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Conserved domains on  [gi|1038986259|ref|NP_001315527|]
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vascular endothelial growth factor Ab isoform 2 precursor [Danio rerio]

Protein Classification

PDGF and VEGF_C domain-containing protein( domain architecture ID 10210585)

PDGF and VEGF_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF super family cl00116
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 47-128 2.81e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


The actual alignment was detected with superfamily member smart00141:

Pssm-ID: 444701  Cd Length: 83  Bit Score: 90.94  E-value: 2.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986259   47 SLCRPREMLVEIQQEYPDDTEHIFIPSCVVLTRCAGCCNDEMMECTPTVTYNITLEIKRLKPLRHQGDIFMSFAEHSECQ 126
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ..
gi 1038986259  127 CR 128
Cdd:smart00141  81 CR 82
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 146-194 3.37e-23

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


:

Pssm-ID: 405273  Cd Length: 49  Bit Score: 87.36  E-value: 3.37e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1038986259 146 CSTCSERRRRLFVQDPETCQCSCKHSEADCRSRQLELNERTCRCDKPRR 194
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 47-128 2.81e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 90.94  E-value: 2.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986259   47 SLCRPREMLVEIQQEYPDDTEHIFIPSCVVLTRCAGCCNDEMMECTPTVTYNITLEIKRLKPLRHQGDIFMSFAEHSECQ 126
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ..
gi 1038986259  127 CR 128
Cdd:smart00141  81 CR 82
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 146-194 3.37e-23

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 87.36  E-value: 3.37e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1038986259 146 CSTCSERRRRLFVQDPETCQCSCKHSEADCRSRQLELNERTCRCDKPRR 194
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
PDGF pfam00341
PDGF/VEGF domain;
49-127 1.63e-22

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 86.19  E-value: 1.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986259  49 CRPREMLVEIQQEYPDDTEHIFIPSCVVLTRCAGCCNDEMMECTPTVTYNIT---LEIKRLKPLRHQGDIFMSFAEHSEC 125
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTmqvLKIEYAPRRPSPELVEVSFEEHVQC 80


                  ..
gi 1038986259 126 QC 127
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 8-136 6.62e-22

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 86.60  E-value: 6.62e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986259   8 LQLFIVTLLYFSAVKSAYIPREGGRSTYDVVPFMEVYNKSLCRPREMLVEIQQEYPDDTEHIFIPSCVVLTRCAGCCNDE 87
Cdd:PHA02661    7 LQFAVALLLCMYNVPWCFSGSTGSSSASSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDE 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1038986259  88 MMECTPTVTYNITLEIKRLKPLRHQGD----IFMSFAEHSECQCRMKKDLPKE 136
Cdd:PHA02661   87 SQICTPTETSNVTVTVMLTSVSGSTGAtsnfQTISVEEHTKCKCEFKTTPPPT 139
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 47-128 4.29e-21

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 82.80  E-value: 4.29e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986259  47 SLCRPREMLVEIQQEYPDDTEHIFIPSCVVLTRCAGCCNDEMMECTPTVTYNITLEIKRLKPLRHQGDIF--MSFAEHSE 124
Cdd:cd00135     1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKRKPRSKLveISFEEHTE 80


                  ....
gi 1038986259 125 CQCR 128
Cdd:cd00135    81 CECR 84
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 47-128 2.81e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 90.94  E-value: 2.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986259   47 SLCRPREMLVEIQQEYPDDTEHIFIPSCVVLTRCAGCCNDEMMECTPTVTYNITLEIKRLKPLRHQGDIFMSFAEHSECQ 126
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ..
gi 1038986259  127 CR 128
Cdd:smart00141  81 CR 82
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 146-194 3.37e-23

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 87.36  E-value: 3.37e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1038986259 146 CSTCSERRRRLFVQDPETCQCSCKHSEADCRSRQLELNERTCRCDKPRR 194
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
PDGF pfam00341
PDGF/VEGF domain;
49-127 1.63e-22

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 86.19  E-value: 1.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986259  49 CRPREMLVEIQQEYPDDTEHIFIPSCVVLTRCAGCCNDEMMECTPTVTYNIT---LEIKRLKPLRHQGDIFMSFAEHSEC 125
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTmqvLKIEYAPRRPSPELVEVSFEEHVQC 80


                  ..
gi 1038986259 126 QC 127
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 8-136 6.62e-22

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 86.60  E-value: 6.62e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986259   8 LQLFIVTLLYFSAVKSAYIPREGGRSTYDVVPFMEVYNKSLCRPREMLVEIQQEYPDDTEHIFIPSCVVLTRCAGCCNDE 87
Cdd:PHA02661    7 LQFAVALLLCMYNVPWCFSGSTGSSSASSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDE 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1038986259  88 MMECTPTVTYNITLEIKRLKPLRHQGD----IFMSFAEHSECQCRMKKDLPKE 136
Cdd:PHA02661   87 SQICTPTETSNVTVTVMLTSVSGSTGAtsnfQTISVEEHTKCKCEFKTTPPPT 139
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 47-128 4.29e-21

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 82.80  E-value: 4.29e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986259  47 SLCRPREMLVEIQQEYPDDTEHIFIPSCVVLTRCAGCCNDEMMECTPTVTYNITLEIKRLKPLRHQGDIF--MSFAEHSE 124
Cdd:cd00135     1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKRKPRSKLveISFEEHTE 80


                  ....
gi 1038986259 125 CQCR 128
Cdd:cd00135    81 CECR 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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