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Conserved domains on  [gi|546231038|ref|NP_001271212|]
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WW domain binding protein VOPP1 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13729 super family cl42933
conjugal transfer pilus assembly protein TraB; Provisional
 102-160 4.71e-04

conjugal transfer pilus assembly protein TraB; Provisional


The actual alignment was detected with superfamily member PRK13729:

Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 39.42  E-value: 4.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 546231038 102 PNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAFqvppnSPQGSVACPPPPAY----CNTPPP 160
Cdd:PRK13729 125 ANPVTATGEPVPQMPASPPGPEGEPQPGNTPVSF-----PPQGSVAVPPPTAFypgnGVTPPP 182
 
Name Accession Description Interval E-value
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 102-160 4.71e-04

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 39.42  E-value: 4.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 546231038 102 PNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAFqvppnSPQGSVACPPPPAY----CNTPPP 160
Cdd:PRK13729 125 ANPVTATGEPVPQMPASPPGPEGEPQPGNTPVSF-----PPQGSVAVPPPTAFypgnGVTPPP 182
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 84-164 5.95e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 36.67  E-value: 5.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231038   84 PPPLIEEPAFNVSYTRQPPNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAfQVPPnSPQGSVA--------CPPPPAYC 155
Cdd:pfam03154 257 PPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQS-QVPP-GPSPAAPgqsqqrihTPPSQSQL 334


                  ....*....
gi 546231038  156 NTPPPPYEQ 164
Cdd:pfam03154 335 QSQQPPREQ 343
 
Name Accession Description Interval E-value
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 102-160 4.71e-04

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 39.42  E-value: 4.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 546231038 102 PNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAFqvppnSPQGSVACPPPPAY----CNTPPP 160
Cdd:PRK13729 125 ANPVTATGEPVPQMPASPPGPEGEPQPGNTPVSF-----PPQGSVAVPPPTAFypgnGVTPPP 182
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 84-164 5.95e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 36.67  E-value: 5.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546231038   84 PPPLIEEPAFNVSYTRQPPNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAfQVPPnSPQGSVA--------CPPPPAYC 155
Cdd:pfam03154 257 PPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQS-QVPP-GPSPAAPgqsqqrihTPPSQSQL 334


                  ....*....
gi 546231038  156 NTPPPPYEQ 164
Cdd:pfam03154 335 QSQQPPREQ 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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