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Conserved domains on  [gi|1016080540|ref|NP_001309155|]
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very low-density lipoprotein receptor isoform d precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 527-567 1.56e-15

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 71.04  E-value: 1.56e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1016080540 527 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLD 567
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
196-232 1.30e-12

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 62.27  E-value: 1.30e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1016080540 196 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 232
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 33-67 2.21e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.21e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1016080540  33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 113-147 2.32e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.32e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1016080540 113 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 147
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
235-271 3.77e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 3.77e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1016080540 235 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 271
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 464-506 4.59e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 4.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1016080540  464 HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 506
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 71-103 3.07e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 3.07e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540   71 TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
151-183 1.98e-09

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.98e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1016080540 151 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 183
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 551-593 6.87e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 6.87e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1016080540  551 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 593
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 440-481 1.01e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.01e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1016080540 440 QKLFWADLSQKA-IFSASIDDKVgRHVKMIDNVYNPAAIAVDW 481
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 614-654 7.12e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.12e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1016080540 614 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 654
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
279-309 1.53e-07

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 1.53e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1016080540 279 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 309
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 319-353 1.79e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.79e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1016080540 319 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 353
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-385 5.71e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 5.71e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540  355 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 385
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 665-708 1.74e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 1.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1016080540 665 CEEDmeNGGCEYLCLPAPQindhspKYTCSCPSGYNVEENGRDC 708
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 420-458 9.07e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 9.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1016080540  420 YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID 458
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 527-567 1.56e-15

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 71.04  E-value: 1.56e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1016080540 527 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLD 567
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
196-232 1.30e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 62.27  E-value: 1.30e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1016080540 196 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 232
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 33-67 2.21e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.21e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1016080540  33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 113-147 2.32e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.32e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1016080540 113 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 147
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 198-232 2.34e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.34e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1016080540 198 CPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 232
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
112-147 2.41e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.80  E-value: 2.41e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1016080540 112 TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 147
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
235-271 3.77e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 3.77e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1016080540 235 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 271
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 464-506 4.59e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 4.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1016080540  464 HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 506
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
32-67 5.74e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 5.74e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1016080540  32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 486-524 7.54e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 7.54e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1016080540 486 IYWTDAASK-TISVATLDGTKRKFLFNSDLREPASIAVDP 524
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 112-144 1.77e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 1.77e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540  112 TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE 144
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 71-103 3.07e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 3.07e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540   71 TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 72-103 8.28e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 8.28e-10
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1016080540  72 CAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 197-229 8.56e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 8.56e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540  197 KCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 229
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-103 9.68e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 9.68e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1016080540  70 KTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 32-64 1.60e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.60e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540   32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE 64
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
151-183 1.98e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.98e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1016080540 151 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 183
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 509-550 2.04e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 2.04e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1016080540  509 LFNSDLREPASIAVDPLSGFVYWSDWGEPaKIEKAGMNGFDR 550
Cdd:smart00135   3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 237-271 2.73e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 2.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1016080540 237 CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 271
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 151-183 3.40e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.40e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540  151 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 183
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 551-593 6.87e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 6.87e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1016080540  551 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 593
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 440-481 1.01e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.01e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1016080540 440 QKLFWADLSQKA-IFSASIDDKVgRHVKMIDNVYNPAAIAVDW 481
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 152-183 3.48e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 3.48e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1016080540 152 CGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 183
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 236-268 5.31e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 5.31e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540  236 TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 268
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 614-654 7.12e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.12e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1016080540 614 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 654
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 572-613 1.12e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1016080540 572 RLYWLDSKLH-MLSSVDLNGQDRRIVLKSLefLAHPLALTIFE 613
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
279-309 1.53e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 1.53e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1016080540 279 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 309
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 319-353 1.79e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.79e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1016080540 319 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 353
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 279-309 2.47e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.55  E-value: 2.47e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1016080540  279 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 309
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 279-309 2.89e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.50  E-value: 2.89e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1016080540 279 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 309
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-385 5.71e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 5.71e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540  355 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 385
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
434-574 1.25e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.38  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080540 434 DADIAAQKLFWADLSQKAIfsASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVatLDGTKRKFLFNSD 513
Cdd:COG3391    74 DAGADGRRLYVANSGSGRV--SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIP 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1016080540 514 L-REPASIAVDPLSGFVYWSDWGEP------AKIEKAGMNgfdrrplVTADI---QWPNGITLDLIKSRLY 574
Cdd:COG3391   150 VgAGPHGIAVDPDGKRLYVANSGSNtvsvivSVIDTATGK-------VVATIpvgGGPVGVAVSPDGRRLY 213
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 355-385 2.45e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.45e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1016080540 355 DIDECQNPGICS--QICINLKGGYKCECSRGYQ 385
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 665-708 1.74e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 1.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1016080540 665 CEEDmeNGGCEYLCLPAPQindhspKYTCSCPSGYNVEENGRDC 708
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 430-533 6.20e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.57  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080540 430 TVALDADiaaQKLFWADLSQKAIFsasIDDKVGRHVKMIDN-----VYNPAAIAVDwVYKTIYWTDAASKTISVATLDGT 504
Cdd:cd14962    16 GVAADGR---GRIYVADTGRGAVF---VFDLPNGKVFVIGNagpnrFVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGK 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 1016080540 505 KRKFLFNSDLRE-PASIAVDPLSGFVYWSD 533
Cdd:cd14962    89 FLRAIGAGALFKrPTGIAVDPAGKRLYVVD 118
EGF_CA pfam07645
Calcium-binding EGF domain;
355-383 3.72e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 3.72e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1016080540 355 DIDECQNPG-ICSQ--ICINLKGGYKCECSRG 383
Cdd:pfam07645   1 DVDECATGThNCPAntVCVNTIGSFECRCPDG 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 420-458 9.07e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 9.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1016080540  420 YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID 458
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 527-567 1.56e-15

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 71.04  E-value: 1.56e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1016080540 527 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLD 567
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
196-232 1.30e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 62.27  E-value: 1.30e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1016080540 196 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 232
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 33-67 2.21e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.21e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1016080540  33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 113-147 2.32e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.32e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1016080540 113 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 147
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 198-232 2.34e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.34e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1016080540 198 CPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 232
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
112-147 2.41e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.80  E-value: 2.41e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1016080540 112 TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 147
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
235-271 3.77e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 3.77e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1016080540 235 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 271
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 464-506 4.59e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 4.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1016080540  464 HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 506
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
32-67 5.74e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 5.74e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1016080540  32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 486-524 7.54e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 7.54e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1016080540 486 IYWTDAASK-TISVATLDGTKRKFLFNSDLREPASIAVDP 524
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 112-144 1.77e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 1.77e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540  112 TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE 144
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 71-103 3.07e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 3.07e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540   71 TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 72-103 8.28e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 8.28e-10
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1016080540  72 CAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 197-229 8.56e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 8.56e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540  197 KCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 229
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-103 9.68e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 9.68e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1016080540  70 KTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 32-64 1.60e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.60e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540   32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE 64
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
151-183 1.98e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.98e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1016080540 151 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 183
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 509-550 2.04e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 2.04e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1016080540  509 LFNSDLREPASIAVDPLSGFVYWSDWGEPaKIEKAGMNGFDR 550
Cdd:smart00135   3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 237-271 2.73e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 2.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1016080540 237 CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 271
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 151-183 3.40e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.40e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540  151 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 183
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 551-593 6.87e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 6.87e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1016080540  551 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 593
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 440-481 1.01e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.01e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1016080540 440 QKLFWADLSQKA-IFSASIDDKVgRHVKMIDNVYNPAAIAVDW 481
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 152-183 3.48e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 3.48e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1016080540 152 CGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 183
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 236-268 5.31e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 5.31e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540  236 TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 268
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 614-654 7.12e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.12e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1016080540 614 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 654
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 572-613 1.12e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1016080540 572 RLYWLDSKLH-MLSSVDLNGQDRRIVLKSLefLAHPLALTIFE 613
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
279-309 1.53e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 1.53e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1016080540 279 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 309
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 319-353 1.79e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.79e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1016080540 319 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 353
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 279-309 2.47e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.55  E-value: 2.47e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1016080540  279 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 309
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 279-309 2.89e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.50  E-value: 2.89e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1016080540 279 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 309
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
355-385 5.71e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 5.71e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1016080540  355 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 385
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
434-574 1.25e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.38  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080540 434 DADIAAQKLFWADLSQKAIfsASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVatLDGTKRKFLFNSD 513
Cdd:COG3391    74 DAGADGRRLYVANSGSGRV--SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIP 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1016080540 514 L-REPASIAVDPLSGFVYWSDWGEP------AKIEKAGMNgfdrrplVTADI---QWPNGITLDLIKSRLY 574
Cdd:COG3391   150 VgAGPHGIAVDPDGKRLYVANSGSNtvsvivSVIDTATGK-------VVATIpvgGGPVGVAVSPDGRRLY 213
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 355-385 2.45e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.45e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1016080540 355 DIDECQNPGICS--QICINLKGGYKCECSRGYQ 385
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
484-631 3.33e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.23  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080540 484 KTIYWTDAASKTISVatLDGTKRKFLFNSDL-REPASIAVDPLSGFVYWSDWGEPA--KIEKAGMNgfdrrplVTADIQ- 559
Cdd:COG3391    80 RRLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNGRvsVIDTATGK-------VVATIPv 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080540 560 --WPNGITLDLIKSRLYWLDSKLHMLS---SVdLNGQDRRiVLKSLEFLAHPLALTIFED--RVYWID-GENEAVYGANK 631
Cdd:COG3391   151 gaGPHGIAVDPDGKRLYVANSGSNTVSvivSV-IDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANrGSNTSNGGSNT 228
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 665-708 1.74e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 1.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1016080540 665 CEEDmeNGGCEYLCLPAPQindhspKYTCSCPSGYNVEENGRDC 708
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
402-535 3.14e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080540 402 LIFTNRRD--IRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSasIDDKVGRHVKMIDNVYNPAAIAV 479
Cdd:COG3391    82 LYVANSGSgrVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVGAGPHGIAV 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1016080540 480 DWVYKTIYWTDAASKTIS--VATLDGTKRKFLFNSDLRE-PASIAVDPLSGFVYWSDWG 535
Cdd:COG3391   160 DPDGKRLYVANSGSNTVSviVSVIDTATGKVVATIPVGGgPVGVAVSPDGRRLYVANRG 218
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 430-533 6.20e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.57  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080540 430 TVALDADiaaQKLFWADLSQKAIFsasIDDKVGRHVKMIDN-----VYNPAAIAVDwVYKTIYWTDAASKTISVATLDGT 504
Cdd:cd14962    16 GVAADGR---GRIYVADTGRGAVF---VFDLPNGKVFVIGNagpnrFVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGK 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 1016080540 505 KRKFLFNSDLRE-PASIAVDPLSGFVYWSD 533
Cdd:cd14962    89 FLRAIGAGALFKrPTGIAVDPAGKRLYVVD 118
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 474-640 2.50e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 40.74  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080540 474 PAAIAVDWVYKtIYWTDAASKTISVATLDGTKRKFLFNSDLRE----PASIAVDplSGFVYWSDWG---------EPAKI 540
Cdd:cd14963    58 PYGIAVDSDGN-IYVADLYNGRIQVFDPDGKFLKYFPEKKDRVklisPAGLAID--DGKLYVSDVKkhkvivfdlEGKLL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016080540 541 EKAGMNGFDRrplvtADIQWPNGITLDLiKSRLYWLDSKLHMLSSVDLNGQDRRIVLKS---LEFLAHPLALTIFED-RV 616
Cdd:cd14963   135 LEFGKPGSEP-----GELSYPNGIAVDE-DGNIYVADSGNGRIQVFDKNGKFIKELNGSpdgKSGFVNPRGIAVDPDgNL 208

                         170       180
                  ....*....|....*....|....
gi 1016080540 617 YWIDGENEAVYGANKfTGSELATL 640
Cdd:cd14963   209 YVVDNLSHRVYVFDE-QGKELFTF 231
EGF_CA pfam07645
Calcium-binding EGF domain;
355-383 3.72e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 3.72e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1016080540 355 DIDECQNPG-ICSQ--ICINLKGGYKCECSRG 383
Cdd:pfam07645   1 DVDECATGThNCPAntVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 360-387 6.25e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 34.91  E-value: 6.25e-03
                          10        20
                  ....*....|....*....|....*...
gi 1016080540 360 QNPGICSQICINLKGGYKCECSRGYQMD 387
Cdd:pfam14670   3 VNNGGCSHLCLNTPGGYTCSCPEGYELQ 30
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 420-458 9.07e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 9.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1016080540  420 YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID 458
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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