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Conserved domains on  [gi|937834186|ref|NP_001303235|]
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integrin alpha-6 isoform c [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192641)

integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 346-820 1.11e-174

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 514.95  E-value: 1.11e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  346 RPVINIQKTITVTPNRIDLRQKTaCGAPSG--ICLQVKSCFEYTANPAgYNPSISIVGTLEAEKERRKsGLSSRVQFrNQ 423
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  424 GSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSDEPKTAHIDVHFL 503
Cdd:pfam08441  77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  504 KEgCGDDNVCNSNLKLEYKFCTREGNqdkfsylpiqkgvPELVLKDQKDIALEITVTNspsnprnptkDGDDAHEAKLIA 583
Cdd:pfam08441 155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  584 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQD 661
Cdd:pfam08441 211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  662 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPltNLGTATLNIQWPK 738
Cdd:pfam08441 289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  739 EISNGKWLLYLVKVEskGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQT----LNCSVNVN 814
Cdd:pfam08441 366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                  ....*.
gi 937834186  815 CVNIRC 820
Cdd:pfam08441 444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 255-306 6.17e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 69.71  E-value: 6.17e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 937834186   255 DSMFGIAVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSANGINTKPTQVL 306
Cdd:smart00191   2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 195-248 4.91e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 4.91e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 937834186   195 SSFGYDVA-VVDLNKDGWQDIVIGAPQYFdrDGEVGGAVYVYMNQQ--GRWNNVKPI 248
Cdd:smart00191   3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSggGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 135-187 3.19e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 39.67  E-value: 3.19e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 937834186   135 MNSYLGFSLDSGkGIVSKDEIT-FVSGAPRANHS---GAVVLLKRDMKSAHLLPEHI 187
Cdd:smart00191   1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVYFGSSGGGNSIPLQN 56
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 919-933 2.37e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


:

Pssm-ID: 459778  Cd Length: 15  Bit Score: 35.94  E-value: 2.37e-03
                          10
                  ....*....|....*
gi 937834186  919 KCGFFKRNKKDHYDA 933
Cdd:pfam00357   1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 312-335 2.40e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.40e-03
                           10        20
                   ....*....|....*....|....
gi 937834186   312 YFGYSIAGNMDLDRNSYPDVAVGS 335
Cdd:smart00191   4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 346-820 1.11e-174

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 514.95  E-value: 1.11e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  346 RPVINIQKTITVTPNRIDLRQKTaCGAPSG--ICLQVKSCFEYTANPAgYNPSISIVGTLEAEKERRKsGLSSRVQFrNQ 423
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  424 GSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSDEPKTAHIDVHFL 503
Cdd:pfam08441  77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  504 KEgCGDDNVCNSNLKLEYKFCTREGNqdkfsylpiqkgvPELVLKDQKDIALEITVTNspsnprnptkDGDDAHEAKLIA 583
Cdd:pfam08441 155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  584 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQD 661
Cdd:pfam08441 211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  662 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPltNLGTATLNIQWPK 738
Cdd:pfam08441 289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  739 EISNGKWLLYLVKVEskGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQT----LNCSVNVN 814
Cdd:pfam08441 366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                  ....*.
gi 937834186  815 CVNIRC 820
Cdd:pfam08441 444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 255-306 6.17e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 69.71  E-value: 6.17e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 937834186   255 DSMFGIAVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSANGINTKPTQVL 306
Cdd:smart00191   2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 195-248 4.91e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 4.91e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 937834186   195 SSFGYDVA-VVDLNKDGWQDIVIGAPQYFdrDGEVGGAVYVYMNQQ--GRWNNVKPI 248
Cdd:smart00191   3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSggGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 197-235 7.02e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 7.02e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 937834186  197 FGYDVAVVDLNKDGWQDIVIGAPQYFDRDgevGGAVYVY 235
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 258-291 3.76e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 44.42  E-value: 3.76e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 937834186  258 FGIAVkNIGDINQDGYPDIAVGAPYDDL---GKVFIY 291
Cdd:pfam01839   1 FGYSV-AVGDLNGDGYADLAVGAPGEGGagaGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 135-187 3.19e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 39.67  E-value: 3.19e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 937834186   135 MNSYLGFSLDSGkGIVSKDEIT-FVSGAPRANHS---GAVVLLKRDMKSAHLLPEHI 187
Cdd:smart00191   1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVYFGSSGGGNSIPLQN 56
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 919-933 2.37e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 35.94  E-value: 2.37e-03
                          10
                  ....*....|....*
gi 937834186  919 KCGFFKRNKKDHYDA 933
Cdd:pfam00357   1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 312-335 2.40e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.40e-03
                           10        20
                   ....*....|....*....|....
gi 937834186   312 YFGYSIAGNMDLDRNSYPDVAVGS 335
Cdd:smart00191   4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 346-820 1.11e-174

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 514.95  E-value: 1.11e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  346 RPVINIQKTITVTPNRIDLRQKTaCGAPSG--ICLQVKSCFEYTANPAgYNPSISIVGTLEAEKERRKsGLSSRVQFrNQ 423
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  424 GSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSDEPKTAHIDVHFL 503
Cdd:pfam08441  77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  504 KEgCGDDNVCNSNLKLEYKFCTREGNqdkfsylpiqkgvPELVLKDQKDIALEITVTNspsnprnptkDGDDAHEAKLIA 583
Cdd:pfam08441 155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  584 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQD 661
Cdd:pfam08441 211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  662 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPltNLGTATLNIQWPK 738
Cdd:pfam08441 289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937834186  739 EISNGKWLLYLVKVEskGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQT----LNCSVNVN 814
Cdd:pfam08441 366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                  ....*.
gi 937834186  815 CVNIRC 820
Cdd:pfam08441 444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 255-306 6.17e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 69.71  E-value: 6.17e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 937834186   255 DSMFGIAVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSANGINTKPTQVL 306
Cdd:smart00191   2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 195-248 4.91e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 4.91e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 937834186   195 SSFGYDVA-VVDLNKDGWQDIVIGAPQYFdrDGEVGGAVYVYMNQQ--GRWNNVKPI 248
Cdd:smart00191   3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSggGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 197-235 7.02e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 7.02e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 937834186  197 FGYDVAVVDLNKDGWQDIVIGAPQYFDRDgevGGAVYVY 235
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 205-278 4.10e-08

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 50.69  E-value: 4.10e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 937834186  205 DLNKDGWQDIVIGAPqyfdrdgevgGAVYVY-MNQQGRWNNVKPIRLNGTKDSMfGIAVkniGDINQDGYPDIAV 278
Cdd:pfam13517   1 DLDGDGKLDLVVAND----------GGLRLYlNNGDGTFTFITSVSLGGGGGGL-SVAV---GDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 258-291 3.76e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 44.42  E-value: 3.76e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 937834186  258 FGIAVkNIGDINQDGYPDIAVGAPYDDL---GKVFIY 291
Cdd:pfam01839   1 FGYSV-AVGDLNGDGYADLAVGAPGEGGagaGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 267-333 2.23e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.98  E-value: 2.23e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 937834186  267 DINQDGYPDIAVGAPyddlGKVFIYHGSANGINTKPTQVL-----KGISPYFGysiagnmDLDRNSYPDVAV 333
Cdd:pfam13517   1 DLDGDGKLDLVVAND----GGLRLYLNNGDGTFTFITSVSlggggGGLSVAVG-------DLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 135-187 3.19e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 39.67  E-value: 3.19e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 937834186   135 MNSYLGFSLDSGkGIVSKDEIT-FVSGAPRANHS---GAVVLLKRDMKSAHLLPEHI 187
Cdd:smart00191   1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVYFGSSGGGNSIPLQN 56
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 919-933 2.37e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 35.94  E-value: 2.37e-03
                          10
                  ....*....|....*
gi 937834186  919 KCGFFKRNKKDHYDA 933
Cdd:pfam00357   1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 312-335 2.40e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.40e-03
                           10        20
                   ....*....|....*....|....
gi 937834186   312 YFGYSIAGNMDLDRNSYPDVAVGS 335
Cdd:smart00191   4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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