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Conserved domains on  [gi|756761754|ref|NP_001291936|]
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high affinity choline transporter 1 isoform c [Homo sapiens]

Protein Classification

sodium:solute symporter family protein( domain architecture ID 10183701)

sodium:solute symporter family protein similar to human high-affinity choline transporter 1 (CHT), also called solute carrier family 5 member 7, which is a sodium ion- and chloride ion-dependent transmembrane transporter that imports choline from the extracellular space into the neuron

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
 1-248 2.34e-103

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


:

Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 311.00  E-value: 2.34e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   1 MLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDpktteEADMILPIVLQYL 80
Cdd:cd11474  232 GLGSIPQQDVFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYGLEE-----DAQLILPLLLQYL 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  81 CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWY 160
Cdd:cd11474  307 TPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVESIYGLVE 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 161 LSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPlifypgyypdDNGIYNQKFPFKTLAMVTS 240
Cdd:cd11474  387 LASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPA----------DIPPQLQGFPFSTLAMVIG 456


                 ....*...
gi 756761754 241 FLTNICIS 248
Cdd:cd11474  457 SLLPLAVS 464
 
Name Accession Description Interval E-value
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
 1-248 2.34e-103

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 311.00  E-value: 2.34e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   1 MLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDpktteEADMILPIVLQYL 80
Cdd:cd11474  232 GLGSIPQQDVFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYGLEE-----DAQLILPLLLQYL 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  81 CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWY 160
Cdd:cd11474  307 TPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVESIYGLVE 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 161 LSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPlifypgyypdDNGIYNQKFPFKTLAMVTS 240
Cdd:cd11474  387 LASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPA----------DIPPQLQGFPFSTLAMVIG 456


                 ....*...
gi 756761754 241 FLTNICIS 248
Cdd:cd11474  457 SLLPLAVS 464
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
1-252 3.21e-35

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 133.40  E-value: 3.21e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   1 MLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIgastdwnqtAYGLPDPKTTEEADMILPIVLQYL 80
Cdd:COG0591  237 GLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLL---------ARALFPDLPLADPDLALPLLILEL 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  81 CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTK-TVYGLW 159
Cdd:COG0591  308 LPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPsSILDLV 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 160 YLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGgepYLYLQPLIFYPGYYPddnGIYnqkfpfktlAMVT 239
Cdd:COG0591  388 LLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLW---KLLGGPLGPFGWLYP---ILP---------GLLV 452

                        250
                 ....*....|...
gi 756761754 240 SFLTNICISYLAK 252
Cdd:COG0591  453 SLLVFVVVSLLTK 465
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
 1-195 1.64e-16

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 79.65  E-value: 1.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754    1 MLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGAS--TDWNQtaygLPDPKTTEEADMILPIVLQ 78
Cdd:TIGR00813 213 ALWYWTNQVIVQRCLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARAlyTDIDP----ALAGAVNQNSDQAYPLLVQ 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   79 YLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNAS-DKEIVWVMRITVFVFGASA-TAMALLTKTVY 156
Cdd:TIGR00813 289 ELMPPGLAGLFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASgEKKIVMRGRIAVLVAAVIAgFVAAAQGGQVL 368

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 756761754  157 GLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSG 195
Cdd:TIGR00813 369 QYVQEAFGGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
 1-195 1.83e-12

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 67.36  E-value: 1.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754    1 MLGGIPWQAYFQRVLSSSSATYAqVLSFLAAFGCLVMaipaILIGAIGASTDWNQTAYGLPDPKTTE--EADMILPIVLQ 78
Cdd:pfam00474 212 VLGTTGLPHILQRCLAAKDAKCI-RCGVLILTPMFII----VMPGMISRGLFAIALAGANPRACGTVvgCSNIAYPTLAV 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   79 YLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQN-ASDKEIVWVMRITVFVFGASATAMALLTKTVYG 157
Cdd:pfam00474 287 KLGPPGLAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKAsATEKELVGRSRIIVLVVISLAILLAVQPAQMGI 366

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 756761754  158 LWYLSSDLVYI--VIFPQLLCVLFVKGTNTYGAVAGYVSG 195
Cdd:pfam00474 367 AFLVQLAFAGLgsAFLPVILLAIFWKRVNEQGALWGMIIG 406
PRK10484 PRK10484
putative transporter; Provisional
 8-202 1.42e-07

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 52.96  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   8 QAYFQRVLSSSSATYAQ----VLSFLAAFGCLVMAIPAILigaigastdwnqtAYGLPdPKTTEEADMILPIVLQYLCPV 83
Cdd:PRK10484 261 QSIVQRALGAKNLAEGQkgalLAAFFKLLGPLILVLPGII-------------AFHLY-GDGLPNADMAYPTLVNDVLPV 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  84 YISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMA-LLTKTVYGLWYLS 162
Cdd:PRK10484 327 PLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINPNASEKQLVKVGKKFGFVLAIISMIVApLIANAPQGLYSYL 406

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 756761754 163 SDLVYIVIFPQLLCVL---FVKGTNTYGAVAGYVSGLFLRITG 202
Cdd:PRK10484 407 QQLNGIYNVPILAIIIvgfFTKRVPALAAKVALGFGIILYIII 449
 
Name Accession Description Interval E-value
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
 1-248 2.34e-103

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 311.00  E-value: 2.34e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   1 MLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDpktteEADMILPIVLQYL 80
Cdd:cd11474  232 GLGSIPQQDVFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYGLEE-----DAQLILPLLLQYL 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  81 CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWY 160
Cdd:cd11474  307 TPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVESIYGLVE 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 161 LSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPlifypgyypdDNGIYNQKFPFKTLAMVTS 240
Cdd:cd11474  387 LASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPA----------DIPPQLQGFPFSTLAMVIG 456


                 ....*...
gi 756761754 241 FLTNICIS 248
Cdd:cd11474  457 SLLPLAVS 464
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
 1-220 3.98e-36

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 135.38  E-value: 3.98e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   1 MLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNqtayglpdpktTEEADMILPIVLQYL 80
Cdd:cd10322  235 GLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPD-----------LENPDLALPTLINSL 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  81 CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWY 160
Cdd:cd10322  304 LPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLALLLALLPPSILLLLS 383

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 161 LSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRItggepYLYLQPLIFYPGYYP 220
Cdd:cd10322  384 LAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTL-----VWLLLPLASPLGIDP 438
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
1-252 3.21e-35

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 133.40  E-value: 3.21e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   1 MLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIgastdwnqtAYGLPDPKTTEEADMILPIVLQYL 80
Cdd:COG0591  237 GLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLL---------ARALFPDLPLADPDLALPLLILEL 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  81 CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTK-TVYGLW 159
Cdd:COG0591  308 LPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPsSILDLV 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 160 YLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGgepYLYLQPLIFYPGYYPddnGIYnqkfpfktlAMVT 239
Cdd:COG0591  388 LLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLW---KLLGGPLGPFGWLYP---ILP---------GLLV 452

                        250
                 ....*....|...
gi 756761754 240 SFLTNICISYLAK 252
Cdd:COG0591  453 SLLVFVVVSLLTK 465
SLC5sbd_PutP cd11475
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ...
 41-197 1.01e-18

Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271369  Cd Length: 464  Bit Score: 86.41  E-value: 1.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  41 AILIGAIGAstdwnqtAYgLPDPkTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLS 120
Cdd:cd11475  281 AVLVGLLGR-------AL-FPDG-LLGDPETVFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAF 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 121 FRQNASDKEIVWVMRITVFVFGASATAMALltktvyglwYLSSDLVYIVIF----------PQLLCVLFVKGTNTYGAVA 190
Cdd:cd11475  352 LRKEASDKELVWVSRLAVLVIALIALLIAL---------NPPSSVFSLVSFawaglgaafgPLLLLSLYWKRTTRQGALA 422


                 ....*..
gi 756761754 191 GYVSGLF 197
Cdd:cd11475  423 GMIAGAV 429
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
 1-195 1.64e-16

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 79.65  E-value: 1.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754    1 MLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGAS--TDWNQtaygLPDPKTTEEADMILPIVLQ 78
Cdd:TIGR00813 213 ALWYWTNQVIVQRCLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARAlyTDIDP----ALAGAVNQNSDQAYPLLVQ 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   79 YLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNAS-DKEIVWVMRITVFVFGASA-TAMALLTKTVY 156
Cdd:TIGR00813 289 ELMPPGLAGLFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASgEKKIVMRGRIAVLVAAVIAgFVAAAQGGQVL 368

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 756761754  157 GLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSG 195
Cdd:TIGR00813 369 QYVQEAFGGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
SLC5sbd_DUR3 cd11476
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ...
 8-248 5.46e-16

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271370  Cd Length: 493  Bit Score: 78.40  E-value: 5.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   8 QAYFQRVLSSSSATYAQVlSFLAafGCLVMAIPAILIGAIGASTdwnqTAYGLPDPKTTEEADMILPIVLQYLCPVYISF 87
Cdd:cd11476  258 QGYWQRAIAARPSAAVKG-YFLG--GLAWFAIPFLLATTLGLAA----LALGLNPTFEEVSAGLVLPYVAAALLGKGGAA 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  88 FGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALltktvyGLWYLSSDLVY 167
Cdd:cd11476  331 AVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGFGLFMGGLAV------GLNYIGISLGW 404

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 168 I----------VIFPqLLCVLFVKGTNTYGAVAGYVSGLflrITGgepylylqpLIFYPGYYPDDNGIYNQKFPFKTLAM 237
Cdd:cd11476  405 LllfmgiligsAVFP-VALGLYWRRQTGTAAVVSPIAGL---VAG---------LAVWLVTAKSYYGEVNVDTTGGNYPM 471

                        250
                 ....*....|.
gi 756761754 238 VTSFLTNICIS 248
Cdd:cd11476  472 LAGNLVALFSP 482
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
 1-195 1.83e-12

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 67.36  E-value: 1.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754    1 MLGGIPWQAYFQRVLSSSSATYAqVLSFLAAFGCLVMaipaILIGAIGASTDWNQTAYGLPDPKTTE--EADMILPIVLQ 78
Cdd:pfam00474 212 VLGTTGLPHILQRCLAAKDAKCI-RCGVLILTPMFII----VMPGMISRGLFAIALAGANPRACGTVvgCSNIAYPTLAV 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   79 YLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQN-ASDKEIVWVMRITVFVFGASATAMALLTKTVYG 157
Cdd:pfam00474 287 KLGPPGLAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKAsATEKELVGRSRIIVLVVISLAILLAVQPAQMGI 366

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 756761754  158 LWYLSSDLVYI--VIFPQLLCVLFVKGTNTYGAVAGYVSG 195
Cdd:pfam00474 367 AFLVQLAFAGLgsAFLPVILLAIFWKRVNEQGALWGMIIG 406
SLC5sbd_u1 cd11477
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 12-216 4.90e-12

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271371  Cd Length: 493  Bit Score: 66.45  E-value: 4.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  12 QRVLSSSSATYA-QVLSFLAAfgcLVMAIPAILIGAIGASTDWNqtaYGLPDPKTTEEAdmILPIVLQYLCPVYISFFGL 90
Cdd:cd11477  255 QRYLSAKSEKAAkAAAWLFAA---LYLVRPWPWMLPALAALVLY---PDLDDPEADFEL--AYPMMIKEYLPAGLLGLVL 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  91 GAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVI 170
Cdd:cd11477  327 AGLLAATMSTVSTHLNWGAAYLVNDIYKRFIKPNASEKHLLKVGRLATVLFGLLSIVVALASDSIGGAFWIVLALGAGLG 406

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 756761754 171 FPQLLCV---LFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYP 216
Cdd:cd11477  407 GPLILPWlwwRFNAWTEIWAMIASIIVGLVVSVLLKVFGLPEDFLFSFL 455
SLC5sbd_SGLT1-like cd10329
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ...
 12-250 6.44e-12

Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271363  Cd Length: 538  Bit Score: 66.06  E-value: 6.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  12 QRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLG 91
Cdd:cd10329  249 QRVLAAKNLKHARRGALFAGYLKLLPLFLMVLPGMIARALFPDLVACVVPCGNGVGCSDIAYPTLVTELLPVGLRGLVLA 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  92 AVSAAVMSSADSSILSASSMFARNIYQLsFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYG-LW-YLSSDLVYIV 169
Cdd:cd10329  329 VLLAALMSSLTSIFNSASTLFTMDIYKR-LRPEASEKELVRVGRIATLVVVVISILWAPIIQAQGGsLFnYIQSVLSYLA 407

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 170 ifPQLLCV----LFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYnqkfpFKTLAMVTSFLTNI 245
Cdd:cd10329  408 --PPIAAVfllgIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYGEPDTRPAIIGGIHFLY-----FAFLLFVVSVIVTV 480


                 ....*
gi 756761754 246 CISYL 250
Cdd:cd10329  481 IVSLL 485
ActP COG4147
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
19-252 6.55e-12

Na+(or H+)/acetate symporter ActP [Energy production and conversion];


Pssm-ID: 443318  Cd Length: 526  Bit Score: 66.33  E-value: 6.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  19 SATYAQVLSFLAAFGCLVMAIPAILIgaIGASTDWNQTAYGLPDPKTTEEADMILPIVLQyLCPVYISFFGLGAVsAAVM 98
Cdd:COG4147  276 SVGWALGFIGLFYLTAPALGFGARAL--VGPLPEWFDTGLIGAADGGGNMAVLALAEIAG-GGNWLLGLVAAGAF-ATIL 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  99 SSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKT--VYGLWYLSSDLVYIVIFPQLLC 176
Cdd:COG4147  352 AVVAGLLLAIASAISHDLYANVIKGKATEKEELRVARIAAVVIGVVAILLGINAPPqnVAFLVALAFALAASANFPVLLL 431

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 756761754 177 VLFVKGTNTYGAVAGYVSGLFLRITggepYLYLQPLIFYPGYypdDNGIynqkFPFK---TLAMVTSFLTNICISYLAK 252
Cdd:COG4147  432 SIFWKRFNTRGAVAGMLVGLISALV----LIVLSPFVWVLGV---DAAL----FPLEnpgLVSMPLGFLVAIVVSLLTP 499
SLC5sbd_u4 cd11480
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 41-250 6.92e-12

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271374  Cd Length: 488  Bit Score: 65.99  E-value: 6.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  41 AILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYIsFFGL---GAVsAAVMSSADSSILSASSMFARNIY 117
Cdd:cd11480  282 APALGFGARALVGPDVIGAPIAGELDGGGDMAVLLLPEIAGLGDL-LLALvaaGAF-AAILATVAGLLLAAASALAHDLY 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 118 QLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTvyglwylsSDLVYIV----------IFPQLLCVLFVKGTNTYG 187
Cdd:cd11480  360 AGVIRPGASERREVRVARIAAVVVGVIAILLALLFPP--------QNVAFLValafaiaasaFFPVLVLGIFWRRFTTRG 431

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 756761754 188 AVAGYVSGLFLRITggepYLYLQPLIFYPGYYPDDNGiynqkFPFKTLAMVT---SFLTNICISYL 250
Cdd:cd11480  432 AIAGMLVGLLVSLV----LIVLSPAVSGAPPGHDFAG-----FPLTNPGLVSvplGFLVAIVVSLL 488
SLC5sbd_u3 cd11479
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 8-195 4.41e-11

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271373  Cd Length: 454  Bit Score: 63.39  E-value: 4.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   8 QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTdwnqtaygLPDPKTTEEAdmiLPIVLQYLCPVYISF 87
Cdd:cd11479  237 QDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVL--------LPDLANPQNA---FATMAQEVLPVGLRG 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  88 FGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVY 167
Cdd:cd11479  306 LVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLFTLLLGVVVIVIAVLVNDVVAALTIAYAILV 385

                        170       180
                 ....*....|....*....|....*...
gi 756761754 168 IVIFPQLLCVLFVKGTNTYGAVAGYVSG 195
Cdd:cd11479  386 GGLLVPILGGLFWKRATGAGALASMVAG 413
SLC5sbd_NIS-like_u2 cd11494
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 8-216 1.43e-10

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271385 [Multi-domain]  Cd Length: 473  Bit Score: 61.85  E-value: 1.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   8 QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAI--------GASTDWNQTAYGLPDPKtteeaDMILPIVLQY 79
Cdd:cd11494  247 QSQVQRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLvfvfyqfnPFPVSFNPAEDETKDTN-----YIFLRFVLNY 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  80 LCPVYISFFgLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMAL---LTKTVY 156
Cdd:cd11494  322 LPPGVIGLL-IAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKDASDEHYLKVSRLLTVFWGLLAIVFALfagLAGSLI 400

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 157 GLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRItggepYLYLQPLIFYP 216
Cdd:cd11494  401 EAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVIVVI-----VLWLFPDVSWL 455
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 12-252 2.38e-09

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271372  Cd Length: 496  Bit Score: 58.07  E-value: 2.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  12 QRVLSSSSATYAQVLSFLAAFgcLVMAIPAILI--GAIGASTDWNQTAYGLPDPktteeaDMILPIVLQYLCPVYISFFG 89
Cdd:cd11478  258 QRAMAAKDLSAARRTPLIAAF--PKMFIPFLVIlpGLIALVLVPELGASGGLDY------NQALPYLMAKYLPPGLLGLG 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  90 LGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVfgasATAMALLTKtvyglwYLSSDLVYIV 169
Cdd:cd11478  330 ITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDAPDKHYLKVGRIATVV----GVLISIGTA------YIASSFNNIM 399

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 170 IFPQLLCVLFV-------------KGTNTYGAVAGYVSGlflriTGGEPYLYlqplIFYPGYYPDDNGIYNQKFPFKTLA 236
Cdd:cd11478  400 DYLQLLFSFFNaplfatfllgmfwKRATPWGGFWGLLAG-----TASAIVLY----GLYELGLIVYHSDMAPNFYGAWWA 470

                        250
                 ....*....|....*.
gi 756761754 237 MVTSFLTNICISYLAK 252
Cdd:cd11478  471 FVVCFVVTVLVSLLTK 486
SLC5sbd_YidK cd10328
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ...
 8-198 4.67e-08

uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271362  Cd Length: 472  Bit Score: 54.08  E-value: 4.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   8 QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIgastdwnqtAYGLPdPKTTEEADMILPIVLQYLCPVYISF 87
Cdd:cd10328  255 QAIIQRALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGII---------AFHLY-GDGLENADMAYPTLVADVLPKWLSG 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  88 FGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMA-LLTKTVYGLWYL---SS 163
Cdd:cd10328  325 FFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKNATDKQLVKVGKIFGIVLALISMIIApFIAYAPEGLFNYlqqFN 404

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 756761754 164 DLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFL 198
Cdd:cd10328  405 GFFSIPILAIVLVGFFTKRVPALAAKIALIFGVIL 439
SLC5sbd_vSGLT cd10325
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ...
 12-198 6.37e-08

Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271360  Cd Length: 523  Bit Score: 53.85  E-value: 6.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  12 QRVLSSSSATYAQVLSFLAAFGCLVM----AIPAILIGAIGASTDwnqtaygLPDPKTTEEADMILPIVLQYLcPVYISF 87
Cdd:cd10325  261 QRALAAKSLSEAQKGIVFAAFLKLLIpfivVIPGIAAYVLASNLL-------LPAATGIEKPDQAYPWLLRNL-PTGLKG 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  88 FGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLtktvygLWYLSSDLVY 167
Cdd:cd10325  333 LVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAAVIALIIAALIAPP------LLGLDQAFQY 406

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 756761754 168 I-----VIFPQLLCV----LFVKGTNTYGAVAGYVSGLFL 198
Cdd:cd10325  407 IqeytgFISPGILAIfllgLFWKRATSAGALVAAILSIVL 446
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 8-196 7.43e-08

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 53.70  E-value: 7.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   8 QAYFQRVLSSSSATYAQVLSFLAAfgclVMAIPAILI-GAIGAS--TDWNQTAyglPDPKTTEEADMILP-IVLQYLcPV 83
Cdd:cd11495  249 QDVVQRYLTTKSIKEAKKSLWTNA----LLALPVALLfFGIGTAlyVFYQQHP---ELLPAGINGDAVFPyFIVTQL-PV 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  84 YISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRITVFVFGASATAMALL-----TKTVYGL 158
Cdd:cd11495  321 GVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYK-RLSPDPSDKQYLKVARLITLLVGLLGTLVALYlanagVKSLLDA 399

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 756761754 159 WYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGL 196
Cdd:cd11495  400 FNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSI 437
PRK10484 PRK10484
putative transporter; Provisional
 8-202 1.42e-07

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 52.96  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   8 QAYFQRVLSSSSATYAQ----VLSFLAAFGCLVMAIPAILigaigastdwnqtAYGLPdPKTTEEADMILPIVLQYLCPV 83
Cdd:PRK10484 261 QSIVQRALGAKNLAEGQkgalLAAFFKLLGPLILVLPGII-------------AFHLY-GDGLPNADMAYPTLVNDVLPV 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  84 YISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMA-LLTKTVYGLWYLS 162
Cdd:PRK10484 327 PLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINPNASEKQLVKVGKKFGFVLAIISMIVApLIANAPQGLYSYL 406

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 756761754 163 SDLVYIVIFPQLLCVL---FVKGTNTYGAVAGYVSGLFLRITG 202
Cdd:PRK10484 407 QQLNGIYNVPILAIIIvgfFTKRVPALAAKVALGFGIILYIII 449
SLC5sbd_PanF cd10327
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ...
 60-196 1.56e-06

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212037  Cd Length: 472  Bit Score: 49.51  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  60 LPDPkttEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFR--QNASDKEIVWVMRIT 137
Cdd:cd10327  295 LPDL---EVPDKVIPTLALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNkeKKTSEKKVKRISLII 371

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 756761754 138 VFVFGASATAMALLTKTVyglwylssdLVYIVIFP----------QLLCVLFVKGTNTYGAVAGYVSGL 196
Cdd:cd10327  372 TIILGLLVFLLAINPPDL---------IVWLNLFAfggleaaffwPLVLGLYWKRANATGALASMVVGL 431
PRK15419 PRK15419
sodium/proline symporter PutP;
78-149 3.50e-06

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 48.47  E-value: 3.50e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 756761754  78 QYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMA 149
Cdd:PRK15419 319 QILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGRVMVLVVALVAIALA 390
SLC5sbd_NIS-like cd10326
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
 69-213 3.40e-05

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271361 [Multi-domain]  Cd Length: 472  Bit Score: 45.24  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  69 ADMILP-IVLQYLCPVYISFFGLGAVSAAvMSSADSSILSASSMFARNIYQLSFRQN--ASDKEIVWVMRITVFVFGASA 145
Cdd:cd10326  305 SDQLFPyFALNGLPPGVSGLFVAGIIAAA-MSSADSALTALTTSFCVDILNRFKRKSekKSERKYVHIAFSLTFVLGILV 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 146 TAMALLTKTVYglwylssDLVYIV---IFPQLLCV----LFVKGTNT--YGAVAG-------YVSGLFLRITGGEPYLYL 209
Cdd:cd10326  384 FGSASNSGSLI-------DAIFKVagyTYGPLLGLfafgLFTKRAVKdkWVPLVGllapvlsYLLVSNSEGFFGYKFGFE 456


                 ....
gi 756761754 210 QPLI 213
Cdd:cd10326  457 LLII 460
SLC5sbd_SGLT6 cd11490
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ...
 8-284 3.74e-05

Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271381  Cd Length: 602  Bit Score: 45.28  E-value: 3.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   8 QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGlpDPKTTEE--------ADMILPIVLQY 79
Cdd:cd11490  263 QVIVQRSLAAKNLSHAKGGSLLAAYLKVLPLFMMVIPGMISRILFPDQVACA--DPEVCKEicgnpsgcSDIAYPKLVME 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  80 LCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYG-- 157
Cdd:cd11490  341 LLPTGLRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWR-HIRPRASEWELMIVGRVFVLVLVVVSILWIPLVQASQGgq 419

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 158 -LWYLSSDLVYI-----VIFpqlLCVLFVKGTNTYGAVAGYVSGLFLRITGGE-PYLYLQPLIfypgYYPDDNGIYNQKF 230
Cdd:cd11490  420 lFIYIQSISSYLqppvaVVF---IAGCFWKRTNEKGAFWGLMVGLAVGLTRMVlDFIYVTPQC----DQPDTRPDIVKYV 492

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 756761754 231 PFKTLAMVTSFLTNICISYLAKYlfesgTLPPKLDV---------FDAVVarhSEENMDKTIL 284
Cdd:cd11490  493 HYLYFSMILTILTLVVVVCVSLA-----TEPPSKEMisrltwftrFDAVV---ESEELKKAIL 547
SLC5sbd_SGLT4 cd11488
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ...
 8-201 2.81e-04

Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.


Pssm-ID: 271380  Cd Length: 605  Bit Score: 42.61  E-value: 2.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754   8 QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTayGLPDPKTTEE--------ADMILPIVLQY 79
Cdd:cd11488  263 QVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRALFPDEV--GCVDPDECQKicgakvgcSNIAYPKLVVE 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  80 LCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRI-TVFVFGASATAMALLTKTVYGL 158
Cdd:cd11488  341 LMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQ-RIRRRASEQELMVVGRVfILLLVVISILWIPIIQTANSGQ 419

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 756761754 159 W--YLSSDLVYIV--IFPQLLCVLFVKGTNTYGAVAGYVSGLFLRIT 201
Cdd:cd11488  420 LfdYIQAVTSYLSppITAVFILAIFWKRVNEPGAFWGLMVGLVVGLV 466
SLC5sbd_SGLT2 cd11487
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ...
 90-198 8.63e-04

Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212056 [Multi-domain]  Cd Length: 583  Bit Score: 41.06  E-value: 8.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754  90 LGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRI-TVFVFGASATAMALLTKTVYGLWYLSSDLVYI 168
Cdd:cd11487  360 LAVMLAALMSSLASIFNSSSTLFTMDIWT-RLRPQAGDKELLLVGRVwVVCIVAVSVAWIPVVQAAQGGQLFDYIQSVSS 438

                         90       100       110
                 ....*....|....*....|....*....|....
gi 756761754 169 VIFPQLLCV----LFVKGTNTYGAVAGYVSGLFL 198
Cdd:cd11487  439 YLAPPIAAVfflaLFVKRVNEPGAFWGLIGGLLM 472
PRK12488 PRK12488
cation/acetate symporter;
106-197 3.65e-03

cation/acetate symporter;


Pssm-ID: 237114 [Multi-domain]  Cd Length: 549  Bit Score: 39.01  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761754 106 LSASSMFARNIYQLSFRQ-NASDKEIVWVMRITVFVFGASATAMALL--TKTVYGLWYLSSDLVYIVIFPQLLCVLFVKG 182
Cdd:PRK12488 376 LSGASAVSHDLYACVIRKgQASEAQEMRVSKIATLGIGLLAVVLGLMfeSQNIAFLSGLVLAIAASVNFPVLFLSMFWKG 455

                         90
                 ....*....|....*
gi 756761754 183 TNTYGAVAGYVSGLF 197
Cdd:PRK12488 456 LTTRGAVAGSYAGLV 470
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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