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Conserved domains on  [gi|751130505|ref|NP_001291380|]
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6-phosphogluconate dehydrogenase, decarboxylating isoform 2 [Homo sapiens]

Protein Classification

NADP(+)-dependent, decarboxylating phosphogluconate dehydrogenase( domain architecture ID 11417508)

NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate, as part of the oxidative branch of the pentose phosphate pathway

CATH:  3.40.50.720|1.20.5.320
EC:  1.1.1.44
Gene Ontology:  GO:0004616|GO:0050661|GO:0006098|GO:0046177
PubMed:  35234135|34709178|26479318
SCOP:  3000048

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 2-447 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 803.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   2 AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAV 81
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  82 DDFIEKL----------------------RRCRDLKAKGILFvgsgvsggeegARYGPSLMPGGNKEAWPHIKTIFQGIA 139
Cdd:COG0362   81 DAVIEQLlpllepgdiiidggnshftdtiRREKELAEKGIHFigmgvsggeegALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 140 AKVGtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILK 219
Cdd:COG0362  161 AKVD-GEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 220 FQDT-DGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFL 298
Cdd:COG0362  240 KKDPeTGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 299 EDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVE 378
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 751130505 379 NCQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFiHTNW 447
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFF-HTEW 467
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 2-447 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 803.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   2 AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAV 81
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  82 DDFIEKL----------------------RRCRDLKAKGILFvgsgvsggeegARYGPSLMPGGNKEAWPHIKTIFQGIA 139
Cdd:COG0362   81 DAVIEQLlpllepgdiiidggnshftdtiRREKELAEKGIHFigmgvsggeegALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 140 AKVGtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILK 219
Cdd:COG0362  161 AKVD-GEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 220 FQDT-DGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFL 298
Cdd:COG0362  240 KKDPeTGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 299 EDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVE 378
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 751130505 379 NCQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFiHTNW 447
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFF-HTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
14-451 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 768.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  14 MGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKL----- 88
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLlplle 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  89 -----------------RRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDW 151
Cdd:PRK09287  81 kgdiiidggnsnykdtiRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 152 VGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDT-DGKHLLP 230
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEeTGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 231 KIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKfQFDGDKKSFLEDIRKALYASKI 310
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAA-KFEGDKAEFIEDVRQALYASKI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 311 ISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVST 390
Cdd:PRK09287 320 VSYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVAL 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 751130505 391 GVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFiHTNWTGHG 451
Cdd:PRK09287 400 AVQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFF-HTEWSEDG 459
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 5-449 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 748.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505    5 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDF 84
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   85 IEKL----------------------RRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKV 142
Cdd:TIGR00873  81 IDSLlpllekgdiiidggnshypdteRRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  143 GtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQD 222
Cdd:TIGR00873 161 D-GEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  223 TDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIR 302
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGVDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  303 KALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQD 382
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 751130505  383 SWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKP-GQFIHTNWTG 449
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPrGEFFHTNWTG 467
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 158-447 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 571.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  158 GHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQD-TDGKHLLPKIRDSA 236
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDpEDGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  237 GQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQG 316
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  317 FMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGI 396
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 751130505  397 PMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGqFIHTNW 447
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEG-FFHTEW 290
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 2-447 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 803.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   2 AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAV 81
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  82 DDFIEKL----------------------RRCRDLKAKGILFvgsgvsggeegARYGPSLMPGGNKEAWPHIKTIFQGIA 139
Cdd:COG0362   81 DAVIEQLlpllepgdiiidggnshftdtiRREKELAEKGIHFigmgvsggeegALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 140 AKVGtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILK 219
Cdd:COG0362  161 AKVD-GEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 220 FQDT-DGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFL 298
Cdd:COG0362  240 KKDPeTGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 299 EDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVE 378
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 751130505 379 NCQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFiHTNW 447
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFF-HTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
14-451 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 768.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  14 MGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKL----- 88
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLlplle 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  89 -----------------RRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDW 151
Cdd:PRK09287  81 kgdiiidggnsnykdtiRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 152 VGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDT-DGKHLLP 230
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEeTGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 231 KIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKfQFDGDKKSFLEDIRKALYASKI 310
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAA-KFEGDKAEFIEDVRQALYASKI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 311 ISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVST 390
Cdd:PRK09287 320 VSYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVAL 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 751130505 391 GVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFiHTNWTGHG 451
Cdd:PRK09287 400 AVQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFF-HTEWSEDG 459
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 5-449 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 748.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505    5 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDF 84
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   85 IEKL----------------------RRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKV 142
Cdd:TIGR00873  81 IDSLlpllekgdiiidggnshypdteRRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  143 GtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQD 222
Cdd:TIGR00873 161 D-GEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  223 TDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIR 302
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGVDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  303 KALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQD 382
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 751130505  383 SWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKP-GQFIHTNWTG 449
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPrGEFFHTNWTG 467
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 3-448 0e+00

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 648.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   3 QADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAK-GTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAV 81
Cdd:PTZ00142   1 MSDIGLIGLAVMGQNLALNIASRGFKISVYNRTYEKTEEFVKKAKEgNTRVKGYHTLEELVNSLKKPRKVILLIKAGEAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  82 DDFIEKL----------------------RRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIA 139
Cdd:PTZ00142  81 DETIDNLlpllekgdiiidggnewylnteRRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 140 AKVGTgEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANIL- 218
Cdd:PTZ00142 161 AKVGD-SPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLMKHILGMSNEELSEVFNKWNEGILNSYLIEITAKILa 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 219 KFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKF--QFDGDKKS 296
Cdd:PTZ00142 240 KKDDLGEEHLVDKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISALKEERTKASSHLAGPNPAnkTETEDKKY 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 297 FLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSA 376
Cdd:PTZ00142 320 FIDDLKNALYCSKIISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFLDPDFNDE 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 751130505 377 VENCQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFiHTNWT 448
Cdd:PTZ00142 400 LKNKQPSWRKVVSMATKNGIPTPAFSASLAYYQMYRSQNLPANLVQAQRDYFGAHTYKRLDRPGAF-HTNWE 470
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 158-447 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 571.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  158 GHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQD-TDGKHLLPKIRDSA 236
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDpEDGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  237 GQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQG 316
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  317 FMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGI 396
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 751130505  397 PMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGqFIHTNW 447
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEG-FFHTEW 290
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 1-448 0e+00

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 542.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   1 MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFL--ANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAG 78
Cdd:PLN02350   4 AALSRIGLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETVerAKKEGNLPLYGFKDPEDFVLSIQKPRSVIILVKAG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  79 QAVDDFIEKL----------------------RRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQ 136
Cdd:PLN02350  84 APVDQTIKALseymepgdciidggnewyenteRRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 137 GIAAKVGTGePCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITAN 216
Cdd:PLN02350 164 KVAAQVDDG-PCVTYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGGLSNEELAEVFAEWNKGELESFLIEITAD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 217 ILKFQD-TDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDG--- 292
Cdd:PLN02350 243 IFSVKDdKGDGYLVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSGLKEERVAAAKVFKEAGLEDILSads 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 293 --DKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLD 370
Cdd:PLN02350 323 gvDKKQLIDDVRQALYASKICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVD 402

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 751130505 371 -DFFKSAVENcQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFiHTNWT 448
Cdd:PLN02350 403 pEFAKEMVER-QAAWRRVVSLAINAGISTPGMSASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDRPGSF-HTEWT 479
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
5-266 3.07e-53

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 180.72  E-value: 3.07e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   5 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDdflanEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDF 84
Cdd:PRK09599   2 QLGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVE-----ALAEEGATGADSLEELVAKLPAPRVVWLMVPAGEITDAT 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  85 IEKL----------------------RRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKV 142
Cdd:PRK09599  77 IDELapllspgdividggnsyykddiRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 143 GTGepccdWV--GDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKdvlgmAQD---EMAQAFEDWNK-TELDSFLIEITAN 216
Cdd:PRK09599 157 EDG-----YLhaGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLE-----ASRfdlDLAAVAEVWRRgSVIRSWLLDLTAD 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 751130505 217 ILKfQDTDGKHLLPKIRDSagqkGTGKWTAISALEYGVPVTLIGEAVFAR 266
Cdd:PRK09599 227 ALA-EDPKLDEISGYVEDS----GEGRWTVEEAIDLAVPAPVIAAALFMR 271
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
6-274 1.87e-52

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 178.36  E-value: 1.87e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   6 IALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFlanEAKGtkVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFI 85
Cdd:COG1023    3 IGMIGLGKMGGNMARRLLRHGHEVVGYDRNPEAVAAL---AAEG--ATGADSLEELVAKLPAPRVVWLMVPAGEITDQVI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  86 EKL----------------------RRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVG 143
Cdd:COG1023   78 EELapllepgdividggnsnykddiRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALAPGAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505 144 TGepcCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDvlgmAQDE--MAQAFEDWNK-TELDSFLIEITANILKf 220
Cdd:COG1023  158 NG---YLHCGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEA----SEFDldLAEVAEVWRRgSVIRSWLLDLTADALA- 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 751130505 221 QDTDGKHLLPKIRDSagqkGTGKWTAISALEYGVPVTLIGEAVFARcLSSLKDE 274
Cdd:COG1023  230 EDPKLEGISGYVEDS----GEGRWTVEEAIELGVPAPVITAALFAR-FRSRQED 278
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 5-153 1.40e-32

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 121.04  E-value: 1.40e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505    5 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGtkvvgAQSLKEMVSKLkkpRRIILLVKAGQAVDDF 84
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAGAIA-----AASPAEFVAGL---DVVITMVPAGAAVDAV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   85 IEKL------------------------RRCRDLKAKGILFVGSGVSGGEEGARYGP-SLMPGGNKEAWPHIKTIFQGIA 139
Cdd:pfam03446  73 IFGEgllpglkpgdiiidgstsspedarRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMG 152

                         170
                  ....*....|....
gi 751130505  140 AkvgtgepCCDWVG 153
Cdd:pfam03446 153 A-------CVTYIG 159
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 6-273 2.18e-30

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 119.57  E-value: 2.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505    6 IALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDdflanEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAG------Q 79
Cdd:TIGR00872   3 LGLIGLGRMGANIVRRLAKRGHDCVGYDHDQDAVK-----AMKEDRTTGVANLRELSQRLSAPRVVWVMVPHGivdavlE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   80 AVDDFIEK---------------LRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKvgt 144
Cdd:TIGR00872  78 ELAPTLEKgdividggnsyykdsLRRYKLLKEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPE--- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  145 gEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDvlGMAQDEMAQAFEDWNK-TELDSFLIEITANILKfQDT 223
Cdd:TIGR00872 155 -EQGYLYCGPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRN--SQFDFDIPEVARVWRRgSVIRSWLLDLTAIAFR-ESP 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 751130505  224 DGKHLLPKIRDSagqkGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKD 273
Cdd:TIGR00872 231 DLAEFSGRVSDS----GEGRWTVIAAIDLGVPAPVIATSLQSRFASRDLD 276
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 6-201 6.81e-11

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 62.83  E-value: 6.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   6 IALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFlanEAKGTKVvgAQSLKEMVSKLkkpRRIILLVKAGQAV---- 81
Cdd:COG2084    4 VGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEAL---VAAGARV--AASPAEAAAAA---DVVITMLPDDAAVeevl 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  82 ---DDFIEKLRR------------------CRDLKAKGIlfvgsgvsggeegaRY-------GP--------SLMPGGNK 125
Cdd:COG2084   76 lgeDGLLAALRPgavvvdmstispetarelAAAAAARGV--------------RYldapvsgGPagaeagtlTIMVGGDE 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 751130505 126 EAWPHIKTIFQGIAAKVgtgepccDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDvLGMAQDEMAQAFEDW 201
Cdd:COG2084  142 AAFERARPVLEAMGKRI-------VHVGDAGAGQAAKLANNLLLAGTMAALAEALALAEK-AGLDPETLLEVLSGG 209
garR PRK11559
tartronate semialdehyde reductase; Provisional
 5-163 3.29e-03

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 39.26  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505   5 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGT---KVVGAQS------------LKEMVSklkKPR 69
Cdd:PRK11559   4 KVGFIGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAETAstaKAVAEQCdviitmlpnsphVKEVAL---GEN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751130505  70 RIILLVKAGQAVDDF--IEKL--RRCRD-LKAKGILFVGSGVSGGEEGARYGP-SLMPGGNKEAWPHIKTIFQGIAAKVg 143
Cdd:PRK11559  81 GIIEGAKPGTVVIDMssIAPLasREIAAaLKAKGIEMLDAPVSGGEPKAIDGTlSVMVGGDKAIFDKYYDLMKAMAGSV- 159

                        170       180
                 ....*....|....*....|
gi 751130505 144 tgepccDWVGDEGAGHFVKM 163
Cdd:PRK11559 160 ------VHTGDIGAGNVTKL 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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