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Conserved domains on  [gi|975830145|ref|NP_001305963|]
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desmoplakin isoform Ia [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 548-625 7.01e-36

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


:

Pssm-ID: 465730  Cd Length: 78  Bit Score: 131.57  E-value: 7.01e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 975830145   548 VSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQ 625
Cdd:pfam18373    1 VSWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 447-513 1.44e-26

SH3 domain; This entry represents an SH3 domain.


:

Pssm-ID: 407754  Cd Length: 65  Bit Score: 104.27  E-value: 1.44e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 975830145   447 QLKPRNpdYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIP 513
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1018-1501 6.50e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 87.38  E-value: 6.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1018 SEMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFL------DQNLQKYQAECSQFKAKLASLEELKRQAELDG 1090
Cdd:TIGR04523  103 SDLSKINSEIKNDKEQKNKLEVELnKLEKQKKENKKNIDKFLteikkkEKELEKLNNKYNDLKKQKEELENELNLLEKEK 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1091 KSAKQNLDKCYGQ----------IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLES 1160
Cdd:TIGR04523  183 LNIQKNIDKIKNKllklelllsnLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQ 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1161 EKAIK---EKEYEIERLRVLLqeegtrkreyeNELAKVRNHYNEEMSNLRNKYETEINitkTTIKEISMQKEDDSKNLRN 1237
Cdd:TIGR04523  263 NKIKKqlsEKQKELEQNNKKI-----------KELEKQLNQLKSEISDLNNQKEQDWN---KELKSELKNQEKKLEEIQN 328

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1238 QLDRLSRENRDLKDEIvrlndSILQATEQRRRAEENALQQkacgsEIMQKKQHLEIELKQvmqqrsedNARHKQSLEEAA 1317
Cdd:TIGR04523  329 QISQNNKIISQLNEQI-----SQLKKELTNSESENSEKQR-----ELEEKQNEIEKLKKE--------NQSYKQEIKNLE 390

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1318 KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAK 1397
Cdd:TIGR04523  391 SQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQL 470

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1398 STLEAETR-VKQRLECEKQQIQ---NDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEErcrRK 1473
Cdd:TIGR04523  471 KVLSRSINkIKQNLEQKQKELKskeKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLED---EL 547

                          490       500
                   ....*....|....*....|....*...
gi 975830145  1474 LEDSTRETQSQLETERSRYQREIDKLRQ 1501
Cdd:TIGR04523  548 NKDDFELKKENLEKEIDEKNKEIEELKQ 575
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2207-2245 3.77e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 71.20  E-value: 3.77e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  2207 LLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2245
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1848-1886 7.75e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 70.05  E-value: 7.75e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1848 LLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKL 1886
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1924-1962 1.38e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 69.28  E-value: 1.38e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1924 LLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEIL 1962
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1681-1719 9.90e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 64.27  E-value: 9.90e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1681 LLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSL 1719
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1605-1643 2.12e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 63.12  E-value: 2.12e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1605 LLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQI 1643
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 285-450 2.99e-12

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


:

Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 68.24  E-value: 2.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  285 WINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQI 364
Cdd:cd00176    15 WLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELREL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  365 TKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKErekILEYKRQVQNLVNKSKK 444
Cdd:cd00176    95 AEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEE---LEAHEPRLKSLNELAEE 171


                  ....*.
gi 975830145  445 IVQLKP 450
Cdd:cd00176   172 LLEEGH 177
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2283-2321 4.19e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 56.57  E-value: 4.19e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  2283 FLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRL 2321
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 190-366 5.24e-08

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


:

Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 55.91  E-value: 5.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  190 ECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA---DLREKSAIY---------QLEEEYEN 257
Cdd:cd00176    11 ELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNElgeQLIEEGHPDaeeiqerleELNQRWEE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  258 LLKASFERMDHL---RQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESD 334
Cdd:cd00176    91 LRELAEERRQRLeeaLDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSLNELAE 170

                         170       180       190
                  ....*....|....*....|....*....|...
gi 975830145  335 QLVLNQHPAS-DKIEAYMDTLQTQWSWILQITK 366
Cdd:cd00176   171 ELLEEGHPDAdEEIEEKLEELNERWEELLELAE 203
PLEC smart00250
Plectin repeat;
1641-1678 1.70e-07

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 49.40  E-value: 1.70e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 975830145   1641 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETG 1678
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2025-2053 2.31e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 48.86  E-value: 2.31e-07
                           10        20
                   ....*....|....*....|....*....
gi 975830145  2025 IVDPETNKEMSVQEAYKKGLIDYETFKEL 2053
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
1808-1845 1.25e-06

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.71  E-value: 1.25e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 975830145   1808 KDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTA 1845
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
1885-1921 9.21e-06

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.40  E-value: 9.21e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 975830145   1885 KLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHG 1921
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2168-2204 5.66e-05

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 42.08  E-value: 5.66e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 975830145   2168 DTLEESSPIAAIFDTENLEKISITEGIERGIVDSITG 2204
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PRK01156 super family cl30905
chromosome segregation protein; Provisional
 707-1281 2.30e-04

chromosome segregation protein; Provisional


The actual alignment was detected with superfamily member PRK01156:

Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  707 NELKSVQND----SQAIAEVLNQLKDMLANF-RGSEKYCYLQNEVFGLFQKLENINGVTD---GYLNSLCTVRALLQAIL 778
Cdd:PRK01156  190 EKLKSSNLEleniKKQIADDEKSHSITLKEIeRLSIEYNNAMDDYNNLKSALNELSSLEDmknRYESEIKTAESDLSMEL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  779 QTEDMLKVYEARLTEEETvcldlDKVEAYR---CGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSqqyplydlDLGK 855
Cdd:PRK01156  270 EKNNYYKELEERHMKIIN-----DPVYKNRnyiNDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLS--------VLQK 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  856 fgekvtqltDRWQRIDKQIdfRLWDLEKQIKQLRNYRDNYQAFCKwlydakrrqdSLESMKFGDSNtvmrFLNEQKNLHS 935
Cdd:PRK01156  337 ---------DYNDYIKKKS--RYDDLNNQILELEGYEMDYNSYLK----------SIESLKKKIEE----YSKNIERMSA 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  936 EISGKRDKS----EEVQKIAELCANSIKDYELQLASYTSGLETLLN--IPIKRTM-IQSPSGVILQEAADVHARYIELLT 1008
Cdd:PRK01156  392 FISEILKIQeidpDAIKKELNEINVKLQDISSKVSSLNQRIRALREnlDELSRNMeMLNGQSVCPVCGTTLGEEKSNHII 471

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1009 RsgDYYrflsemlkslEDLKLKNTKIEVLEEElrlARDANSENCNKNKFLD----QNLQKYQAECSQFKAKLASLEELK- 1083
Cdd:PRK01156  472 N--HYN----------EKKSRLEEKIREIEIE---VKDIDEKIVDLKKRKEylesEEINKSINEYNKIESARADLEDIKi 536

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1084 RQAELDGKSAKQNldkcygqikELNEKITRLTYEIEDEKR----RRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLE 1159
Cdd:PRK01156  537 KINELKDKHDKYE---------EIKNRYKSLKLEDLDSKRtswlNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIE 607

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1160 S---------EKAIKEKEYEIERLRVLLQEEGTRKREYEnELAKVRNHYNEEMSNLRnkyetEINITKTTIKEISMQKED 1230
Cdd:PRK01156  608 IgfpddksyiDKSIREIENEANNLNNKYNEIQENKILIE-KLRGKIDNYKKQIAEID-----SIIPDLKEITSRINDIED 681

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 975830145 1231 DSKNLRNQLD-------RLSRENRDLKDEIVRLNDSIlqaTEQRRRAEENALQQKACG 1281
Cdd:PRK01156  682 NLKKSRKALDdakanraRLESTIEILRTRINELSDRI---NDINETLESMKKIKKAIG 736
PLEC smart00250
Plectin repeat;
2319-2356 2.67e-03

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 2.67e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 975830145   2319 QRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG 2356
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
 
Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 548-625 7.01e-36

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


Pssm-ID: 465730  Cd Length: 78  Bit Score: 131.57  E-value: 7.01e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 975830145   548 VSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQ 625
Cdd:pfam18373    1 VSWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 447-513 1.44e-26

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 104.27  E-value: 1.44e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 975830145   447 QLKPRNpdYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIP 513
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1018-1501 6.50e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 87.38  E-value: 6.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1018 SEMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFL------DQNLQKYQAECSQFKAKLASLEELKRQAELDG 1090
Cdd:TIGR04523  103 SDLSKINSEIKNDKEQKNKLEVELnKLEKQKKENKKNIDKFLteikkkEKELEKLNNKYNDLKKQKEELENELNLLEKEK 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1091 KSAKQNLDKCYGQ----------IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLES 1160
Cdd:TIGR04523  183 LNIQKNIDKIKNKllklelllsnLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQ 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1161 EKAIK---EKEYEIERLRVLLqeegtrkreyeNELAKVRNHYNEEMSNLRNKYETEINitkTTIKEISMQKEDDSKNLRN 1237
Cdd:TIGR04523  263 NKIKKqlsEKQKELEQNNKKI-----------KELEKQLNQLKSEISDLNNQKEQDWN---KELKSELKNQEKKLEEIQN 328

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1238 QLDRLSRENRDLKDEIvrlndSILQATEQRRRAEENALQQkacgsEIMQKKQHLEIELKQvmqqrsedNARHKQSLEEAA 1317
Cdd:TIGR04523  329 QISQNNKIISQLNEQI-----SQLKKELTNSESENSEKQR-----ELEEKQNEIEKLKKE--------NQSYKQEIKNLE 390

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1318 KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAK 1397
Cdd:TIGR04523  391 SQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQL 470

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1398 STLEAETR-VKQRLECEKQQIQ---NDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEErcrRK 1473
Cdd:TIGR04523  471 KVLSRSINkIKQNLEQKQKELKskeKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLED---EL 547

                          490       500
                   ....*....|....*....|....*...
gi 975830145  1474 LEDSTRETQSQLETERSRYQREIDKLRQ 1501
Cdd:TIGR04523  548 NKDDFELKKENLEKEIDEKNKEIEELKQ 575
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1002-1499 2.49e-16

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 85.89  E-value: 2.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
Cdd:PRK03918  180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEE 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1082 LKRQAELDGKSAKQNLDKCYGQIKELNE---------KITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKEN 1152
Cdd:PRK03918  260 KIRELEERIEELKKEIEELEEKVKELKElkekaeeyiKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEER 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1153 LGWQKLESEK------AIKEKEYEIERLRVLLQE-EGTRKREYENELAKVRNHYnEEMSNLRNKYETEINITKTTIKEIS 1225
Cdd:PRK03918  340 LEELKKKLKElekrleELEERHELYEEAKAKKEElERLKKRLTGLTPEKLEKEL-EELEKAKEEIEEEISKITARIGELK 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1226 MQKEDDSKNL----------------------RNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGS- 1282
Cdd:PRK03918  419 KEIKELKKAIeelkkakgkcpvcgrelteehrKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKl 498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1283 -EIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAA-------KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNR 1354
Cdd:PRK03918  499 kELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLiklkgeiKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKE 578

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1355 IQESKNQCTQVVQER----ESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSr 1430
Cdd:PRK03918  579 LEELGFESVEELEERlkelEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYS- 657

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 975830145 1431 kEEAIRKIESEREksereknSLRSEIERLQAEIKRIEERcRRKLEDSTRETQSQLEtERSRYQREIDKL 1499
Cdd:PRK03918  658 -EEEYEELREEYL-------ELSRELAGLRAELEELEKR-REEIKKTLEKLKEELE-EREKAKKELEKL 716
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1128-1462 2.67e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 82.68  E-value: 2.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1128 VEDRFDQQKNDYDQLQK-ARQCEKenlgWQKLESEKAIKEKEYEIERLRVLLQEegtrKREYENELAKVRNHYNEEMSNL 1206
Cdd:COG1196   191 LEDILGELERQLEPLERqAEKAER----YRELKEELKELEAELLLLKLRELEAE----LEELEAELEELEAELEELEAEL 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1207 RNKyETEINITKTTIKEismqkeddsknLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKAcgsEIMQ 1286
Cdd:COG1196   263 AEL-EAELEELRLELEE-----------LELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE---ELAE 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1287 KKQHLEiELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVV 1366
Cdd:COG1196   328 LEEELE-ELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELE 406

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1367 QERESLLVKIKVLEQDKARLQ----RLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESER 1442
Cdd:COG1196   407 EAEEALLERLERLEEELEELEealaELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486

                         330       340
                  ....*....|....*....|
gi 975830145 1443 EKSEREKNSLRSEIERLQAE 1462
Cdd:COG1196   487 AEAAARLLLLLEAEADYEGF 506
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2207-2245 3.77e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 71.20  E-value: 3.77e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  2207 LLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2245
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1848-1886 7.75e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 70.05  E-value: 7.75e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1848 LLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKL 1886
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1924-1962 1.38e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 69.28  E-value: 1.38e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1924 LLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEIL 1962
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1102-1498 8.82e-14

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 77.09  E-value: 8.82e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1102 GQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKE---YEIERLRVLL 1178
Cdd:pfam17380  240 KESFNLAEDVTTMTPEYTVRYNGQTMTENEFLNQLLHIVQHQKAVSERQQQEKFEKMEQERLRQEKEekaREVERRRKLE 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1179 QEEGTRKREYENELAKVRNHynEEMSNLRNKyeteinitkttikeismqkeddsknlrnQLDRLSRENRDLKDEIVRLND 1258
Cdd:pfam17380  320 EAEKARQAEMDRQAAIYAEQ--ERMAMERER----------------------------ELERIRQEERKRELERIRQEE 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1259 SILQATEQRrraeenalqqkacgseimqkkqhleiELKQVMQQRSEDNARHKQSLEEAAK-TIQDKNKEiERLKAEFQEE 1337
Cdd:pfam17380  370 IAMEISRMR--------------------------ELERLQMERQQKNERVRQELEAARKvKILEEERQ-RKIQQQKVEM 422

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1338 AKRRWEYENELSKASNRIQESKnqctqvvqERESLLVKIKVLE--QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQ 1415
Cdd:pfam17380  423 EQIRAEQEEARQREVRRLEEER--------AREMERVRLEEQErqQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRR 494

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1416 QIQNDLNQWKTQYSRKEEAIRKIesereksereknsLRSEIERLQAEIkrIEERCRRKLEDStRETQSQLEtERSRYQRE 1495
Cdd:pfam17380  495 KILEKELEERKQAMIEEERKRKL-------------LEKEMEERQKAI--YEEERRREAEEE-RRKQQEME-ERRRIQEQ 557


                   ...
gi 975830145  1496 IDK 1498
Cdd:pfam17380  558 MRK 560
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1681-1719 9.90e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 64.27  E-value: 9.90e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1681 LLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSL 1719
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1605-1643 2.12e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 63.12  E-value: 2.12e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1605 LLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQI 1643
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 285-450 2.99e-12

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 68.24  E-value: 2.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  285 WINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQI 364
Cdd:cd00176    15 WLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELREL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  365 TKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKErekILEYKRQVQNLVNKSKK 444
Cdd:cd00176    95 AEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEE---LEAHEPRLKSLNELAEE 171


                  ....*.
gi 975830145  445 IVQLKP 450
Cdd:cd00176   172 LLEEGH 177
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2283-2321 4.19e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 56.57  E-value: 4.19e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  2283 FLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRL 2321
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
2205-2242 4.75e-10

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 56.72  E-value: 4.75e-10
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 975830145   2205 QRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2242
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2281-2314 2.60e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 51.71  E-value: 2.60e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 975830145   2281 QRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFID 2314
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLID 34
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 190-366 5.24e-08

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 55.91  E-value: 5.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  190 ECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA---DLREKSAIY---------QLEEEYEN 257
Cdd:cd00176    11 ELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNElgeQLIEEGHPDaeeiqerleELNQRWEE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  258 LLKASFERMDHL---RQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESD 334
Cdd:cd00176    91 LRELAEERRQRLeeaLDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSLNELAE 170

                         170       180       190
                  ....*....|....*....|....*....|...
gi 975830145  335 QLVLNQHPAS-DKIEAYMDTLQTQWSWILQITK 366
Cdd:cd00176   171 ELLEEGHPDAdEEIEEKLEELNERWEELLELAE 203
PLEC smart00250
Plectin repeat;
1641-1678 1.70e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 49.40  E-value: 1.70e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 975830145   1641 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETG 1678
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
1605-1640 2.05e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 49.02  E-value: 2.05e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 975830145   1605 LLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1640
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2025-2053 2.31e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 48.86  E-value: 2.31e-07
                           10        20
                   ....*....|....*....|....*....
gi 975830145  2025 IVDPETNKEMSVQEAYKKGLIDYETFKEL 2053
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
1848-1882 4.81e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 47.86  E-value: 4.81e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 975830145   1848 LLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEF 1882
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
PLEC smart00250
Plectin repeat;
1808-1845 1.25e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.71  E-value: 1.25e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 975830145   1808 KDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTA 1845
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
1922-1957 4.68e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 45.17  E-value: 4.68e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 975830145   1922 IRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEE 1957
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
PLEC smart00250
Plectin repeat;
2020-2050 6.28e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.78  E-value: 6.28e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 975830145   2020 KRRVVIVDPETNKEMSVQEAYKKGLIDYETF 2050
Cdd:smart00250    8 SAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
1680-1716 9.12e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.40  E-value: 9.12e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 975830145   1680 RLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY 1716
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
1885-1921 9.21e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.40  E-value: 9.21e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 975830145   1885 KLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHG 1921
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1810-1848 1.30e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 43.86  E-value: 1.30e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1810 FLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALEL 1848
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC smart00150
Spectrin repeats;
285-373 3.53e-05

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 44.63  E-value: 3.53e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145    285 WINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQI 364
Cdd:smart00150   13 WLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLEELNERWEELKEL 92


                    ....*....
gi 975830145    365 TKCIDVHLK 373
Cdd:smart00150   93 AEERRQKLE 101
PLEC smart00250
Plectin repeat;
2168-2204 5.66e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 42.08  E-value: 5.66e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 975830145   2168 DTLEESSPIAAIFDTENLEKISITEGIERGIVDSITG 2204
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1160-1481 1.27e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.32  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1160 SEKAIKEKEYEIERLRVLLQEEGTRKREYEN-----ELAKVRNHYNEEMSNLRNKYETEIniTKTTIKEISMQKEDDSKN 1234
Cdd:NF033838   56 QKEHAKEVESHLEKILSEIQKSLDKRKHTQNvalnkKLSDIKTEYLYELNVLKEKSEAEL--TSKTKKELDAAFEQFKKD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1235 LRNQLDRLSRENRDLKDEIVRLNDsilQATEQRRRAEENA---LQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQ 1311
Cdd:NF033838  134 TLEPGKKVAEATKKVEEAEKKAKD---QKEEDRRNYPTNTyktLELEIAESDVEVKKAELELVKEEAKEPRDEEKIKQAK 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1312 SLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYE-----------NELSKASNRIQ---------------ESKNQCTQV 1365
Cdd:NF033838  211 AKVESKKAEATRLEKIKTDREKAEEEAKRRADAKlkeaveknvatSEQDKPKRRAKrgvlgepatpdkkenDAKSSDSSV 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1366 VQE---RESLLVKIKVLE--------QDKARLQRLEDELNRAKST---LE---AETRVKQRlECEKQQIQNDLNQwktqy 1428
Cdd:NF033838  291 GEEtlpSPSLKPEKKVAEaekkveeaKKKAKDQKEEDRRNYPTNTyktLEleiAESDVKVK-EAELELVKEEAKE----- 364

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 975830145 1429 SRKEEAIRKIESEREKSEREKNSLrseiERLQAEIKRIEERCRRK--LEDSTRET 1481
Cdd:NF033838  365 PRNEEKIKQAKAKVESKKAEATRL----EKIKTDRKKAEEEAKRKaaEEDKVKEK 415
PRK01156 PRK01156
chromosome segregation protein; Provisional
 707-1281 2.30e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  707 NELKSVQND----SQAIAEVLNQLKDMLANF-RGSEKYCYLQNEVFGLFQKLENINGVTD---GYLNSLCTVRALLQAIL 778
Cdd:PRK01156  190 EKLKSSNLEleniKKQIADDEKSHSITLKEIeRLSIEYNNAMDDYNNLKSALNELSSLEDmknRYESEIKTAESDLSMEL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  779 QTEDMLKVYEARLTEEETvcldlDKVEAYR---CGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSqqyplydlDLGK 855
Cdd:PRK01156  270 EKNNYYKELEERHMKIIN-----DPVYKNRnyiNDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLS--------VLQK 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  856 fgekvtqltDRWQRIDKQIdfRLWDLEKQIKQLRNYRDNYQAFCKwlydakrrqdSLESMKFGDSNtvmrFLNEQKNLHS 935
Cdd:PRK01156  337 ---------DYNDYIKKKS--RYDDLNNQILELEGYEMDYNSYLK----------SIESLKKKIEE----YSKNIERMSA 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  936 EISGKRDKS----EEVQKIAELCANSIKDYELQLASYTSGLETLLN--IPIKRTM-IQSPSGVILQEAADVHARYIELLT 1008
Cdd:PRK01156  392 FISEILKIQeidpDAIKKELNEINVKLQDISSKVSSLNQRIRALREnlDELSRNMeMLNGQSVCPVCGTTLGEEKSNHII 471

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1009 RsgDYYrflsemlkslEDLKLKNTKIEVLEEElrlARDANSENCNKNKFLD----QNLQKYQAECSQFKAKLASLEELK- 1083
Cdd:PRK01156  472 N--HYN----------EKKSRLEEKIREIEIE---VKDIDEKIVDLKKRKEylesEEINKSINEYNKIESARADLEDIKi 536

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1084 RQAELDGKSAKQNldkcygqikELNEKITRLTYEIEDEKR----RRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLE 1159
Cdd:PRK01156  537 KINELKDKHDKYE---------EIKNRYKSLKLEDLDSKRtswlNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIE 607

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1160 S---------EKAIKEKEYEIERLRVLLQEEGTRKREYEnELAKVRNHYNEEMSNLRnkyetEINITKTTIKEISMQKED 1230
Cdd:PRK01156  608 IgfpddksyiDKSIREIENEANNLNNKYNEIQENKILIE-KLRGKIDNYKKQIAEID-----SIIPDLKEITSRINDIED 681

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 975830145 1231 DSKNLRNQLD-------RLSRENRDLKDEIVRLNDSIlqaTEQRRRAEENALQQKACG 1281
Cdd:PRK01156  682 NLKKSRKALDdakanraRLESTIEILRTRINELSDRI---NDINETLESMKKIKKAIG 736
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1013-1347 2.37e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 46.54  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1013 YYRFLSEMLKSLE----------DLKLKNTKIEVLEEELRLARDANSENCNKNKF-LDQNLQKYQAECSQFKAKLASLEE 1081
Cdd:NF033838   67 LEKILSEIQKSLDkrkhtqnvalNKKLSDIKTEYLYELNVLKEKSEAELTSKTKKeLDAAFEQFKKDTLEPGKKVAEATK 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1082 LKRQAELDGKSAKQNLDKCYgqikelnEKITRLTYEIEDEKRRRKSVEDRFDQQKndyDQLQKARQCEKENLGWQKLESE 1161
Cdd:NF033838  147 KVEEAEKKAKDQKEEDRRNY-------PTNTYKTLELEIAESDVEVKKAELELVK---EEAKEPRDEEKIKQAKAKVESK 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKeismQKEDDSKNLRNQLDR 1241
Cdd:NF033838  217 KAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPD----KKENDAKSSDSSVGE 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1242 LSRENRDLKDEivrlnDSILQATEQRRRAEENALQQKA------------------CGSEIMQKKQHLEIELKQVMQQRS 1303
Cdd:NF033838  293 ETLPSPSLKPE-----KKVAEAEKKVEEAKKKAKDQKEedrrnyptntyktleleiAESDVKVKEAELELVKEEAKEPRN 367

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 975830145 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENE 1347
Cdd:NF033838  368 EEKIKQAKAKVESKKAEATRLEKIKTDRKKAEEEAKRKAAEEDK 411
PLEC smart00250
Plectin repeat;
2319-2356 2.67e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 2.67e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 975830145   2319 QRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG 2356
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
 
Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 548-625 7.01e-36

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


Pssm-ID: 465730  Cd Length: 78  Bit Score: 131.57  E-value: 7.01e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 975830145   548 VSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQ 625
Cdd:pfam18373    1 VSWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 447-513 1.44e-26

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 104.27  E-value: 1.44e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 975830145   447 QLKPRNpdYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIP 513
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1018-1501 6.50e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 87.38  E-value: 6.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1018 SEMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFL------DQNLQKYQAECSQFKAKLASLEELKRQAELDG 1090
Cdd:TIGR04523  103 SDLSKINSEIKNDKEQKNKLEVELnKLEKQKKENKKNIDKFLteikkkEKELEKLNNKYNDLKKQKEELENELNLLEKEK 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1091 KSAKQNLDKCYGQ----------IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLES 1160
Cdd:TIGR04523  183 LNIQKNIDKIKNKllklelllsnLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQ 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1161 EKAIK---EKEYEIERLRVLLqeegtrkreyeNELAKVRNHYNEEMSNLRNKYETEINitkTTIKEISMQKEDDSKNLRN 1237
Cdd:TIGR04523  263 NKIKKqlsEKQKELEQNNKKI-----------KELEKQLNQLKSEISDLNNQKEQDWN---KELKSELKNQEKKLEEIQN 328

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1238 QLDRLSRENRDLKDEIvrlndSILQATEQRRRAEENALQQkacgsEIMQKKQHLEIELKQvmqqrsedNARHKQSLEEAA 1317
Cdd:TIGR04523  329 QISQNNKIISQLNEQI-----SQLKKELTNSESENSEKQR-----ELEEKQNEIEKLKKE--------NQSYKQEIKNLE 390

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1318 KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAK 1397
Cdd:TIGR04523  391 SQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQL 470

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1398 STLEAETR-VKQRLECEKQQIQ---NDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEErcrRK 1473
Cdd:TIGR04523  471 KVLSRSINkIKQNLEQKQKELKskeKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLED---EL 547

                          490       500
                   ....*....|....*....|....*...
gi 975830145  1474 LEDSTRETQSQLETERSRYQREIDKLRQ 1501
Cdd:TIGR04523  548 NKDDFELKKENLEKEIDEKNKEIEELKQ 575
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1104-1438 2.28e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.26  E-value: 2.28e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1104 IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRvLLQEEGT 1183
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIA-QLSKELT 757

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1184 RKREYENELAKVRNHYNEEMSNLR----------NKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEI 1253
Cdd:TIGR02168  758 ELEAEIEELEERLEEAEEELAEAEaeieeleaqiEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATE 837

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1254 VRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRsEDNARHKQSLEEAAKTIQDKNKEIERLKAE 1333
Cdd:TIGR02168  838 RRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLE-EALALLRSELEELSEELRELESKRSELRRE 916

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1334 FQEEAKRRWEYENELSKASNRIQESKNQCT-------QVVQERESLLV-KIKVLEQDKARLQRLEDELNRAKSTLEAETR 1405
Cdd:TIGR02168  917 LEELREKLAQLELRLEGLEVRIDNLQERLSeeysltlEEAEALENKIEdDEEEARRRLKRLENKIKELGPVNLAAIEEYE 996

                          330       340       350
                   ....*....|....*....|....*....|....
gi 975830145  1406 -VKQRLECEKQQIqNDLNQWKTQYsrkEEAIRKI 1438
Cdd:TIGR02168  997 eLKERYDFLTAQK-EDLTEAKETL---EEAIEEI 1026
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1002-1499 2.49e-16

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 85.89  E-value: 2.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
Cdd:PRK03918  180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEE 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1082 LKRQAELDGKSAKQNLDKCYGQIKELNE---------KITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKEN 1152
Cdd:PRK03918  260 KIRELEERIEELKKEIEELEEKVKELKElkekaeeyiKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEER 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1153 LGWQKLESEK------AIKEKEYEIERLRVLLQE-EGTRKREYENELAKVRNHYnEEMSNLRNKYETEINITKTTIKEIS 1225
Cdd:PRK03918  340 LEELKKKLKElekrleELEERHELYEEAKAKKEElERLKKRLTGLTPEKLEKEL-EELEKAKEEIEEEISKITARIGELK 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1226 MQKEDDSKNL----------------------RNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGS- 1282
Cdd:PRK03918  419 KEIKELKKAIeelkkakgkcpvcgrelteehrKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKl 498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1283 -EIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAA-------KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNR 1354
Cdd:PRK03918  499 kELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLiklkgeiKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKE 578

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1355 IQESKNQCTQVVQER----ESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSr 1430
Cdd:PRK03918  579 LEELGFESVEELEERlkelEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYS- 657

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 975830145 1431 kEEAIRKIESEREksereknSLRSEIERLQAEIKRIEERcRRKLEDSTRETQSQLEtERSRYQREIDKL 1499
Cdd:PRK03918  658 -EEEYEELREEYL-------ELSRELAGLRAELEELEKR-REEIKKTLEKLKEELE-EREKAKKELEKL 716
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1128-1462 2.67e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 82.68  E-value: 2.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1128 VEDRFDQQKNDYDQLQK-ARQCEKenlgWQKLESEKAIKEKEYEIERLRVLLQEegtrKREYENELAKVRNHYNEEMSNL 1206
Cdd:COG1196   191 LEDILGELERQLEPLERqAEKAER----YRELKEELKELEAELLLLKLRELEAE----LEELEAELEELEAELEELEAEL 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1207 RNKyETEINITKTTIKEismqkeddsknLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKAcgsEIMQ 1286
Cdd:COG1196   263 AEL-EAELEELRLELEE-----------LELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE---ELAE 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1287 KKQHLEiELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVV 1366
Cdd:COG1196   328 LEEELE-ELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELE 406

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1367 QERESLLVKIKVLEQDKARLQ----RLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESER 1442
Cdd:COG1196   407 EAEEALLERLERLEEELEELEealaELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486

                         330       340
                  ....*....|....*....|
gi 975830145 1443 EKSEREKNSLRSEIERLQAE 1462
Cdd:COG1196   487 AEAAARLLLLLEAEADYEGF 506
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1235-1502 3.33e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 82.29  E-value: 3.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1235 LRNQLDRLSRE------NRDLKDEIVRLNDSILQATEQRRRAEENALQQKAcgseimqkkQHLEIELKQVMQQRSEDNAR 1308
Cdd:COG1196   198 LERQLEPLERQaekaerYRELKEELKELEAELLLLKLRELEAELEELEAEL---------EELEAELEELEAELAELEAE 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1309 hkqsLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLvkiKVLEQDKARLQR 1388
Cdd:COG1196   269 ----LEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELE---EELEELEEELEE 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1389 LEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEE 1468
Cdd:COG1196   342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421

                         250       260       270
                  ....*....|....*....|....*....|....
gi 975830145 1469 RCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1502
Cdd:COG1196   422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELE 455
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2207-2245 3.77e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 71.20  E-value: 3.77e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  2207 LLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2245
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1848-1886 7.75e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 70.05  E-value: 7.75e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1848 LLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKL 1886
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1924-1962 1.38e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 69.28  E-value: 1.38e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1924 LLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEIL 1962
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1166-1501 1.42e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 80.10  E-value: 1.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1166 EKEYEIERLRVLLQEEGTRKREYENELAKVRnhynEEMSNLRNKYEteinitktTIKEISMQKEDDSKNLRNQLDRLSRE 1245
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIAELEKALAELR----KELEELEEELE--------QLRKELEELSRQISALRKDLARLEAE 741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1246 NRDLKDEIVRLNDSILQATEQRRRAEENalqqkacgseiMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNK 1325
Cdd:TIGR02168  742 VEQLEERIAQLSKELTELEAEIEELEER-----------LEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRA 810

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1326 EIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLlvkIKVLEQDKARLQRLEDELNRAKSTLEAETR 1405
Cdd:TIGR02168  811 ELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESL---AAEIEELEELIEELESELEALLNERASLEE 887

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1406 VKQRLECEKQQIQNDLNQWktqysrkEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTR---ETQ 1482
Cdd:TIGR02168  888 ALALLRSELEELSEELREL-------ESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEeaeALE 960

                          330
                   ....*....|....*....
gi 975830145  1483 SQLETERSRYQREIDKLRQ 1501
Cdd:TIGR02168  961 NKIEDDEEEARRRLKRLEN 979
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1159-1502 4.20e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 78.57  E-value: 4.20e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1159 ESEKA---IKEKEYEIERLRVLLQEegtrKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEddskNL 1235
Cdd:TIGR02169  171 KKEKAleeLEEVEENIERLDLIIDE----KRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKE----AI 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1236 RNQLDRLSRENRDLKDEIVRLNDSILQAtEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNArhKQSLEE 1315
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEI-EQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEK--ERELED 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1316 AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKV----LEQDKARLQRLED 1391
Cdd:TIGR02169  320 AEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAEtrdeLKDYREKLEKLKR 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1392 ELNRAKSTLEAETRVKQRLECEKQQIQNDLnqwktqySRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCR 1471
Cdd:TIGR02169  400 EINELKRELDRLQEELQRLSEELADLNAAI-------AGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELY 472

                          330       340       350
                   ....*....|....*....|....*....|.
gi 975830145  1472 RkledsTRETQSQLETERSRYQREIDKLRQR 1502
Cdd:TIGR02169  473 D-----LKEEYDRVEKELSKLQRELAEAEAQ 498
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1074-1471 4.53e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 78.57  E-value: 4.53e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKsvedrFDQQKNDYDQLQKARqcEKENL 1153
Cdd:TIGR02169  163 AGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQA-----LLKEKREYEGYELLK--EKEAL 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1154 GWQKLESEKAIKEKEYEIERLRVLLQEegtRKREYEnELAKVRNHYNEEmsnLRNKYETEINITKTTIKEISMQKEDDSK 1233
Cdd:TIGR02169  236 ERQKEAIERQLASLEEELEKLTEEISE---LEKRLE-EIEQLLEELNKK---IKDLGEEEQLRVKEKIGELEAEIASLER 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1234 NLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEiELKQVMQQRSEDNARHKQSL 1313
Cdd:TIGR02169  309 SIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELE-DLRAELEEVDKEFAETRDEL 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1314 EEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQdkarlqrledel 1393
Cdd:TIGR02169  388 KDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEW------------ 455

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 975830145  1394 nrakstleaetrvkqrlecEKQQIQNDLNQWKTQYSRKEEAIRKIESEREksereknSLRSEIERLQAEIKRIEERCR 1471
Cdd:TIGR02169  456 -------------------KLEQLAADLSKYEQELYDLKEEYDRVEKELS-------KLQRELAEAEAQARASEERVR 507
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1102-1498 8.82e-14

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 77.09  E-value: 8.82e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1102 GQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKE---YEIERLRVLL 1178
Cdd:pfam17380  240 KESFNLAEDVTTMTPEYTVRYNGQTMTENEFLNQLLHIVQHQKAVSERQQQEKFEKMEQERLRQEKEekaREVERRRKLE 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1179 QEEGTRKREYENELAKVRNHynEEMSNLRNKyeteinitkttikeismqkeddsknlrnQLDRLSRENRDLKDEIVRLND 1258
Cdd:pfam17380  320 EAEKARQAEMDRQAAIYAEQ--ERMAMERER----------------------------ELERIRQEERKRELERIRQEE 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1259 SILQATEQRrraeenalqqkacgseimqkkqhleiELKQVMQQRSEDNARHKQSLEEAAK-TIQDKNKEiERLKAEFQEE 1337
Cdd:pfam17380  370 IAMEISRMR--------------------------ELERLQMERQQKNERVRQELEAARKvKILEEERQ-RKIQQQKVEM 422

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1338 AKRRWEYENELSKASNRIQESKnqctqvvqERESLLVKIKVLE--QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQ 1415
Cdd:pfam17380  423 EQIRAEQEEARQREVRRLEEER--------AREMERVRLEEQErqQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRR 494

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1416 QIQNDLNQWKTQYSRKEEAIRKIesereksereknsLRSEIERLQAEIkrIEERCRRKLEDStRETQSQLEtERSRYQRE 1495
Cdd:pfam17380  495 KILEKELEERKQAMIEEERKRKL-------------LEKEMEERQKAI--YEEERRREAEEE-RRKQQEME-ERRRIQEQ 557


                   ...
gi 975830145  1496 IDK 1498
Cdd:pfam17380  558 MRK 560
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1208-1542 9.81e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 77.40  E-value: 9.81e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1208 NKYETEINITKTtikEISMQK-EDDSKNLRNQLDRLSREN------RDLKDEI--VRLNDSILQATEQRRRAEENALQQK 1278
Cdd:TIGR02168  173 RRKETERKLERT---RENLDRlEDILNELERQLKSLERQAekaeryKELKAELreLELALLVLRLEELREELEELQEELK 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1279 ACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQsLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQES 1358
Cdd:TIGR02168  250 EAEEELEELTAELQELEEKLEELRLEVSELEEE-IEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1359 KNQctqvvqeresllvkikvLEQDKARLQRLEDELNRAKSTLEAEtrvKQRLECEKQQIQNDLNQWKTQysrkEEAIRKI 1438
Cdd:TIGR02168  329 ESK-----------------LDELAEELAELEEKLEELKEELESL---EAELEELEAELEELESRLEEL----EEQLETL 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1439 ESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQrpygSHRETQTECEWTV 1518
Cdd:TIGR02168  385 RSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEE----ELEELQEELERLE 460

                          330       340
                   ....*....|....*....|....
gi 975830145  1519 DTSKLVFDGLRKKVTAMQLYECQL 1542
Cdd:TIGR02168  461 EALEELREELEEAEQALDAAEREL 484
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1064-1501 1.02e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 76.98  E-value: 1.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1064 KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143
Cdd:TIGR04523   30 KQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKIN 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1144 KARQCEKENLGWQKLESEKAIKEKEyEIERLRVLLQEEGTRKreyENELAKVRNHYN------EEMSNLRNKYETEINIT 1217
Cdd:TIGR04523  110 SEIKNDKEQKNKLEVELNKLEKQKK-ENKKNIDKFLTEIKKK---EKELEKLNNKYNdlkkqkEELENELNLLEKEKLNI 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1218 KTTIKEISMQ-------------KEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEEnalqqkacgsEI 1284
Cdd:TIGR04523  186 QKNIDKIKNKllklelllsnlkkKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQT----------QL 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1285 MQKKQHLEIELKQVMQQRSEdnarhkqsLEEAAKTIQDKNKEIERLKAEFQE---EAKRRW--EYENELSKASNRIQESK 1359
Cdd:TIGR04523  256 NQLKDEQNKIKKQLSEKQKE--------LEQNNKKIKELEKQLNQLKSEISDlnnQKEQDWnkELKSELKNQEKKLEEIQ 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1360 NQCTQVVQERESLLVKIKVLEQDKARL----QRLEDELNRAKSTLEAETRVKQ-------RLECEKQQIQNDLNQWKTQY 1428
Cdd:TIGR04523  328 NQISQNNKIISQLNEQISQLKKELTNSesenSEKQRELEEKQNEIEKLKKENQsykqeikNLESQINDLESKIQNQEKLN 407

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 975830145  1429 SRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER--CRRKLEDSTRETQSQLETERSRYQREIDKLRQ 1501
Cdd:TIGR04523  408 QQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQdsVKELIIKNLDNTRESLETQLKVLSRSINKIKQ 482
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1033-1499 2.80e-13

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 75.98  E-value: 2.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1033 KIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQ-----AELDGKSAK-----QNLDKCY- 1101
Cdd:pfam01576  132 KIKKLEEDILLLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKheamiSDLEERLKKeekgrQELEKAKr 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1102 ---GQIKELNEKITRLTYEIEdekrrrksvEDRFDQQKNDyDQLQKArQCEKENLGWQKLESEKAIKEKEYEIERLrvll 1178
Cdd:pfam01576  212 kleGESTDLQEQIAELQAQIA---------ELRAQLAKKE-EELQAA-LARLEEETAQKNNALKKIRELEAQISEL---- 276

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1179 QEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTiKEISMQKEDDSKNLRNQLDRLSRENR-DLKDEIVRLN 1257
Cdd:pfam01576  277 QEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQ-QELRSKREQEVTELKKALEEETRSHEaQLQEMRQKHT 355

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1258 DSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQsLEEAAKTIQDKNKEIERLKAEFQEE 1337
Cdd:pfam01576  356 QALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKK-LEGQLQELQARLSESERQRAELAEK 434

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1338 AKRrweYENELSKASNRIQESKNQCTQVVQERESL---LVKIKVLEQDKAR--------LQRLEDELNRAKSTLEAETRV 1406
Cdd:pfam01576  435 LSK---LQSELESVSSLLNEAEGKNIKLSKDVSSLesqLQDTQELLQEETRqklnlstrLRQLEDERNSLQEQLEEEEEA 511

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1407 KQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE---ERCRRKLEDSTRE--T 1481
Cdd:pfam01576  512 KRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEktkNRLQQELDDLLVDldH 591

                          490
                   ....*....|....*...
gi 975830145  1482 QSQLETERSRYQREIDKL 1499
Cdd:pfam01576  592 QRQLVSNLEKKQKKFDQM 609
PTZ00121 PTZ00121
MAEBL; Provisional
 1002-1588 5.45e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 75.18  E-value: 5.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKnkfldqnlQKYQAECSQFKAKLASL-- 1079
Cdd:PTZ00121 1302 KKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEA--------AADEAEAAEEKAEAAEKkk 1373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1080 EELKRQAELDGKSA--KQNLDKCYGQIKELNEKITRLTYEIEDEKR----RRKSVEDR-FDQQKNDYDQLQKARQCEKEN 1152
Cdd:PTZ00121 1374 EEAKKKADAAKKKAeeKKKADEAKKKAEEDKKKADELKKAAAAKKKadeaKKKAEEKKkADEAKKKAEEAKKADEAKKKA 1453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1153 LGWQKLESEKAIKEKEYEIERLRVLLQEEgtRKREyenELAKVRNHYNEEMSNLRNKYETeinitKTTIKEISMQKEDDS 1232
Cdd:PTZ00121 1454 EEAKKAEEAKKKAEEAKKADEAKKKAEEA--KKAD---EAKKKAEEAKKKADEAKKAAEA-----KKKADEAKKAEEAKK 1523

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1233 KNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQS 1312
Cdd:PTZ00121 1524 ADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEE 1603

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1313 lEEAAKTIQDKNKEIERLKAEfqeEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDE 1392
Cdd:PTZ00121 1604 -EKKMKAEEAKKAEEAKIKAE---ELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEE 1679

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1393 LNRAKSTLEAETRVKQRLECEKQQIQnDLNQWKTQYSRKEEAIRKIESEREKSEREKNSlRSEIERLQAEIKRIEERCRR 1472
Cdd:PTZ00121 1680 AKKAEEDEKKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAEELKKAEEENKIKAEEAKK-EAEEDKKKAEEAKKDEEEKK 1757

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1473 KLEDSTRETQSQLETERSRYQREIDK-LRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQlyECQLIDKTTLDKL 1551
Cdd:PTZ00121 1758 KIAHLKKEEEKKAEEIRKEKEAVIEEeLDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVIN--DSKEMEDSAIKEV 1835

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 975830145 1552 LKGKKSVEEVASEIQPFLRGAGSIAGASA-----SPKEKYSL 1588
Cdd:PTZ00121 1836 ADSKNMQLEEADAFEKHKFNKNNENGEDGnkeadFNKEKDLK 1877
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1681-1719 9.90e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 64.27  E-value: 9.90e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1681 LLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSL 1719
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1021-1345 1.51e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 73.43  E-value: 1.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1021 LKSLED--------LKLKnTKIEVLEEELRLARDansencnknKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKS 1092
Cdd:COG1196   202 LEPLERqaekaeryRELK-EELKELEAELLLLKL---------RELEAELEELEAELEELEAELEELEAELAELEAELEE 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1093 AKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRfdqqkndydqlQKARQCEKENLGWQKLESEKAIKEKEYEIE 1172
Cdd:COG1196   272 LRLELEELELELEEAQAEEYELLAELARLEQDIARLEER-----------RRELEERLEELEEELAELEEELEELEEELE 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1173 RLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRnkyetEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDE 1252
Cdd:COG1196   341 ELEEELEEAEEELEEAEAELAEAEEALLEAEAELA-----EAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLER 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1253 IVRLNDSILQATEQRRRAEENALQQKacgsEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKA 1332
Cdd:COG1196   416 LERLEEELEELEEALAELEEEEEEEE----EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAA 491

                         330
                  ....*....|...
gi 975830145 1333 EFQEEAKRRWEYE 1345
Cdd:COG1196   492 RLLLLLEAEADYE 504
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1605-1643 2.12e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 63.12  E-value: 2.12e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1605 LLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQI 1643
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 285-450 2.99e-12

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 68.24  E-value: 2.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  285 WINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQI 364
Cdd:cd00176    15 WLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELREL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  365 TKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKErekILEYKRQVQNLVNKSKK 444
Cdd:cd00176    95 AEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEE---LEAHEPRLKSLNELAEE 171


                  ....*.
gi 975830145  445 IVQLKP 450
Cdd:cd00176   172 LLEEGH 177
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1231-1502 3.68e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 72.41  E-value: 3.68e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1231 DSKNLRNQLDRLSRENRDLKDEIvrlndSILQATEQRRRAEENALQQKACGSEimqkKQHLEIELKQvmQQRSEDNARHK 1310
Cdd:TIGR02169  668 FSRSEPAELQRLRERLEGLKREL-----SSLQSELRRIENRLDELSQELSDAS----RKIGEIEKEI--EQLEQEEEKLK 736

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1311 QSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYE---NELSKASNRIQESKNQctQVVQERESLLVKIKvleqdkARLQ 1387
Cdd:TIGR02169  737 ERLEELEEDLSSLEQEIENVKSELKELEARIEELEedlHKLEEALNDLEARLSH--SRIPEIQAELSKLE------EEVS 808

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1388 RLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREksereknSLRSEIERLQAEIKRIE 1467
Cdd:TIGR02169  809 RIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKE-------ELEEELEELEAALRDLE 881

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 975830145  1468 ERcRRKLEDSTRETQSQLETERSRYQR---EIDKLRQR 1502
Cdd:TIGR02169  882 SR-LGDLKKERDELEAQLRELERKIEEleaQIEKKRKR 918
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 793-1537 4.97e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 72.01  E-value: 4.97e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   793 EEETVCLDL--DKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTsqqyplyDLDLGKFGEKVTQLTDRWQ-- 868
Cdd:TIGR02168  221 ELRELELALlvLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEEL-------RLEVSELEEEIEELQKELYal 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   869 -----RIDKQI---DFRLWDLEKQIKQLRNYRDNYQafcKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGK 940
Cdd:TIGR02168  294 aneisRLEQQKqilRERLANLERQLEELEAQLEELE---SKLDELAEELAELEEKLEELKEELESLEAELEELEAELEEL 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   941 RDKSEEVQKIAELCANSIKDYELQLASYTSGLETLlnipikRTMIQSpsgviLQEAADVHARYIELLTRSGDyyrfLSEM 1020
Cdd:TIGR02168  371 ESRLEELEEQLETLRSKVAQLELQIASLNNEIERL------EARLER-----LEDRRERLQQEIEELLKKLE----EAEL 435

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKC 1100
Cdd:TIGR02168  436 KELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQ 515

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1101 ygqiKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY--DQLQKARQC----EKENLGWQKLESEKAIKEKEYEIERL 1174
Cdd:TIGR02168  516 ----SGLSGILGVLSELISVDEGYEAAIEAALGGRLQAVvvENLNAAKKAiaflKQNELGRVTFLPLDSIKGTEIQGNDR 591

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1175 RVLLQEEGTRKreYENELAKVRNHYNEEMSNLRNKYETEINItkttikeismqkeDDSKNLRNQLDRLSReNRDLKDEIV 1254
Cdd:TIGR02168  592 EILKNIEGFLG--VAKDLVKFDPKLRKALSYLLGGVLVVDDL-------------DNALELAKKLRPGYR-IVTLDGDLV 655

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1255 RLNDSI--------LQATEQRRRAEENALQQKACGSEIMQkkqhLEIELKQVMQQRSEDNarhkQSLEEAAKTIQDKNKE 1326
Cdd:TIGR02168  656 RPGGVItggsaktnSSILERRREIEELEEKIEELEEKIAE----LEKALAELRKELEELE----EELEQLRKELEELSRQ 727

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1327 IERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ----RLEDELNRAKSTLEA 1402
Cdd:TIGR02168  728 ISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEaqieQLKEELKALREALDE 807

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1403 ETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKsereknsLRSEIERLQAEIkrieERCRRKLEDSTRETQ 1482
Cdd:TIGR02168  808 LRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEE-------LSEDIESLAAEI----EELEELIEELESELE 876

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 975830145  1483 SQLEtERSRYQREIDKLRQRpYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQL 1537
Cdd:TIGR02168  877 ALLN-ERASLEEALALLRSE-LEELSEELRELESKRSELRRELEELREKLAQLEL 929
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1017-1502 8.50e-12

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 70.84  E-value: 8.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1017 LSEMLKSLE-DLKLKNTKIEVLEEELRLARDANSEncnknkfLDQNLQKY---QAECSQFKAKLASLEELKRQAELDGKS 1092
Cdd:PRK02224  204 LHERLNGLEsELAELDEEIERYEEQREQARETRDE-------ADEVLEEHeerREELETLEAEIEDLRETIAETEREREE 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1093 AKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQcekenlgwqklESEKAIKEKEYEIE 1172
Cdd:PRK02224  277 LAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLE-----------ECRVAAQAHNEEAE 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1173 RLR---VLLQEEGTRKREYENELAKvrnhyneEMSNLRNKYETEinitKTTIKEISMQKEDDSKNLRN---QLDRLSREN 1246
Cdd:PRK02224  346 SLRedaDDLEERAEELREEAAELES-------ELEEAREAVEDR----REEIEELEEEIEELRERFGDapvDLGNAEDFL 414

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1247 RDLKDEIVRLNDSI--LQAT---EQRRRAEENALQQKA----CGSEI------------MQKKQHLEIELKQVMQQRSED 1305
Cdd:PRK02224  415 EELREERDELREREaeLEATlrtARERVEEAEALLEAGkcpeCGQPVegsphvetieedRERVEELEAELEDLEEEVEEV 494

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1306 NARHKQ--SLEEAAK---TIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRI----QESKNQCTQVVQERESLLVKI 1376
Cdd:PRK02224  495 EERLERaeDLVEAEDrieRLEERREDLEELIAERRETIEEKRERAEELRERAAELeaeaEEKREAAAEAEEEAEEAREEV 574

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1377 KVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLEC--EKQQIQNDLN---------------------------QWKTQ 1427
Cdd:PRK02224  575 AELNSKLAELKERIESLERIRTLLAAIADAEDEIERlrEKREALAELNderrerlaekrerkreleaefdearieEARED 654

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1428 YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEE-RCRRKLEDSTRET----QSQLETERSRYQREIDKLRQR 1502
Cdd:PRK02224  655 KERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEElRERREALENRVEAlealYDEAEELESMYGDLRAELRQR 734
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1079-1498 1.39e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 69.80  E-value: 1.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1079 LEELKRQAELDGKSAKQNLDKCYGQIKELNEKIT----------RLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQC 1148
Cdd:COG4717    48 LERLEKEADELFKPQGRKPELNLKELKELEEELKeaeekeeeyaELQEELEELEEELEELEAELEELREELEKLEKLLQL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1149 EKENLGWQKLESEKAIKEKEYE-IERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQ 1227
Cdd:COG4717   128 LPLYQELEALEAELAELPERLEeLEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQR 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1228 KEddskNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQ------------------------------ 1277
Cdd:COG4717   208 LA----ELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLiaaallallglggsllsliltiagvlflvl 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1278 --KACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRI 1355
Cdd:COG4717   284 glLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL 363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1356 QESKNQctqvvQERESLLVKIKV--------LEQDKARLQRLEDELNRAKSTLEAETRvkqrlECEKQQIQNDLNQWKTQ 1427
Cdd:COG4717   364 QLEELE-----QEIAALLAEAGVedeeelraALEQAEEYQELKEELEELEEQLEELLG-----ELEELLEALDEEELEEE 433

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 975830145 1428 YSRKEEAIRKIESERekserekNSLRSEIERLQAEIKRIEErcrrklEDSTRETQSQLETERSRYQREIDK 1498
Cdd:COG4717   434 LEELEEELEELEEEL-------EELREELAELEAELEQLEE------DGELAELLQELEELKAELRELAEE 491
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 855-1466 1.41e-11

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 70.85  E-value: 1.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   855 KFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRR---QDSLESMKFGDSNTVMRF----- 926
Cdd:TIGR01612 1108 KYADEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLEDVADKaisNDDPEEIEKKIENIVTKIdkkkn 1187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   927 -LNEQKNLHSEISG-KRDKS--EEVQKIAELCANSI------------KDYELQLASYTSGLETLLNIPIKRTMIQSPSG 990
Cdd:TIGR01612 1188 iYDEIKKLLNEIAEiEKDKTslEEVKGINLSYGKNLgklflekideekKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMG 1267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   991 VILQEAADVHARYIELlTRSGDYYRFLSEMLKSLEDLKLKNTKIEvleeelrlarDANSENCNKN---KFLDQNL---QK 1064
Cdd:TIGR01612 1268 IEMDIKAEMETFNISH-DDDKDHHIISKKHDENISDIREKSLKII----------EDFSEESDINdikKELQKNLldaQK 1336

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1065 YQAECSQFKAKLASLEELKRQaeldgksakQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNdydqlqk 1144
Cdd:TIGR01612 1337 HNSDINLYLNEIANIYNILKL---------NKIKKIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDIN------- 1400

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1145 ARQCEkenlgwQKLESEKAIKEKEYEIERLRVL----LQEEGTRKREYENElakvrNHYNEEMSNLRNKYETEINITKTT 1220
Cdd:TIGR01612 1401 LEECK------SKIESTLDDKDIDECIKKIKELknhiLSEESNIDTYFKNA-----DENNENVLLLFKNIEMADNKSQHI 1469

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1221 IKeisMQKEDDSKNLRNQLDRLsRENRDLKDEIVRLNDSILQATEQRRRAEEnalQQKACGSEIMQKkqHLEIELKQVMQ 1300
Cdd:TIGR01612 1470 LK---IKKDNATNDHDFNINEL-KEHIDKSKGCKDEADKNAKAIEKNKELFE---QYKKDVTELLNK--YSALAIKNKFA 1540

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1301 QRSEDNAR--------HKQSLEEAAKTIQdKNKEIERLKAEFQEEAKRRWE--------------YENELSKASNrIQES 1358
Cdd:TIGR01612 1541 KTKKDSEIiikeikdaHKKFILEAEKSEQ-KIKEIKKEKFRIEDDAAKNDKsnkaaidiqlslenFENKFLKISD-IKKK 1618

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1359 KNQCtqvVQERESLLVKIKVLEQD--KARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ----------IQNDLNQWKT 1426
Cdd:TIGR01612 1619 INDC---LKETESIEKKISSFSIDsqDTELKENGDNLNSLQEFLESLKDQKKNIEDKKKEldeldseiekIEIDVDQHKK 1695

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 975830145  1427 QYSrkeeaIRKIESEREKSEREKNSLRSEIERLQAEIKRI 1466
Cdd:TIGR01612 1696 NYE-----IGIIEKIKEIAIANKEEIESIKELIEPTIENL 1730
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1002-1523 5.92e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 68.56  E-value: 5.92e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1002 RYIELLTRSGDY--YRFLSEMLKSLEDLKLKNTKIEVLEEEL----RLARDANSENCNKNKFLDQNLQKYQA----ECSQ 1071
Cdd:TIGR02169  212 RYQALLKEKREYegYELLKEKEALERQKEAIERQLASLEEELekltEEISELEKRLEEIEQLLEELNKKIKDlgeeEQLR 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1072 FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR-------LTYEIEDEKRRRKSVEDRFDQQKNDYDQL-Q 1143
Cdd:TIGR02169  292 VKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKllaeieeLEREIEEERKRRDKLTEEYAELKEELEDLrA 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1144 KARQCEKENLGW-QKLESEK----AIKEKEYEIERLRVLLQEEGTRKR----EYENELAKVRNHYNEEMSNLRNKYEtEI 1214
Cdd:TIGR02169  372 ELEEVDKEFAETrDELKDYRekleKLKREINELKRELDRLQEELQRLSeelaDLNAAIAGIEAKINELEEEKEDKAL-EI 450

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1215 NITKTTIKEISMQKEDDSK---NLRNQLDRLSRENRDLKDEIVRLN---DSILQATEQRRRAEE---------------- 1272
Cdd:TIGR02169  451 KKQEWKLEQLAADLSKYEQelyDLKEEYDRVEKELSKLQRELAEAEaqaRASEERVRGGRAVEEvlkasiqgvhgtvaql 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1273 --------------------------------------------------NALQQKACGSEIMQKKQHLEIEL------- 1295
Cdd:TIGR02169  531 gsvgeryataievaagnrlnnvvveddavakeaiellkrrkagratflplNKMRDERRDLSILSEDGVIGFAVdlvefdp 610

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1296 ------KQVMQ------------------------------------------QRSEDNARHKQSLEEAAKTIQDKNKEI 1327
Cdd:TIGR02169  611 kyepafKYVFGdtlvvedieaarrlmgkyrmvtlegelfeksgamtggsraprGGILFSRSEPAELQRLRERLEGLKREL 690

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1328 ERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQER-------ESLLVKIKVLEQ----DKARLQRLEDELNRA 1396
Cdd:TIGR02169  691 SSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEeklkerlEELEEDLSSLEQeienVKSELKELEARIEEL 770

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1397 KSTL----EAETRVKQRLECEK-QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIK----RIE 1467
Cdd:TIGR02169  771 EEDLhkleEALNDLEARLSHSRiPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIdlkeQIK 850

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 975830145  1468 ERCR---------RKLEDSTRETQSQLETERSRY---QREIDKLRQRpYGSHRETQTECEWTVDTSKL 1523
Cdd:TIGR02169  851 SIEKeienlngkkEELEEELEELEAALRDLESRLgdlKKERDELEAQ-LRELERKIEELEAQIEKKRK 917
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 928-1416 6.84e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 67.82  E-value: 6.84e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   928 NEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLlNIPIKRTMIQSPSgviLQEAADVHARYIELL 1007
Cdd:pfam05483  254 NKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDI-KMSLQRSMSTQKA---LEEDLQIATKTICQL 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEV--LEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKA----KLASLEE 1081
Cdd:pfam05483  330 TEEKEAQMEELNKAKAAHSFVVTEFEATTcsLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKfknnKEVELEE 409

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1082 LKRQAELDGK--SAKQNLDKCYGQIKELNEKITRL-------TYEIEDEKRRRKSVEDRFDQQKNDYD-QLQKARQCEKE 1151
Cdd:pfam05483  410 LKKILAEDEKllDEKKQFEKIAEELKGKEQELIFLlqarekeIHDLEIQLTAIKTSEEHYLKEVEDLKtELEKEKLKNIE 489

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1152 ---NLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMsNLRNKYETEINITKTTIKEISMQK 1228
Cdd:pfam05483  490 ltaHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEM-NLRDELESVREEFIQKGDEVKCKL 568

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1229 EDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEE----NALQQKACGSEIMQ------KKQHLEIELKQV 1298
Cdd:pfam05483  569 DKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEElhqeNKALKKKGSAENKQlnayeiKVNKLELELASA 648

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1299 MQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEY----ENELSKASNRIQESKNQCTQVVQERESLLV 1374
Cdd:pfam05483  649 KQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEIdkrcQHKIAEMVALMEKHKHQYDKIIEERDSELG 728

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 975830145  1375 KIKVLEQDKA--------RLQRLEDELNRAKSTLEAETRVKQRLECEKQQ 1416
Cdd:pfam05483  729 LYKNKEQEQSsakaaleiELSNIKAELLSLKKQLEIEKEEKEKLKMEAKE 778
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1118-1489 9.92e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 67.40  E-value: 9.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1118 IEDEKRRRKSVED--RFDQQKNDYDQLQ------KARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYE 1189
Cdd:PRK03918  141 LESDESREKVVRQilGLDDYENAYKNLGevikeiKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELR 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1190 NELAKVRNHYnEEMSNLRNKYEtEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR 1269
Cdd:PRK03918  221 EELEKLEKEV-KELEELKEEIE-ELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKL 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1270 AEENalqqkacgSEIMQKKQHLEIELkqvmqqrsednarhkQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELS 1349
Cdd:PRK03918  299 SEFY--------EEYLDELREIEKRL---------------SRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLE 355

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1350 KASNRIQESkNQCTQVVQERESLLVKIKVLEQDKarLQRLEDELNRAKSTLEAETRvkqRLECEKQQIQNDLNQWKTQYS 1429
Cdd:PRK03918  356 ELEERHELY-EEAKAKKEELERLKKRLTGLTPEK--LEKELEELEKAKEEIEEEIS---KITARIGELKKEIKELKKAIE 429

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 975830145 1430 RKEEAIRKI-----ESEREKSEREKNSLRSEIERLQAEIKRIEERcRRKLEDSTRETQSQLETER 1489
Cdd:PRK03918  430 ELKKAKGKCpvcgrELTEEHRKELLEEYTAELKRIEKELKEIEEK-ERKLRKELRELEKVLKKES 493
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
995-1502 1.79e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 66.86  E-value: 1.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  995 EAADVHARYIELLtrsgDYYRFLSEMLKSLEDLKlknTKIEVLE--EELRLARDANSENCNKNKFLDQNLQKYQA----- 1067
Cdd:COG4913   219 EEPDTFEAADALV----EHFDDLERAHEALEDAR---EQIELLEpiRELAERYAAARERLAELEYLRAALRLWFAqrrle 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1068 ----ECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKEL-NEKITRLTYEIEDEKRRRKSVEDRFDQQKN----- 1137
Cdd:COG4913   292 lleaELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEAllaal 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1138 ---------DYDQLQKARQCEKENLGwqklESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRN 1208
Cdd:COG4913   372 glplpasaeEFAALRAEAAALLEALE----EELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRD 447

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1209 KYETEINITKTTIK----EISMQKEDDS------KNLRNQ----------LDRLSR--ENRDLKDEIVRLNDSILQATEQ 1266
Cdd:COG4913   448 ALAEALGLDEAELPfvgeLIEVRPEEERwrgaieRVLGGFaltllvppehYAAALRwvNRLHLRGRLVYERVRTGLPDPE 527

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1267 RRRAEENALQQKacgseimqkkqhLEIE-------LKQVMQQRS--------EDNARHKQSL------------------ 1313
Cdd:COG4913   528 RPRLDPDSLAGK------------LDFKphpfrawLEAELGRRFdyvcvdspEELRRHPRAItragqvkgngtrhekddr 595

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1314 ----------EEAAKTIQDKNKEIERLKAEFQEEAKRRweyeNELSKASNRIQESKNQCTQVVQ-------------ERE 1370
Cdd:COG4913   596 rrirsryvlgFDNRAKLAALEAELAELEEELAEAEERL----EALEAELDALQERREALQRLAEyswdeidvasaerEIA 671

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1371 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSerekn 1450
Cdd:COG4913   672 ELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLE----- 746

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 975830145 1451 sLRSEIERLQAEIkrIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1502
Cdd:COG4913   747 -LRALLEERFAAA--LGDAVERELRENLEERIDALRARLNRAEEELERAMRA 795
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1017-1565 2.76e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 65.86  E-value: 2.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1017 LSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAEL-------- 1088
Cdd:PRK03918  223 LEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEyiklsefy 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1089 -DGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQK-ARQCEKENLGWQKLESEKAiKE 1166
Cdd:PRK03918  303 eEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEErHELYEEAKAKKEELERLKK-RL 381

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1167 KEYEIERLRVLLQEEGTRKREYENELAKVRnhynEEMSNLRNkyetEINITKTTIKEISMQK-----------EDDSKNL 1235
Cdd:PRK03918  382 TGLTPEKLEKELEELEKAKEEIEEEISKIT----ARIGELKK----EIKELKKAIEELKKAKgkcpvcgreltEEHRKEL 453

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1236 rnqLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGS--EIMQKKQHLEIELKQVMQQRSEDNARHKQSL 1313
Cdd:PRK03918  454 ---LEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKlkELAEQLKELEEKLKKYNLEELEKKAEEYEKL 530

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1314 EEAAKTIQdknKEIERLKaefqEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLlvKIKVLEQDKARLQRLEDEL 1393
Cdd:PRK03918  531 KEKLIKLK---GEIKSLK----KELEKLEELKKKLAELEKKLDELEEELAELLKELEEL--GFESVEELEERLKELEPFY 601

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1394 NRAKSTLEAETRVKQRLECEKqqiqndlnqwktqysrkeeairkiesereKSEREKNSLRSEIERLQAEIKRIEERCRRK 1473
Cdd:PRK03918  602 NEYLELKDAEKELEREEKELK-----------------------------KLEEELDKAFEELAETEKRLEELRKELEEL 652

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1474 LEDSTRETQSQLETERSRYQREIDKLRQRPYG--SHREtqtECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTL-DK 1550
Cdd:PRK03918  653 EKKYSEEEYEELREEYLELSRELAGLRAELEEleKRRE---EIKKTLEKLKEELEEREKAKKELEKLEKALERVEELrEK 729

                         570       580
                  ....*....|....*....|...
gi 975830145 1551 LLKGK--------KSVEEVASEI 1565
Cdd:PRK03918  730 VKKYKallkeralSKVGEIASEI 752
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
993-1415 3.00e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 65.56  E-value: 3.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  993 LQEAADVHARYIELLTRsgdyyrfLSEMLKSLEDLKLKNTKIEVLEEELRLARDAnSENCNKNKFLDQNLQKYQAECSQF 1072
Cdd:COG4717    80 LKEAEEKEEEYAELQEE-------LEELEEELEELEAELEELREELEKLEKLLQL-LPLYQELEALEAELAELPERLEEL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1073 KAKLASLEELKRQAEldgkSAKQNLDKCYGQIKELNEKITRLTY-EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKE 1151
Cdd:COG4717   152 EERLEELRELEEELE----ELEAELAELQEELEELLEQLSLATEeELQDLAEELEELQQRLAELEEELEEAQEELEELEE 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1152 NLgwQKLESEKAIKEKEYEIERLRVLLQEEGTR------------KREYENELAKVRNHYNEEMSNLRNKYETEINITKT 1219
Cdd:COG4717   228 EL--EQLENELEAAALEERLKEARLLLLIAAALlallglggsllsLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAE 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1220 TIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEEnaLQQKAcgseimqKKQHLEIELKQVM 1299
Cdd:COG4717   306 ELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEE--LEEEL-------QLEELEQEIAALL 376

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1300 QQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEY---------ENELSKASNRIQESKNQCTQVVQERE 1370
Cdd:COG4717   377 AEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELlealdeeelEEELEELEEELEELEEELEELREELA 456

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 975830145 1371 SLLVKIKVLEQD-------------KARLQRLEDELNRAKSTLEAETRVKQRLECEKQ 1415
Cdd:COG4717   457 ELEAELEQLEEDgelaellqeleelKAELRELAEEWAALKLALELLEEAREEYREERL 514
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1005-1368 3.08e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.85  E-value: 3.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1005 ELLTRSGDYYRFLSEMLKSLEDLKlknTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKR 1084
Cdd:TIGR02168  716 QLRKELEELSRQISALRKDLARLE---AEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIE 792

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1085 QAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDqqkndydqlqkarqcekenlgwqklESEKAI 1164
Cdd:TIGR02168  793 QLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLE-------------------------DLEEQI 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1165 KEKEYEIERLRVLLQEEGTRKREYENELakvrnhynEEMSNLRNKYETEInitkttikeisMQKEDDSKNLRNQLDRLSR 1244
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELESEL--------EALLNERASLEEAL-----------ALLRSELEELSEELRELES 908

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1245 ENRDLKDEIVRLNDSI--LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMqqrSEDNARHKQ-SLEEAAKTIQ 1321
Cdd:TIGR02168  909 KRSELRRELEELREKLaqLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIED---DEEEARRRLkRLENKIKELG 985

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 975830145  1322 DKNKE-IErlkaEFQEEAKRRweyeNELSKASNRIQESKNQCTQVVQE 1368
Cdd:TIGR02168  986 PVNLAaIE----EYEELKERY----DFLTAQKEDLTEAKETLEEAIEE 1025
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1104-1509 3.39e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 65.86  E-value: 3.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1104 IKELNEKITRLTYEI---EDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGwqKLESE-KAIKEKEYEIERLRVLLQ 1179
Cdd:PRK03918  171 IKEIKRRIERLEKFIkrtENIEELIKEKEKELEEVLREINEISSELPELREELE--KLEKEvKELEELKEEIEELEKELE 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1180 EEGTRKREYE---NELAKVRNHYNEEMSNLRNKYE--TEINITKTTIKEISMQKEDDSKNLRN---QLDRLSRENRDLKD 1251
Cdd:PRK03918  249 SLEGSKRKLEekiRELEERIEELKKEIEELEEKVKelKELKEKAEEYIKLSEFYEEYLDELREiekRLSRLEEEINGIEE 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1252 EIVRLNDSILQATEQRRRAEE-----NALQQKA-CGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNK 1325
Cdd:PRK03918  329 RIKELEEKEERLEELKKKLKElekrlEELEERHeLYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEIS 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1326 EIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQvvQERESLLVK----IKVLEQDKARLQRLEDELNRAKSTLE 1401
Cdd:PRK03918  409 KITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTE--EHRKELLEEytaeLKRIEKELKEIEEKERKLRKELRELE 486

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1402 AETRVKQRLECEKQ------QIQNDLNQW-KTQYSRKEEAIRKIesereksEREKNSLRSEIERLQAEIKRIEErcrrkL 1474
Cdd:PRK03918  487 KVLKKESELIKLKElaeqlkELEEKLKKYnLEELEKKAEEYEKL-------KEKLIKLKGEIKSLKKELEKLEE-----L 554

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 975830145 1475 EDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE 1509
Cdd:PRK03918  555 KKKLAELEKKLDELEEELAELLKELEELGFESVEE 589
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2283-2321 4.19e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 56.57  E-value: 4.19e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  2283 FLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRL 2321
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1032-1495 4.38e-10

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 65.38  E-value: 4.38e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1032 TKIEVLEEELRLARDANSENCNKNKFLDQNL------QKYQAECSQFKAKLASLEEL-----KRQAELDGKSAKQNLDKC 1100
Cdd:TIGR00618  219 ERKQVLEKELKHLREALQQTQQSHAYLTQKReaqeeqLKKQQLLKQLRARIEELRAQeavleETQERINRARKAAPLAAH 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1101 YGQIKELNEKITRLTYEIEDEKRRRKS--------VEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIE 1172
Cdd:TIGR00618  299 IKAVTQIEQQAQRIHTELQSKMRSRAKllmkraahVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLT 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1173 RLRVLLQEEGTRKREYENELAKVRNHYNEEMSN---------------LRNKYETEINITKTTIKEISMQKEDDSKNLRN 1237
Cdd:TIGR00618  379 QHIHTLQQQKTTLTQKLQSLCKELDILQREQATidtrtsafrdlqgqlAHAKKQQELQQRYAELCAAAITCTAQCEKLEK 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1238 QLDRLSRENRDLKDEIVRLNDSILQaTEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAA 1317
Cdd:TIGR00618  459 IHLQESAQSLKEREQQLQTKEQIHL-QETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTY 537

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1318 KTIQdknKEIERLKAEFQEEAKRRWEYENElskasnrIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAK 1397
Cdd:TIGR00618  538 AQLE---TSEEDVYHQLTSERKQRASLKEQ-------MQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAE 607

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1398 STLEAETRV----------KQRLECEKQQIQNDLNQWKTQ---------YSRKEEAIRKIESEREKSEREKNSLRSEIER 1458
Cdd:TIGR00618  608 DMLACEQHAllrklqpeqdLQDVRLHLQQCSQELALKLTAlhalqltltQERVREHALSIRVLPKELLASRQLALQKMQS 687

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 975830145  1459 LQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1495
Cdd:TIGR00618  688 EKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIE 724
PLEC smart00250
Plectin repeat;
2205-2242 4.75e-10

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 56.72  E-value: 4.75e-10
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 975830145   2205 QRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2242
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1062-1613 5.20e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 65.14  E-value: 5.20e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1062 LQKYQAECSQFKAKL----ASLEELKRQAELDGKSA-KQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD--- 1133
Cdd:pfam15921  226 LRELDTEISYLKGRIfpveDQLEALKSESQNKIELLlQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEiiq 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1134 QQKNDYDQLQKARQCEKEN----LGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYenelakvRNHYNEEMSNLRNK 1209
Cdd:pfam15921  306 EQARNQNSMYMRQLSDLEStvsqLRSELREAKRMYEDKIEELEKQLVLANSELTEARTE-------RDQFSQESGNLDDQ 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1210 YETEINITKTTIKEISMQKEDDSK----NLRNQL--DRLSRENRDLKDEIVRLnDSILQA--TEQRRRAEEN--ALQQKa 1279
Cdd:pfam15921  379 LQKLLADLHKREKELSLEKEQNKRlwdrDTGNSItiDHLRRELDDRNMEVQRL-EALLKAmkSECQGQMERQmaAIQGK- 456

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1280 cgSEIMQKKQHLEIEL---KQVMQQRSEDNARHKQSLEEAAKTIQDknkeierLKAEFQEEAKRRWEYENELSKASNRIQ 1356
Cdd:pfam15921  457 --NESLEKVSSLTAQLestKEMLRKVVEELTAKKMTLESSERTVSD-------LTASLQEKERAIEATNAEITKLRSRVD 527

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1357 ESKNQCTQVVQERESL--------LVKIKVLEQDKArLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLN------ 1422
Cdd:pfam15921  528 LKLQELQHLKNEGDHLrnvqteceALKLQMAEKDKV-IEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINdrrlel 606

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1423 -QWKTQYSRKEEAIRKIESEREKSEREKNSL-RSEIERLQAeIKRIEERcRRKLEDSTRETQSQLETERSRYQ------- 1493
Cdd:pfam15921  607 qEFKILKDKKDAKIRELEARVSDLELEKVKLvNAGSERLRA-VKDIKQE-RDQLLNEVKTSRNELNSLSEDYEvlkrnfr 684

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1494 ---REIDKLRQRPYGSHRETQTECEWTVDTSKLV--FDGLRKKVT-AMQlyecqlidkttlDKLLKGKKSVEEVASEIQp 1567
Cdd:pfam15921  685 nksEEMETTTNKLKMQLKSAQSELEQTRNTLKSMegSDGHAMKVAmGMQ------------KQITAKRGQIDALQSKIQ- 751

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*.
gi 975830145  1568 FLRGAGSIAGasaspKEKYSLVEAKRKklISPESTVMLLEAQAATG 1613
Cdd:pfam15921  752 FLEEAMTNAN-----KEKHFLKEEKNK--LSQELSTVATEKNKMAG 790
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1083-1387 6.30e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.08  E-value: 6.30e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1083 KRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED-EKRRRKSVE----------DRFDQQKNDYDQLQKarqcEKE 1151
Cdd:TIGR02168  174 RKETERKLERTRENLDRLEDILNELERQLKSLERQAEKaERYKELKAElrelelallvLRLEELREELEELQE----ELK 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1152 NLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN----------HYNEEMSNLRNKYET--------- 1212
Cdd:TIGR02168  250 EAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANeisrleqqkqILRERLANLERQLEEleaqleele 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1213 -EINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHL 1291
Cdd:TIGR02168  330 sKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARL 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1292 EIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRweyENELSKASNRIQESKNQCTQVVQERES 1371
Cdd:TIGR02168  410 ERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERL---EEALEELREELEEAEQALDAAERELAQ 486

                          330
                   ....*....|....*.
gi 975830145  1372 LLVKIKVLEQDKARLQ 1387
Cdd:TIGR02168  487 LQARLDSLERLQENLE 502
PTZ00121 PTZ00121
MAEBL; Provisional
 1018-1549 7.39e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 64.78  E-value: 7.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1018 SEMLKSLEDLKLKntkievlEEELRLARDANSENCNKNKFLDQnlQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNL 1097
Cdd:PTZ00121 1298 AEEKKKADEAKKK-------AEEAKKADEAKKKAEEAKKKADA--AKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEA 1368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1098 DKCygQIKELNEKITRLTYEIEdEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKE---KEYEIERL 1174
Cdd:PTZ00121 1369 AEK--KKEEAKKKADAAKKKAE-EKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADeakKKAEEAKK 1445

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1175 RVLLQEEGTRKREYENelAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRdlKDEIV 1254
Cdd:PTZ00121 1446 ADEAKKKAEEAKKAEE--AKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAK--KAEEA 1521

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEF 1334
Cdd:PTZ00121 1522 KKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLY 1601

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1335 QEEAKRRWEyenELSKAsnriQESKNQCTQVVQERE-----SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAetrvkqR 1409
Cdd:PTZ00121 1602 EEEKKMKAE---EAKKA----EEAKIKAEELKKAEEekkkvEQLKKKEAEEKKKAEELKKAEEENKIKAAEEA------K 1668

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1410 LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQaEIKRIEERCRRKLEDSTRETQSQLETER 1489
Cdd:PTZ00121 1669 KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE-ELKKAEEENKIKAEEAKKEAEEDKKKAE 1747

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1490 SRYQREIDKLRQRPYGSHRETQTEcEWTVDTSKLVFDGLRKKVTAMQLYecqlIDKTTLD 1549
Cdd:PTZ00121 1748 EAKKDEEEKKKIAHLKKEEEKKAE-EIRKEKEAVIEEELDEEDEKRRME----VDKKIKD 1802
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1222-1513 1.18e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 63.99  E-value: 1.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1222 KEISMQKEDDsKNLRNQLDRLSRENRDLKDEIVRLNDsiLQATEQRRRAEENalQQKACGSEIMQKKQHLEIELKQVMQQ 1301
Cdd:pfam17380  282 KAVSERQQQE-KFEKMEQERLRQEKEEKAREVERRRK--LEEAEKARQAEMD--RQAAIYAEQERMAMERERELERIRQE 356

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1302 -RSEDNARHKQslEEAAKTIQdKNKEIERLKAEFQEEAKR-RWEYEnelSKASNRIQESKNQCTQVVQERESLLVKIKVL 1379
Cdd:pfam17380  357 eRKRELERIRQ--EEIAMEIS-RMRELERLQMERQQKNERvRQELE---AARKVKILEEERQRKIQQQKVEMEQIRAEQE 430

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1380 EQDKARLQRLEDELNRakstlEAEtRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIE-R 1458
Cdd:pfam17380  431 EARQREVRRLEEERAR-----EME-RVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEeR 504

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 975830145  1459 LQAEIKriEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE 1513
Cdd:pfam17380  505 KQAMIE--EERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQ 557
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1028-1502 1.49e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 63.25  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1028 KLKNTKIEVLEEELRLARDANSENcnknKFLDQNLQKYQAECSQFKAKLASLEElkrqaELDGKSAKQNLDKCYGQIKEL 1107
Cdd:COG4717    67 ELNLKELKELEEELKEAEEKEEEY----AELQEELEELEEELEELEAELEELRE-----ELEKLEKLLQLLPLYQELEAL 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1108 NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRvllqeegTRKRE 1187
Cdd:COG4717   138 EAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQ-------QRLAE 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1188 YENELAKVRnhynEEMSNLRNKYEteinitkttikeiSMQKEDDSKNLRNQLDRLSRenrdlkdeIVRLNDSILQATEQR 1267
Cdd:COG4717   211 LEEELEEAQ----EELEELEEELE-------------QLENELEAAALEERLKEARL--------LLLIAAALLALLGLG 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1268 RRAEENALQQK----------ACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEE 1337
Cdd:COG4717   266 GSLLSLILTIAgvlflvlgllALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDR 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1338 AKRRWEYENELSKASNRIQESKNQctqvvQERESLLVKIKV--------LEQDKARLQRLEDELNRAKSTLEAETRvkqr 1409
Cdd:COG4717   346 IEELQELLREAEELEEELQLEELE-----QEIAALLAEAGVedeeelraALEQAEEYQELKEELEELEEQLEELLG---- 416

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1410 lECEKQQIQNDLNQWKTQYSRKEEAIrkieserekserekNSLRSEIERLQAEIKRIEERcRRKLEDStrETQSQLETER 1489
Cdd:COG4717   417 -ELEELLEALDEEELEEELEELEEEL--------------EELEEELEELREELAELEAE-LEQLEED--GELAELLQEL 478

                         490
                  ....*....|...
gi 975830145 1490 SRYQREIDKLRQR 1502
Cdd:COG4717   479 EELKAELRELAEE 491
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1028-1566 2.90e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 62.68  E-value: 2.90e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1028 KLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKEL 1107
Cdd:pfam02463  212 YYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLL 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1108 NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA---RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184
Cdd:pfam02463  292 AKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKElkkEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQL 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1185 KREYENELAKVRNHYNEEMSnLRNKYETEINITK---TTIKEISMQKEDDSKNLRNQLDRLSRENRDLKdEIVRLNDSIL 1261
Cdd:pfam02463  372 EEELLAKKKLESERLSSAAK-LKEEELELKSEEEkeaQLLLELARQLEDLLKEEKKEELEILEEEEESI-ELKQGKLTEE 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1262 QATEQRRRAEENALQQKAcgseimQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRR 1341
Cdd:pfam02463  450 KEELEKQELKLLKDELEL------KKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGR 523

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1342 WEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKarLQRLEDELNRAKSTLEAETRVKQrleCEKQQIQNDL 1421
Cdd:pfam02463  524 IISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQK--LVRALTELPLGARKLRLLIPKLK---LPLKSIAVLE 598

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1422 NQWKTQYSRKEEAIRKIesereKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQ 1501
Cdd:pfam02463  599 IDPILNLAQLDKATLEA-----DEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTK 673

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 975830145  1502 RPYGShRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQ 1566
Cdd:pfam02463  674 ELLEI-QELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEE 737
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 715-1469 3.16e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 62.83  E-value: 3.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   715 DSQAIAEVLNQLKDMLANFRGSEKYCY--LQNEVFGLFQKLENINGVTDGYLNSLCTvrallqAILQTEDMLKVYEARLT 792
Cdd:pfam15921  114 DLQTKLQEMQMERDAMADIRRRESQSQedLRNQLQNTVHELEAAKCLKEDMLEDSNT------QIEQLRKMMLSHEGVLQ 187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   793 EEETVCLDLDKVEAyrcglKKIKNDLNLKKSLLATMKTELQKA-QQIHSQTS----QQYPLYDL-------DLGKFGEKV 860
Cdd:pfam15921  188 EIRSILVDFEEASG-----KKIYEHDSMSTMHFRSLGSAISKIlRELDTEISylkgRIFPVEDQlealkseSQNKIELLL 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   861 TQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLesmkfgdsntVMRFLNEqknLHSEISGK 940
Cdd:pfam15921  263 QQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSM----------YMRQLSD---LESTVSQL 329

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   941 RDKSEEVQKIAElcaNSIKDYELQLASYTSgleTLLNIPIKRTMIQSPSGVI---LQEA-ADVHARYIELLTRSGDYYRF 1016
Cdd:pfam15921  330 RSELREAKRMYE---DKIEELEKQLVLANS---ELTEARTERDQFSQESGNLddqLQKLlADLHKREKELSLEKEQNKRL 403

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1017 ----------LSEMLKSLEDlklKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQA 1086
Cdd:pfam15921  404 wdrdtgnsitIDHLRRELDD---RNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKV 480

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1087 ELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQ-------KNDYDQLQKArQCEKENLGWQKLE 1159
Cdd:pfam15921  481 VEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKlqelqhlKNEGDHLRNV-QTECEALKLQMAE 559

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1160 SEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVrnhyneemsnlrnkyETEINITKTTIKEISMQKEDDSKNLRNQL 1239
Cdd:pfam15921  560 KDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQL---------------EKEINDRRLELQEFKILKDKKDAKIRELE 624

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1240 DRLSrenrDLKDEIVRLndsiLQATEQRRRAEEnalqqkacgsEIMQKKQHLeieLKQVMQQRSEDNARhKQSLEEAAKT 1319
Cdd:pfam15921  625 ARVS----DLELEKVKL----VNAGSERLRAVK----------DIKQERDQL---LNEVKTSRNELNSL-SEDYEVLKRN 682

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1320 IQDKNKEIERLKAEFQEEAKrrwEYENELSKASNRIQE---SKNQCTQV-VQERESLLVKIKVLEQDKARLQRLEDELNR 1395
Cdd:pfam15921  683 FRNKSEEMETTTNKLKMQLK---SAQSELEQTRNTLKSmegSDGHAMKVaMGMQKQITAKRGQIDALQSKIQFLEEAMTN 759

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 975830145  1396 AkstleaeTRVKQRLECEKQQIQNDLNQWKTQysrkeeairkiesereksereKNSLRSEIERLQAEIKRIEER 1469
Cdd:pfam15921  760 A-------NKEKHFLKEEKNKLSQELSTVATE---------------------KNKMAGELEVLRSQERRLKEK 805
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 671-1377 9.07e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 60.89  E-value: 9.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   671 ELQKIRRQIEhcEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLA-NFRGSEKYCYLQNEVFGL 749
Cdd:pfam05483  107 KLQENRKIIE--AQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCArSAEKTKKYEYEREETRQV 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   750 FQKLENingvtdgylNSLCTVRALLQAILQTEDmlkvyeARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMK 829
Cdd:pfam05483  185 YMDLNN---------NIEKMILAFEELRVQAEN------ARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQI 249

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   830 TE-----------LQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQidfrlwdLEKQIKQLRNYRDNYQAF 898
Cdd:pfam05483  250 TEkenkmkdltflLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMS-------LQRSMSTQKALEEDLQIA 322

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   899 CKWLYDAKRRQDslesmkfgdsnTVMRFLNEQKNLHS----EISGKRDKSEEV----QKIAELCANSIKDYELQLASYTS 970
Cdd:pfam05483  323 TKTICQLTEEKE-----------AQMEELNKAKAAHSfvvtEFEATTCSLEELlrteQQRLEKNEDQLKIITMELQKKSS 391

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   971 GLETLLNIPIKRTM-------IQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEE-LR 1042
Cdd:pfam05483  392 ELEEMTKFKNNKEVeleelkkILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHyLK 471

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1043 LARDANSENCN---KNKFLDQNLQKYQAECSQFKAKLASLE-ELKRQAElDGKSAKQNLDKCYGQIKELNEKITRLTYEI 1118
Cdd:pfam05483  472 EVEDLKTELEKeklKNIELTAHCDKLLLENKELTQEASDMTlELKKHQE-DIINCKKQEERMLKQIENLEEKEMNLRDEL 550

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1119 EdekrrrkSVEDRFDQQKNDYD-QLQKARQcEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197
Cdd:pfam05483  551 E-------SVREEFIQKGDEVKcKLDKSEE-NARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKK 622

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1198 HYNEEMSNLrNKYETEINITKTTIKEISMQKEDDSKNLRNQLD--RLSRENrdlkdeivrlndsILQATEQRRRAEENAL 1275
Cdd:pfam05483  623 KGSAENKQL-NAYEIKVNKLELELASAKQKFEEIIDNYQKEIEdkKISEEK-------------LLEEVEKAKAIADEAV 688

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1276 QQKacgSEIMQKKQHLEIELKQVMQqrsednaRHKQSLEeaaKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRI 1355
Cdd:pfam05483  689 KLQ---KEIDKRCQHKIAEMVALME-------KHKHQYD---KIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAEL 755

                          730       740
                   ....*....|....*....|..
gi 975830145  1356 QESKNQCTQVVQERESLLVKIK 1377
Cdd:pfam05483  756 LSLKKQLEIEKEEKEKLKMEAK 777
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1038-1497 1.02e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 60.96  E-value: 1.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1038 EEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAEldgksakQNLDKCYGQIKELNEKITRLTYE 1117
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAE-------EMRARLAARKQELEEILHELESR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1118 IEDEkrrrksvEDRFDQQKNDYDQLQK-----ARQCEKENLGWQKLESEKAIKE-KEYEIERLRVLLQEEGTR----KRE 1187
Cdd:pfam01576   84 LEEE-------EERSQQLQNEKKKMQQhiqdlEEQLDEEEAARQKLQLEKVTTEaKIKKLEEDILLLEDQNSKlskeRKL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1188 YENELAKVRNHYNEE------MSNLRNKYETEINITKTTIKEISMQKEDDSKNLRnqldRLSRENRDLKDEIVRLNDSIL 1261
Cdd:pfam01576  157 LEERISEFTSNLAEEeekaksLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKR----KLEGESTDLQEQIAELQAQIA 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1262 QATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS---EDNARHKQSLEEAAKTIQDKNKEIERLKAEF---- 1334
Cdd:pfam01576  233 ELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISelqEDLESERAARNKAEKQRRDLGEELEALKTELedtl 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1335 -----QEEAKRRWEYE-NELSKA--------SNRIQESKNQCTQVVQERESLLVKIK----VLEQDKARLQRLEDELNRA 1396
Cdd:pfam01576  313 dttaaQQELRSKREQEvTELKKAleeetrshEAQLQEMRQKHTQALEELTEQLEQAKrnkaNLEKAKQALESENAELQAE 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1397 KSTL-----EAETRvKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE---- 1467
Cdd:pfam01576  393 LRTLqqakqDSEHK-RKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLEsqlq 471

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 975830145  1468 -------ERCRRKLEDSTRetQSQLETERSRYQREID 1497
Cdd:pfam01576  472 dtqellqEETRQKLNLSTR--LRQLEDERNSLQEQLE 506
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 949-1383 1.21e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 60.85  E-value: 1.21e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   949 KIAELCANSIKDYELQLASYTSGLETLLN-IPIKRTMIQSPSGVILQEAADVHAryiELLTRSGDYYRFLSEMLKSLEDL 1027
Cdd:TIGR02169  663 RGGILFSRSEPAELQRLRERLEGLKRELSsLQSELRRIENRLDELSQELSDASR---KIGEIEKEIEQLEQEEEKLKERL 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1028 KLKNTKIEVLEEELRLARDansencnKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDgksakqnldkcygqikel 1107
Cdd:TIGR02169  740 EELEEDLSSLEQEIENVKS-------ELKELEARIEELEEDLHKLEEALNDLEARLSHSRIP------------------ 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1108 neKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRvllqeegTRKRE 1187
Cdd:TIGR02169  795 --EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLN-------GKKEE 865

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1188 YENELAKVRNHYNEemsnlrnkyeteinitkttikeismqkeddsknLRNQLDRLSRENRDLKDEIVRLNDSILQATEQR 1267
Cdd:TIGR02169  866 LEEELEELEAALRD---------------------------------LESRLGDLKKERDELEAQLRELERKIEELEAQI 912

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1268 RRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDnarhkQSLEEAAKTIQDKNKEIERL-----KA--EFQEEAKR 1340
Cdd:TIGR02169  913 EKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEE-----LSLEDVQAELQRVEEEIRALepvnmLAiqEYEEVLKR 987

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 975830145  1341 RweyeNELSKASNRIQEsknqctqvvqERESLLVKIKVLEQDK 1383
Cdd:TIGR02169  988 L----DELKEKRAKLEE----------ERKAILERIEEYEKKK 1016
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1105-1413 1.48e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 60.14  E-value: 1.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1105 KELNEKITRLTYEIEDEKRRRKSVED--RFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRvllQEEg 1182
Cdd:pfam17380  282 KAVSERQQQEKFEKMEQERLRQEKEEkaREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIR---QEE- 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1183 tRKREYEN--------ELAKVRN----HYNEEMSNLRNKYETE---------------INITKTTIKEISMQKED-DSKN 1234
Cdd:pfam17380  358 -RKRELERirqeeiamEISRMRElerlQMERQQKNERVRQELEaarkvkileeerqrkIQQQKVEMEQIRAEQEEaRQRE 436

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1235 LR-------NQLDRLSRENRDLKDEIVRLNDsilQATEQRRRAEENALQQKacgseimqKKQHLEIELKQVMQQRSEDNa 1307
Cdd:pfam17380  437 VRrleeeraREMERVRLEEQERQQQVERLRQ---QEEERKRKKLELEKEKR--------DRKRAEEQRRKILEKELEER- 504

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1308 RHKQSLEEAAKTIQDKNKEiERLKAEFQEEAKRRWEyenelskasnriQESKNQctQVVQERESLLVKIKVLEQDKARLQ 1387
Cdd:pfam17380  505 KQAMIEEERKRKLLEKEME-ERQKAIYEEERRREAE------------EERRKQ--QEMEERRRIQEQMRKATEERSRLE 569

                          330       340
                   ....*....|....*....|....*.
gi 975830145  1388 RLEDELNRAKSTLEAEtrvKQRLECE 1413
Cdd:pfam17380  570 AMEREREMMRQIVESE---KARAEYE 592
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1105-1459 1.74e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 60.08  E-value: 1.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1105 KELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG-----WQKLESEKAiKEKEyEIERLRVLLQ 1179
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGeiekeIEQLEQEEE-KLKE-RLEELEEDLS 747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1180 EEGTRKREYENELAKVRNHYnEEMSNLRNKYETEINitkttikeismqkEDDSKNLRNQLDRLSRENRDLKDEIVRLnDS 1259
Cdd:TIGR02169  748 SLEQEIENVKSELKELEARI-EELEEDLHKLEEALN-------------DLEARLSHSRIPEIQAELSKLEEEVSRI-EA 812

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1260 ILQATEQ---RRRAEENALQQKAcgSEIMQKKQHLEIELKQVMQQRSEDNARhkqsLEEAAKTIQDKNKEIERLKAEFQE 1336
Cdd:TIGR02169  813 RLREIEQklnRLTLEKEYLEKEI--QELQEQRIDLKEQIKSIEKEIENLNGK----KEELEEELEELEAALRDLESRLGD 886

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1337 EAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQdkaRLQRLEDELNRAKS----TLEAETRVKQRLEC 1412
Cdd:TIGR02169  887 LKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEE---ELSEIEDPKGEDEEipeeELSLEDVQAELQRV 963

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 975830145  1413 EkQQIQ--NDLNQWKTQ-YSRKEEAIRKIESEREKSEREKNSLRSEIERL 1459
Cdd:TIGR02169  964 E-EEIRalEPVNMLAIQeYEEVLKRLDELKEKRAKLEEERKAILERIEEY 1012
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1303-1502 2.04e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.01  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1303 SEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQD 1382
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1383 KARLQRLEDELNRAKSTLEAETRVKQRLECEK-QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQA 1461
Cdd:COG4942    99 LEAQKEELAELLRALYRLGRQPPLALLLSPEDfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEA 178

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 975830145 1462 EIKRIEERCRR--KLEDSTRETQSQLETERSRYQREIDKLRQR 1502
Cdd:COG4942   179 LLAELEEERAAleALKAERQKLLARLEKELAELAAELAELQQE 221
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1027-1502 2.14e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 59.74  E-value: 2.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1027 LKLKNTKIEVLEEELRlaRDANSENCNKNKFLDQNLQKYqaecSQFKAKLASLEELKRQA-ELDGKSAKQNLDkcygqIK 1105
Cdd:pfam05483  217 LKEDHEKIQHLEEEYK--KEINDKEKQVSLLLIQITEKE----NKMKDLTFLLEESRDKAnQLEEKTKLQDEN-----LK 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1106 ELNEKITRLTYEIEDEK-------RRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLL 1178
Cdd:pfam05483  286 ELIEKKDHLTKELEDIKmslqrsmSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELL 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1179 QEEGTRKREYENELAKV------RNHYNEEMSNLRNKYETEINITKTTIKEisMQKEDDSKnlrNQLDRLSREnrdlkde 1252
Cdd:pfam05483  366 RTEQQRLEKNEDQLKIItmelqkKSSELEEMTKFKNNKEVELEELKKILAE--DEKLLDEK---KQFEKIAEE------- 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1253 ivrlndsiLQATEQrrraeenalqqkacgseimqkkqhleiELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKA 1332
Cdd:pfam05483  434 --------LKGKEQ---------------------------ELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKT 478

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1333 EFQEEAKRrweyENELSKASNRIQ-ESKnqctQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTL-EAETRVKQRL 1410
Cdd:pfam05483  479 ELEKEKLK----NIELTAHCDKLLlENK----ELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLeEKEMNLRDEL 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1411 ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK-------NSLRSEIERLQAEIKRIEERCRRKLEDSTRETQ- 1482
Cdd:pfam05483  551 ESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMkilenkcNNLKKQIENKNKNIEELHQENKALKKKGSAENKq 630

                          490       500
                   ....*....|....*....|.
gi 975830145  1483 -SQLETERSRYQREIDKLRQR 1502
Cdd:pfam05483  631 lNAYEIKVNKLELELASAKQK 651
PLEC smart00250
Plectin repeat;
2281-2314 2.60e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 51.71  E-value: 2.60e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 975830145   2281 QRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFID 2314
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLID 34
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1062-1211 2.72e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 56.86  E-value: 2.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN--DY 1139
Cdd:COG1579    12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNnkEY 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 975830145 1140 DQLQKarqcEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYE 1211
Cdd:COG1579    92 EALQK----EIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1258-1502 3.16e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.30  E-value: 3.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1258 DSILQATEQRRRA--EENA--LQQKACGSEIMQKKQHLEIELKQVMQQRSEDNaRHKQSLEEAAKtiqdKNKEIERLKAE 1333
Cdd:TIGR02168  147 SEIIEAKPEERRAifEEAAgiSKYKERRKETERKLERTRENLDRLEDILNELE-RQLKSLERQAE----KAERYKELKAE 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1334 fqEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQD----KARLQRLEDELNRAKSTLEAETRVKQR 1409
Cdd:TIGR02168  222 --LRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKleelRLEVSELEEEIEELQKELYALANEISR 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1410 LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRK------LEDSTRETQS 1483
Cdd:TIGR02168  300 LEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELeaeleeLESRLEELEE 379

                          250       260
                   ....*....|....*....|..
gi 975830145  1484 QLETERSRY---QREIDKLRQR 1502
Cdd:TIGR02168  380 QLETLRSKVaqlELQIASLNNE 401
PTZ00121 PTZ00121
MAEBL; Provisional
 1026-1498 4.28e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.00  E-value: 4.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1026 DLKLKNTKIEVLEEELRLARDANSENCNKNKfldqnlQKYQAECSQFKAKLASLEELKRQAElDGKSAKQNLDKCYGQIK 1105
Cdd:PTZ00121 1082 DAKEDNRADEATEEAFGKAEEAKKTETGKAE------EARKAEEAKKKAEDARKAEEARKAE-DARKAEEARKAEDAKRV 1154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1106 ELNEKI--TRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGwQKLESEKAIKE-KEYEIERL--RVLLQE 1180
Cdd:PTZ00121 1155 EIARKAedARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAA-RKAEEERKAEEaRKAEDAKKaeAVKKAE 1233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1181 EGTRKREYENELAKVRNhyNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQldRLSRENRdlKDEIVRLNDSI 1260
Cdd:PTZ00121 1234 EAKKDAEEAKKAEEERN--NEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEK--KKADEAK--KAEEKKKADEA 1307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1261 LQATEQRRRAEEnaLQQKA----CGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEiERLKAefqE 1336
Cdd:PTZ00121 1308 KKKAEEAKKADE--AKKKAeeakKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEE-AKKKA---D 1381

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1337 EAKRRWEYENELSKASNRIQESKNQCTQVVQERESllvKIKVLE-QDKARLQRLEDELNRAKSTLEAETRVKQRLEcEKQ 1415
Cdd:PTZ00121 1382 AAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAA---KKKADEaKKKAEEKKKADEAKKKAEEAKKADEAKKKAE-EAK 1457

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1416 QIQNDLNqwKTQYSRKEEAIRKiesereksereknslRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1495
Cdd:PTZ00121 1458 KAEEAKK--KAEEAKKADEAKK---------------KAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEE 1520


                  ...
gi 975830145 1496 IDK 1498
Cdd:PTZ00121 1521 AKK 1523
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1156-1409 4.88e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 4.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1156 QKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEeMSNLRNKYETEINITKTTIKEismqkeddsknL 1235
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAA-LARRIRALEQELAALEAELAE-----------L 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1236 RNQLDRLSRENRDLKDEIVRLndsiLQATEQRRRAEENALQQKACGSEIMQKKQHLeieLKQVMQQRsednarhkqslEE 1315
Cdd:COG4942    89 EKEIAELRAELEAQKEELAEL----LRALYRLGRQPPLALLLSPEDFLDAVRRLQY---LKYLAPAR-----------RE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1316 AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESllvKIKVLEQDKARLQRLEDELNR 1395
Cdd:COG4942   151 QAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEK---ELAELAAELAELQQEAEELEA 227

                         250
                  ....*....|....
gi 975830145 1396 AKSTLEAETRVKQR 1409
Cdd:COG4942   228 LIARLEAEAAAAAE 241
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1230-1473 4.96e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 4.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1230 DDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARH 1309
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1310 KQSLEEAAKTIQD--KNKEIERLKAEFQ----EEAKRRWEYENELSKASnriqesKNQCTQVVQERESLLVKIKVLEQDK 1383
Cdd:COG4942   100 EAQKEELAELLRAlyRLGRQPPLALLLSpedfLDAVRRLQYLKYLAPAR------REQAEELRADLAELAALRAELEAER 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1384 ARLQRLEDELNRAKSTLEAETRvkqrlecEKQQIQNDLNQwktQYSRKEEAIRKiesereksereknsLRSEIERLQAEI 1463
Cdd:COG4942   174 AELEALLAELEEERAALEALKA-------ERQKLLARLEK---ELAELAAELAE--------------LQQEAEELEALI 229

                         250
                  ....*....|
gi 975830145 1464 KRIEERCRRK 1473
Cdd:COG4942   230 ARLEAEAAAA 239
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 190-366 5.24e-08

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 55.91  E-value: 5.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  190 ECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA---DLREKSAIY---------QLEEEYEN 257
Cdd:cd00176    11 ELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNElgeQLIEEGHPDaeeiqerleELNQRWEE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  258 LLKASFERMDHL---RQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESD 334
Cdd:cd00176    91 LRELAEERRQRLeeaLDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSLNELAE 170

                         170       180       190
                  ....*....|....*....|....*....|...
gi 975830145  335 QLVLNQHPAS-DKIEAYMDTLQTQWSWILQITK 366
Cdd:cd00176   171 ELLEEGHPDAdEEIEEKLEELNERWEELLELAE 203
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1017-1494 1.23e-07

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 57.49  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1017 LSEMLKSLEDLKlkNTKIEVLEEELRLARDANSENCNknkfLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQN 1096
Cdd:pfam01576  487 LSTRLRQLEDER--NSLQEQLEEEEEAKRNVERQLST----LQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQ 560

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1097 LDKCYGQIKELNEKITRLTYEIEDekrrrksVEDRFDQQKNDYDQLQKarqceKENLGWQKLESEKAIKEKeYEIERLRV 1176
Cdd:pfam01576  561 LEEKAAAYDKLEKTKNRLQQELDD-------LLVDLDHQRQLVSNLEK-----KQKKFDQMLAEEKAISAR-YAEERDRA 627

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1177 llqEEGTRKREYEnelAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLrNQLDRLSR----ENRDLKDE 1252
Cdd:pfam01576  628 ---EAEAREKETR---ALSLARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNV-HELERSKRaleqQVEEMKTQ 700

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1253 IVRLNDSiLQATEQRR-RAEENALQQKACGSEIMQKKQHLEIE-----LKQVMQQRSE-DNARHKQSLEEAAKtiqdKNK 1325
Cdd:pfam01576  701 LEELEDE-LQATEDAKlRLEVNMQALKAQFERDLQARDEQGEEkrrqlVKQVRELEAElEDERKQRAQAVAAK----KKL 775

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1326 EIERLKAEFQEEA--KRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKvlEQDKaRLQRLEDELNRAKSTLEAE 1403
Cdd:pfam01576  776 ELDLKELEAQIDAanKGREEAVKQLKKLQAQMKDLQRELEEARASRDEILAQSK--ESEK-KLKNLEAELLQLQEDLAAS 852

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1404 TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKsereknsLRSEIERLQAEIKRIEERcRRKLEDSTRETQS 1483
Cdd:pfam01576  853 ERARRQAQQERDELADEIASGASGKSALQDEKRRLEARIAQ-------LEEELEEEQSNTELLNDR-LRKSTLQVEQLTT 924

                          490
                   ....*....|.
gi 975830145  1484 QLETERSRYQR 1494
Cdd:pfam01576  925 ELAAERSTSQK 935
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1125-1500 1.42e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 56.97  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1125 RKSVEDRFDQQKNDYDQLqKARQCEKENLGWQKL--ESEKAIKEKEYEIERLrvllQEEGTRKREYENELAKVRNHYNEE 1202
Cdd:PRK02224  175 RLGVERVLSDQRGSLDQL-KAQIEEKEEKDLHERlnGLESELAELDEEIERY----EEQREQARETRDEADEVLEEHEER 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1203 MSNLrNKYETEINITKTTIKEISMQKEDDS---KNLRNQLDRLSRENRDLKDEiVRLNDSILQATEQRRraEENALQQKA 1279
Cdd:PRK02224  250 REEL-ETLEAEIEDLRETIAETEREREELAeevRDLRERLEELEEERDDLLAE-AGLDDADAEAVEARR--EELEDRDEE 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1280 CGSEIMQKKQHLEIELKQVMQQRS-----EDNARHKQS--------LEEAAKTIQDKNKEIERLKAEFQEEAKR------ 1340
Cdd:PRK02224  326 LRDRLEECRVAAQAHNEEAESLREdaddlEERAEELREeaaeleseLEEAREAVEDRREEIEELEEEIEELRERfgdapv 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1341 ----------------------RWEYENELSKASNRIQESKN--------QCTQ---------VVQERESLLVKIKV-LE 1380
Cdd:PRK02224  406 dlgnaedfleelreerdelrerEAELEATLRTARERVEEAEAlleagkcpECGQpvegsphveTIEEDRERVEELEAeLE 485

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1381 QDKARLQRLEDELNRAKSTLEAETRVkQRLECEKQQIQNDLNQWKTQYSRKEEAIrkieserekserekNSLRSEIERLQ 1460
Cdd:PRK02224  486 DLEEEVEEVEERLERAEDLVEAEDRI-ERLEERREDLEELIAERRETIEEKRERA--------------EELRERAAELE 550

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 975830145 1461 AEIKRIEERCRRKLE--DSTRETQSQLETERSRYQREIDKLR 1500
Cdd:PRK02224  551 AEAEEKREAAAEAEEeaEEAREEVAELNSKLAELKERIESLE 592
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1233-1485 1.43e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.23  E-value: 1.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1233 KNLRNqLDRLSREN----RDLKDEIVRLNDSILQATEQRRRAEEnALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNA- 1307
Cdd:COG4913   204 KPIGD-LDDFVREYmleePDTFEAADALVEHFDDLERAHEALED-AREQIELLEPIRELAERYAAARERLAELEYLRAAl 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1308 ---RHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQctqvvqERESLLVKIKVLEQDKA 1384
Cdd:COG4913   282 rlwFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGD------RLEQLEREIERLERELE 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1385 RLQRLEDELNRAKSTLEAET-RVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEI 1463
Cdd:COG4913   356 ERERRRARLEALLAALGLPLpASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRK 435

                         250       260
                  ....*....|....*....|....*
gi 975830145 1464 KRIEER---CRRKLEDSTRETQSQL 1485
Cdd:COG4913   436 SNIPARllaLRDALAEALGLDEAEL 460
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1106-1512 1.54e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 57.29  E-value: 1.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1106 ELNEKITRLTYEIEDEKRRRKSVED---RFDQQKNDYDQL-QKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEE 1181
Cdd:TIGR00618   82 SLGTKIYRVHRTLRCTRSHRKTEQPeqlYLEQKKGRGRILaAKKSETEEVIHDLLKLDYKTFTRVVLLPQGEFAQFLKAK 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1182 GTRKREYENELAKVrNHYNEEMSNLRNKY---ETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLND 1258
Cdd:TIGR00618  162 SKEKKELLMNLFPL-DQYTQLALMEFAKKkslHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQ 240

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1259 SILQATEQRRRAEENALQQKACGsEIMQKKQHLEIELKQVMQQRSEDN-ARHKQSLEEAAKTIQDKNKEIERLKAEFQEE 1337
Cdd:TIGR00618  241 SHAYLTQKREAQEEQLKKQQLLK-QLRARIEELRAQEAVLEETQERINrARKAAPLAAHIKAVTQIEQQAQRIHTELQSK 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1338 akrrweyENELSKAsnriqesKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLE---AETRVKQRLECEK 1414
Cdd:TIGR00618  320 -------MRSRAKL-------LMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREiscQQHTLTQHIHTLQ 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1415 QQIQNDLNQWKTQySRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQ------LETE 1488
Cdd:TIGR00618  386 QQKTTLTQKLQSL-CKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEklekihLQES 464

                          410       420
                   ....*....|....*....|....
gi 975830145  1489 RSRYQREIDKLRQRPYGSHRETQT 1512
Cdd:TIGR00618  465 AQSLKEREQQLQTKEQIHLQETRK 488
PLEC smart00250
Plectin repeat;
1641-1678 1.70e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 49.40  E-value: 1.70e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 975830145   1641 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETG 1678
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 993-1467 1.98e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.87  E-value: 1.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  993 LQEAADVHARYIELLTR-SGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQ 1071
Cdd:COG1196   269 LEELRLELEELELELEEaQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEE 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1072 FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKE 1151
Cdd:COG1196   349 AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEE 428

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1152 NLGwQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINItKTTIKEISMQKEDD 1231
Cdd:COG1196   429 ALA-ELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAAR-LLLLLEAEADYEGF 506

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1232 S-----KNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRR--RAEENALQQKACGSEIMQKKQH--LEIELKQVMQQR 1302
Cdd:COG1196   507 LegvkaALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALqnIVVEDDEVAAAAIEYLKAAKAGraTFLPLDKIRARA 586

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1303 SEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLV-------- 1374
Cdd:COG1196   587 ALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAggsltggs 666

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1375 KIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK----- 1449
Cdd:COG1196   667 RRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELleeee 746

                         490       500       510
                  ....*....|....*....|....*....|....
gi 975830145 1450 ----------------NSLRSEIERLQAEIKRIE 1467
Cdd:COG1196   747 lleeealeelpeppdlEELERELERLEREIEALG 780
PLEC smart00250
Plectin repeat;
1605-1640 2.05e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 49.02  E-value: 2.05e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 975830145   1605 LLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1640
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1134-1501 2.30e-07

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 56.12  E-value: 2.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1134 QQKNDY----DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNK 1209
Cdd:COG5185   140 VEKLDEiadiEASYGEVETGIIKDIFGKLTQELNQNLKKLEIFGLTLGLLKGISELKKAEPSGTVNSIKESETGNLGSES 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1210 YETEINITKTTIKEI---SMQKEDDSKNLRNQLDRLSR---ENRDLKDEIVRlndsilQATEQRRRAEENALQQKacgSE 1283
Cdd:COG5185   220 TLLEKAKEIINIEEAlkgFQDPESELEDLAQTSDKLEKlveQNTDLRLEKLG------ENAESSKRLNENANNLI---KQ 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1284 IMQKKQHLEIELKQVmqqrseDNARHKQSLEEAAKTIQdKNKEIERLKAEFQEEAKRRW-EYENELSKASNRIQESKNQC 1362
Cdd:COG5185   291 FENTKEKIAEYTKSI------DIKKATESLEEQLAAAE-AEQELEESKRETETGIQNLTaEIEQGQESLTENLEAIKEEI 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1363 TQVVQERESLLVKIKvLEQDKARLQRLEDEL--------NRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEA 1434
Cdd:COG5185   364 ENIVGEVELSKSSEE-LDSFKDTIESTKESLdeipqnqrGYAQEILATLEDTLKAADRQIEELQRQIEQATSSNEEVSKL 442

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 975830145 1435 IRKIESEREKSEREKNSLRSE---------IERLQAEIKRIEERcRRKLEDSTRETQSQLETERSRYQREIDKLRQ 1501
Cdd:COG5185   443 LNELISELNKVMREADEESQSrleeaydeiNRSVRSKKEDLNEE-LTQIESRVSTLKATLEKLRAKLERQLEGVRS 517
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2025-2053 2.31e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 48.86  E-value: 2.31e-07
                           10        20
                   ....*....|....*....|....*....
gi 975830145  2025 IVDPETNKEMSVQEAYKKGLIDYETFKEL 2053
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
1848-1882 4.81e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 47.86  E-value: 4.81e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 975830145   1848 LLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEF 1882
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1103-1352 5.09e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.38  E-value: 5.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1103 QIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQcekenlgwqklESEKAIKEKEYEIERLRVLLQEEG 1182
Cdd:COG4942    28 ELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIR-----------ALEQELAALEAELAELEKEIAELR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1183 TRKREYENELAKVrnhyneemsnLRNKYETEINitkTTIKEISMQkeDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQ 1262
Cdd:COG4942    97 AELEAQKEELAEL----------LRALYRLGRQ---PPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1263 ATEQRRRAEENALQQKACGSEIMQKKQhleiELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRW 1342
Cdd:COG4942   162 LAALRAELEAERAELEALLAELEEERA----ALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237

                         250
                  ....*....|
gi 975830145 1343 EYENELSKAS 1352
Cdd:COG4942   238 AAAERTPAAG 247
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1004-1500 5.38e-07

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 55.13  E-value: 5.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1004 IELLTRSGDYYRFLSEMLKSLEDLKlknTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083
Cdd:pfam05557   30 IELEKKASALKRQLDRESDRNQELQ---KRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKLNEKESQLADAREVI 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1084 RqaeldgkSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKE-NLGWQKLESE- 1161
Cdd:pfam05557  107 S-------CLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSLAEaEQRIKELEFEi 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1162 ----------KAIKEK-------EYEIERLRV-------------LLQEEgtrKREYENELAKVRNhYNEEMSNL---RN 1208
Cdd:pfam05557  180 qsqeqdseivKNSKSElaripelEKELERLREhnkhlnenienklLLKEE---VEDLKRKLEREEK-YREEAATLeleKE 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1209 KYETEINITKTTIKE--ISMQKEDDsknLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQ 1286
Cdd:pfam05557  256 KLEQELQSWVKLAQDtgLNLRSPED---LSRRIEQLQQREIVLKEENSSLTSSARQLEKARRELEQELAQYLKKIEDLNK 332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1287 KKQHLEiELKQVMQQR----SEDNARHKQSLEE------AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQ 1356
Cdd:pfam05557  333 KLKRHK-ALVRRLQRRvlllTKERDGYRAILESydkeltMSNYSPQLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELG 411

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1357 ESKNQCTQVvqERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE-TRVKQR-----LECEKQQIQNDLNQWKTqysr 1430
Cdd:pfam05557  412 GYKQQAQTL--ERELQALRQQESLADPSYSKEEVDSLRRKLETLELErQRLREQkneleMELERRCLQGDYDPKKT---- 485

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1431 keeaiRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCrRKLEDSTRETQSQLETERSRYQREIDKLR 1500
Cdd:pfam05557  486 -----KVLHLSMNPAAEAYQQRKNQLEKLQAEIERLKRLL-KKLEDDLEQVLRLPETTSTMNFKEVLDLR 549
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
993-1315 6.53e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.92  E-value: 6.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  993 LQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEncnknkfldqnlqkyqaecsqf 1072
Cdd:COG4913   629 AEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDD---------------------- 686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1073 kakLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY--DQLQKARQCEK 1150
Cdd:COG4913   687 ---LAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALleERFAAALGDAV 763

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1151 ENLGWQKLESE--KAIKEKEYEIERLRVLLQEegtRKREYENELAKV------RNHYNEEMSNLRN----KYETEIN--I 1216
Cdd:COG4913   764 ERELRENLEERidALRARLNRAEEELERAMRA---FNREWPAETADLdadlesLPEYLALLDRLEEdglpEYEERFKelL 840

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1217 TKTTIKEISmqkeddskNLRNQLDrlsRENRDLKDEIVRLNDSILQ-----------ATEQRRRAEENALQQ--KACGS- 1282
Cdd:COG4913   841 NENSIEFVA--------DLLSKLR---RAIREIKERIDPLNDSLKRipfgpgrylrlEARPRPDPEVREFRQelRAVTSg 909

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 975830145 1283 ---EIMQKKQHLEIELKQVMQQ-RSEDNARHKQSLEE 1315
Cdd:COG4913   910 aslFDEELSEARFAALKRLIERlRSEEEESDRRWRAR 946
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1236-1525 6.82e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.92  E-value: 6.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1236 RNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQqkacgseimqkkqhleieLKQVMQQRSEDnarhkQSLEE 1315
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREA------------------LQRLAEYSWDE-----IDVAS 665

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1316 AAKTIQDKNKEIERLKAEfqeeakrrweyENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNR 1395
Cdd:COG4913   666 AEREIAELEAELERLDAS-----------SDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQD 734

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1396 AKSTLEAETRVKQRLECEKQ---------------QIQNDLNQWKTQYSRKEEAIRKIESE-----REKSEREKNSLRS- 1454
Cdd:COG4913   735 RLEAAEDLARLELRALLEERfaaalgdaverelreNLEERIDALRARLNRAEEELERAMRAfnrewPAETADLDADLESl 814

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1455 -EIERLQAEIKRI-----EERCRRKLEDSTRET----QSQLETERSRYQREIDK----LRQRPYGSHRETQTECEWTVDT 1520
Cdd:COG4913   815 pEYLALLDRLEEDglpeyEERFKELLNENSIEFvadlLSKLRRAIREIKERIDPlndsLKRIPFGPGRYLRLEARPRPDP 894


                  ....*
gi 975830145 1521 SKLVF 1525
Cdd:COG4913   895 EVREF 899
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1304-1515 6.90e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 55.07  E-value: 6.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAE------FQEEAKRRWEYE-NELSKASNRIQESKNQCTQVVQEREsllvki 1376
Cdd:TIGR02169  177 EELEEVEENIERLDLIIDEKRQQLERLRRErekaerYQALLKEKREYEgYELLKEKEALERQKEAIERQLASLE------ 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1377 KVLEQDKARLQRLEDELNRAKSTL-EAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSE 1455
Cdd:TIGR02169  251 EELEKLTEEISELEKRLEEIEQLLeELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAE 330

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 975830145  1456 IERLQAEIKRIEERC------RRKLEDSTRETQSQLETERSRYQrEIDKLRQRPYGSHRETQTECE 1515
Cdd:TIGR02169  331 IDKLLAEIEELEREIeeerkrRDKLTEEYAELKEELEDLRAELE-EVDKEFAETRDELKDYREKLE 395
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 670-1423 7.88e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 55.06  E-value: 7.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   670 MELQKIRRQIEHCEGRMTLKNLPLADQGSS-----HHITVKINELKSvQNDSQAIAEVLNQLKDMLANFRGSEKYCYlQN 744
Cdd:TIGR01612 1814 IEAKEFDRIINHFKKKLDHVNDKFTKEYSKinegfDDISKSIENVKN-STDENLLFDILNKTKDAYAGIIGKKYYSY-KD 1891

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   745 EVFGLFQK--------------------LENINGVTDGYLNSlctvrallqailQTEDMLKVYEARLTEEET-------- 796
Cdd:TIGR01612 1892 EAEKIFINisklansiniqiqnnsgidlFDNINIAILSSLDS------------EKEDTLKFIPSPEKEPEIytkirdsy 1959

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   797 -VCLDL-------------------------DKVEAYRcGLKKIKNDLNLKKS-LLATMKTELQKAQQIHSQT--SQQYP 847
Cdd:TIGR01612 1960 dTLLDIfkksqdlhkkeqdtlniifenqqlyEKIQASN-ELKDTLSDLKYKKEkILNDVKLLLHKFDELNKLScdSQNYD 2038

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   848 LYdLDLGKFgEKVTQLTDRWQRIDKQ--IDFRLWDLEKQ----IKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSN 921
Cdd:TIGR01612 2039 TI-LELSKQ-DKIKEKIDNYEKEKEKfgIDFDVKAMEEKfdndIKDIEKFENNYKHSEKDNHDFSEEKDNIIQSKKKLKE 2116

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   922 TVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCAnsikdyelqLASYTSGLETLlnipiKRTMIQspsgvilqeaadvHA 1001
Cdd:TIGR01612 2117 LTEAFNTEIKIIEDKIIEKNDLIDKLIEMRKECL---------LFSYATLVETL-----KSKVIN-------------HS 2169

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1002 RYIELLTR-SGDYYRFLSEMLKSLEDlklkntKIEVLEEELRLardansencnknkfldqnlqkyqaecSQFKAKLASLE 1080
Cdd:TIGR01612 2170 EFITSAAKfSKDFFEFIEDISDSLND------DIDALQIKYNL--------------------------NQTKKHMISIL 2217

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1081 ElkrqaelDGKSAKQNLDKcygQIKELNEKITRLT--YEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKE---NLGW 1155
Cdd:TIGR01612 2218 A-------DATKDHNNLIE---KEKEATKIINNLTelFTIDFNNADADILHNNKIQIIYFNSELHKSIESIKKlykKINA 2287

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1156 QKLESEKAIKEKEYEIER-LRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISmqkeDDSKN 1234
Cdd:TIGR01612 2288 FKLLNISHINEKYFDISKeFDNIIQLQKHKLTENLNDLKEIDQYISDKKNIFLHALNENTNFNFNALKEIY----DDIIN 2363

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQrrraeenaLQQKACGSEIMQKKQHLeieLKQVMQQRSEDN-ARHKQSL 1313
Cdd:TIGR01612 2364 RENKADEIENINNKENENIMQYIDTITKLTEK--------IQDILIFVTTYENDNNI---IKQHIQDNDENDvSKIKDNL 2432

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1314 EEAAKTIQDKNKEIERLKAEFqeeakrrweYENelskasNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ-RLED- 1391
Cdd:TIGR01612 2433 KKTIQSFQEILNKIDEIKAQF---------YGG------NNINNIIITISQNANDVKNHFSKDLTIENELIQIQkRLEDi 2497

                          810       820       830
                   ....*....|....*....|....*....|....*.
gi 975830145  1392 ----ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQ 1423
Cdd:TIGR01612 2498 knaaHEIRSEQITKYTNAIHNHIEEQFKKIENNSNK 2533
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1039-1331 1.03e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 54.41  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1039 EELRLARDansENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD-------------GKSAKQNlDKcygqiK 1105
Cdd:pfam01576  815 EEARASRD---EILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQErdeladeiasgasGKSALQD-EK-----R 885

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLgwQKLESekAIKEKEYEIERLRVLLQE-EGTr 1184
Cdd:pfam01576  886 RLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTS--QKSES--ARQQLERQNKELKAKLQEmEGT- 960

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1185 kreyenelakvrnhyneemsnLRNKYETEINITKTTIKEISMQKEDDSKNlRNQLDRLSRENRDlkdeivRLNDSILQAT 1264
Cdd:pfam01576  961 ---------------------VKSKFKSSIAALEAKIAQLEEQLEQESRE-RQAANKLVRRTEK------KLKEVLLQVE 1012

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 975830145  1265 EQRRRAEENALQQKACGSEIMQKKQHLEIELKQVmqQRSEDNARHKQ-SLEEAAKTIQDKNKEIERLK 1331
Cdd:pfam01576 1013 DERRHADQYKDQAEKGNSRMKQLKRQLEEAEEEA--SRANAARRKLQrELDDATESNESMNREVSTLK 1078
PLEC smart00250
Plectin repeat;
1808-1845 1.25e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.71  E-value: 1.25e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 975830145   1808 KDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTA 1845
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 824-1499 1.42e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 53.82  E-value: 1.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   824 LLATMKTELQKAQQIHSQTSQQyplydldlgkfgEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLY 903
Cdd:TIGR00618  227 ELKHLREALQQTQQSHAYLTQK------------REAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAP 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   904 DAKrRQDSLESMKFgDSNTVMRFLNEQKNLHSEISGKRdkseevqkiaelcANSIKDyELQLASYTSGLETLLNIPIKRT 983
Cdd:TIGR00618  295 LAA-HIKAVTQIEQ-QAQRIHTELQSKMRSRAKLLMKR-------------AAHVKQ-QSSIEEQRRLLQTLHSQEIHIR 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   984 MIQSPSGVILQEAADVHARYIELLTRSGDyYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ 1063
Cdd:TIGR00618  359 DAHEVATSIREISCQQHTLTQHIHTLQQQ-KTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQ 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1064 KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143
Cdd:TIGR00618  438 RYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPAR 517

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1144 KA---------RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRnkyetei 1214
Cdd:TIGR00618  518 QDidnpgpltrRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQ------- 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1215 NITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRR-----RAEENALQQK---ACGSEIMQ 1286
Cdd:TIGR00618  591 NITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKltalhALQLTLTQERvreHALSIRVL 670

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1287 KKQHLEIELK--QVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQeeakrrwEYENELSKASNRIQ---ESKNQ 1361
Cdd:TIGR00618  671 PKELLASRQLalQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFN-------EIENASSSLGSDLAareDALNQ 743

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1362 CTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAK-STLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIES 1440
Cdd:TIGR00618  744 SLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAElSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQC 823

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1441 EREKSEREK-NSLRSEIERLQAEIKRIEErcrrKLEDsTRETQSQLETERSRYQREIDKL 1499
Cdd:TIGR00618  824 ETLVQEEEQfLSRLEEKSATLGEITHQLL----KYEE-CSKQLAQLTQEQAKIIQLSDKL 878
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1019-1287 1.61e-06

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 52.22  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1019 EMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKfldQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLD 1098
Cdd:COG1340     5 ELSSSLEELEEKIEELREEIEELKEKRDELNEELKELA---EKRDELNAQVKELREEAQELREKRDELNEKVKELKEERD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1099 KCYGQIKELNEKITRLTYEIEDEKRRRKSVedrfDQQKNDYDQLQKARQCEKENLGWQK------------LESEKAIKE 1166
Cdd:COG1340    82 ELNEKLNELREELDELRKELAELNKAGGSI----DKLRKEIERLEWRQQTEVLSPEEEKelvekikelekeLEKAKKALE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1167 KEYEIERLRVLLQEEGTRKREYEN---ELAKVRNHYNEEMSNLRNKYET---EINITKTTIKEISmqkeDDSKNLRNQLD 1240
Cdd:COG1340   158 KNEKLKELRAELKELRKEAEEIHKkikELAEEAQELHEEMIELYKEADElrkEADELHKEIVEAQ----EKADELHEEII 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 975830145 1241 RLSRENRDLKDEIVRLNDsilQATEQRRRAEENALQQKAcgSEIMQK 1287
Cdd:COG1340   234 ELQKELRELRKELKKLRK---KQRALKREKEKEELEEKA--EEIFEK 275
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1058-1270 1.61e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1058 LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
Cdd:COG4942    25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKE 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1138 DYDQ----LQKARQCEKENLGWQKLESEKAIKEKEY----------EIERLRVLLQEEGTRKREYENELAKVRNHYnEEM 1203
Cdd:COG4942   105 ELAEllraLYRLGRQPPLALLLSPEDFLDAVRRLQYlkylaparreQAEELRADLAELAALRAELEAERAELEALL-AEL 183

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 975830145 1204 SNLRNKYETEINITKTTIKEISMQKeddsKNLRNQLDRLSRENRDLKDEIVRLndsILQATEQRRRA 1270
Cdd:COG4942   184 EEERAALEALKAERQKLLARLEKEL----AELAAELAELQQEAEELEALIARL---EAEAAAAAERT 243
PRK12704 PRK12704
phosphodiesterase; Provisional
 1160-1341 1.87e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 53.24  E-value: 1.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1160 SEKAIKEKEYEIERLrvlLQEEgtrKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQL 1239
Cdd:PRK12704   29 AEAKIKEAEEEAKRI---LEEA---KKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1240 DRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHleiELKQVMQQRSEDNARHkqsleEAAKT 1319
Cdd:PRK12704  103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAE---EAKEILLEKVEEEARH-----EAAVL 174

                         170       180
                  ....*....|....*....|..
gi 975830145 1320 IqdknKEIErlkAEFQEEAKRR 1341
Cdd:PRK12704  175 I----KEIE---EEAKEEADKK 189
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 927-1502 2.27e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 53.43  E-value: 2.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   927 LNEQKNLHSEISGKRDKSEEVQKIAELCAN---SIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV--ILQEAADVHA 1001
Cdd:TIGR00618  235 LQQTQQSHAYLTQKREAQEEQLKKQQLLKQlraRIEELRAQEAVLEETQERINRARKAAPLAAHIKAVtqIEQQAQRIHT 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANS------ENCNKNKFLDQNLQKYQAECSQFKAK 1075
Cdd:TIGR00618  315 ELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEvatsirEISCQQHTLTQHIHTLQQQKTTLTQK 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1076 LASLEELKRQ-AELDGKSAKQNLDKcygqiKELNEKITRLTYEIEDEKRR----RKSVEDRFDQQKNDYDQLQKARQCEK 1150
Cdd:TIGR00618  395 LQSLCKELDIlQREQATIDTRTSAF-----RDLQGQLAHAKKQQELQQRYaelcAAAITCTAQCEKLEKIHLQESAQSLK 469

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1151 ENLgwQKLESEKAIKEKEYEIERLRVLLQEEgtrKREYENELAKVRNHYNEEMSNLrnkYETEINITKT-TIKEISMQKE 1229
Cdd:TIGR00618  470 ERE--QQLQTKEQIHLQETRKKAVVLARLLE---LQEEPCPLCGSCIHPNPARQDI---DNPGPLTRRMqRGEQTYAQLE 541

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1230 DDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR--------------------AEENALQQKACGSEIMQKKQ 1289
Cdd:TIGR00618  542 TSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRskedipnlqnitvrlqdlteKLSEAEDMLACEQHALLRKL 621

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1290 HLEIELKQV---MQQRSEDNARHKQSLEEAAKTI-QDKNKEIERLKAEFQEEAKRRweYENELSKASNRIQesknQCTQV 1365
Cdd:TIGR00618  622 QPEQDLQDVrlhLQQCSQELALKLTALHALQLTLtQERVREHALSIRVLPKELLAS--RQLALQKMQSEKE----QLTYW 695

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1366 VQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAEtrVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKS 1445
Cdd:TIGR00618  696 KEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSD--LAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAA 773

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 975830145  1446 EREKNSL----------RSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1502
Cdd:TIGR00618  774 LQTGAELshlaaeiqffNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEK 840
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 1250-1417 2.30e-06

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 52.93  E-value: 2.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1250 KDEIVRLNDSI--LQATEQRRRAEENALQQK---------ACGSEIMQKKQH---LEIELKQVMQQRSEDnarhKQSLEE 1315
Cdd:pfam09726  394 PDALVRLEQDIkkLKAELQASRQTEQELRSQissltslerSLKSELGQLRQEndlLQTKLHNAVSAKQKD----KQTVQQ 469

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1316 AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTqvvqerESLlvkikvleqdKARLQRLEDELNR 1395
Cdd:pfam09726  470 LEKRLKAEQEARASAEKQLAEEKKRKKEEEATAARAVALAAASRGECT------ESL----------KQRKRELESEIKK 533

                          170       180
                   ....*....|....*....|....*.
gi 975830145  1396 akstLEAETRVKQR----LECEKQQI 1417
Cdd:pfam09726  534 ----LTHDIKLKEEqireLEIKVQEL 555
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1289-1502 2.87e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.85  E-value: 2.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1289 QHLEIELKQVMQQRSEDNARHKQSLEEA-----AKTIQDKNKEIERLKAEFQEEAKRRWEyenELSKASNRIQESKNQCT 1363
Cdd:COG4717    15 RDRTIEFSPGLNVIYGPNEAGKSTLLAFiramlLERLEKEADELFKPQGRKPELNLKELK---ELEEELKEAEEKEEEYA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1364 QVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQrLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE 1443
Cdd:COG4717    92 ELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEA-LEAELAELPERLEELEERLEELRELEEELEELEA 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 975830145 1444 KSEREKNSLRSEIERLQAEIKRIEERCRRKLEDStRETQSQLETERSRYQREIDKLRQR 1502
Cdd:COG4717   171 ELAELQEELEELLEQLSLATEEELQDLAEELEEL-QQRLAELEEELEEAQEELEELEEE 228
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 713-1487 3.28e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 52.74  E-value: 3.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   713 QNDSQAIAEVLNQLKDMLANfrGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLT 792
Cdd:TIGR00606  404 EDEAKTAAQLCADLQSKERL--KQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELR 481

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   793 EEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKfgekvtqlTDRWQRIDK 872
Cdd:TIGR00606  482 KAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDK--------MDKDEQIRK 553

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   873 QidfrLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESmkfgdsntvmRFLNEQKNLHS-EISGKRDKSEEVQKIA 951
Cdd:TIGR00606  554 I----KSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRD----------RLAKLNKELASlEQNKNHINNELESKEE 619

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   952 ELCANSIKDYElqlASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT-----------RSGDYYRFLSEM 1020
Cdd:TIGR00606  620 QLSSYEDKLFD---VCGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTdenqsccpvcqRVFQTEAELQEF 696

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1021 LKSLED-LKLKNTKIEVLEEELRlardansencNKNKFLDQNLQKYQAECSQFKAKLASLEELK---RQAELDGKSAKQN 1096
Cdd:TIGR00606  697 ISDLQSkLRLAPDKLKSTESELK----------KKEKRRDEMLGLAPGRQSIIDLKEKEIPELRnklQKVNRDIQRLKND 766

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1097 LDKCYGQIKELNEKItrltyEIEDEKRRRKSVEDRFDQQKND----YDQLQKARQCEKENLGWQKLESEKAIKEKEY--- 1169
Cdd:TIGR00606  767 IEEQETLLGTIMPEE-----ESAKVCLTDVTIMERFQMELKDverkIAQQAAKLQGSDLDRTVQQVNQEKQEKQHELdtv 841

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1170 --EIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKyeteinitkttikeisMQKEDDSKNLRNQLDRLSRENR 1247
Cdd:TIGR00606  842 vsKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRR----------------QQFEEQLVELSTEVQSLIREIK 905

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1248 DLKDEIVRLNdsilQATEQRRRAEENALQQKACGSEIMQKK-QHLEIELKQVMQQRSEDNARHKQSLEEAAKtiqDKNKE 1326
Cdd:TIGR00606  906 DAKEQDSPLE----TFLEKDQQEKEELISSKETSNKKAQDKvNDIKEKVKNIHGYMKDIENKIQDGKDDYLK---QKETE 978

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1327 IERLKAEFQEEAKRRWEYENELSKASNRIQESKnqctqvvqERESLLvkikvleQDKARLQRLEDELNRAKSTLeaetrv 1406
Cdd:TIGR00606  979 LNTVNAQLEECEKHQEKINEDMRLMRQDIDTQK--------IQERWL-------QDNLTLRKRENELKEVEEEL------ 1037

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1407 KQRLeceKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKriEERCRRKlEDSTRETQSQLE 1486
Cdd:TIGR00606 1038 KQHL---KEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELR--EPQFRDA-EEKYREMMIVMR 1111


                   .
gi 975830145  1487 T 1487
Cdd:TIGR00606 1112 T 1112
PLEC smart00250
Plectin repeat;
1922-1957 4.68e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 45.17  E-value: 4.68e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 975830145   1922 IRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEE 1957
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1058-1473 4.92e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.21  E-value: 4.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1058 LDQNLQKY----------QAECSQFKAKLASLEELKRQA------ELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
Cdd:PRK01156  317 IDAEINKYhaiikklsvlQKDYNDYIKKKSRYDDLNNQIlelegyEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEI 396

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1122 KRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGwqklESEKAIKEKEYEIERLRVLLQEE------GTRKREYENElaKV 1195
Cdd:PRK01156  397 LKIQEIDPDAIKKELNEINVKLQDISSKVSSLN----QRIRALRENLDELSRNMEMLNGQsvcpvcGTTLGEEKSN--HI 470

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1196 RNHYNEEMSNLrnkyETEINITKTTIKEISMQKEDDSKNL----RNQLDRLSRENRDLKD---EIVRLNDSILQATEQRR 1268
Cdd:PRK01156  471 INHYNEKKSRL----EEKIREIEIEVKDIDEKIVDLKKRKeyleSEEINKSINEYNKIESaraDLEDIKIKINELKDKHD 546

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1269 RAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQslEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENEL 1348
Cdd:PRK01156  547 KYEEIKNRYKSLKLEDLDSKRTSWLNALAVISLIDIETNRSRS--NEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREI 624

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1349 SKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNrakstleaetrvkqrlecekqQIQNDLNQWKTQY 1428
Cdd:PRK01156  625 ENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLK---------------------EITSRINDIEDNL 683

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 975830145 1429 SRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRK 1473
Cdd:PRK01156  684 KKSRKALDDAKANRARLESTIEILRTRINELSDRINDINETLESM 728
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1281-1491 5.95e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 51.06  E-value: 5.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1281 GSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKN 1360
Cdd:COG4372     1 GDRLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1361 QctqVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIrkies 1440
Cdd:COG4372    81 E---LEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEEL----- 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 975830145 1441 erekserekNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1491
Cdd:COG4372   153 ---------KELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANR 194
PLEC smart00250
Plectin repeat;
2020-2050 6.28e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.78  E-value: 6.28e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 975830145   2020 KRRVVIVDPETNKEMSVQEAYKKGLIDYETF 2050
Cdd:smart00250    8 SAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 971-1407 7.14e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 51.05  E-value: 7.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   971 GLETLLNIPiKRTMIQSPSGVILQEAADVH-ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANS 1049
Cdd:pfam07888   19 GTDMLLVVP-RAELLQNRLEECLQERAELLqAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHE 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1050 ENCNKNKfldqNLQKYQAECSQFKAKLASLEELKRQaeldgksakqnldkcygQIKELNEKITRLT---YEIEDEKRRRK 1126
Cdd:pfam07888   98 ELEEKYK----ELSASSEELSEEKDALLAQRAAHEA-----------------RIRELEEDIKTLTqrvLERETELERMK 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1127 svedrfDQQKNDYDQLqkarqcekenlgwqklesekaiKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNL 1206
Cdd:pfam07888  157 ------ERAKKAGAQR----------------------KEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQV 208

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1207 RNKYETeinITKTTIK-EISMQKEDDSKNLRNQLdRLSREnrdlkdeivRLNDSILQATEQRRRAEENALQQKACGSEIM 1285
Cdd:pfam07888  209 LQLQDT---ITTLTQKlTTAHRKEAENEALLEEL-RSLQE---------RLNASERKVEGLGEELSSMAAQRDRTQAELH 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1286 QKK---QHLEIELKQVMQQRSEDNAR---HKQSLEEAAKTIQDK----NKEIERLKAEFQEEAKRRWEYENELS--KASN 1353
Cdd:pfam07888  276 QARlqaAQLTLQLADASLALREGRARwaqERETLQQSAEADKDRieklSAELQRLEERLQEERMEREKLEVELGreKDCN 355

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 975830145  1354 RIQESKNqCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVK 1407
Cdd:pfam07888  356 RVQLSES-RRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQRLETVADAK 408
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1199-1502 8.42e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.19  E-value: 8.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1199 YNEEMSNLRNKYETEINITKTTIKEISMQKED-DSKNLRNQLDRLSRENRDLKDEIVRLNdsilqatEQRRRAEENALQQ 1277
Cdd:PRK02224  167 YRERASDARLGVERVLSDQRGSLDQLKAQIEEkEEKDLHERLNGLESELAELDEEIERYE-------EQREQARETRDEA 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1278 KACGSEIMQKKQHLEiELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEE--------------AKRRWE 1343
Cdd:PRK02224  240 DEVLEEHEERREELE-TLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLlaeaglddadaeavEARREE 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1344 YENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ----RLEDELNRAKSTLeaETRVKQRLECEKQqiqn 1419
Cdd:PRK02224  319 LEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELReeaaELESELEEAREAV--EDRREEIEELEEE---- 392

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1420 dLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER---------------CRRKLEDS------- 1477
Cdd:PRK02224  393 -IEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERveeaealleagkcpeCGQPVEGSphvetie 471

                         330       340
                  ....*....|....*....|....*.
gi 975830145 1478 -TRETQSQLETERSRYQREIDKLRQR 1502
Cdd:PRK02224  472 eDRERVEELEAELEDLEEEVEEVEER 497
PLEC smart00250
Plectin repeat;
1680-1716 9.12e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.40  E-value: 9.12e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 975830145   1680 RLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY 1716
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
1885-1921 9.21e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.40  E-value: 9.21e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 975830145   1885 KLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHG 1921
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
MutS2 COG1193
dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];
1240-1390 1.01e-05

dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];


Pssm-ID: 440806 [Multi-domain]  Cd Length: 784  Bit Score: 50.91  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1240 DRLSRENRDLKDEIVRLNDSILQATEQRRRAEEnaLQQkacgsEIMQKKQHLEIELKQVMQQRsedNARHKQSLEEAAKT 1319
Cdd:COG1193   507 ELLGEESIDVEKLIEELERERRELEEEREEAER--LRE-----ELEKLREELEEKLEELEEEK---EEILEKAREEAEEI 576

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 975830145 1320 IQDKNKEIERLKAEFQEEAKRrweyENELSKASNRIQESKnqctqvvQERESLLVKIKVLEQDKARLQRLE 1390
Cdd:COG1193   577 LREARKEAEELIRELREAQAE----EEELKEARKKLEELK-------QELEEKLEKPKKKAKPAKPPEELK 636
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1295-1502 1.29e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.79  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1295 LKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEakrrweyeNELSKASNRIQESKNQCTQVVQERESLLV 1374
Cdd:COG3206   162 LEQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQK--------NGLVDLSEEAKLLLQQLSELESQLAEARA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1375 KikvLEQDKARLQRLEDELNRAKSTLEA--ETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRkiesereksereknSL 1452
Cdd:COG3206   234 E---LAEAEARLAALRAQLGSGPDALPEllQSPVIQQLRAQLAELEAELAELSARYTPNHPDVI--------------AL 296

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 975830145 1453 RSEIERLQAEIKRIEERcrrkLEDSTRETQSQLETERSRYQREIDKLRQR 1502
Cdd:COG3206   297 RAQIAALRAQLQQEAQR----ILASLEAELEALQAREASLQAQLAQLEAR 342
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1810-1848 1.30e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 43.86  E-value: 1.30e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 975830145  1810 FLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALEL 1848
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1229-1502 2.11e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 50.22  E-value: 2.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1229 EDDSKNLRNQLDRLSRENRDLKDEIVRLndsilqATEQRRRAEENAlqqkacgseimQKKQHLEIELKQVMQQRSEDNAR 1308
Cdd:pfam12128  247 QQEFNTLESAELRLSHLHFGYKSDETLI------ASRQEERQETSA-----------ELNQLLRTLDDQWKEKRDELNGE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1309 hkqsLEEAAKTIQDKNKEIERLkaefqEEAKRRWEYENELSKASNRIQES--KNQCTQVVQERESLLVKIKVLEQDKARL 1386
Cdd:pfam12128  310 ----LSAADAAVAKDRSELEAL-----EDQHGAFLDADIETAAADQEQLPswQSELENLEERLKALTGKHQDVTAKYNRR 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1387 -----QRLEDELNRAKSTLEA--ETRVKQRLECEK--QQIQNDLNQWKTQYSR--KEEAIRKIESEREKSEREKNSLRSE 1455
Cdd:pfam12128  381 rskikEQNNRDIAGIKDKLAKirEARDRQLAVAEDdlQALESELREQLEAGKLefNEEEYRLKSRLGELKLRLNQATATP 460

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 975830145  1456 IERLQAEIKriEERCRRkledsTRETQSQLETERSRYQREIDKLRQR 1502
Cdd:pfam12128  461 ELLLQLENF--DERIER-----AREEQEAANAEVERLQSELRQARKR 500
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1153-1393 2.99e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.53  E-value: 2.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1153 LGWQkleSEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYnEEMSNLRNKYETEINI--TKTTIKEISMQKE- 1229
Cdd:COG4913   604 LGFD---NRAKLAALEAELAELEEELAEAEERLEALEAELDALQERR-EALQRLAEYSWDEIDVasAEREIAELEAELEr 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1230 -----DDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEEN-----ALQQKACGSEIMQKKQHLEIELKQVM 1299
Cdd:COG4913   680 ldassDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEEldelqDRLEAAEDLARLELRALLEERFAAAL 759

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1300 QQRSEDNARHK--QSLEEAAKTIQDKNKEIERLKAEFqeeaKRRW---------------EYENELSKASN--------R 1354
Cdd:COG4913   760 GDAVERELRENleERIDALRARLNRAEEELERAMRAF----NREWpaetadldadleslpEYLALLDRLEEdglpeyeeR 835

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 975830145 1355 IQESKNQCTQvvQERESLLVKIKVLEQD-KARLQRLEDEL 1393
Cdd:COG4913   836 FKELLNENSI--EFVADLLSKLRRAIREiKERIDPLNDSL 873
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1025-1338 3.37e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 48.75  E-value: 3.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1025 EDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQI 1104
Cdd:COG4372    52 EELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQR 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1105 KELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLR---VLLQEE 1181
Cdd:COG4372   132 KQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELaeaEKLIES 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1182 GTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSIL 1261
Cdd:COG4372   212 LPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEA 291

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 975830145 1262 QATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEA 1338
Cdd:COG4372   292 ALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVA 368
Caldesmon pfam02029
Caldesmon;
1077-1351 3.41e-05

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 49.10  E-value: 3.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1077 ASLEELKRQAELDGKSAKQNLDKCygqiKELNEKITRLTYEIEdEKRRRKSVEDRFDQQKNDYDQLQKARQCEKEnlgwq 1156
Cdd:pfam02029   63 AFLDRTAKREERRQKRLQEALERQ----KEFDPTIADEKESVA-ERKENNEEEENSSWEKEEKRDSRLGRYKEEE----- 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1157 KLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINIT--------KTTIKEISMQK 1228
Cdd:pfam02029  133 TEIREKEYQENKWSTEVRQAEEEGEEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYEskvfldqkRGHPEVKSQNG 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1229 EDDSKNLRNQLDRLSRENRDL---KDEIVRLNDSILQATEQRRRAEENALQQKacgSEIMQKKQHLEIELKQVMQQRSED 1305
Cdd:pfam02029  213 EEEVTKLKVTTKRRQGGLSQSqerEEEAEVFLEAEQKLEELRRRRQEKESEEF---EKLRQKQQEAELELEELKKKREER 289

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 975830145  1306 narhKQSLEEAAKtiQDKNKEIERLKAEfqEEAKRRWEYENELSKA 1351
Cdd:pfam02029  290 ----RKLLEEEEQ--RRKQEEAERKLRE--EEEKRRMKEEIERRRA 327
SPEC smart00150
Spectrin repeats;
285-373 3.53e-05

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 44.63  E-value: 3.53e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145    285 WINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQI 364
Cdd:smart00150   13 WLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLEELNERWEELKEL 92


                    ....*....
gi 975830145    365 TKCIDVHLK 373
Cdd:smart00150   93 AEERRQKLE 101
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1054-1417 5.20e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 48.66  E-value: 5.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1054 KNKF--LDQNLQKYQAECSQFKAKLASL-----------EELKR------------QAELDG-----KSAKQNLDKCYGQ 1103
Cdd:pfam10174  288 KNKIdqLKQELSKKESELLALQTKLETLtnqnsdckqhiEVLKEsltakeqraailQTEVDAlrlrlEEKESFLNKKTKQ 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1104 IKELNEKITRLTYEIEDEKrrrksveDRFDQQKNDYDQLQKarqcEKENLGWQklesekaIKEKEYEIERLRVLLQEEGT 1183
Cdd:pfam10174  368 LQDLTEEKSTLAGEIRDLK-------DMLDVKERKINVLQK----KIENLQEQ-------LRDKDKQLAGLKERVKSLQT 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1184 RKREYENELAKVRNHYNEEmsnlrnkyeteinitKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQA 1263
Cdd:pfam10174  430 DSSNTDTALTTLEEALSEK---------------ERIIERLKEQREREDRERLEELESLKKENKDLKEKVSALQPELTEK 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1264 TEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHK--QSLEEAAKT---IQDKNKEIERLKAEFQEEA 1338
Cdd:pfam10174  495 ESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKkaHNAEEAVRTnpeINDRIRLLEQEVARYKEES 574

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1339 KRRW-----------EYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQD--KARLQRLEDELNRAKS------- 1398
Cdd:pfam10174  575 GKAQaeverllgilrEVENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEmkKKGAQLLEEARRREDNladnsqq 654

                          410       420
                   ....*....|....*....|....
gi 975830145  1399 -----TLEAETRVKQRLECEKQQI 1417
Cdd:pfam10174  655 lqleeLMGALEKTRQELDATKARL 678
PRK12704 PRK12704
phosphodiesterase; Provisional
 1349-1496 5.41e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 48.24  E-value: 5.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1349 SKASNRIQESKNQCTQVVQERESllvKIKVLEQDKarLQRLEDELNRAKSTLEAETRVKQRlecEKQQIQNDLNQWKTQY 1428
Cdd:PRK12704   27 KIAEAKIKEAEEEAKRILEEAKK---EAEAIKKEA--LLEAKEEIHKLRNEFEKELRERRN---ELQKLEKRLLQKEENL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1429 SRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDS---TRE---------TQSQLETERSRYQREI 1496
Cdd:PRK12704   99 DRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERIsglTAEeakeillekVEEEARHEAAVLIKEI 178
PLEC smart00250
Plectin repeat;
2168-2204 5.66e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 42.08  E-value: 5.66e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 975830145   2168 DTLEESSPIAAIFDTENLEKISITEGIERGIVDSITG 2204
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1227-1500 5.78e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 48.35  E-value: 5.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1227 QKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLeielkqvMQQRSEDN 1306
Cdd:pfam07888   56 QREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDAL-------LAQRAAHE 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1307 ARHKQsLEEAAKTIqdknkeierlkaefqeeAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKikvLEQDKARL 1386
Cdd:pfam07888  129 ARIRE-LEEDIKTL-----------------TQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAK---LQQTEEEL 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1387 QRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKE---EAIRKIESEREKSEREKNSLRSEIE------ 1457
Cdd:pfam07888  188 RSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEallEELRSLQERLNASERKVEGLGEELSsmaaqr 267

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 975830145  1458 -RLQAEIKRIEERCRR---KLEDST---RETQSQLETERSRYQR--EIDKLR 1500
Cdd:pfam07888  268 dRTQAELHQARLQAAQltlQLADASlalREGRARWAQERETLQQsaEADKDR 319
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1292-1502 6.24e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 48.80  E-value: 6.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1292 EIELKQVMQQRSE----------DNARHKQSLEEAAKTIQDKNKEIERLKAEFQEE-AKRRWEYENELSKAsnriQESKN 1360
Cdd:COG3096   835 EAELAALRQRRSElerelaqhraQEQQLRQQLDQLKEQLQLLNKLLPQANLLADETlADRLEELREELDAA----QEAQA 910

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1361 ---QCTQVVQERESLLVkikVLEQD-------KARLQRLEDELNRAKSTLEAETRVKQRLE-----------CEKQ---- 1415
Cdd:COG3096   911 fiqQHGKALAQLEPLVA---VLQSDpeqfeqlQADYLQAKEQQRRLKQQIFALSEVVQRRPhfsyedavgllGENSdlne 987

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1416 QIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRS-------EIERLQAEIKRI--------EERC---RRKLED- 1476
Cdd:COG3096   988 KLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSsrdakqqTLQELEQELEELgvqadaeaEERArirRDELHEe 1067

                         250       260
                  ....*....|....*....|....*...
gi 975830145 1477 --STRETQSQLETERSRYQREIDKLRQR 1502
Cdd:COG3096  1068 lsQNRSRRSQLEKQLTRCEAEMDSLQKR 1095
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1251-1462 7.26e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.52  E-value: 7.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1251 DEIVRLNDSILQATEQRRRAEE--NALQQKAcgSEIMQKKQHLEIELKQVmqqrsednarhKQSLEEAAKTIQDKNKEIE 1328
Cdd:COG3883    16 PQIQAKQKELSELQAELEAAQAelDALQAEL--EELNEEYNELQAELEAL-----------QAEIDKLQAEIAEAEAEIE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1329 RLKAEFQEEAK-------------------------RRWEYENELSKASNRIQEsknqctQVVQERESLLVKIKVLEQDK 1383
Cdd:COG3883    83 ERREELGERARalyrsggsvsyldvllgsesfsdflDRLSALSKIADADADLLE------ELKADKAELEAKKAELEAKL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1384 ARLQRLEDELNRAKSTLEAE----TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERL 1459
Cdd:COG3883   157 AELEALKAELEAAKAELEAQqaeqEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAA 236


                  ...
gi 975830145 1460 QAE 1462
Cdd:COG3883   237 AAA 239
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
770-1277 7.66e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 48.14  E-value: 7.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  770 VRALLQAILQTEDMLKVYEARLTEEETVCLDLD----KVEAYRcGLKKIKNDLNLKKS----LLATMKTELQKAQQIHSQ 841
Cdd:PRK03918  254 KRKLEEKIRELEERIEELKKEIEELEEKVKELKelkeKAEEYI-KLSEFYEEYLDELReiekRLSRLEEEINGIEERIKE 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  842 TSQQyplyDLDLGKFGEKVTQLTDRWQRIDKqiDFRLWDLEKQIK-QLRNYRDNYQafCKWLYDAKRRQDSLESMKFGDS 920
Cdd:PRK03918  333 LEEK----EERLEELKKKLKELEKRLEELEE--RHELYEEAKAKKeELERLKKRLT--GLTPEKLEKELEELEKAKEEIE 404

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  921 NTVMRFLNEQKNLHSEISGKRDKSEEVQK---IAELCANSIKDYELQ--LASYTSGLETLLNIPIKRTMIQSPSGVILQE 995
Cdd:PRK03918  405 EEISKITARIGELKKEIKELKKAIEELKKakgKCPVCGRELTEEHRKelLEEYTAELKRIEKELKEIEEKERKLRKELRE 484

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  996 AADVHARYIELLTrsgdyYRFLSEMLKSLEDlKLKNTKIEVLEEELRLARDANSEncnknkfldqnLQKYQAECSQFKAK 1075
Cdd:PRK03918  485 LEKVLKKESELIK-----LKELAEQLKELEE-KLKKYNLEELEKKAEEYEKLKEK-----------LIKLKGEIKSLKKE 547

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1076 LASLEEL-KRQAELDGKsakqnLDKCYGQIKELNEKITRLTYEIEDEkrrrksVEDRFDQQKNDYDQLQKARQCEKEnlg 1154
Cdd:PRK03918  548 LEKLEELkKKLAELEKK-----LDELEEELAELLKELEELGFESVEE------LEERLKELEPFYNEYLELKDAEKE--- 613

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1155 wqKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN-EEMSNLRNKY---ETEINITKTTIKEISMQKED 1230
Cdd:PRK03918  614 --LEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSeEEYEELREEYlelSRELAGLRAELEELEKRREE 691

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 975830145 1231 DSKNLRNqLDRLSRENRDLKDEIVRLNDSILQATEQRRR-------AEENALQQ 1277
Cdd:PRK03918  692 IKKTLEK-LKEELEEREKAKKELEKLEKALERVEELREKvkkykalLKERALSK 744
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1023-1375 8.66e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 48.04  E-value: 8.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1023 SLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLasLEELKRQAELDGKSAKQNLDKCYG 1102
Cdd:pfam02463  669 SELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEEL--LADRVQEAQDKINEELKLLKQKID 746

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1103 QIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNdYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLR---VLLQ 1179
Cdd:pfam02463  747 EEEEEEEKSRLKKEEKEEEKSELSLKEKELAEERE-KTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEeeqLLIE 825

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1180 EEGTRKREYENELAK------VRNHYNEEMSNLRNKYETEinITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEI 1253
Cdd:pfam02463  826 QEEKIKEEELEELALelkeeqKLEKLAEEELERLEEEITK--EELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELE 903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1254 VRLNDSILQATEQRRRAEENALQQkacgsEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAE 1333
Cdd:pfam02463  904 EESQKLNLLEEKENEIEERIKEEA-----EILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLM 978

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 975830145  1334 FQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVK 1375
Cdd:pfam02463  979 AIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLK 1020
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1219-1502 8.69e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 46.83  E-value: 8.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1219 TTIKEISMQKEDdsknLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRraeenalqqkacgSEIMQKKQHLEiELKQV 1298
Cdd:COG1340     1 SKTDELSSSLEE----LEEKIEELREEIEELKEKRDELNEELKELAEKRD-------------ELNAQVKELRE-EAQEL 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1299 MQQRSEDN---ARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYEnELSKASNRIqESKNQCTQVVQERESLLV- 1374
Cdd:COG1340    63 REKRDELNekvKELKEERDELNEKLNELREELDELRKELAELNKAGGSID-KLRKEIERL-EWRQQTEVLSPEEEKELVe 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1375 KIKVLEQdkaRLQRLEDELNRAKSTLEAETRVKQrLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRS 1454
Cdd:COG1340   141 KIKELEK---ELEKAKKALEKNEKLKELRAELKE-LRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHK 216

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 975830145 1455 EIERLQAEIKRIeercrrkledstRETQSQLETERSRYQREIDKLRQR 1502
Cdd:COG1340   217 EIVEAQEKADEL------------HEEIIELQKELRELRKELKKLRKK 252
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1073-1204 9.18e-05

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 47.93  E-value: 9.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1073 KAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNdydQLQKARQCEKEn 1152
Cdd:COG2433   384 ELIEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLER---ELSEARSEERR- 459

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 975830145 1153 lgwqKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMS 1204
Cdd:COG2433   460 ----EIRKDREISRLDREIERLERELEEERERIEELKRKLERLKELWKLEHS 507
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1313-1594 1.19e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.75  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1313 LEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDE 1392
Cdd:PRK03918  160 YENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEE 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1393 LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKnSLRSEIERLQAEIKRIEERCRR 1472
Cdd:PRK03918  240 IEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYI-KLSEFYEEYLDELREIEKRLSR 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1473 kLEDSTRETQSQLEtERSRYQREIDKLRQRpygsHRETQTECEwTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLD--- 1549
Cdd:PRK03918  319 -LEEEINGIEERIK-ELEEKEERLEELKKK----LKELEKRLE-ELEERHELYEEAKAKKEELERLKKRLTGLTPEKlek 391

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 975830145 1550 KLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYS-LVEAKRK 1594
Cdd:PRK03918  392 ELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEeLKKAKGK 437
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1159-1415 1.27e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 46.44  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1159 ESEKAIKEKeyeIERLRVLLQEEGTRKREYENELAKV---RNHYNEEMSNLRNKYETEINITKTTIKEIsmqkeddsKNL 1235
Cdd:COG1340     8 SSLEELEEK---IEELREEIEELKEKRDELNEELKELaekRDELNAQVKELREEAQELREKRDELNEKV--------KEL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1236 RNQLDRLSRENRDLKDEIVRLNDsiLQATEQRRRAEENALQQKACGSEIMQKKQHLEIEL-KQVMQQRSEdnarhKQSLE 1314
Cdd:COG1340    77 KEERDELNEKLNELREELDELRK--ELAELNKAGGSIDKLRKEIERLEWRQQTEVLSPEEeKELVEKIKE-----LEKEL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKI------------------ 1376
Cdd:COG1340   150 EKAKKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEAdelhkeiveaqekadelh 229

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 975830145 1377 KVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQ 1415
Cdd:COG1340   230 EEIIELQKELRELRKELKKLRKKQRALKREKEKEELEEK 268
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1160-1481 1.27e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.32  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1160 SEKAIKEKEYEIERLRVLLQEEGTRKREYEN-----ELAKVRNHYNEEMSNLRNKYETEIniTKTTIKEISMQKEDDSKN 1234
Cdd:NF033838   56 QKEHAKEVESHLEKILSEIQKSLDKRKHTQNvalnkKLSDIKTEYLYELNVLKEKSEAEL--TSKTKKELDAAFEQFKKD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1235 LRNQLDRLSRENRDLKDEIVRLNDsilQATEQRRRAEENA---LQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQ 1311
Cdd:NF033838  134 TLEPGKKVAEATKKVEEAEKKAKD---QKEEDRRNYPTNTyktLELEIAESDVEVKKAELELVKEEAKEPRDEEKIKQAK 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1312 SLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYE-----------NELSKASNRIQ---------------ESKNQCTQV 1365
Cdd:NF033838  211 AKVESKKAEATRLEKIKTDREKAEEEAKRRADAKlkeaveknvatSEQDKPKRRAKrgvlgepatpdkkenDAKSSDSSV 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1366 VQE---RESLLVKIKVLE--------QDKARLQRLEDELNRAKST---LE---AETRVKQRlECEKQQIQNDLNQwktqy 1428
Cdd:NF033838  291 GEEtlpSPSLKPEKKVAEaekkveeaKKKAKDQKEEDRRNYPTNTyktLEleiAESDVKVK-EAELELVKEEAKE----- 364

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 975830145 1429 SRKEEAIRKIESEREKSEREKNSLrseiERLQAEIKRIEERCRRK--LEDSTRET 1481
Cdd:NF033838  365 PRNEEKIKQAKAKVESKKAEATRL----EKIKTDRKKAEEEAKRKaaEEDKVKEK 415
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1289-1498 1.39e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.69  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1289 QHLEIELKQVMQQRsednARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQE 1368
Cdd:COG1579    13 QELDSELDRLEHRL----KELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1369 RE--SLLvkiKVLEQDKARLQRLEDELnrakstLEAETRVKQrlecekqqiqndlnqwktqysrKEEAIRKieserekse 1446
Cdd:COG1579    89 KEyeALQ---KEIESLKRRISDLEDEI------LELMERIEE----------------------LEEELAE--------- 128

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 975830145 1447 reknsLRSEIERLQAEIKRIEERCRRKLEDsTRETQSQLETERSRYQREIDK 1498
Cdd:COG1579   129 -----LEAELAELEAELEEKKAELDEELAE-LEAELEELEAEREELAAKIPP 174
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1270-1493 1.58e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1270 AEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARhkqsLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELS 1349
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEE----YNELQAELEALQAEIDKLQAEIAEAEAEIEERREELG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1350 KASNRIQESKNQCTQVvqereSLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYS 1429
Cdd:COG3883    90 ERARALYRSGGSVSYL-----DVLLGSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKA 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 975830145 1430 RKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQ 1493
Cdd:COG3883   165 ELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAA 228
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1126-1476 1.79e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 1.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1126 KSVEDRFDQQKNDYDQLQ---KARQCEKENLGWQKLESEKAIKEKEYEIERLRVllqeegtrkrEYENELAKvRNHYNEE 1202
Cdd:PRK01156  172 KDVIDMLRAEISNIDYLEeklKSSNLELENIKKQIADDEKSHSITLKEIERLSI----------EYNNAMDD-YNNLKSA 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1203 MSNL------RNKYETEINITKTTIKEISMqKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQ 1276
Cdd:PRK01156  241 LNELssledmKNRYESEIKTAESDLSMELE-KNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDA 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1277 QKACGSEIMQKKQHLEIELKQ--VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNR 1354
Cdd:PRK01156  320 EINKYHAIIKKLSVLQKDYNDyiKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKI 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1355 -------IQESKNQCTQVVQERESllvKIKVLEQDKARLQRLEDELNRAKSTLEAETRVK---QRLECEKqqIQNDLNQW 1424
Cdd:PRK01156  400 qeidpdaIKKELNEINVKLQDISS---KVSSLNQRIRALRENLDELSRNMEMLNGQSVCPvcgTTLGEEK--SNHIINHY 474

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 975830145 1425 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED 1476
Cdd:PRK01156  475 NEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIES 526
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1103-1496 1.80e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.14  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1103 QIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY----DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERL---- 1174
Cdd:pfam12128  252 TLESAELRLSHLHFGYKSDETLIASRQEERQETSAELnqllRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALedqh 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1175 RVLLQEE-GTRKREYENeLAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRL--SRENRDLKD 1251
Cdd:pfam12128  332 GAFLDADiETAAADQEQ-LPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDIAGIKDKLakIREARDRQL 410

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1252 EIVRlndSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSED---NARHKQSLEEAAKTIQDK-NKEI 1327
Cdd:pfam12128  411 AVAE---DDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPElllQLENFDERIERAREEQEAaNAEV 487

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1328 ERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQE-------------------RESL-------------LVK 1375
Cdd:pfam12128  488 ERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQlfpqagtllhflrkeapdwEQSIgkvispellhrtdLDP 567

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1376 IKVLEQDKARL---------------------QRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEA 1434
Cdd:pfam12128  568 EVWDGSVGGELnlygvkldlkridvpewaaseEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTA 647

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 975830145  1435 IRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLE--------------DSTRETQSQLETERSRYQREI 1496
Cdd:pfam12128  648 LKNARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEaqlkqldkkhqawlEEQKEQKREARTEKQAYWQVV 723
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1018-1500 1.92e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.14  E-value: 1.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1018 SEMLKSLEdLKLKNTKIEVLEEELRLARdansencnknkfldqnLQKyqaecsQFKAKLASLEELKRQAEldgKSAKQNL 1097
Cdd:pfam12128  250 FNTLESAE-LRLSHLHFGYKSDETLIAS----------------RQE------ERQETSAELNQLLRTLD---DQWKEKR 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1098 DKCYGQIKELNEKITRLTYEIED-EKRRRKSVEDRFDQQKNDYDQLQKAR-QCEKENLGWQKLESEKAIKEKEYEIERLR 1175
Cdd:pfam12128  304 DELNGELSAADAAVAKDRSELEAlEDQHGAFLDADIETAAADQEQLPSWQsELENLEERLKALTGKHQDVTAKYNRRRSK 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1176 VLLQ--------EEGT--RKREYENELAKVRNHYNEEMSNLRNKYE---TEINITKTTIKE-ISMQK---------EDDS 1232
Cdd:pfam12128  384 IKEQnnrdiagiKDKLakIREARDRQLAVAEDDLQALESELREQLEagkLEFNEEEYRLKSrLGELKlrlnqatatPELL 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1233 KNLRNQLDRLSR----------ENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQK---KQHLEIE-LKQV 1298
Cdd:pfam12128  464 LQLENFDERIERareeqeaanaEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQlfpQAGTLLHfLRKE 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1299 MQQRSEDNAR-------HKQSL--EEAAKTIQDKN---------KEIERLKAEFQEEAKRRweyenELSKASNRIQESKn 1360
Cdd:pfam12128  544 APDWEQSIGKvispellHRTDLdpEVWDGSVGGELnlygvkldlKRIDVPEWAASEEELRE-----RLDKAEEALQSAR- 617

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1361 qctQVVQERESLLVKIKvleqdkARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQwktqysRKEEAIRKIES 1440
Cdd:pfam12128  618 ---EKQAAAEEQLVQAN------GELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNK------ALAERKDSANE 682

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1441 EREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLR 1500
Cdd:pfam12128  683 RLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAARR 742
46 PHA02562
endonuclease subunit; Provisional
 1272-1470 1.99e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 46.55  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1272 ENALQQKACGSEIMQKKQHLEIELKQVMQQRS---EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENEL 1348
Cdd:PHA02562  178 ELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKkngENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAAL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1349 SKASNRIQESKNQ-------------------CTQVVQERESLLVKIKvlEQDKARLQRLEDELNRAKstlEAETRVKQR 1409
Cdd:PHA02562  258 NKLNTAAAKIKSKieqfqkvikmyekggvcptCTQQISEGPDRITKIK--DKLKELQHSLEKLDTAID---ELEEIMDEF 332

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 975830145 1410 LECEK--QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERC 1470
Cdd:PHA02562  333 NEQSKklLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTK 395
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1339-1501 2.09e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.05  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1339 KRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDkarLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQ 1418
Cdd:COG4372    10 KARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREE---LEQAREELEQLEEELEQARSELEQLEEELEELN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1419 NDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERC-RRKLEDSTRETQ-SQLETERSRYQREI 1496
Cdd:COG4372    87 EQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIaELQSEIAEREEElKELEEQLESLQEEL 166


                  ....*
gi 975830145 1497 DKLRQ 1501
Cdd:COG4372   167 AALEQ 171
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 1235-1461 2.23e-04

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 46.21  E-value: 2.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1235 LRNQLDRLsRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSE---------- 1304
Cdd:pfam19220   12 LGEMADRL-EDLRSLKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAaegeleelva 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1305 DNARHKQSL-------EEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIK 1377
Cdd:pfam19220   91 RLAKLEAALreaeaakEELRIELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATARERLA 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1378 VLEQDKARLQRLEDELNRAKSTLEAE-TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEI 1456
Cdd:pfam19220  171 LLEQENRRLQALSEEQAAELAELTRRlAELETQLDATRARLRALEGQLAAEQAERERAEAQLEEAVEAHRAERASLRMKL 250


                   ....*
gi 975830145  1457 ERLQA 1461
Cdd:pfam19220  251 EALTA 255
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1258-1515 2.29e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 46.58  E-value: 2.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1258 DSILQAT---EQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQsLEEAAKTIQDKNKEIERLK--- 1331
Cdd:TIGR00606  176 DEIFSATryiKALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQ-LESSREIVKSYENELDPLKnrl 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1332 AEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLV----KIKVLEQDKARLQR-LEDELNRAKSTLEAETRV 1406
Cdd:TIGR00606  255 KEIEHNLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKVFQgtdeQLNDLYHNHQRTVReKERELVDCQRELEKLNKE 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1407 KQRLECEKQQIQNDLNQWKTQYSRKEEAIRKieserEKSEREKNSLRSEIERLQ------AEIKRIEERCRRKLEDSTR- 1479
Cdd:TIGR00606  335 RRLLNQEKTELLVEQGRLQLQADRHQEHIRA-----RDSLIQSLATRLELDGFErgpfseRQIKNFHTLVIERQEDEAKt 409

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 975830145  1480 --ETQSQLETERSRYQREIDKLRQRPYGSHRETQTECE 1515
Cdd:TIGR00606  410 aaQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKE 447
PRK01156 PRK01156
chromosome segregation protein; Provisional
 707-1281 2.30e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  707 NELKSVQND----SQAIAEVLNQLKDMLANF-RGSEKYCYLQNEVFGLFQKLENINGVTD---GYLNSLCTVRALLQAIL 778
Cdd:PRK01156  190 EKLKSSNLEleniKKQIADDEKSHSITLKEIeRLSIEYNNAMDDYNNLKSALNELSSLEDmknRYESEIKTAESDLSMEL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  779 QTEDMLKVYEARLTEEETvcldlDKVEAYR---CGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSqqyplydlDLGK 855
Cdd:PRK01156  270 EKNNYYKELEERHMKIIN-----DPVYKNRnyiNDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLS--------VLQK 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  856 fgekvtqltDRWQRIDKQIdfRLWDLEKQIKQLRNYRDNYQAFCKwlydakrrqdSLESMKFGDSNtvmrFLNEQKNLHS 935
Cdd:PRK01156  337 ---------DYNDYIKKKS--RYDDLNNQILELEGYEMDYNSYLK----------SIESLKKKIEE----YSKNIERMSA 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  936 EISGKRDKS----EEVQKIAELCANSIKDYELQLASYTSGLETLLN--IPIKRTM-IQSPSGVILQEAADVHARYIELLT 1008
Cdd:PRK01156  392 FISEILKIQeidpDAIKKELNEINVKLQDISSKVSSLNQRIRALREnlDELSRNMeMLNGQSVCPVCGTTLGEEKSNHII 471

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1009 RsgDYYrflsemlkslEDLKLKNTKIEVLEEElrlARDANSENCNKNKFLD----QNLQKYQAECSQFKAKLASLEELK- 1083
Cdd:PRK01156  472 N--HYN----------EKKSRLEEKIREIEIE---VKDIDEKIVDLKKRKEylesEEINKSINEYNKIESARADLEDIKi 536

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1084 RQAELDGKSAKQNldkcygqikELNEKITRLTYEIEDEKR----RRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLE 1159
Cdd:PRK01156  537 KINELKDKHDKYE---------EIKNRYKSLKLEDLDSKRtswlNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIE 607

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1160 S---------EKAIKEKEYEIERLRVLLQEEGTRKREYEnELAKVRNHYNEEMSNLRnkyetEINITKTTIKEISMQKED 1230
Cdd:PRK01156  608 IgfpddksyiDKSIREIENEANNLNNKYNEIQENKILIE-KLRGKIDNYKKQIAEID-----SIIPDLKEITSRINDIED 681

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 975830145 1231 DSKNLRNQLD-------RLSRENRDLKDEIVRLNDSIlqaTEQRRRAEENALQQKACG 1281
Cdd:PRK01156  682 NLKKSRKALDdakanraRLESTIEILRTRINELSDRI---NDINETLESMKKIKKAIG 736
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1013-1347 2.37e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 46.54  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1013 YYRFLSEMLKSLE----------DLKLKNTKIEVLEEELRLARDANSENCNKNKF-LDQNLQKYQAECSQFKAKLASLEE 1081
Cdd:NF033838   67 LEKILSEIQKSLDkrkhtqnvalNKKLSDIKTEYLYELNVLKEKSEAELTSKTKKeLDAAFEQFKKDTLEPGKKVAEATK 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1082 LKRQAELDGKSAKQNLDKCYgqikelnEKITRLTYEIEDEKRRRKSVEDRFDQQKndyDQLQKARQCEKENLGWQKLESE 1161
Cdd:NF033838  147 KVEEAEKKAKDQKEEDRRNY-------PTNTYKTLELEIAESDVEVKKAELELVK---EEAKEPRDEEKIKQAKAKVESK 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKeismQKEDDSKNLRNQLDR 1241
Cdd:NF033838  217 KAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPD----KKENDAKSSDSSVGE 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1242 LSRENRDLKDEivrlnDSILQATEQRRRAEENALQQKA------------------CGSEIMQKKQHLEIELKQVMQQRS 1303
Cdd:NF033838  293 ETLPSPSLKPE-----KKVAEAEKKVEEAKKKAKDQKEedrrnyptntyktleleiAESDVKVKEAELELVKEEAKEPRN 367

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 975830145 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENE 1347
Cdd:NF033838  368 EEKIKQAKAKVESKKAEATRLEKIKTDRKKAEEEAKRKAAEEDK 411
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1248-1418 2.90e-04

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 46.02  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1248 DLKDEivrlnDSILQATEQRRRAEenaLQQKAcgsEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEI 1327
Cdd:COG2268   178 DLEDE-----NNYLDALGRRKIAE---IIRDA---RIAEAEAERETEIAIAQANREAEEAELEQEREIETARIAEAEAEL 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1328 ERLKAEFQEEAKRrweyENELSKASNRIQESKNQctQVVQeresllVKIKVLEQDKA-RLQRLEDElnRAKSTLEAEtrV 1406
Cdd:COG2268   247 AKKKAEERREAET----ARAEAEAAYEIAEANAE--REVQ------RQLEIAEREREiELQEKEAE--REEAELEAD--V 310

                         170
                  ....*....|..
gi 975830145 1407 KQRLECEKQQIQ 1418
Cdd:COG2268   311 RKPAEAEKQAAE 322
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1025-1509 3.35e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 45.97  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1025 EDLKLKNTKIEVLEEELRLARDANsencnknkfldQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNldkcygQI 1104
Cdd:pfam10174   67 EENQHLQLTIQALQDELRAQRDLN-----------QLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHER------QA 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1105 KELneKITRLTYEiEDEKR---RRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQklESEKAIKEKEYEIERLRVLLQEe 1181
Cdd:pfam10174  130 KEL--FLLRKTLE-EMELRietQKQTLGARDESIKKLLEMLQSKGLPKKSGEEDW--ERTRRIAEAEMQLGHLEVLLDQ- 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1182 gtrkREYENelakvrNHYNEEMSNlRNKYETEINITKTTIKEISMQkedDSKnlrnqLDRLSRENRDLKDEIVRLNDSIL 1261
Cdd:pfam10174  204 ----KEKEN------IHLREELHR-RNQLQPDPAKTKALQTVIEMK---DTK-----ISSLERNIRDLEDEVQMLKTNGL 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1262 QATEQRrraEENALQQKACGSEIMQKKQHLEiELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRR 1341
Cdd:pfam10174  265 LHTEDR---EEEIKQMEVYKSHSKFMKNKID-QLKQELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLTAKEQRA 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1342 WEYENELSKASNRIqesknqctqvvQERESLLVKikvlEQDKarLQRLEDElnraKSTLEAETR-------VKQR-LECE 1413
Cdd:pfam10174  341 AILQTEVDALRLRL-----------EEKESFLNK----KTKQ--LQDLTEE----KSTLAGEIRdlkdmldVKERkINVL 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1414 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLqAEIKRIEERCRRKLEDSTRETQSQLETersrYQ 1493
Cdd:pfam10174  400 QKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEAL-SEKERIIERLKEQREREDRERLEELES----LK 474

                          490
                   ....*....|....*.
gi 975830145  1494 REIDKLRQRPYGSHRE 1509
Cdd:pfam10174  475 KENKDLKEKVSALQPE 490
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1078-1332 3.78e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 3.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNekitRLTYEIEDEKRRRKSVE------DRFDQQKNDYDQLQKARQceke 1151
Cdd:COG4913   208 DLDDFVREYMLEEPDTFEAADALVEHFDDLE----RAHEALEDAREQIELLEpirelaERYAAARERLAELEYLRA---- 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1152 nlGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEemsnLRNKYETeinitkttikeismQKEDD 1231
Cdd:COG4913   280 --ALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDE----LEAQIRG--------------NGGDR 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1232 SKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKAcgsEIMQKKQHLEIELKQVMQQRsednARHKQ 1311
Cdd:COG4913   340 LEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRA---EAAALLEALEEELEALEEAL----AEAEA 412

                         250       260
                  ....*....|....*....|.
gi 975830145 1312 SLEEAAKTIQDKNKEIERLKA 1332
Cdd:COG4913   413 ALRDLRRELRELEAEIASLER 433
FPP pfam05911
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ...
 1272-1414 4.50e-04

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.


Pssm-ID: 461778 [Multi-domain]  Cd Length: 859  Bit Score: 45.82  E-value: 4.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1272 ENALQQKACGSEimqKKQHLEIELKQVMQQRSEDNARHKQSLEEAaktIQDKNKEIERLKAEFqeEAKRRwEYENELSKA 1351
Cdd:pfam05911   34 ESVTLQKLTAEE---RAAHLDGALKECMQQLRNVKEEQEQKIHDV---VLKKTKEWEKIKAEL--EAKLV-ETEQELLRA 104

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 975830145  1352 SnriQESkNQCTQVVQERESLLVKIKvleqdkarlqrleDELNRAKSTLEAetrVKQRLE-CEK 1414
Cdd:pfam05911  105 A---AEN-DALSRSLQERENLLMKLS-------------EEKSQAEAEIEA---LKSRLEsCEK 148
PRK11637 PRK11637
AmiB activator; Provisional
 1257-1502 4.91e-04

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 45.07  E-value: 4.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1257 NDSILQATEQRRRAEENALQQkacgseimQKKQHLEIeLKQVMQQRsEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQE 1336
Cdd:PRK11637   45 NRDQLKSIQQDIAAKEKSVRQ--------QQQQRASL-LAQLKKQE-EAISQASRKLRETQNTLNQLNKQIDELNASIAK 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1337 EAKRRWEYENELSK---ASNRiqESKNQCTQVV------QERESLLVKIKVLEQDK----ARLQRLEDELNRAKSTLEAE 1403
Cdd:PRK11637  115 LEQQQAAQERLLAAqldAAFR--QGEHTGLQLIlsgeesQRGERILAYFGYLNQARqetiAELKQTREELAAQKAELEEK 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1404 TRVKQRLECEKQQIQNDLNQwkTQYSRKEeairkieserekserEKNSLRSEIERLQ---AEIKRIEERCRRKLEDSTRE 1480
Cdd:PRK11637  193 QSQQKTLLYEQQAQQQKLEQ--ARNERKK---------------TLTGLESSLQKDQqqlSELRANESRLRDSIARAERE 255

                         250       260
                  ....*....|....*....|..
gi 975830145 1481 TQSQLETErsryQREIDKLRQR 1502
Cdd:PRK11637  256 AKARAERE----AREAARVRDK 273
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1112-1499 4.98e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 45.48  E-value: 4.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1112 TRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKenlgwqkleseKAIKEKEYEIERLRVLLQEEGTRKREYENE 1191
Cdd:pfam05483   81 SKLYKEAEKIKKWKVSIEAELKQKENKLQENRKIIEAQR-----------KAIQELQFENEKVSLKLEEEIQENKDLIKE 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1192 lakvrNHYNEEMSNLrnkyeteinitkttIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLndsILQATEQRRRAE 1271
Cdd:pfam05483  150 -----NNATRHLCNL--------------LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKM---ILAFEELRVQAE 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1272 ENALQQKACGSEIMQKKQHLEIELKQ-----------VMQQRSEDNARHKQ---SLEEAaktiQDKNKEIERLKAEFQEE 1337
Cdd:pfam05483  208 NARLEMHFKLKEDHEKIQHLEEEYKKeindkekqvslLLIQITEKENKMKDltfLLEES----RDKANQLEEKTKLQDEN 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1338 AKRRWEYENELSKASNRIQES--KNQCTQVVQErESLLVKIKVLEQDKARLQRLEDELNRAKST-------LEAET-RVK 1407
Cdd:pfam05483  284 LKELIEKKDHLTKELEDIKMSlqRSMSTQKALE-EDLQIATKTICQLTEEKEAQMEELNKAKAAhsfvvteFEATTcSLE 362

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1408 QRLECEKQQIQNDLNQWK------TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEercrrKLEDSTRET 1481
Cdd:pfam05483  363 ELLRTEQQRLEKNEDQLKiitmelQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFE-----KIAEELKGK 437

                          410
                   ....*....|....*...
gi 975830145  1482 QSQLETERSRYQREIDKL 1499
Cdd:pfam05483  438 EQELIFLLQAREKEIHDL 455
mukB PRK04863
chromosome partition protein MukB;
1262-1502 5.11e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 45.72  E-value: 5.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1262 QATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNA--RHKQSLEEAAKTIQDKNKEIERLKAEFQEEAK 1339
Cdd:PRK04863  377 QQEENEARAEAAEEEVDELKSQLADYQQALDVQQTRAIQYQQAVQAleRAKQLCGLPDLTADNAEDWLEEFQAKEQEATE 456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1340 RRWEYENELSKAsnriQESKNQCTQVVQ---------ERE-------SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE 1403
Cdd:PRK04863  457 ELLSLEQKLSVA----QAAHSQFEQAYQlvrkiagevSRSeawdvarELLRRLREQRHLAEQLQQLRMRLSELEQRLRQQ 532

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1404 TRVKQRL-ECEKQQIQNDLNQWKTQ--YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE------------- 1467
Cdd:PRK04863  533 QRAERLLaEFCKRLGKNLDDEDELEqlQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAarapawlaaqdal 612

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 975830145 1468 ----ERCRRKLEDS----------------TRETQSQLETERSRYQREIDKLRQR 1502
Cdd:PRK04863  613 arlrEQSGEEFEDSqdvteymqqllerereLTVERDELAARKQALDEEIERLSQP 667
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1012-1498 5.63e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 45.43  E-value: 5.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1012 DYYRFLSEMLKSleDLKLKNTKI-EVLEE-----ELRLARDANSENCNKNKFLDQNLQK----------YQAECSQFKAK 1075
Cdd:TIGR01612  448 DFDEFNKPIPKS--KLKALEKRFfEIFEEewgsyDIKKDIDENSKQDNTVKLILMRMKDfkdiidfmelYKPDEVPSKNI 525

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1076 LASLEELKRQAELdGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDrfdQQKNDYDQLQKarqCEKENLGW 1155
Cdd:TIGR01612  526 IGFDIDQNIKAKL-YKEIEAGLKESYELAKNWKKLIHEIKKELEEENEDSIHLEK---EIKDLFDKYLE---IDDEIIYI 598

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1156 QKLESE-----KAIKEKEYEIERlRVLLQEEGTRKREYENELAKVRNHYNEEmsNLRNKyeteiNITKTTIK-EISMQKE 1229
Cdd:TIGR01612  599 NKLKLElkekiKNISDKNEYIKK-AIDLKKIIENNNAYIDELAKISPYQVPE--HLKNK-----DKIYSTIKsELSKIYE 670

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1230 DDSKNLRNQLDRLSREN-----------RDLKDEIVRLNDSILQATEQRRRAEENALQQKA--CGSEIMQKKQHLEIELK 1296
Cdd:TIGR01612  671 DDIDALYNELSSIVKENaidntedkaklDDLKSKIDKEYDKIQNMETATVELHLSNIENKKneLLDIIVEIKKHIHGEIN 750

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1297 QVMQQRSEDnarHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKI 1376
Cdd:TIGR01612  751 KDLNKILED---FKNKEKELSNKINDYAKEKDELNKYKSKISEIKNHYNDQINIDNIKDEDAKQNYDKSKEYIKTISIKE 827

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1377 KVLEQDKARLQRLEDE-LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI--RKIESEREKSEREKNSLR 1453
Cdd:TIGR01612  828 DEIFKIINEMKFMKDDfLNKVDKFINFENNCKEKIDSEHEQFAELTNKIKAEISDDKLNDyeKKFNDSKSLINEINKSIE 907

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 975830145  1454 SEIERLQAeIKRIEERCrrKLEDSTRETQSQLETERSRYQREIDK 1498
Cdd:TIGR01612  908 EEYQNINT-LKKVDEYI--KICENTKESIEKFHNKQNILKEILNK 949
46 PHA02562
endonuclease subunit; Provisional
 1124-1369 6.09e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 45.01  E-value: 6.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1124 RRKSVEDRFDQQK-NDYDQLQKAR----QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKRE-YENELAKVRN 1197
Cdd:PHA02562  152 RRKLVEDLLDISVlSEMDKLNKDKirelNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNkYDELVEEAKT 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1198 HyneemsnlrnkyETEINITKTTIKEISMQKEDDS---KNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENA 1274
Cdd:PHA02562  232 I------------KAEIEELTDELLNLVMDIEDPSaalNKLNTAAAKIKSKIEQFQKVIKMYEKGGVCPTCTQQISEGPD 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1275 LQqkacgSEIMQKKQHLEIELKQVMQQRSEDNARhKQSLEEAAKTIQDKNKEIE--------------RLKAEFQEEAKR 1340
Cdd:PHA02562  300 RI-----TKIKDKLKELQHSLEKLDTAIDELEEI-MDEFNEQSKKLLELKNKIStnkqslitlvdkakKVKAAIEELQAE 373

                         250       260
                  ....*....|....*....|....*....
gi 975830145 1341 RWEYENELSKASNRIQESKNQCTQVVQER 1369
Cdd:PHA02562  374 FVDNAEELAKLQDELDKIVKTKSELVKEK 402
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1226-1496 7.11e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 45.02  E-value: 7.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1226 MQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKacgseimqkkQHLEIELKQVMQQRSED 1305
Cdd:pfam05667  222 WEEEWNSQGLASRLTPEEYRKRKRTKLLKRIAEQLRSAALAGTEATSGASRSA----------QDLAELLSSFSGSSTTD 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1306 NARHKQSL---EEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIK----V 1378
Cdd:pfam05667  292 TGLTKGSRfthTEKLQFTNEAPAATSSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKqveeE 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1379 LEQDKARLQRLEDELNRAKSTLE----AETRVKQrLECE----KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKN 1450
Cdd:pfam05667  372 LEELKEQNEELEKQYKVKKKTLDllpdAEENIAK-LQALvdasAQRLVELAGQWEKHRVPLIEEYRALKEAKSNKEDESQ 450

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 975830145  1451 SLRSEIERLQAEIKRIEERCRRKlEDSTRETQSQLE-----TERSRYQREI 1496
Cdd:pfam05667  451 RKLEEIKELREKIKEVAEEAKQK-EELYKQLVAEYErlpkdVSRSAYTRRI 500
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1170-1360 7.93e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 43.37  E-value: 7.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1170 EIERLrVLLQEEGTRKREYENELAKVRNHYnEEMSNLRNKYETEINITKTTIKEISMQ---KEDDSKNLRNQLDRLS--- 1243
Cdd:COG1579     5 DLRAL-LDLQELDSELDRLEHRLKELPAEL-AELEDELAALEARLEAAKTELEDLEKEikrLELEIEEVEARIKKYEeql 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1244 ---RENRDLKDeivrLNDSILQATEQRRRAEENALqqkacgsEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI 1320
Cdd:COG1579    83 gnvRNNKEYEA----LQKEIESLKRRISDLEDEIL-------ELMERIEELEEELAELEAELAELEAELEEKKAELDEEL 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 975830145 1321 QDKNKEIERLKAEFQEEAKrrwEYENELSKASNRIQESKN 1360
Cdd:COG1579   152 AELEAELEELEAEREELAA---KIPPELLALYERIRKRKN 188
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1060-1494 9.27e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 44.65  E-value: 9.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1060 QNLQKYQAECSQFKAKLASLEELKrqaelDGKSAKQNLDKCYGQIKELNEKitrltyEIEDEKRRRKSVEDRFDQQKNDY 1139
Cdd:TIGR00606  200 QKVQEHQMELKYLKQYKEKACEIR-----DQITSKEAQLESSREIVKSYEN------ELDPLKNRLKEIEHNLSKIMKLD 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVR------NHYNEEMSNLRNKYETE 1213
Cdd:TIGR00606  269 NEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQreleklNKERRLLNQEKTELLVE 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1214 INITKTTIKEISMQ-KEDDSKNLRNQLD-RLSRENRDLKDEIVRLNDSILQATEQRRRAEE-NALQQKACGSEIMQKKQH 1290
Cdd:TIGR00606  349 QGRLQLQADRHQEHiRARDSLIQSLATRlELDGFERGPFSERQIKNFHTLVIERQEDEAKTaAQLCADLQSKERLKQEQA 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1291 LEIELKQVMQQRSEDNarHKQSLEEAAKTIQDKNKEIERLKAEfqeeAKRRWEYENELSKASNRIQES-KNQCTQVVQER 1369
Cdd:TIGR00606  429 DEIRDEKKGLGRTIEL--KKEILEKKQEELKFVIKELQQLEGS----SDRILELDQELRKAERELSKAeKNSLTETLKKE 502

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1370 ESLLVKIKV-LEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQ-------------WKTQYSR----- 1430
Cdd:TIGR00606  503 VKSLQNEKAdLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRhsdeltsllgyfpNKKQLEDwlhsk 582

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 975830145  1431 ------KEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER----CRRKLEDSTRETQSQlETERSRYQR 1494
Cdd:TIGR00606  583 skeinqTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKlfdvCGSQDEESDLERLKE-EIEKSSKQR 655
RNase_Y_N pfam12072
RNase Y N-terminal region;
1310-1411 9.96e-04

RNase Y N-terminal region;


Pssm-ID: 463456 [Multi-domain]  Cd Length: 201  Bit Score: 42.57  E-value: 9.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1310 KQSLEEAAKTIQDKNKEIE--------RLKAEFQEEAKRRweyENELSKASNRIQesknqctqvvQERESLLVKIKVLEQ 1381
Cdd:pfam12072   37 KRIIEEAKKEAETKKKEALleakeeihKLRAEAERELKER---RNELQRQERRLL----------QKEETLDRKDESLEK 103

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 975830145  1382 DKARLQRLEDELNRAKSTL-----EAETRVKQRLE 1411
Cdd:pfam12072  104 KEESLEKKEKELEAQQQQLeekeeELEELIEEQRQ 138
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1004-1329 1.11e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 44.18  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1004 IELLTRSGDYYRFLSEMLKSLEDLKL--KNTKIEVLEE---ELRLARDANSENCNKNKFLDQNLQKYQAECSQFKA--KL 1076
Cdd:COG5185   245 LEDLAQTSDKLEKLVEQNTDLRLEKLgeNAESSKRLNEnanNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAaeAE 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1077 ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKItrltyeieDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQ 1156
Cdd:COG5185   325 QELEESKRETETGIQNLTAEIEQGQESLTENLEAI--------KEEIENIVGEVELSKSSEELDSFKDTIESTKESLDEI 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1157 KLESEKAIKEKEYEIERlrvllqeegtRKREYENELAKVR------NHYNEEMSNLRNKYETEINITKTTIKEISMQKED 1230
Cdd:COG5185   397 PQNQRGYAQEILATLED----------TLKAADRQIEELQrqieqaTSSNEEVSKLLNELISELNKVMREADEESQSRLE 466

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1231 DSKNLRNQldRLSRENRDLKDEIVRLNDSI--LQATEQRRRAEENALQQKacgseIMQKKQHLEIELKQVMQQRSEDNAR 1308
Cdd:COG5185   467 EAYDEINR--SVRSKKEDLNEELTQIESRVstLKATLEKLRAKLERQLEG-----VRSKLDQVAESLKDFMRARGYAHIL 539

                         330       340
                  ....*....|....*....|.
gi 975830145 1309 HKQSLEEAAKTIQDKNKEIER 1329
Cdd:COG5185   540 ALENLIPASELIQASNAKTDG 560
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 1108-1499 1.28e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 43.98  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1108 NEKITRLTYEIEDEKRRRKSvEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEyeiERLRVLLQEEGTRKRE 1187
Cdd:pfam09731   72 VSAVTGESKEPKEEKKQVKI-PRQSGVSSEVAEEEKEATKDAAEAKAQLPKSEQEKEKALE---EVLKEAISKAESATAV 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1188 YENELAKVRNHYNEEMSNLRNKYETEinitkttikeismqKEDDSKNLRNQLDRLSRENRDLKDEIVRLN-DSILQATEQ 1266
Cdd:pfam09731  148 AKEAKDDAIQAVKAHTDSLKEASDTA--------------EISREKATDSALQKAEALAEKLKEVINLAKqSEEEAAPPL 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQ--QRSEDNARhkQSLEEAAKTIQDKNKEIERLKAEFQEEakrrweY 1344
Cdd:pfam09731  214 LDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQykELVASERI--VFQQELVSIFPDIIPVLKEDNLLSNDD------L 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1345 ENELSKASNRIQEsknqctqvvqeresllVKIKVLEQDKARLQRLEDELNRAKSTLE-AETRVKQRLEcekQQIQNDLNQ 1423
Cdd:pfam09731  286 NSLIAHAHREIDQ----------------LSKKLAELKKREEKHIERALEKQKEELDkLAEELSARLE---EVRAADEAQ 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1424 WKTQYSRKEEAIRKieserekseREKNSLRSEIERLQAEI-KRIEERCRRKLEDSTRETQ----SQLETERSRYQREIDK 1498
Cdd:pfam09731  347 LRLEFEREREEIRE---------SYEEKLRTELERQAEAHeEHLKDVLVEQEIELQREFLqdikEKVEEERAGRLLKLNE 417


                   .
gi 975830145  1499 L 1499
Cdd:pfam09731  418 L 418
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1002-1394 1.43e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.19  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASL-- 1079
Cdd:TIGR00618  536 TYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEqh 615

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1080 -EELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRfdQQKNDYDQLQKARQCEKENlgwqKL 1158
Cdd:TIGR00618  616 aLLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIR--VLPKELLASRQLALQKMQS----EK 689

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1159 ESEKAIKEkeyEIERLRVLLQEEGTRKREYENElakvRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQ 1238
Cdd:TIGR00618  690 EQLTYWKE---MLAQCQTLLRELETHIEEYDRE----FNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEA 762

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1239 LDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAK 1318
Cdd:TIGR00618  763 HFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSA 842

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 975830145  1319 TIQdknkEIERLKAEFQEEAKRRweyeNELSKASNRIqesknqcTQVVQERESLLVKIKVLEQDkaRLQRLEDELN 1394
Cdd:TIGR00618  843 TLG----EITHQLLKYEECSKQL----AQLTQEQAKI-------IQLSDKLNGINQIKIQFDGD--ALIKFLHEIT 901
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1262-1415 1.44e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 43.64  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1262 QATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSlEEAAKTIQDKNKEIERLKAEFQEEAKRR 1341
Cdd:PRK09510   70 QQKSAKRAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQA-EEAAKQAALKQKQAEEAAAKAAAAAKAK 148

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 975830145 1342 WEYENE-LSKASNRIQESKnqctqvvqeresllvkiKVLEQDKARLQRLEDelnrAKSTLEAETRVKQRLECEKQ 1415
Cdd:PRK09510  149 AEAEAKrAAAAAKKAAAEA-----------------KKKAEAEAAKKAAAE----AKKKAEAEAAAKAAAEAKKK 202
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1311-1501 2.04e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 43.31  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1311 QSLEEA-AKTIQDKNKEIERlkaefqEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQdkaRLQRL 1389
Cdd:COG2433   376 LSIEEAlEELIEKELPEEEP------EAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDE---RIERL 446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1390 EDELNRAKSTLEAETRvkqrlecekqqiqndlnqwktqysrKEEAIRKiesereksereknsLRSEIERLQAEIKRIEER 1469
Cdd:COG2433   447 ERELSEARSEERREIR-------------------------KDREISR--------------LDREIERLERELEEERER 487

                         170       180       190
                  ....*....|....*....|....*....|..
gi 975830145 1470 cRRKLEDSTRETQSQLETERSRYQREIDKLRQ 1501
Cdd:COG2433   488 -IEELKRKLERLKELWKLEHSGELVPVKVVEK 518
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1025-1489 2.07e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.67  E-value: 2.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1025 EDLKLKNTKIEVLEEELRLARDANSEncnKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLD-KCYGQ 1103
Cdd:pfam12128  315 AAVAKDRSELEALEDQHGAFLDADIE---TAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKeQNNRD 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1104 IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE-----KENLGWQKLESEKAIKEKEY--------- 1169
Cdd:pfam12128  392 IAGIKDKLAKIREARDRQLAVAEDDLQALESELREQLEAGKLEFNEeeyrlKSRLGELKLRLNQATATPELllqlenfde 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1170 EIERLRVLlQEEGTRKRE-YENELAKVRNHYNEEMSNLRNKyETEINITKTTIKEISMQKEDDSKNLrnqLDRLSRENRD 1248
Cdd:pfam12128  472 RIERAREE-QEAANAEVErLQSELRQARKRRDQASEALRQA-SRRLEERQSALDELELQLFPQAGTL---LHFLRKEAPD 546

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1249 LKDEIVRLNDSIL--------QATEQRRRAEEN----ALQQKACG-SEIMQKKQHLEIELKQV---MQQRSEDNARHKQS 1312
Cdd:pfam12128  547 WEQSIGKVISPELlhrtdldpEVWDGSVGGELNlygvKLDLKRIDvPEWAASEEELRERLDKAeeaLQSAREKQAAAEEQ 626

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1313 LEEAAKTIQDKNKEIERLKAEFQ--EEAKRRW--EYENELSKASNRIQESKNQctqVVQERESLLVKIKVLEQD-KARLQ 1387
Cdd:pfam12128  627 LVQANGELEKASREETFARTALKnaRLDLRRLfdEKQSEKDKKNKALAERKDS---ANERLNSLEAQLKQLDKKhQAWLE 703

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1388 RLEDELNRAKSTLEA------------ETRVKQRLECEKQQIQNDLNQWKTQYSRK------------------EEAIRK 1437
Cdd:pfam12128  704 EQKEQKREARTEKQAywqvvegaldaqLALLKAAIAARRSGAKAELKALETWYKRDlaslgvdpdviaklkreiRTLERK 783

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 975830145  1438 IESEREKS---------------------EREKNSLRSEIERLQAEIKRIEERCRRKLedstretqSQLETER 1489
Cdd:pfam12128  784 IERIAVRRqevlryfdwyqetwlqrrprlATQLSNIERAISELQQQLARLIADTKLRR--------AKLEMER 848
mukB PRK04863
chromosome partition protein MukB;
1207-1502 2.14e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 43.41  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1207 RNKYETEINITKTTIKEISmQKEDDSKNLRNQLDRLSRENRDLKDEivRLNDSILQATEQRRRAEENALQQKACGSEIMQ 1286
Cdd:PRK04863  846 RVELERALADHESQEQQQR-SQLEQAKEGLSALNRLLPRLNLLADE--TLADRVEEIREQLDEAEEAKRFVQQHGNALAQ 922

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1287 KKQHLeielkQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQ-------EEAKRRWEYENELSkasnriqesk 1359
Cdd:PRK04863  923 LEPIV-----SVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQrrahfsyEDAAEMLAKNSDLN---------- 987

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1360 nqctqvvqeresllvkikvlEQDKARLQRLEDELNRAKstlEAETRVKQRLEcEKQQIQNDLnqwKTQYSRKEEAIRKIE 1439
Cdd:PRK04863  988 --------------------EKLRQRLEQAEQERTRAR---EQLRQAQAQLA-QYNQVLASL---KSSYDAKRQMLQELK 1040

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 975830145 1440 SEREKSEREKNSlrSEIERLQAEIKRIEERCRRkledsTRETQSQLETERSRYQREIDKLRQR 1502
Cdd:PRK04863 1041 QELQDLGVPADS--GAEERARARRDELHARLSA-----NRSRRNQLEKQLTFCEAEMDNLTKK 1096
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 1294-1499 2.15e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.88  E-value: 2.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1294 ELKQVMQQRSEDNARHKQsLEeaaktiqdknKEIERLKAEFQEEAKRRWEYENELSKASNRIQesknqctQVVQERESLL 1373
Cdd:pfam15905   60 ELKKKSQKNLKESKDQKE-LE----------KEIRALVQERGEQDKRLQALEEELEKVEAKLN-------AAVREKTSLS 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1374 VKIKVLEQ--------------------DKARLQRLEDELNRAKSTLEAETR---VKQR-LECEKQQIQNDLNQWKTQYS 1429
Cdd:pfam15905  122 ASVASLEKqlleltrvnellkakfsedgTQKKMSSLSMELMKLRNKLEAKMKevmAKQEgMEGKLQVTQKNLEHSKGKVA 201

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 975830145  1430 RKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCR--RKLEDSTRETQSQLETERSRYQREIDKL 1499
Cdd:pfam15905  202 QLEEKLVSTEKEKIEEKSETEKLLEYITELSCVSEQVEKYKLdiAQLEELLKEKNDEIESLKQSLEEKEQEL 273
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1002-1393 2.15e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 43.53  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKnTKIEVLEEELRLaRDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
Cdd:COG5022   772 KKIQVIQHGFRLRRLVDYELKWRLFIKLQ-PLLSLLGSRKEY-RSYLACIIKLQKTIKREKKLRETEEVEFSLKAEVLIQ 849

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1082 LKRQAELDGKSAKQNLDK-CYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE---------KE 1151
Cdd:COG5022   850 KFGRSLKAKKRFSLLKKEtIYLQSAQRVELAERQLQELKIDVKSISSLKLVNLELESEIIELKKSLSSDlienlefktEL 929

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1152 NLGWQKLESEKAIKE---KEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLrNKYETEINITKTTIKEISMQK 1228
Cdd:COG5022   930 IARLKKLLNNIDLEEgpsIEYVKLPELNKLHEVESKLKETSEEYEDLLKKSTILVREG-NKANSELKNFKKELAELSKQY 1008

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1229 EDDSKNLRnQLDRLSRENRDLKDEIVRLNDsilQATEQRRRAEENALQqkacgSEIMQKKQHLEIELKQVMQQRSEDNAR 1308
Cdd:COG5022  1009 GALQESTK-QLKELPVEVAELQSASKIISS---ESTELSILKPLQKLK-----GLLLLENNQLQARYKALKLRRENSLLD 1079

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1309 HKQSleeaaKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKAsNRIQESKNQCTQvvQERESLLVKIKVLEQDKARLQR 1388
Cdd:COG5022  1080 DKQL-----YQLESTENLLKTINVKDLEVTNRNLVKPANVLQF-IVAQMIKLNLLQ--EISKFLSQLVNTLEPVFQKLSV 1151


                  ....*
gi 975830145 1389 LEDEL 1393
Cdd:COG5022  1152 LQLEL 1156
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1242-1501 2.16e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1242 LSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKacgSEIMQKKQHLEiELKQVMQQRSEDNARHKQSLEEAAKTIQ 1321
Cdd:COG4372    29 LSEQLRKALFELDKLQEELEQLREELEQAREELEQLE---EELEQARSELE-QLEEELEELNEQLQAAQAELAQAQEELE 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1322 DKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLE 1401
Cdd:COG4372   105 SLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQA 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1402 AETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRS------EIERLQAEIKRIEERCRRKLE 1475
Cdd:COG4372   185 LDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSAlldaleLEEDKEELLEEVILKEIEELE 264

                         250       260
                  ....*....|....*....|....*.
gi 975830145 1476 DSTRETQSQLETERSRYQREIDKLRQ 1501
Cdd:COG4372   265 LAILVEKDTEEEELEIAALELEALEE 290
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 992-1476 2.22e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  992 ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQ 1071
Cdd:COG1196   360 LAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEE 439

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1072 FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKE 1151
Cdd:COG1196   440 EEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGL 519

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1152 NLGWQKLeSEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHyneemsNLRNKYETEINITKTTIKEISMQKEDD 1231
Cdd:COG1196   520 RGLAGAV-AVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEY------LKAAKAGRATFLPLDKIRARAALAAAL 592

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1232 SKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALqqkacgsEIMQKKQHLEIELKQVMQQRSEDNARHKQ 1311
Cdd:COG1196   593 ARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAAL-------RRAVTLAGRLREVTLEGEGGSAGGSLTGG 665

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1312 SLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQctqvvQERESLLVKIKVLEQDKARLQRLED 1391
Cdd:COG1196   666 SRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEE-----RLEEELEEEALEEQLEAEREELLEE 740

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1392 ELNRAKSTLEAETRVKQRLEcekqqiqnDLNQWKTQYSRKEEAIRKI--------------ESEREKSEREKNSLRSEIE 1457
Cdd:COG1196   741 LLEEEELLEEEALEELPEPP--------DLEELERELERLEREIEALgpvnllaieeyeelEERYDFLSEQREDLEEARE 812

                         490
                  ....*....|....*....
gi 975830145 1458 RLQAEIKRIEERCRRKLED 1476
Cdd:COG1196   813 TLEEAIEEIDRETRERFLE 831
DUF4686 pfam15742
Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins ...
 1218-1491 2.32e-03

Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.


Pssm-ID: 464838 [Multi-domain]  Cd Length: 384  Bit Score: 42.74  E-value: 2.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1218 KTTIKEISMQKEDDSKN---LRNQLDRLSRENRDLKDEIVRLNdsilQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294
Cdd:pfam15742   61 KAELKQAQQKLLDSTKMcssLTAEWKHCQQKIRELELEVLKQA----QSIKSQNSLQEKLAQEKSRVADAEEKILELQQK 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1295 LKQVMQQRSEDN-ARHKQSLEEAAKTIQDKnkeIERLKAEFQEEAKRRW---EYENELSKASNRIQESKNQCTQVVQERE 1370
Cdd:pfam15742  137 LEHAHKVCLTDTcILEKKQLEERIKEASEN---EAKLKQQYQEEQQKRKlldQNVNELQQQVRSLQDKEAQLEMTNSQQQ 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1371 SLlvkikvLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQ--IQNDLNQWKTQYSRKEEairkiesere 1443
Cdd:pfam15742  214 LR------IQQQEAQLKQLENEKRKSDEHLKSNQELSEKLsslqqEKEALQeeLQQVLKQLDVHVRKYNE---------- 277

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 975830145  1444 KSEREKNSLRSEIERLQAEIKRIEERCrRKLEDSTRETQSQLETERSR 1491
Cdd:pfam15742  278 KHHHHKAKLRRAKDRLVHEVEQRDERI-KQLENEIGILQQQSEKEKAF 324
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 1291-1466 2.35e-03

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 42.44  E-value: 2.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1291 LEIELKQVMQQRsednarhkqslEEAAKTIQDKNKEIERLKAEFQEEAKRrweYENELSKASNRIQESKNQCTQVVQERE 1370
Cdd:pfam09787   45 LTLELEELRQER-----------DLLREEIQKLRGQIQQLRTELQELEAQ---QQEEAESSREQLQELEEQLATERSARR 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1371 SLLVKikvLEQDKARLQRLEDELNRAKSTLEaeTRVKQRlECEKQQIQNDLNQwKTQYSRKE-----------EAIRKIE 1439
Cdd:pfam09787  111 EAEAE---LERLQEELRYLEEELRRSKATLQ--SRIKDR-EAEIEKLRNQLTS-KSQSSSSQselenrlhqltETLIQKQ 183

                          170       180
                   ....*....|....*....|....*..
gi 975830145  1440 SEREKSEREKNSLRSEIERLQAEIKRI 1466
Cdd:pfam09787  184 TMLEALSTEKNSLVLQLERMEQQIKEL 210
46 PHA02562
endonuclease subunit; Provisional
 1193-1392 2.44e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.08  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1193 AKVR--NHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRA 1270
Cdd:PHA02562  174 DKIRelNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDP 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1271 EE--NALQQKAC--GSEIMQ-KKQHLEIELKQV----MQQRSEDNARhkqsLEEAAKTIQDKNKEIERLKAEFQEEAKRr 1341
Cdd:PHA02562  254 SAalNKLNTAAAkiKSKIEQfQKVIKMYEKGGVcptcTQQISEGPDR----ITKIKDKLKELQHSLEKLDTAIDELEEI- 328

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 975830145 1342 weyENELSKASNRIQESKNQCTQVVQERESLLVKIKVLEqdkARLQRLEDE 1392
Cdd:PHA02562  329 ---MDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVK---AAIEELQAE 373
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 858-1271 2.44e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 42.92  E-value: 2.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   858 EKVTQLTDRWQRIdkqIDFRLWDLEKQIKQLRNYRDNYQAFckwlyDAKRRQDSLESMkfgdsntVMRFLNEQKNLHSEI 937
Cdd:pfam06160   45 EKFEEWRKKWDDI---VTKSLPDIEELLFEAEELNDKYRFK-----KAKKALDEIEEL-------LDDIEEDIKQILEEL 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   938 SGKRDK----SEEVQKIAELCANSIKDYELQLASYTSGLETLLNIpikrtmiqspsgviLQEAADVHARYIELlTRSGDY 1013
Cdd:pfam06160  110 DELLESeeknREEVEELKDKYRELRKTLLANRFSYGPAIDELEKQ--------------LAEIEEEFSQFEEL-TESGDY 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1014 Y---RFLSEMLKSLEDLKLKNTKIEVLEEELrlardansencnKNKFLDQnLQKYQAECSQFKAKLASLEELKRQAELdg 1090
Cdd:pfam06160  175 LearEVLEKLEEETDALEELMEDIPPLYEEL------------KTELPDQ-LEELKEGYREMEEEGYALEHLNVDKEI-- 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1091 KSAKQNLDKCYGQIKEL------------NEKITRLtYEI-EDEKRRRKSVEdrfDQQKNDYDQLQKARqcekenlgwqk 1157
Cdd:pfam06160  240 QQLEEQLEENLALLENLeldeaeealeeiEERIDQL-YDLlEKEVDAKKYVE---KNLPEIEDYLEHAE----------- 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1158 lESEKAIKEkeyEIERLR---VLLQEEGTRKREYENELAKVRNHYNEEMSNLRNK---YeTEINITKTTIKEISMQKEDD 1231
Cdd:pfam06160  305 -EQNKELKE---ELERVQqsyTLNENELERVRGLEKQLEELEKRYDEIVERLEEKevaY-SELQEELEEILEQLEEIEEE 379

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 975830145  1232 SKNLRNQLDRLSRENRDLKDEIVRLNDSILqatEQRRRAE 1271
Cdd:pfam06160  380 QEEFKESLQSLRKDELEAREKLDEFKLELR---EIKRLVE 416
PLEC smart00250
Plectin repeat;
2319-2356 2.67e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 2.67e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 975830145   2319 QRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG 2356
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Filament pfam00038
Intermediate filament protein;
1171-1499 2.74e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 42.21  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1171 IERLRVLLQEegtrKREYENELAKVRNHYNEEMSNLRNKYETEINitkttikeismqkeddskNLRNQLDRLSRENRDLK 1250
Cdd:pfam00038   17 IDKVRFLEQQ----NKLLETKISELRQKKGAEPSRLYSLYEKEIE------------------DLRRQLDTLTVERARLQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1251 DEIvrlnDSILQATEQRRRAEENALQqkacgseimqKKQHLEIELkqVMQQRSEDNAR-HKQSLEeaaKTIQDKNKEIER 1329
Cdd:pfam00038   75 LEL----DNLRLAAEDFRQKYEDELN----------LRTSAENDL--VGLRKDLDEATlARVDLE---AKIESLKEELAF 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1330 LKAEFQEEAKrrweyenELSKasnriqesKNQCTQVVqeresllvkikvLEQDKARLQRLEDELNRAKSTLEAETRvKQR 1409
Cdd:pfam00038  136 LKKNHEEEVR-------ELQA--------QVSDTQVN------------VEMDAARKLDLTSALAEIRAQYEEIAA-KNR 187

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1410 LECEKQqiqndlnqWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRrKLEDSTRETQSQLETER 1489
Cdd:pfam00038  188 EEAEEW--------YQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQKA-SLERQLAETEERYELQL 258

                          330
                   ....*....|
gi 975830145  1490 SRYQREIDKL 1499
Cdd:pfam00038  259 ADYQELISEL 268
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1234-1434 2.89e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.08  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1234 NLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRR--RAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARH-- 1309
Cdd:COG3206   165 NLELRREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLaa 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1310 -KQSLEEAAKTIQD--KNKEIERLKAEFQEEAKRRWEYENELSKASNRIQESKNQCTQVVQERESLLVKIKV-LEQDKAR 1385
Cdd:COG3206   245 lRAQLGSGPDALPEllQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILAsLEAELEA 324

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 975830145 1386 LQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQY----SRKEEA 1434
Cdd:COG3206   325 LQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYesllQRLEEA 377
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 1054-1402 3.20e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 43.28  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1054 KNKFLDQNLQKYQAECSQFKAKLASLEelkrqAELDGKSAKQNLDKcyGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133
Cdd:PTZ00440 1036 KGKEIEEKVDQYISLLEKMKTKLSSFH-----FNIDIKKYKNPKIK--EEIKLLEEKVEALLKKIDENKNKLIEIKNKSH 1108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1134 QQKNDYDQlQKARQCEKENLGWQKLES-----EKAIKEKEyEIERLRVLLQEEGTRKREYENELAkvrNHYNEEMSNLRN 1208
Cdd:PTZ00440 1109 EHVVNADK-EKNKQTEHYNKKKKSLEKiykqmEKTLKELE-NMNLEDITLNEVNEIEIEYERILI---DHIVEQINNEAK 1183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1209 KYETEINITKTTIKEISMQKEDDSKNLRNQLDRLsrENRDLKDEIVRLNDSILQATEqrrraEENALQQKACGSEIMQKK 1288
Cdd:PTZ00440 1184 KSKTIMEEIESYKKDIDQVKKNMSKERNDHLTTF--EYNAYYDKATASYENIEELTT-----EAKGLKGEANRSTNVDEL 1256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1289 QHLEIELKQVMQQRSEDNarhkQSLEEAAKTIQDKNK-----EIERLKAEFQEEAKRRWEYEN----ELSKASNRIQESK 1359
Cdd:PTZ00440 1257 KEIKLQVFSYLQQVIKEN----NKMENALHEIKNMYEflisiDSEKILKEILNSTKKAEEFSNdakkELEKTDNLIKQVE 1332

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 975830145 1360 NQCTQVVQ---------ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEA 1402
Cdd:PTZ00440 1333 AKIEQAKEhknkiygslEDKQIDDEIKKIEQIKEEISNKRKEINKYLSNIKS 1384
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
 1017-1327 3.57e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 42.53  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1017 LSEMLKSLE---DLKLKNTKIEV-LEEELRLARD----ANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAEL 1088
Cdd:PLN03229  460 LNEMIEKLKkeiDLEYTEAVIAMgLQERLENLREefskANSQDQLMHPVLMEKIEKLKDEFNKRLSRAPNYLSLKYKLDM 539

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1089 --DGKSAKQNLdkcygqikELNEKITRLTYEIEDekrRRKSVEDRFDQQkndydqlqkarqcekenlgwQKLESEKAI-- 1164
Cdd:PLN03229  540 lnEFSRAKALS--------EKKSKAEKLKAEINK---KFKEVMDRPEIK--------------------EKMEALKAEva 588

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1165 KEKEYEIERLRVLLQEEGTR-KREYENELAKVRNHYNEEMSNLR-NKYETEINITKTTIKE-ISMQKEDDSKNLRNQLDR 1241
Cdd:PLN03229  589 SSGASSGDELDDDLKEKVEKmKKEIELELAGVLKSMGLEVIGVTkKNKDTAEQTPPPNLQEkIESLNEEINKKIERVIRS 668

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1242 LSRENR--DLKDEIVRLNDSILQATEQRRRAEENALQQKACG----SEIMQKKQHLEIELKQVMQQRSEDNARHKQ-SLE 1314
Cdd:PLN03229  669 SDLKSKieLLKLEVAKASKTPDVTEKEKIEALEQQIKQKIAEalnsSELKEKFEELEAELAAARETAAESNGSLKNdDDK 748

                         330
                  ....*....|...
gi 975830145 1315 EAAKTIQDKNKEI 1327
Cdd:PLN03229  749 EEDSKEDGSRVEV 761
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 1304-1491 4.38e-03

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 41.13  E-value: 4.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEY------ENELSKASNRIQESKNQCTQV---VQERESLLV 1374
Cdd:pfam12795   37 QRAAAYQKALDDAPAELRELRQELAALQAKAEAAPKEILASlsleelEQRLLQTSAQLQELQNQLAQLnsqLIELQTRPE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1375 KI-KVLEQDKARLQRLEDELNRAKSTLEAETRVKQrlecEKQQIQNDLNQWKTQYSRKEEAIrkIESEREKSEREKNSLR 1453
Cdd:pfam12795  117 RAqQQLSEARQRLQQIRNRLNGPAPPGEPLSEAQR----WALQAELAALKAQIDMLEQELLS--NNNRQDLLKARRDLLT 190

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 975830145  1454 SEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1491
Cdd:pfam12795  191 LRIQRLEQQLQALQELLNEKRLQEAEQAVAQTEQLAEE 228
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 1062-1252 4.78e-03

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 41.67  E-value: 4.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1062 LQKYQAECSQFKAKLASLEElKRQAELDgksakqnldkcygqikELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQ 1141
Cdd:pfam09787   63 IQKLRGQIQQLRTELQELEA-QQQEEAE----------------SSREQLQELEEQLATERSARREAEAELERLQEELRY 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1142 LqkarqceKENLGWQKLESEKAIKEKEYEIERLRVLL---QEEGTRKREYENELAKVrnhyneemsnlrnkyeTEINITK 1218
Cdd:pfam09787  126 L-------EEELRRSKATLQSRIKDREAEIEKLRNQLtskSQSSSSQSELENRLHQL----------------TETLIQK 182

                          170       180       190
                   ....*....|....*....|....*....|....
gi 975830145  1219 TTIKEiSMQKEDDSknLRNQLDRLSRENRDLKDE 1252
Cdd:pfam09787  183 QTMLE-ALSTEKNS--LVLQLERMEQQIKELQGE 213
PRK11281 PRK11281
mechanosensitive channel MscK;
1288-1502 5.66e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.21  E-value: 5.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1288 KQHLE--IELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRW------EYENELSKASNRIQESK 1359
Cdd:PRK11281   62 QQDLEqtLALLDKIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLstlslrQLESRLAQTLDQLQNAQ 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1360 NQCTQVvqerESLLVKI--------KVLEQDKARLQRLEDELNR---AKSTLEAETRVKqrLECEKQQI--QNDLNQWKT 1426
Cdd:PRK11281  142 NDLAEY----NSQLVSLqtqperaqAALYANSQRLQQIRNLLKGgkvGGKALRPSQRVL--LQAEQALLnaQNDLQRKSL 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1427 Q---------YSRKEEAIRKIeserekserekNSLRSEIERLQAEI--KRIEERcrrklEDSTRETQSQLETERSR---- 1491
Cdd:PRK11281  216 EgntqlqdllQKQRDYLTARI-----------QRLEHQLQLLQEAInsKRLTLS-----EKTVQEAQSQDEAARIQanpl 279

                         250
                  ....*....|....
gi 975830145 1492 YQREID---KLRQR 1502
Cdd:PRK11281  280 VAQELEinlQLSQR 293
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 1233-1495 5.99e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 41.44  E-value: 5.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1233 KNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQS 1312
Cdd:pfam13868   31 KKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERI 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1313 LEEAAKTIQDKNKEIERLKAEFQE--EAKRRWEyenELSKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR---LQ 1387
Cdd:pfam13868  111 QEEDQAEAEEKLEKQRQLREEIDEfnEEQAEWK---ELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKereIA 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1388 RLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQwktqysrKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1467
Cdd:pfam13868  188 RLRAQQEKAQDEKAERDELRAKLYQEEQERKERQKE-------REEAEKKARQRQELQQAREEQIELKERRLAEEAEREE 260

                          250       260
                   ....*....|....*....|....*....
gi 975830145  1468 ERCRRKLED-STRETQSQLETERSRYQRE 1495
Cdd:pfam13868  261 EEFERMLRKqAEDEEIEQEEAEKRRMKRL 289
RNase_Y_N pfam12072
RNase Y N-terminal region;
1222-1361 6.22e-03

RNase Y N-terminal region;


Pssm-ID: 463456 [Multi-domain]  Cd Length: 201  Bit Score: 40.25  E-value: 6.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1222 KEISMQKEDDSKNLRNQLDRlsrENRDLKDEIVRLNDSILQATEQRRRAEEnALQQKacgseimqkkqhlEIELKQVMQQ 1301
Cdd:pfam12072   52 KEALLEAKEEIHKLRAEAER---ELKERRNELQRQERRLLQKEETLDRKDE-SLEKK-------------EESLEKKEKE 114

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 975830145  1302 RSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRW--EYENELSK-ASNRIQESKNQ 1361
Cdd:pfam12072  115 LEAQQQQLEEKEEELEELIEEQRQELERISGLTSEEAKEILldEVEEELRHeAAVMIKEIEEE 177
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 1385-1489 6.32e-03

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 38.75  E-value: 6.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1385 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIK 1464
Cdd:pfam20492   14 RLKQYEEETKKAQEELEESEETAEELEEERRQAEEEAERLEQKRQEAEEEKERLEESAEMEAEEKEQLEAELAEAQEEIA 93

                           90       100
                   ....*....|....*....|....*
gi 975830145  1465 RIEERCRRKlEDSTRETQSQLETER 1489
Cdd:pfam20492   94 RLEEEVERK-EEEARRLQEELEEAR 117
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1233-1332 6.81e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.77  E-value: 6.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1233 KNLRNQLDRLSRENRDLKDEIvrlndsilqaTEQRRRAEEnaLQQKacgSEIMQKKQHLEIELKQVMQQRSEDNARHKQS 1312
Cdd:COG2433   416 RRLEEQVERLEAEVEELEAEL----------EEKDERIER--LERE---LSEARSEERREIRKDREISRLDREIERLERE 480

                          90       100
                  ....*....|....*....|
gi 975830145 1313 LEEAAKTIQDKNKEIERLKA 1332
Cdd:COG2433   481 LEEERERIEELKRKLERLKE 500
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1017-1361 8.05e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 41.36  E-value: 8.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1017 LSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC-NKNKFLDQNLQKYQAECSQFkaklaslEELKrqaeldgksAKQ 1095
Cdd:PRK04778  128 LQELLESEEKNREEVEQLKDLYRELRKSLLANRFSFgPALDELEKQLENLEEEFSQF-------VELT---------ESG 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1096 NLDKCYGQIKELNEKITRLTYEIEDekrrrksVEDRFDQQKNDY-DQLQK----ARQCEKENLGWQKLESEKAIKEKEYE 1170
Cdd:PRK04778  192 DYVEAREILDQLEEELAALEQIMEE-------IPELLKELQTELpDQLQElkagYRELVEEGYHLDHLDIEKEIQDLKEQ 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1171 IERLRVLLQEEGTRKREYENElakvrnHYNEEMSNLRNKYETEINITKTTIKEIsmqkeddsKNLRNQLDRLSRENRDLK 1250
Cdd:PRK04778  265 IDENLALLEELDLDEAEEKNE------EIQERIDQLYDILEREVKARKYVEKNS--------DTLPDFLEHAKEQNKELK 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1251 DEIVRLNDS-ILQATE-QRRRAEENALQqkacgseiMQKKQHLEIelkqvmQQRSEDNARHKQSLEEAAKTIQDKNKEIE 1328
Cdd:PRK04778  331 EEIDRVKQSyTLNESElESVRQLEKQLE--------SLEKQYDEI------TERIAEQEIAYSELQEELEEILKQLEEIE 396

                         330       340       350
                  ....*....|....*....|....*....|...
gi 975830145 1329 RLKAEFQEEAKRRWEYENElskASNRIQESKNQ 1361
Cdd:PRK04778  397 KEQEKLSEMLQGLRKDELE---AREKLERYRNK 426
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1261-1470 9.05e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.98  E-value: 9.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1261 LQATEQRRRAEE--NALQQKAcgsEIMQKKQHLEIELKQVMQQRSEDNARHKQSlEEAAKTIQDKNKEIERLKAEFQEEA 1338
Cdd:TIGR02794   57 QQKKPAAKKEQErqKKLEQQA---EEAEKQRAAEQARQKELEQRAAAEKAAKQA-EQAAKQAEEKQKQAEEAKAKQAAEA 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1339 KRRWEYENELSKAsnriQESKNQCTQVVQERESLLVKIKVLE---------------QDKARLQRLEDELNRAKSTLEAE 1403
Cdd:TIGR02794  133 KAKAEAEAERKAK----EEAAKQAEEEAKAKAAAEAKKKAEEakkkaeaeakakaeaEAKAKAEEAKAKAEAAKAKAAAE 208

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 975830145  1404 TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERC 1470
Cdd:TIGR02794  209 AAAKAEAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQGGARGAAAGSEVDKYAAIIQQAIQQN 275
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1060-1339 9.24e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 9.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1060 QNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
Cdd:COG4372    38 FELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEEL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1140 DQLQKARQC---EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN-HYNEEMSNLRNKYETEIN 1215
Cdd:COG4372   118 EELQKERQDleqQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEaEAEQALDELLKEANRNAE 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145 1216 ITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIEL 1295
Cdd:COG4372   198 KEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEE 277

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 975830145 1296 KQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAK 1339
Cdd:COG4372   278 LEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAAL 321
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 825-1383 9.76e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 41.36  E-value: 9.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   825 LATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGeKVTQLTDRW-QRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLY 903
Cdd:pfam12128  339 IETAAADQEQLPSWQSELENLEERLKALTGKHQ-DVTAKYNRRrSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDL 417

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   904 DAkrrqdsLESmkfgdsntvmrFLNEQKNlhseiSGKRDKSEEvqkiAELCANSIKDYELQLASYTSGLETLLNIPIKRT 983
Cdd:pfam12128  418 QA------LES-----------ELREQLE-----AGKLEFNEE----EYRLKSRLGELKLRLNQATATPELLLQLENFDE 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145   984 MIQSPSGVILQEAADVHARYIELLT----------RSGDYYRFLSEMLKSLEDLKLK-----NTKIEVLEEEL-----RL 1043
Cdd:pfam12128  472 RIERAREEQEAANAEVERLQSELRQarkrrdqaseALRQASRRLEERQSALDELELQlfpqaGTLLHFLRKEApdweqSI 551

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1044 ARDANSE---NCNKNKFLDQNLQKyqAECSQFKAKL-----------ASLEELKR---QAELDGKSAKQNLDKCYGQIKE 1106
Cdd:pfam12128  552 GKVISPEllhRTDLDPEVWDGSVG--GELNLYGVKLdlkridvpewaASEEELRErldKAEEALQSAREKQAAAEEQLVQ 629

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1107 LNEKITRLTYEIEDEKRRRKSVEDR----FDQQKNDYDQLQKARQCEKENLG--WQKLESEKAIKEKEyeierLRVLLQE 1180
Cdd:pfam12128  630 ANGELEKASREETFARTALKNARLDlrrlFDEKQSEKDKKNKALAERKDSANerLNSLEAQLKQLDKK-----HQAWLEE 704

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1181 EGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIK-EISMQKEDDSKNLR------NQLDRLSRENRDLKDEI 1253
Cdd:pfam12128  705 QKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAARRSGAKaELKALETWYKRDLAslgvdpDVIAKLKREIRTLERKI 784

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975830145  1254 VRLNDSILQATEQRRRAEENALQQK----ACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329
Cdd:pfam12128  785 ERIAVRRQEVLRYFDWYQETWLQRRprlaTQLSNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSENLRG 864

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 975830145  1330 LKAEFQEEAKRRWEYENElsKASNRIQESKNQCTQVVQERESLLVKI-KVLEQDK 1383
Cdd:pfam12128  865 LRCEMSKLATLKEDANSE--QAQGSIGERLAQLEDLKLKRDYLSESVkKYVEHFK 917
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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