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Conserved domains on  [gi|874507485|ref|NP_001297256|]
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putative transferase CAF17, mitochondrial isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ygfZ_signature TIGR03317
folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the ...
 24-91 1.64e-30

folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the glycine cleavage system T protein, or aminomethyltransferase, GcvT (TIGR00528). Homologs of YgfZ other than members of the GcvT family share a well-conserved signature region that includes the motif, KGCYxGQE. Elsewhere, sequence diverge and length variation are substantial. Members of this family are mostly bacterial, largely absent from the Firmicutes and otherwise usually present. A few eukaryotic examples are found among the Apicomplexa, and a few archaeal sequences are found. Two functions implicated for this folate-binding protein are RNA modification (a function likely to be conserved) and replication initiation (a function likely to be highly variable). Many members of this family are, at the time of construction of this model, misnamed as the glycine cleavage system T protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


:

Pssm-ID: 274518 [Multi-domain]  Cd Length: 67  Bit Score: 105.32  E-value: 1.64e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 874507485   24 WDYHQHRYLQGVPEGVRDLPpGVALPLESNLAFMNGVSFTKGCYIGQELTARTHHMGVIRKRLFPVRF 91
Cdd:TIGR03317   1 EAWELLRIAAGIPEGGAETS-GEFIPQELNLDALGGVSFDKGCYVGQEVVARMHYRGKVKRRLVPLSL 67
YgfZ super family cl33847
Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational ...
 1-151 1.21e-28

Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG0354:

Pssm-ID: 440123 [Multi-domain]  Cd Length: 317  Bit Score: 107.28  E-value: 1.21e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874507485   1 MGWRLLTQDEG-----PALVPGGRLGDLWDYHQHRYLQGVPEGVRDLPPGvALPLESNLAFMNGVSFTKGCYIGQELTAR 75
Cdd:COG0354  153 PGYLLIVPAAAaaalwEALAAGAAPAGSAAWEALRIAAGIPRIGADTDED-FIPQELNLDALGGVSFKKGCYPGQETVAR 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874507485  76 THHMGVIRKRLFPVRF-LDPLPTSGitpgaTVLTASGQTVGK-----FRAGQGNVGLALL--WSEKIKGPLHIRASEGAQ 147
Cdd:COG0354  232 MHYRGKVKRRLVLLHLdGSALPAPG-----TELLAGGRPVGTvtsaaRHPEGGPIALAVLrrDAADAGAELRVGGAAATV 306


                 ....
gi 874507485 148 VALA 151
Cdd:COG0354  307 IVLP 310
 
Name Accession Description Interval E-value
ygfZ_signature TIGR03317
folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the ...
 24-91 1.64e-30

folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the glycine cleavage system T protein, or aminomethyltransferase, GcvT (TIGR00528). Homologs of YgfZ other than members of the GcvT family share a well-conserved signature region that includes the motif, KGCYxGQE. Elsewhere, sequence diverge and length variation are substantial. Members of this family are mostly bacterial, largely absent from the Firmicutes and otherwise usually present. A few eukaryotic examples are found among the Apicomplexa, and a few archaeal sequences are found. Two functions implicated for this folate-binding protein are RNA modification (a function likely to be conserved) and replication initiation (a function likely to be highly variable). Many members of this family are, at the time of construction of this model, misnamed as the glycine cleavage system T protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274518 [Multi-domain]  Cd Length: 67  Bit Score: 105.32  E-value: 1.64e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 874507485   24 WDYHQHRYLQGVPEGVRDLPpGVALPLESNLAFMNGVSFTKGCYIGQELTARTHHMGVIRKRLFPVRF 91
Cdd:TIGR03317   1 EAWELLRIAAGIPEGGAETS-GEFIPQELNLDALGGVSFDKGCYVGQEVVARMHYRGKVKRRLVPLSL 67
YgfZ COG0354
Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational ...
 1-151 1.21e-28

Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440123 [Multi-domain]  Cd Length: 317  Bit Score: 107.28  E-value: 1.21e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874507485   1 MGWRLLTQDEG-----PALVPGGRLGDLWDYHQHRYLQGVPEGVRDLPPGvALPLESNLAFMNGVSFTKGCYIGQELTAR 75
Cdd:COG0354  153 PGYLLIVPAAAaaalwEALAAGAAPAGSAAWEALRIAAGIPRIGADTDED-FIPQELNLDALGGVSFKKGCYPGQETVAR 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874507485  76 THHMGVIRKRLFPVRF-LDPLPTSGitpgaTVLTASGQTVGK-----FRAGQGNVGLALL--WSEKIKGPLHIRASEGAQ 147
Cdd:COG0354  232 MHYRGKVKRRLVLLHLdGSALPAPG-----TELLAGGRPVGTvtsaaRHPEGGPIALAVLrrDAADAGAELRVGGAAATV 306


                 ....
gi 874507485 148 VALA 151
Cdd:COG0354  307 IVLP 310
PRK09559 PRK09559
putative global regulator; Reviewed
 48-87 3.46e-06

putative global regulator; Reviewed


Pssm-ID: 236567 [Multi-domain]  Cd Length: 327  Bit Score: 45.44  E-value: 3.46e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 874507485  48 LPLESNLAFMNGVSFTKGCYIGQELTARTHHMGVIRKRLF 87
Cdd:PRK09559 210 IPQATNLQALGGISFKKGCYTGQEMVARAKFRGANKRALW 249
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 49-129 1.04e-03

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 38.14  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874507485  49 PLESNLAFMngVSFTKGCYIGQELTARTHHMGViRKRLFPVRFLDPLPtsgITPGATVLtASGQTVGKFRAG------QG 122
Cdd:COG0404  254 PLEAGLGWA--VKLDKGDFIGKEALLRQKEEGP-RRKLVGLELDGRGV---PRAGAPVL-ADGEVVGEVTSGtfsptlGK 326


                 ....*..
gi 874507485 123 NVGLALL 129
Cdd:COG0404  327 SIALAYV 333
 
Name Accession Description Interval E-value
ygfZ_signature TIGR03317
folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the ...
 24-91 1.64e-30

folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the glycine cleavage system T protein, or aminomethyltransferase, GcvT (TIGR00528). Homologs of YgfZ other than members of the GcvT family share a well-conserved signature region that includes the motif, KGCYxGQE. Elsewhere, sequence diverge and length variation are substantial. Members of this family are mostly bacterial, largely absent from the Firmicutes and otherwise usually present. A few eukaryotic examples are found among the Apicomplexa, and a few archaeal sequences are found. Two functions implicated for this folate-binding protein are RNA modification (a function likely to be conserved) and replication initiation (a function likely to be highly variable). Many members of this family are, at the time of construction of this model, misnamed as the glycine cleavage system T protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274518 [Multi-domain]  Cd Length: 67  Bit Score: 105.32  E-value: 1.64e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 874507485   24 WDYHQHRYLQGVPEGVRDLPpGVALPLESNLAFMNGVSFTKGCYIGQELTARTHHMGVIRKRLFPVRF 91
Cdd:TIGR03317   1 EAWELLRIAAGIPEGGAETS-GEFIPQELNLDALGGVSFDKGCYVGQEVVARMHYRGKVKRRLVPLSL 67
YgfZ COG0354
Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational ...
 1-151 1.21e-28

Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440123 [Multi-domain]  Cd Length: 317  Bit Score: 107.28  E-value: 1.21e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874507485   1 MGWRLLTQDEG-----PALVPGGRLGDLWDYHQHRYLQGVPEGVRDLPPGvALPLESNLAFMNGVSFTKGCYIGQELTAR 75
Cdd:COG0354  153 PGYLLIVPAAAaaalwEALAAGAAPAGSAAWEALRIAAGIPRIGADTDED-FIPQELNLDALGGVSFKKGCYPGQETVAR 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874507485  76 THHMGVIRKRLFPVRF-LDPLPTSGitpgaTVLTASGQTVGK-----FRAGQGNVGLALL--WSEKIKGPLHIRASEGAQ 147
Cdd:COG0354  232 MHYRGKVKRRLVLLHLdGSALPAPG-----TELLAGGRPVGTvtsaaRHPEGGPIALAVLrrDAADAGAELRVGGAAATV 306


                 ....
gi 874507485 148 VALA 151
Cdd:COG0354  307 IVLP 310
PRK09559 PRK09559
putative global regulator; Reviewed
 48-87 3.46e-06

putative global regulator; Reviewed


Pssm-ID: 236567 [Multi-domain]  Cd Length: 327  Bit Score: 45.44  E-value: 3.46e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 874507485  48 LPLESNLAFMNGVSFTKGCYIGQELTARTHHMGVIRKRLF 87
Cdd:PRK09559 210 IPQATNLQALGGISFKKGCYTGQEMVARAKFRGANKRALW 249
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 49-129 1.04e-03

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 38.14  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874507485  49 PLESNLAFMngVSFTKGCYIGQELTARTHHMGViRKRLFPVRFLDPLPtsgITPGATVLtASGQTVGKFRAG------QG 122
Cdd:COG0404  254 PLEAGLGWA--VKLDKGDFIGKEALLRQKEEGP-RRKLVGLELDGRGV---PRAGAPVL-ADGEVVGEVTSGtfsptlGK 326


                 ....*..
gi 874507485 123 NVGLALL 129
Cdd:COG0404  327 SIALAYV 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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