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Conserved domains on  [gi|1174821552|ref|NP_001337091|]
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testis-expressed protein 15 [Homo sapiens]

Protein Classification

TASOR family protein( domain architecture ID 10575941)

TASOR family protein is a DUF3715 domain-containing protein; similar to Homo sapiens protein TASOR, which is a component of the HUSH complex, a multiprotein complex that mediates epigenetic repression

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TEX15 pfam15326
Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for ...
1920-2153 1.91e-149

Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.


:

Pssm-ID: 464647  Cd Length: 234  Bit Score: 463.59  E-value: 1.91e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552 1920 NKREKKGEIKVSKDSQSDLTLHSEIAYISKPGILGVNHTPILPAHSETCKVPTLLKKPASYVSDFKEKHCSANHTALIAN 1999
Cdd:pfam15326    1 NKREKKGKIKVSNDSQSDSTLHSEITCISKPGILEINHMPVLHAHSETSEVTTLPKKPTSYMNELKEKHCSANHTALLTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552 2000 LSQILQRADEASSLQILQEETKVCLNILPLFVEAFERKQECSVEQILISRELLVDQNLWNNCKHTLKPCAVDTLVELQMM 2079
Cdd:pfam15326   81 LSQILQRADEASSLQILQEETKVCQNILPLFVEAFERKQECSLEQILISRELLVEQNLWNNCKHKLKPCAVDTLVELQMM 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1174821552 2080 METIQFIENKKRHLEGEPTLRSLLWYDETLYAELLGKPRGFQQQSNFYPGFQGRLKYNAFCELQTYHDQLVELL 2153
Cdd:pfam15326  161 METIQFIENKKRLLEGEPTFRSLLWYDETLYGELLGRPRGYQQQSNFYPAFQGRLKYNAFCELQNYHNQLIELF 234
DUF3715 pfam12509
Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is ...
103-250 3.04e-41

Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is approximately 170 amino acids in length.


:

Pssm-ID: 463613 [Multi-domain]  Cd Length: 150  Bit Score: 149.74  E-value: 3.04e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552  103 EMRESGRHCRELEEQFCFLALPQSDVAQIYQNGISTRASTLKILGNPLLGIYMFRHVDIALNYSHSQSITVESILIFKVL 182
Cdd:pfam12509    1 EMRRDGRCSSELPENFAFLLSDENSVRGICDHGLHVGSSKGTLLGKPSSGVYLSRHSDLALSQEEEKLGPCGPLIVFKVL 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1174821552  183 FGKVKKIQPSVDKNkvSLDPSPNFDCHMSRNA---PSLKDTIELQAYSSAVYFYEYS-VLSKPVDKPRQCLP 250
Cdd:pfam12509   81 KGKTKEISDSSQKS--FLEPTPSYDCHVAEHSkkhLQQRGLPGPAFAKSQTYGYEYGtPVGKVFRRPRHVLP 150
TEX15 super family cl21170
Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for ...
2372-2486 7.94e-08

Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.


The actual alignment was detected with superfamily member pfam15326:

Pssm-ID: 464647  Cd Length: 234  Bit Score: 56.05  E-value: 7.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552 2372 ISEILDQA-EFADLKKLQDLTLRCTDHLEILKKYFQMLQDNNMDNIFITEENVLDVVI--NHSHEaiiLKPEAIEMYIEI 2448
Cdd:pfam15326   81 LSQILQRAdEASSLQILQEETKVCQNILPLFVEAFERKQECSLEQILISRELLVEQNLwnNCKHK---LKPCAVDTLVEL 157
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1174821552 2449 VMVSETIHFLKNSIAKKLDKQRFRGMLWFDLSLLPELV 2486
Cdd:pfam15326  158 QMMMETIQFIENKKRLLEGEPTFRSLLWYDETLYGELL 195
 
Name Accession Description Interval E-value
TEX15 pfam15326
Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for ...
1920-2153 1.91e-149

Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.


Pssm-ID: 464647  Cd Length: 234  Bit Score: 463.59  E-value: 1.91e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552 1920 NKREKKGEIKVSKDSQSDLTLHSEIAYISKPGILGVNHTPILPAHSETCKVPTLLKKPASYVSDFKEKHCSANHTALIAN 1999
Cdd:pfam15326    1 NKREKKGKIKVSNDSQSDSTLHSEITCISKPGILEINHMPVLHAHSETSEVTTLPKKPTSYMNELKEKHCSANHTALLTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552 2000 LSQILQRADEASSLQILQEETKVCLNILPLFVEAFERKQECSVEQILISRELLVDQNLWNNCKHTLKPCAVDTLVELQMM 2079
Cdd:pfam15326   81 LSQILQRADEASSLQILQEETKVCQNILPLFVEAFERKQECSLEQILISRELLVEQNLWNNCKHKLKPCAVDTLVELQMM 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1174821552 2080 METIQFIENKKRHLEGEPTLRSLLWYDETLYAELLGKPRGFQQQSNFYPGFQGRLKYNAFCELQTYHDQLVELL 2153
Cdd:pfam15326  161 METIQFIENKKRLLEGEPTFRSLLWYDETLYGELLGRPRGYQQQSNFYPAFQGRLKYNAFCELQNYHNQLIELF 234
DUF3715 pfam12509
Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is ...
103-250 3.04e-41

Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is approximately 170 amino acids in length.


Pssm-ID: 463613 [Multi-domain]  Cd Length: 150  Bit Score: 149.74  E-value: 3.04e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552  103 EMRESGRHCRELEEQFCFLALPQSDVAQIYQNGISTRASTLKILGNPLLGIYMFRHVDIALNYSHSQSITVESILIFKVL 182
Cdd:pfam12509    1 EMRRDGRCSSELPENFAFLLSDENSVRGICDHGLHVGSSKGTLLGKPSSGVYLSRHSDLALSQEEEKLGPCGPLIVFKVL 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1174821552  183 FGKVKKIQPSVDKNkvSLDPSPNFDCHMSRNA---PSLKDTIELQAYSSAVYFYEYS-VLSKPVDKPRQCLP 250
Cdd:pfam12509   81 KGKTKEISDSSQKS--FLEPTPSYDCHVAEHSkkhLQQRGLPGPAFAKSQTYGYEYGtPVGKVFRRPRHVLP 150
TEX15 pfam15326
Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for ...
2372-2486 7.94e-08

Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.


Pssm-ID: 464647  Cd Length: 234  Bit Score: 56.05  E-value: 7.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552 2372 ISEILDQA-EFADLKKLQDLTLRCTDHLEILKKYFQMLQDNNMDNIFITEENVLDVVI--NHSHEaiiLKPEAIEMYIEI 2448
Cdd:pfam15326   81 LSQILQRAdEASSLQILQEETKVCQNILPLFVEAFERKQECSLEQILISRELLVEQNLwnNCKHK---LKPCAVDTLVEL 157
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1174821552 2449 VMVSETIHFLKNSIAKKLDKQRFRGMLWFDLSLLPELV 2486
Cdd:pfam15326  158 QMMMETIQFIENKKRLLEGEPTFRSLLWYDETLYGELL 195
 
Name Accession Description Interval E-value
TEX15 pfam15326
Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for ...
1920-2153 1.91e-149

Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.


Pssm-ID: 464647  Cd Length: 234  Bit Score: 463.59  E-value: 1.91e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552 1920 NKREKKGEIKVSKDSQSDLTLHSEIAYISKPGILGVNHTPILPAHSETCKVPTLLKKPASYVSDFKEKHCSANHTALIAN 1999
Cdd:pfam15326    1 NKREKKGKIKVSNDSQSDSTLHSEITCISKPGILEINHMPVLHAHSETSEVTTLPKKPTSYMNELKEKHCSANHTALLTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552 2000 LSQILQRADEASSLQILQEETKVCLNILPLFVEAFERKQECSVEQILISRELLVDQNLWNNCKHTLKPCAVDTLVELQMM 2079
Cdd:pfam15326   81 LSQILQRADEASSLQILQEETKVCQNILPLFVEAFERKQECSLEQILISRELLVEQNLWNNCKHKLKPCAVDTLVELQMM 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1174821552 2080 METIQFIENKKRHLEGEPTLRSLLWYDETLYAELLGKPRGFQQQSNFYPGFQGRLKYNAFCELQTYHDQLVELL 2153
Cdd:pfam15326  161 METIQFIENKKRLLEGEPTFRSLLWYDETLYGELLGRPRGYQQQSNFYPAFQGRLKYNAFCELQNYHNQLIELF 234
DUF3715 pfam12509
Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is ...
103-250 3.04e-41

Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is approximately 170 amino acids in length.


Pssm-ID: 463613 [Multi-domain]  Cd Length: 150  Bit Score: 149.74  E-value: 3.04e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552  103 EMRESGRHCRELEEQFCFLALPQSDVAQIYQNGISTRASTLKILGNPLLGIYMFRHVDIALNYSHSQSITVESILIFKVL 182
Cdd:pfam12509    1 EMRRDGRCSSELPENFAFLLSDENSVRGICDHGLHVGSSKGTLLGKPSSGVYLSRHSDLALSQEEEKLGPCGPLIVFKVL 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1174821552  183 FGKVKKIQPSVDKNkvSLDPSPNFDCHMSRNA---PSLKDTIELQAYSSAVYFYEYS-VLSKPVDKPRQCLP 250
Cdd:pfam12509   81 KGKTKEISDSSQKS--FLEPTPSYDCHVAEHSkkhLQQRGLPGPAFAKSQTYGYEYGtPVGKVFRRPRHVLP 150
TEX15 pfam15326
Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for ...
2372-2486 7.94e-08

Testis expressed sequence 15; TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.


Pssm-ID: 464647  Cd Length: 234  Bit Score: 56.05  E-value: 7.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174821552 2372 ISEILDQA-EFADLKKLQDLTLRCTDHLEILKKYFQMLQDNNMDNIFITEENVLDVVI--NHSHEaiiLKPEAIEMYIEI 2448
Cdd:pfam15326   81 LSQILQRAdEASSLQILQEETKVCQNILPLFVEAFERKQECSLEQILISRELLVEQNLwnNCKHK---LKPCAVDTLVEL 157
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1174821552 2449 VMVSETIHFLKNSIAKKLDKQRFRGMLWFDLSLLPELV 2486
Cdd:pfam15326  158 QMMMETIQFIENKKRLLEGEPTFRSLLWYDETLYGELL 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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