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Conserved domains on  [gi|1009287599|ref|NP_001308408|]
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THUMP domain-containing protein 2 isoform 7 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 40-185 2.67e-30

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam01170:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 184  Bit Score: 111.68  E-value: 2.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  40 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVY-----------YVGADVSDSQLLGTWDNL 108
Cdd:pfam01170   4 RPFNGPAPLKETLAAAMVNLAGWKPGDPLLDPMCGSGTILIEAALMGANIApgkfdarvrapLYGSDIDRRMVQGARLNA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599 109 KAAGLEDKIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKDI----KSILQEMERVLHVGGTIVLLLSEdhHRRLTD 184
Cdd:pfam01170  84 ENAGVGDLIEFVQADAADLPLLEGSVDVIVTNPPYGIRLGSKGALealyPEFLREAKRVLRGGGWLVLLTAE--NKDFEK 161


                  .
gi 1009287599 185 C 185
Cdd:pfam01170 162 A 162
 
Name Accession Description Interval E-value
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 40-185 2.67e-30

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 111.68  E-value: 2.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  40 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVY-----------YVGADVSDSQLLGTWDNL 108
Cdd:pfam01170   4 RPFNGPAPLKETLAAAMVNLAGWKPGDPLLDPMCGSGTILIEAALMGANIApgkfdarvrapLYGSDIDRRMVQGARLNA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599 109 KAAGLEDKIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKDI----KSILQEMERVLHVGGTIVLLLSEdhHRRLTD 184
Cdd:pfam01170  84 ENAGVGDLIEFVQADAADLPLLEGSVDVIVTNPPYGIRLGSKGALealyPEFLREAKRVLRGGGWLVLLTAE--NKDFEK 161


                  .
gi 1009287599 185 C 185
Cdd:pfam01170 162 A 162
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 52-184 1.52e-26

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 101.56  E-value: 1.52e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  52 IAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVYyvGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIELPLPS 131
Cdd:COG1041    14 LARALVNLAGAKEGDTVLDPFCGTGTILIEAGLLGRRVI--GSDIDPKMVEGARENLEHYGYED-ADVIRGDARDLPLAD 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1009287599 132 ESVDIIISDIPFGKKFKLGKD-----IKSILQEMERVLHVGGTIVLLLSEDHHRRLTD 184
Cdd:COG1041    91 ESVDAIVTDPPYGRSSKISGEellelYEKALEEAARVLKPGGRVVIVTPRDIDELLEE 148
TIGR01177 TIGR01177
putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is ...
 5-171 9.04e-19

putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is found exclusively in the Archaea. [Hypothetical proteins, Conserved]


Pssm-ID: 273486 [Multi-domain]  Cd Length: 329  Bit Score: 84.03  E-value: 9.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599   5 GWKADLRNPQLEIFI-HLNDIYSVVGIPVFRV-------SLASRAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLG 76
Cdd:TIGR01177 115 GFKVSLRRPDIVVRVvITEDIFYLGRVLEERDkeqfierKPDRRPFFKPGSMDPKLARAMVNLARVTEGDRVLDPFCGTG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  77 TILLEAAKEWPDVYyvGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKD---- 152
Cdd:TIGR01177 195 GFLIEAGLMGAKVI--GCDIDWKMVAGARINLEHYGIED-FFVKRGDATKLPLSSESVDAIATDPPYGRSTTAAGDgles 271

                         170       180
                  ....*....|....*....|
gi 1009287599 153 -IKSILQEMERVLHVGGTIV 171
Cdd:TIGR01177 272 lYERSLEEFHEVLKSEGWIV 291
Trm14_Arch NF040721
tRNA (guanine(6)-N2)-methyltransferase;
40-177 2.16e-16

tRNA (guanine(6)-N2)-methyltransferase;


Pssm-ID: 468685 [Multi-domain]  Cd Length: 370  Bit Score: 77.79  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  40 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAA---------------------------KEWPDVYY- 91
Cdd:NF040721  167 RVYQHPAHLNPTIASSLIYLSGWKDEESLLDPMCGSGTILIEAAlikrnippgkfredfafkkifghelleKIKKDVELk 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  92 -VGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPLPSESVDIIISDIPFG----KKFKLGKDIKSILQEMERVLHV 166
Cdd:NF040721  247 iYGIEKFRKHLEGAKKNAENAGVDDTIKFIQGDATKLDKYFDSVDVIVTNPPYGlrigKKRIIKKLYNNFLRSAKKILHK 326

                         170
                  ....*....|.
gi 1009287599 167 GGTIVLLLSED 177
Cdd:NF040721  327 RSRIVVITAEK 337
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 68-172 6.07e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.51  E-value: 6.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  68 VLDPMCGLGTILLEAAkEWPDVYYVGADVSDSQLlGTWDNLKAAGLEDKIELLKISVIELPL-PSESVDIIISDIPFgkk 146
Cdd:cd02440     2 VLDLGCGTGALALALA-SGPGARVTGVDISPVAL-ELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPL--- 76

                          90       100
                  ....*....|....*....|....*.
gi 1009287599 147 FKLGKDIKSILQEMERVLHVGGTIVL 172
Cdd:cd02440    77 HHLVEDLARFLEEARRLLKPGGVLVL 102
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 49-173 3.78e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 55.54  E-value: 3.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  49 RSTIAWAmaslaDIKAGAFVLDPMCGLGTILLEAAKEWPDV-YYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIEL 127
Cdd:PRK00216   41 RKTIKWL-----GVRPGDKVLDLACGTGDLAIALAKAVGKTgEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEAL 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1009287599 128 PLPSESVDII-ISdipFGkkfkLG--KDIKSILQEMERVLHVGGTIVLL 173
Cdd:PRK00216  116 PFPDNSFDAVtIA---FG----LRnvPDIDKALREMYRVLKPGGRLVIL 157
 
Name Accession Description Interval E-value
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 40-185 2.67e-30

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 111.68  E-value: 2.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  40 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVY-----------YVGADVSDSQLLGTWDNL 108
Cdd:pfam01170   4 RPFNGPAPLKETLAAAMVNLAGWKPGDPLLDPMCGSGTILIEAALMGANIApgkfdarvrapLYGSDIDRRMVQGARLNA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599 109 KAAGLEDKIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKDI----KSILQEMERVLHVGGTIVLLLSEdhHRRLTD 184
Cdd:pfam01170  84 ENAGVGDLIEFVQADAADLPLLEGSVDVIVTNPPYGIRLGSKGALealyPEFLREAKRVLRGGGWLVLLTAE--NKDFEK 161


                  .
gi 1009287599 185 C 185
Cdd:pfam01170 162 A 162
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 52-184 1.52e-26

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 101.56  E-value: 1.52e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  52 IAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVYyvGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIELPLPS 131
Cdd:COG1041    14 LARALVNLAGAKEGDTVLDPFCGTGTILIEAGLLGRRVI--GSDIDPKMVEGARENLEHYGYED-ADVIRGDARDLPLAD 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1009287599 132 ESVDIIISDIPFGKKFKLGKD-----IKSILQEMERVLHVGGTIVLLLSEDHHRRLTD 184
Cdd:COG1041    91 ESVDAIVTDPPYGRSSKISGEellelYEKALEEAARVLKPGGRVVIVTPRDIDELLEE 148
TIGR01177 TIGR01177
putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is ...
 5-171 9.04e-19

putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is found exclusively in the Archaea. [Hypothetical proteins, Conserved]


Pssm-ID: 273486 [Multi-domain]  Cd Length: 329  Bit Score: 84.03  E-value: 9.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599   5 GWKADLRNPQLEIFI-HLNDIYSVVGIPVFRV-------SLASRAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLG 76
Cdd:TIGR01177 115 GFKVSLRRPDIVVRVvITEDIFYLGRVLEERDkeqfierKPDRRPFFKPGSMDPKLARAMVNLARVTEGDRVLDPFCGTG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  77 TILLEAAKEWPDVYyvGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKD---- 152
Cdd:TIGR01177 195 GFLIEAGLMGAKVI--GCDIDWKMVAGARINLEHYGIED-FFVKRGDATKLPLSSESVDAIATDPPYGRSTTAAGDgles 271

                         170       180
                  ....*....|....*....|
gi 1009287599 153 -IKSILQEMERVLHVGGTIV 171
Cdd:TIGR01177 272 lYERSLEEFHEVLKSEGWIV 291
Trm14_Arch NF040721
tRNA (guanine(6)-N2)-methyltransferase;
40-177 2.16e-16

tRNA (guanine(6)-N2)-methyltransferase;


Pssm-ID: 468685 [Multi-domain]  Cd Length: 370  Bit Score: 77.79  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  40 RAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAA---------------------------KEWPDVYY- 91
Cdd:NF040721  167 RVYQHPAHLNPTIASSLIYLSGWKDEESLLDPMCGSGTILIEAAlikrnippgkfredfafkkifghelleKIKKDVELk 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  92 -VGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPLPSESVDIIISDIPFG----KKFKLGKDIKSILQEMERVLHV 166
Cdd:NF040721  247 iYGIEKFRKHLEGAKKNAENAGVDDTIKFIQGDATKLDKYFDSVDVIVTNPPYGlrigKKRIIKKLYNNFLRSAKKILHK 326

                         170
                  ....*....|.
gi 1009287599 167 GGTIVLLLSED 177
Cdd:NF040721  327 RSRIVVITAEK 337
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 9-164 2.69e-13

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 68.97  E-value: 2.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599   9 DLRNPQLEIFIHL-NDIYSV----VGIPVFRvslasRAYIKTAG---LRSTIAWAMASLADIKAGAFVLDPMCGLGTILL 80
Cdd:COG0116   130 DEDGPDVRIHVHLlKDRATLsldtSGESLHK-----RGYREAQGeapLKETLAAALLLLSGWDGDRPLVDPMCGSGTILI 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  81 EAA----------------KEWPD----------------------VYYVGADVSDSQLLGTWDNLKAAGLEDKIELLKI 122
Cdd:COG0116   205 EAAliaaniapglnrdfafEKWPDfdaelwqelreeaearikrdppLPIFGSDIDPRAIEAARENAERAGVADLIEFEQA 284

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1009287599 123 SVIELPLPSESvDIIISDIPFGKKFKLGKDIKSILQEMERVL 164
Cdd:COG0116   285 DFRDLEPPAEP-GLIITNPPYGERLGEEEELEALYRELGDVL 325
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 55-184 1.92e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 63.09  E-value: 1.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  55 AMASLADIKAGAFVLDPMCGLGTILLEAAKEwpDVYYVGADVSDSQLLGTWDNLKAAGLedKIELLKISVIELPLPSESV 134
Cdd:COG2226    13 ALLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDLPFPDGSF 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1009287599 135 DIIIS-----DIPfgkkfklgkDIKSILQEMERVLHVGGTIVLL-LSEDHHRRLTD 184
Cdd:COG2226    89 DLVISsfvlhHLP---------DPERALAEIARVLKPGGRLVVVdFSPPDLAELEE 135
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 68-172 6.07e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.51  E-value: 6.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  68 VLDPMCGLGTILLEAAkEWPDVYYVGADVSDSQLlGTWDNLKAAGLEDKIELLKISVIELPL-PSESVDIIISDIPFgkk 146
Cdd:cd02440     2 VLDLGCGTGALALALA-SGPGARVTGVDISPVAL-ELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPL--- 76

                          90       100
                  ....*....|....*....|....*.
gi 1009287599 147 FKLGKDIKSILQEMERVLHVGGTIVL 172
Cdd:cd02440    77 HHLVEDLARFLEEARRLLKPGGVLVL 102
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 49-173 3.78e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 55.54  E-value: 3.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  49 RSTIAWAmaslaDIKAGAFVLDPMCGLGTILLEAAKEWPDV-YYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIEL 127
Cdd:PRK00216   41 RKTIKWL-----GVRPGDKVLDLACGTGDLAIALAKAVGKTgEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEAL 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1009287599 128 PLPSESVDII-ISdipFGkkfkLG--KDIKSILQEMERVLHVGGTIVLL 173
Cdd:PRK00216  116 PFPDNSFDAVtIA---FG----LRnvPDIDKALREMYRVLKPGGRLVIL 157
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 69-172 6.49e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 52.28  E-value: 6.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  69 LDPMCGLGTILLEAAKEWPDVYyvGADVSDSQLlgtwDNLKAAGLEDKIELLKISVIELPLPSESVDIIISdipfgkKFK 148
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVT--GVDISPEML----ELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLS------SEV 68

                          90       100
                  ....*....|....*....|....*.
gi 1009287599 149 LG--KDIKSILQEMERVLHVGGTIVL 172
Cdd:pfam08241  69 LHhvEDPERALREIARVLKPGGILII 94
PRK08317 PRK08317
hypothetical protein; Provisional
 58-173 8.61e-09

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 54.56  E-value: 8.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  58 SLADIKAGAFVLDPMCGLGTILLEAAKE-WPDVYYVGADVSDSQLLGTwdNLKAAGLEDKIELLKISVIELPLPSESVDI 136
Cdd:PRK08317   13 ELLAVQPGDRVLDVGCGPGNDARELARRvGPEGRVVGIDRSEAMLALA--KERAAGLGPNVEFVRGDADGLPFPDGSFDA 90

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1009287599 137 IISDipfgKKFKLGKDIKSILQEMERVLHVGGTIVLL 173
Cdd:PRK08317   91 VRSD----RVLQHLEDPARALAEIARVLRPGGRVVVL 123
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 68-168 1.14e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.41  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  68 VLDPMCGLGTILLEAAKEWpDVYYVGADVSDSQLLGTWDNLKAAGLedKIELLKISVIELPLPSESVDIIISDIPFGkkF 147
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPFPDGSFDLVVSSGVLH--H 75

                          90       100
                  ....*....|....*....|.
gi 1009287599 148 KLGKDIKSILQEMERVLHVGG 168
Cdd:pfam13649  76 LPDPDLEAALREIARVLKPGG 96
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 9-144 6.88e-08

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 53.27  E-value: 6.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599   9 DLRNPQLEIFIHLNDIYSVVGIPVFRVSLASRAYIKTAG---LRSTIAWAMASLAD-IKAGAFVLDPMCGLGTILLEAA- 83
Cdd:PRK11783  131 DKEQPDIRINARLNKGEATISLDLSGESLHQRGYRQATGeapLKENLAAAILLRSGwPQEGTPLLDPMCGSGTLLIEAAm 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  84 -----------KEW------------------------------PDVYYVGADvSDSQLLGT-WDNLKAAGLEDKIELLK 121
Cdd:PRK11783  211 maadiapglhrERWgfsgwlghdealwqelleeaqeraraglaeLPSKFYGSD-IDPRVIQAaRKNARRAGVAELITFEV 289

                         170       180
                  ....*....|....*....|....*
gi 1009287599 122 ISVIEL--PLPSESVDIIISDIPFG 144
Cdd:PRK11783  290 KDVADLknPLPKGPTGLVISNPPYG 314
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 56-172 1.01e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 50.31  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  56 MASLADIKAGAFVLDPMCGLGTILLEAAKEWpDVYYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPlPSESVD 135
Cdd:COG2230    43 ILRKLGLKPGMRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLP-ADGQFD 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1009287599 136 IIISdipfgkkfkLG-------KDIKSILQEMERVLHVGGTIVL 172
Cdd:COG2230   121 AIVS---------IGmfehvgpENYPAYFAKVARLLKPGGRLLL 155
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 62-172 2.94e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 48.48  E-value: 2.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  62 IKAGAFVLDPMCGLGTILLEAAKEWPDVyyVGADVSDSQLlgtwDNLKAAGLEDKIELLKISVIELPLPSESVDIIIS-- 139
Cdd:COG2227    22 LPAGGRVLDVGCGTGRLALALARRGADV--TGVDISPEAL----EIARERAAELNVDFVQGDLEDLPLEDGSFDLVICse 95

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1009287599 140 ---DIPfgkkfklgkDIKSILQEMERVLHVGGTIVL 172
Cdd:COG2227    96 vleHLP---------DPAALLRELARLLKPGGLLLL 122
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 57-203 3.53e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 49.53  E-value: 3.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  57 ASLADIKAGAFVLDPMCGLGTILLEAAKEwPDVYYVGADVSDSQLLGTWDNLKAAGLeDKIELLKISVIEL-PLPSESVD 135
Cdd:COG0500    19 ALLERLPKGGRVLDLGCGTGRNLLALAAR-FGGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLAELdPLPAESFD 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1009287599 136 IIIS-----DIPFGKkfklgkdIKSILQEMERVLHVGGtIVLLLSEDHHRRLTDCKESNIPFNSKDSHTDEPG 203
Cdd:COG0500    97 LVVAfgvlhHLPPEE-------REALLRELARALKPGG-VLLLSASDAAAALSLARLLLLATASLLELLLLLR 161
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 62-172 4.00e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 45.49  E-value: 4.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  62 IKAGAFVLDPMCGLGTILLEAAKE-WPDVYYVGADVSDSQLLGTWDNLKAAGLED-KIELLKISVIELPLPSESVDIIIS 139
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEElGPNAEVVGIDISEEAIEKARENAQKLGFDNvEFEQGDIEELPELLEDDKFDVVIS 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1009287599 140 DipfgKKFKLGKDIKSILQEMERVLHVGGTIVL 172
Cdd:pfam13847  81 N----CVLNHIPDPDKVLQEILRVLKPGGRLII 109
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
63-173 2.37e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 44.35  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  63 KAGAFVLDPMCGLGTI---LLEAAKEWPDVyyVGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIELPLPSESVDIIIs 139
Cdd:pfam01209  41 KRGNKFLDVAGGTGDWtfgLSDSAGSSGKV--VGLDINENMLKEGEKKAKEEGKYN-IEFLQGNAEELPFEDDSFDIVT- 116

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1009287599 140 dIPFGkkFKLGKDIKSILQEMERVLHVGGTIVLL 173
Cdd:pfam01209 117 -ISFG--LRNFPDYLKVLKEAFRVLKPGGRVVCL 147
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 52-172 6.69e-05

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 43.23  E-value: 6.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  52 IAWAMAsLADIKAGAFVLDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKaAGLEDKIELLKISVIElPLPS 131
Cdd:PRK09328   97 VEWALE-ALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAK-HGLGARVEFLQGDWFE-PLPG 173

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1009287599 132 ESVDIIISD---IPFGKKFKL---------------GKD----IKSILQEMERVLHVGGTIVL 172
Cdd:PRK09328  174 GRFDLIVSNppyIPEADIHLLqpevrdhephlalfgGEDgldfYRRIIEQAPRYLKPGGWLLL 236
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 52-139 9.26e-05

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 42.83  E-value: 9.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  52 IAWAMASLADIKAgAFVLDpmcgLGT----ILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIEl 127
Cdd:COG2890   101 VELALALLPAGAP-PRVLD----LGTgsgaIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFE- 174

                          90
                  ....*....|...
gi 1009287599 128 PLPS-ESVDIIIS 139
Cdd:COG2890   175 PLPGdGRFDLIVS 187
arsM PRK11873
arsenite methyltransferase;
59-168 1.19e-04

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 42.63  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  59 LADIKAGAFVLDPMCGLG-TILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIELPLPSESVDII 137
Cdd:PRK11873   72 LAELKPGETVLDLGSGGGfDCFLAARRVGPTGKVIGVDMTPEMLAKARANARKAGYTN-VEFRLGEIEALPVADNSVDVI 150

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1009287599 138 ISD--IpfgkkfKLGKDIKSILQEMERVLHVGG 168
Cdd:PRK11873  151 ISNcvI------NLSPDKERVFKEAFRVLKPGG 177
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 68-172 3.53e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 40.56  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  68 VLDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIElPLPSESVDIIISDIPfgkkF 147
Cdd:COG2813    53 VLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLEN-VEVLWSDGLS-GVPDGSFDLILSNPP----F 126

                          90       100       110
                  ....*....|....*....|....*....|
gi 1009287599 148 KLGKDI-KSILQEM----ERVLHVGGTIVL 172
Cdd:COG2813   127 HAGRAVdKEVAHALiadaARHLRPGGELWL 156
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 68-143 4.01e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 40.27  E-value: 4.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1009287599  68 VLDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLEDkIELLKISVIElPLPSESVDIIISDIPF 143
Cdd:pfam05175  35 VLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLEN-GEVVASDVYS-GVEDGKFDLIISNPPF 108
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
52-151 4.05e-04

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 40.94  E-value: 4.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  52 IAWAMASLADIKAGAFVLDPMCGLGTILLEAAK--------EWPDVYYVGADVSDSqllgTWD----NLKAAGLEDKIEL 119
Cdd:COG0286    31 VVRLMVELLDPKPGETVYDPACGSGGFLVEAAEylkehggdERKKLSLYGQEINPT----TYRlakmNLLLHGIGDPNIE 106

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1009287599 120 LKISVIELPLPSESVDIIISDIPFGKKFKLGK 151
Cdd:COG0286   107 LGDTLSNDGDELEKFDVVLANPPFGGKWKKEE 138
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 60-139 4.64e-04

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 40.77  E-value: 4.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  60 ADIKAGAFVLDPMCGLGTILLEAAKEWpDVYYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPlpsESVDIIIS 139
Cdd:pfam02353  57 LGLKPGMTLLDIGCGWGGLMRRAAERY-DVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFD---EPFDRIVS 132
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 73-170 1.55e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 36.96  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  73 CGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLED--KIELLKISVIELPLPseSVDIIISdipfgkkfkLG 150
Cdd:pfam08242   5 CGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNavRVELFQLDLGELDPG--SFDVVVA---------SN 73

                          90       100
                  ....*....|....*....|....*
gi 1009287599 151 -----KDIKSILQEMERVLHVGGTI 170
Cdd:pfam08242  74 vlhhlADPRAVLRNIRRLLKPGGVL 98
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
129-172 3.28e-03

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 37.98  E-value: 3.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599 129 LPSESVDIIISDIPF--GKKFKLGKD--------------IKSILQEMERVLHVGGTIVL 172
Cdd:COG0863    14 LPDESVDLIVTDPPYnlGKKYGLGRReignelsfeeylefLREWLAECYRVLKPGGSLYV 73
PRK14968 PRK14968
putative methyltransferase; Provisional
 56-175 7.62e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.42  E-value: 7.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287599  56 MASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVyyVGADVSDSQLLGTWDNLKAAGLEDKiellKISVIE----LPLPS 131
Cdd:PRK14968   15 LAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKV--VGVDINPYAVECAKCNAKLNNIRNN----GVEVIRsdlfEPFRG 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1009287599 132 ESVDIIISDIPF-------------GKKFKLGKD----IKSILQEMERVLHVGGTIVLLLS 175
Cdd:PRK14968   89 DKFDVILFNPPYlpteeeeewddwlNYALSGGKDgrevIDRFLDEVGRYLKPGGRILLLQS 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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