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Conserved domains on  [gi|881717124|ref|NP_001297391|]
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sonic hedgehog protein isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HH_signal super family cl03090
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 12-97 1.95e-68

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


The actual alignment was detected with superfamily member pfam01085:

Pssm-ID: 460055  Cd Length: 161  Bit Score: 205.30  E-value: 1.95e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881717124   12 SSRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESK 91
Cdd:pfam01085  76 TKRCKDKLNILAILVMNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESR 155


                  ....*.
gi 881717124   92 AHIHCS 97
Cdd:pfam01085 156 AHIHCS 161
 
Name Accession Description Interval E-value
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 12-97 1.95e-68

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 205.30  E-value: 1.95e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881717124   12 SSRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESK 91
Cdd:pfam01085  76 TKRCKDKLNILAILVMNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESR 155


                  ....*.
gi 881717124   92 AHIHCS 97
Cdd:pfam01085 156 AHIHCS 161
 
Name Accession Description Interval E-value
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 12-97 1.95e-68

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 205.30  E-value: 1.95e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881717124   12 SSRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESK 91
Cdd:pfam01085  76 TKRCKDKLNILAILVMNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESR 155


                  ....*.
gi 881717124   92 AHIHCS 97
Cdd:pfam01085 156 AHIHCS 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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