCQVYGRNALNLKGFFILNCPDLTPLafQLIYLNLSFNDLHYFPTEILclKNLQILKLRNNPI 380
Cdd:PRK15370 162 AANREEAVQRMRD-----CLKNNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQ--GNIKTLYANSNQL 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 381 KEIPSEIQqlEFLRIFTIAFNLITVLPIGLfsLSYLEELDVSYNELTFIPNEIQKlrSLEKLTVDGNEL----SFFPHGI 456
Cdd:PRK15370 233 TSIPATLP--DTIQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIrtlpAHLPSGI 306

                        170
                 ....*....|....*
gi 540344560 457 LKLNLtkiqFENNFT 471
Cdd:PRK15370 307 THLNV----QSNSLT 317
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-514 1.47e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 352 LSFNDLH--YFPTEILClKNLQILKLRNNPIKEIP------------------SEIQQLEFLRIFT---IAFNLITVLpI 408
Cdd:cd21340    7 LYLNDKNitKIDNLSLC-KNLKVLYLYDNKITKIEnlefltnlthlylqnnqiEKIENLENLVNLKklyLGGNRISVV-E 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 409 GLFSLSYLEELDVSY------NELTFIPNEIQKL-RSLEKLTVDGNELSfFPHGILKL-NLTKIQFENnfthpcfwrdNY 480
Cdd:cd21340   85 GLENLTNLEELHIENqrlppgEKLTFDPRSLAALsNSLRVLNISGNNID-SLEPLAPLrNLEQLDASN----------NQ 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 540344560 481 LNNPQQLTQIIS-------LFIVQN---KLHKFYDKIPVEVQKL 514
Cdd:cd21340  154 ISDLEELLDLLSswpslreLDLTGNpvcKKPKYRDKIILASKSL 197
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
306-501 2.63e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 306 ETITAMTNLAIVNCqvyGRNALNlkgffilNCPDLTPLAfQLIYLNLSFNDLHYFPtEILCLKNLQILKLRNNPIKEIPS 385
Cdd:COG4886  222 EPLANLTNLETLDL---SNNQLT-------DLPELGNLT-NLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKL 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 386 EIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKLNLTkIQ 465
Cdd:COG4886  290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL-LT 368

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 540344560 466 FENNFTHPCFWRDNYLNNPQQLTQIISLFIVQNKLH 501
Cdd:COG4886  369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLT 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 340-449 5.95e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 5.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344560 340 LTPLAFQLIYL---NLSFNDLHY-FPTEILCL-KNLQILKLRNNPIK-EIPS-EIQQLEFLRIFTIAFNLITVLPIGLFS 412
Cdd:PLN00113  85 ISSAIFRLPYIqtiNLSNNQLSGpIPDDIFTTsSSLRYLNLSNNNFTgSIPRgSIPNLETLDLSNNMLSGEIPNDIGSFS 164

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 540344560 413 lsYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 449
Cdd:PLN00113 165 --SLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQL 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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