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Conserved domains on  [gi|1045561217|ref|NP_001316578|]
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zinc finger protein 25 isoform a [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
12-72 1.14e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.38  E-value: 1.14e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1045561217   12 VTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVGYHVNKPNAVFKLKQGKEPWI 72
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-457 1.69e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 148 KSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYEC--KECKKIFYHLSSLSRHLRTHAGEKPYECNQCE-KSFYQKPHLTEH 224
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLpLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 225 QKTHT---GEKPFECTECGKFFYVKAYlMVHQKTHTGEKPYE-CKECGKAFSQKSHL-------------------TVHQ 281
Cdd:COG5048   112 SSSSNsndNNLLSSHSLPPSSRDPQLP-DLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 282 RMHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYEC------KECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTF 355
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 356 YYKSDLTKHQRKHTG-EKPYECTECGKSFAVNSVLRLHQRT--HTGE--KPYACKE--CGKSFSQKSHFIIHQRKHTGEK 428
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1045561217 429 PYECQECGETFIQKSQLTA--HQKTHTKKRN 457
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNepPQSLQQYKDL 381
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
12-72 1.14e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.38  E-value: 1.14e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1045561217   12 VTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVGYHVNKPNAVFKLKQGKEPWI 72
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 11-52 5.00e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.30  E-value: 5.00e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1045561217  11 PVTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVG 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 12-50 3.27e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 3.27e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1045561217  12 VTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVS 50
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-457 1.69e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 148 KSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYEC--KECKKIFYHLSSLSRHLRTHAGEKPYECNQCE-KSFYQKPHLTEH 224
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLpLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 225 QKTHT---GEKPFECTECGKFFYVKAYlMVHQKTHTGEKPYE-CKECGKAFSQKSHL-------------------TVHQ 281
Cdd:COG5048   112 SSSSNsndNNLLSSHSLPPSSRDPQLP-DLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 282 RMHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYEC------KECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTF 355
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 356 YYKSDLTKHQRKHTG-EKPYECTECGKSFAVNSVLRLHQRT--HTGE--KPYACKE--CGKSFSQKSHFIIHQRKHTGEK 428
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1045561217 429 PYECQECGETFIQKSQLTA--HQKTHTKKRN 457
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNepPQSLQQYKDL 381
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-273 6.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1045561217 248 YLMVHQKTHTGEKPYECKECGKAFSQ 273
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
12-72 1.14e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.38  E-value: 1.14e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1045561217   12 VTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVGYHVNKPNAVFKLKQGKEPWI 72
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 11-52 5.00e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.30  E-value: 5.00e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1045561217  11 PVTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVG 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 12-50 3.27e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 3.27e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1045561217  12 VTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVS 50
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-457 1.69e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 148 KSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYEC--KECKKIFYHLSSLSRHLRTHAGEKPYECNQCE-KSFYQKPHLTEH 224
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLpLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 225 QKTHT---GEKPFECTECGKFFYVKAYlMVHQKTHTGEKPYE-CKECGKAFSQKSHL-------------------TVHQ 281
Cdd:COG5048   112 SSSSNsndNNLLSSHSLPPSSRDPQLP-DLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 282 RMHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYEC------KECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTF 355
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 356 YYKSDLTKHQRKHTG-EKPYECTECGKSFAVNSVLRLHQRT--HTGE--KPYACKE--CGKSFSQKSHFIIHQRKHTGEK 428
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1045561217 429 PYECQECGETFIQKSQLTA--HQKTHTKKRN 457
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNepPQSLQQYKDL 381
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-436 8.75e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 8.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 184 KKIFYHLSSLSRHLRTHAGEKPYECNQCEKSFYQKPHLTEHQKTHTGEKPFECTECGKFF--------YVKAYLMvHQKT 255
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqsPSSLSSS-DSSS 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 256 HTGEKPYECKeCGKAFSQKSHLTVHQRMHTG-EKPYKCKECGKFFSRNSHLKTHQRS--HTGE--KPYECKE--CRKCFY 328
Cdd:COG5048   256 SASESPRSSL-PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFS 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 329 QKSALTVHQRTHTGEKPFECNKCGKTFYYKSDLTK-------HQRKHTGEKPYECT--ECGKSFAVNSVLRLHQRTHTGE 399
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSF 414

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1045561217 400 KPYACK--ECGKSFSQKSHFIIHQRKHTGEKPYECQECG 436
Cdd:COG5048   415 RPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
175-460 1.36e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 175 DKTYECKECKKIFYHLSSLSRHLRTHAGEKPYECNQ--CEKSFYQKPHLTEHQKTHTGEKPFECT-ECGKFFYVKAYLMV 251
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 252 HQKTHTGEKPYECKECGKAFSQKSHLTVHQRMHTGEKPYKCKEC-GKFFSRNSHLKTHQRSHTgekpyecKECRKCFYQK 330
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 331 SALTVHQRTHTGEKPFECNKCGKTFYYKSDLTKHQRKHTGEKPYECTECG-----------KSFAVNSVLRLHQRTH--- 396
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqsPSSLSSSDSSSSASESprs 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 397 ---------------------TGEKPYACKECGKSFSQKSHFIIHQRK--HTGE--KPYEC--QECGETFIQKSQLTAHQ 449
Cdd:COG5048   264 slptassqssspnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHI 343

                         330
                  ....*....|.
gi 1045561217 450 KTHTKKRNAEK 460
Cdd:COG5048   344 LLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
260-415 2.63e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 260 KPYECKECGKAFSQKSHLTVHQRM--HTGE--KPYKCKE--CGKFFSRNSHLKTHQRSHTGEKPYECKECRKCFYQKSAL 333
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 334 T-------VHQRTHTGEKPFEC--NKCGKTFYYKSDLTKHQRKHTGEKPYEC--TECGKSFAVNSVLRLHQRTHTGEKPY 402
Cdd:COG5048   368 NneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|...
gi 1045561217 403 ACKECGKSFSQKS 415
Cdd:COG5048   448 LCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-460 1.00e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217  99 SQAGNSRNGELTKHQKTHttekacECKECGKFFCQKSALIVHQHTHSKGKSYDC--DKCGKSFSKNEDLIRHQKIHTRDK 176
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPD------SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 177 TYECkeCKKIFYHLSSLSRHLRTHAGEKPYECNQCE-------------KSFYQKPHLTEHQKTHTGEKPFECTEC---- 239
Cdd:COG5048    91 SDLN--SKSLPLSNSKASSSSLSSSSSNSNDNNLLSshslppssrdpqlPDLLSISNLRNNPLPGNNSSSVNTPQSnslh 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 240 --------GKFFYVKAYLMVHQKTHTGEKPYECKECGKAFSQKSHLTVHQRMHTGEKPYKCKECGKFFSRnsHLKTHQRS 311
Cdd:COG5048   169 pplpanslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK--SLLSQSPS 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 312 HTGeKPYECKECRKC---------FYQKSALTVHQRTHTG-EKPFECNKCGKTFYYKSDLTKHQRK--HTGE--KPYECT 377
Cdd:COG5048   247 SLS-SSDSSSSASESprsslptasSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCP 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 378 E--CGKSFAVNSVLRLHQRTHTGEKPYACK--ECGKSFSQKSH-----FIIHQRKHTGEKPYEC--QECGETFIQKSQLT 446
Cdd:COG5048   326 YslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLS 405

                         410
                  ....*....|....
gi 1045561217 447 AHQKTHTKKRNAEK 460
Cdd:COG5048   406 LHIITHLSFRPYNC 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
111-308 6.06e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 6.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 111 KHQKTHTTEKACECKECGKFFCQKSALIVHQHTHS-------KGKSYDCDKCGKSFSKNEDLIRHQ--KIHTR--DKTYE 179
Cdd:COG5048   244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFS 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045561217 180 CKE--CKKIFYHLSSLSRHLRTHAGEKPYEC--NQCEKSFYQKPH-----LTEHQKTHTGEKPFECT--ECGKFFYVKAY 248
Cdd:COG5048   324 CPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSN 403

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1045561217 249 LMVHQKTHTGEKPYECK--ECGKAFSQKSHLTVHQRMHTGEKPYKCkECGKFFSRNSHLKTH 308
Cdd:COG5048   404 LSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-273 6.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1045561217 248 YLMVHQKTHTGEKPYECKECGKAFSQ 273
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
389-413 8.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.58e-04
                          10        20
                  ....*....|....*....|....*
gi 1045561217 389 LRLHQRTHTGEKPYACKECGKSFSQ 413
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-301 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045561217 276 HLTVHQRMHTGEKPYKCKECGKFFSR 301
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
360-384 1.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1045561217 360 DLTKHQRKHTGEKPYECTECGKSFA 384
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-329 1.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045561217 304 HLKTHQRSHTGEKPYECKECRKCFYQ 329
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 290-312 2.17e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.17e-03
                          10        20
                  ....*....|....*....|...
gi 1045561217 290 YKCKECGKFFSRNSHLKTHQRSH 312
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 262-284 2.98e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.98e-03
                          10        20
                  ....*....|....*....|...
gi 1045561217 262 YECKECGKAFSQKSHLTVHQRMH 284
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-217 5.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.94e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045561217 192 SLSRHLRTHAGEKPYECNQCEKSFYQ 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
220-243 6.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.18e-03
                          10        20
                  ....*....|....*....|....
gi 1045561217 220 HLTEHQKTHTGEKPFECTECGKFF 243
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
332-357 8.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.71e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045561217 332 ALTVHQRTHTGEKPFECNKCGKTFYY 357
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 346-368 9.57e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 9.57e-03
                          10        20
                  ....*....|....*....|...
gi 1045561217 346 FECNKCGKTFYYKSDLTKHQRKH 368
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 402-424 9.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 9.95e-03
                          10        20
                  ....*....|....*....|...
gi 1045561217 402 YACKECGKSFSQKSHFIIHQRKH 424
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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