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Conserved domains on  [gi|770478883|ref|NP_001292510|]
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leucine-rich melanocyte differentiation-associated protein isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 705725)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_9 super family cl25994
Leucine-rich repeat;
36-159 1.37e-15

Leucine-rich repeat;


The actual alignment was detected with superfamily member pfam14580:

Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 71.72  E-value: 1.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883   36 LDLSFNLLRSLEGLSAFRSLEELILDNNQL---GDDLVlPGLPRLHTLTLNKNRITDLENLlDHLAEVtPALEYLSLLGN 112
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRIcriGEGLG-EALPNLTELILTNNNLQELGDL-DPLASL-KKLTFLSLLRN 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 770478883  113 VacpnelVSLEKDeedykrYRCFVLYKLPNLKFLDAQKVTRQEREEA 159
Cdd:pfam14580 124 P------VTNKPH------YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
36-159 1.37e-15

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 71.72  E-value: 1.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883   36 LDLSFNLLRSLEGLSAFRSLEELILDNNQL---GDDLVlPGLPRLHTLTLNKNRITDLENLlDHLAEVtPALEYLSLLGN 112
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRIcriGEGLG-EALPNLTELILTNNNLQELGDL-DPLASL-KKLTFLSLLRN 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 770478883  113 VacpnelVSLEKDeedykrYRCFVLYKLPNLKFLDAQKVTRQEREEA 159
Cdd:pfam14580 124 P------VTNKPH------YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-147 1.51e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883  34 KRLDLSFNLLRSL-EGLSAFRSLEELILDNNQLGD-DLVLPGLPRLHTLTLNKNRITDLENLLDHLaevtPALEYLSLLG 111
Cdd:COG4886  116 ESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDlPEPLGNLTNLKSLDLSNNQLTDLPEELGNL----TNLKELDLSN 191

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 770478883 112 nvacpNELVSLEKdeedykryrcfVLYKLPNLKFLD 147
Cdd:COG4886  192 -----NQITDLPE-----------PLGNLTNLEELD 211
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 34-157 1.87e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883  34 KRLDLSFNLLRSLEGLSAFRSLEELILDNNQLGDDLVLPGLPR--------LHTLTLNKNRITDLE-------------- 91
Cdd:cd21340   71 KKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLTFDPRslaalsnsLRVLNISGNNIDSLEplaplrnleqldas 150

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 770478883  92 -NLLDHLAEVT------PALEYLSLLGNVACPNelvslekdeedyKRYRCFVLYKLPNLKFLDAQKVTRQERE 157
Cdd:cd21340  151 nNQISDLEELLdllsswPSLRELDLTGNPVCKK------------PKYRDKIILASKSLEVLDGKEITDTERQ 211
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
36-159 1.37e-15

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 71.72  E-value: 1.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883   36 LDLSFNLLRSLEGLSAFRSLEELILDNNQL---GDDLVlPGLPRLHTLTLNKNRITDLENLlDHLAEVtPALEYLSLLGN 112
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRIcriGEGLG-EALPNLTELILTNNNLQELGDL-DPLASL-KKLTFLSLLRN 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 770478883  113 VacpnelVSLEKDeedykrYRCFVLYKLPNLKFLDAQKVTRQEREEA 159
Cdd:pfam14580 124 P------VTNKPH------YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-147 1.51e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883  34 KRLDLSFNLLRSL-EGLSAFRSLEELILDNNQLGD-DLVLPGLPRLHTLTLNKNRITDLENLLDHLaevtPALEYLSLLG 111
Cdd:COG4886  116 ESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDlPEPLGNLTNLKSLDLSNNQLTDLPEELGNL----TNLKELDLSN 191

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 770478883 112 nvacpNELVSLEKdeedykryrcfVLYKLPNLKFLD 147
Cdd:COG4886  192 -----NQITDLPE-----------PLGNLTNLEELD 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-147 2.73e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 2.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883  34 KRLDLSFNLLRSL-EGLSAFRSLEELILDNNQLGD-DLVLPGLPRLHTLTLNKNRITDLENLLDHLaevtPALEYLSLLG 111
Cdd:COG4886  162 KSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDlPEPLGNLTNLEELDLSGNQLTDLPEPLANL----TNLETLDLSN 237

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 770478883 112 nvacpNELVSLEKdeedykryrcfvLYKLPNLKFLD 147
Cdd:COG4886  238 -----NQLTDLPE------------LGNLTNLEELD 256
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-129 1.31e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 1.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883  34 KRLDLSFNLLRSLEGLSAFRSLEELILDNNQLGDDLVLPGLPRLHTLTLNKNRITD--LENLLDHLAEVTPALEYLSLLG 111
Cdd:COG4886  231 ETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNL 310

                         90
                 ....*....|....*...
gi 770478883 112 NVACPNELVSLEKDEEDY 129
Cdd:COG4886  311 LELLILLLLLTTLLLLLL 328
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 34-157 1.87e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883  34 KRLDLSFNLLRSLEGLSAFRSLEELILDNNQLGDDLVLPGLPR--------LHTLTLNKNRITDLE-------------- 91
Cdd:cd21340   71 KKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLTFDPRslaalsnsLRVLNISGNNIDSLEplaplrnleqldas 150

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 770478883  92 -NLLDHLAEVT------PALEYLSLLGNVACPNelvslekdeedyKRYRCFVLYKLPNLKFLDAQKVTRQERE 157
Cdd:cd21340  151 nNQISDLEELLdllsswPSLRELDLTGNPVCKK------------PKYRDKIILASKSLEVLDGKEITDTERQ 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-147 2.99e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883  34 KRLDLSFNLLRSL-EGLSAFRSLEELILDNNQLGDDLVLPGLPRLHTLTLNKNRITDLENLLDhlaevTPALEYLSLLGN 112
Cdd:COG4886  208 EELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN-----LTNLKTLDLSNN 282

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 770478883 113 VACPNELVSLEKDEEDYKRYRCFVLYKLPNLKFLD 147
Cdd:COG4886  283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 41-99 7.88e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 7.88e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 770478883  41 NLLRSLEGLSAFRSLEELILDNNQLGDDLVLPGLPRLHTLTLNKNRITDLENL--LDHLAE 99
Cdd:cd21340   34 NKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLenLTNLEE 94
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 54-93 1.90e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 1.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 770478883   54 SLEELILDNNQLGDDLVLPGLPRLHTLTL-NKNRITDLENL 93
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDL 42
LRR_8 pfam13855
Leucine rich repeat;
53-112 3.42e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 3.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 770478883   53 RSLEELILDNNQLG--DDLVLPGLPRLHTLTLNKNRITDLE-NLLDHLaevtPALEYLSLLGN 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTslDDGAFKGLSNLKVLDLSNNLLTTLSpGAFSGL----PSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 27-113 5.56e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 5.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883  27 RDCGHFAKRLDLSFNLLRS------LEGLSAFRSLEELILDNNQLGDDLV------LPGLPRLHTLTLNKNRITDLE-NL 93
Cdd:cd00116  133 KDLPPALEKLVLGRNRLEGascealAKALRANRDLKELNLANNGIGDAGIralaegLKANCNLEVLDLNNNGLTDEGaSA 212

                         90       100
                 ....*....|....*....|
gi 770478883  94 LDHLAEVTPALEYLSLLGNV 113
Cdd:cd00116  213 LAETLASLKSLEVLNLGDNN 232
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 4-112 7.15e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 7.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478883   4 LVVRGTQVSYIGQDcrEIPEHLGRDCGHFAKR---------LDLSFNLLrSLEGLSAF-------RSLEELILDNNQLGD 67
Cdd:COG5238  146 VLKDPLGGNAVHLL--GLAARLGLLAAISMAKalqnnsvetVYLGCNQI-GDEGIEELaealtqnTTVTTLWLKRNPIGD 222

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 770478883  68 D------LVLPGLPRLHTLTLNKNRITD--LENLLDHLAEVTpALEYLSLLGN 112
Cdd:COG5238  223 EgaeilaEALKGNKSLTTLDLSNNQIGDegVIALAEALKNNT-TVETLYLSGN 274
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 34-69 2.96e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 2.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 770478883   34 KRLDLSFNLLRSLEGLSAFRSLEELILDNNQLGDDL 69
Cdd:pfam12799   4 EVLDLSNNQITDIPPLAKLPNLETLDLSGNNKITDL 39
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 75-112 6.67e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 6.67e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 770478883   75 PRLHTLTLNKNRITDLENLldhlaEVTPALEYLSLLGN 112
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPL-----AKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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