|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
56-358 |
7.62e-141 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 416.10 E-value: 7.62e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 56 VHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVT 135
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEDLTPFRDMSKKVY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 136 ELLEEFSP--VVERLGFDENFVDLTEM---VEKRL-----QQLQ------------SDELSAVTVSG-HVYNNQC----- 187
Cdd:cd01703 81 RLLRSYSWndRVERLGFDENFMDVTEMrllVASHIayemrERIEnelgltccagiaSNKLLAKLVGSvNKPNQQTtllpp 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 188 -------------------IGYKTAKCLEALGINSVRDLQTFSP---------------KILEKELGISVAQRIQKLSFG 233
Cdd:cd01703 161 scadlmdfmdlhdlrkipgIGYKTAAKLEAHGISSVRDLQEFSNrnrqtvgaapsllelLLMVKEFGEGIGQRIWKLLFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 234 EDNSPVI-LSGPPQSFSEEDSFKKCSSEV--EAKNKIEELLASLLNRVCQ--------DGRKPHTVRLIIRRYSSEKH-Y 301
Cdd:cd01703 241 RDTSPVKpASDFPQQISIEDSYKKCSLEEirEARNKIEELLASLLERMKQdlqevkagDGRRPHTLRLTLRRYTSTKKhY 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1192732161 302 GRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMVNVK--MPFHLTLLSVCFCN 358
Cdd:cd01703 321 NRESKQAPIPSHVFQKLTGGNEIAARPIEKILMRLFRELVPPKnvKGFNLTLLNVCFTN 379
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
53-294 |
5.81e-53 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 185.35 E-value: 5.81e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 53 RVIVHVDLDCFYAQVEMISNPELKDKPLGV---QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYRE 129
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVggdNNRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPP-DFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 130 MSYKVTELLEEFSPVVERLGFDENFVDLTEMV------EKRLQQLQSD--ELSAVTVS-G--------------HVYNNQ 186
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSArlfgsaEAIARRIRRRirRETGLTVSvGiapnkflakiasdlAKPDGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 187 C---------------------IGYKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPP 245
Cdd:COG0389 160 TvippgevaaflaplpveklwgVGPKTAEKLARLGIRTIGDLAALPRAELRRRFG-KVGERLYRLARGIDPRPVEPRRPR 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1192732161 246 QSFSEEDSFKKcssEVEAKNKIEELLASLLNRVC----QDGRKPHTVRLIIRR 294
Cdd:COG0389 239 KSIGVERTFGE---DLTDLEELEAALRRLAERLAerlrRQGLGARTVTVKLRT 288
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
52-303 |
5.76e-41 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 154.42 E-value: 5.76e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 52 SRVIVHVDLDCFYAQVEMISNPELKDKPLGV-----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTR 126
Cdd:PRK01810 4 GRVIFHVDMNSFFASVEIAYDPSLQGKPLAVagnekERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRR-PNFDR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 127 YREMSYKVTELLEEFSPVVERLGFDENFVDLT------------EMVEKRLQQ--------------------------- 167
Cdd:PRK01810 83 YREASRQMFQILSEFTPLVQPVSIDEGYLDITdcyalgspleiaKMIQQRLLTelqlpcsigiapnkflakmasdmkkpl 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 168 ----LQSDELSAVTVSGHVYNNQCIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISvAQRIQKLSFGEDNSPVilsg 243
Cdd:PRK01810 163 gitvLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGIN-GVRLQRRANGIDDRPV---- 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1192732161 244 PPQSFSEEDS------FKKCSSEV-EAKNKIEELLASLLNRVCQDGRKPHTVRLIIrRYSSEKHYGR 303
Cdd:PRK01810 238 DPEAIYQFKSvgnsttLSHDMDEEkELLDVLRRLSKSVSKRLQKKTVVSYNVQIMI-RYHDRRTITR 303
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
58-179 |
6.82e-38 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 137.71 E-value: 6.82e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 58 VDLDCFYAQVEMISNPELKDKPLGVQQKY---LVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVnGEDLTRYREMSYKV 134
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGGNgrgIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVV-PPDLELYRRASRKI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1192732161 135 TELLEEFSPV-VERLGFDENFVDLTEMVE---------KRLQQLQSDELSaVTVS 179
Cdd:pfam00817 80 FEILRRFSTPkVEQASIDEAFLDLTGLEKlfgaeealaKRLRREIAEETG-LTCS 133
|
|
| Rev1_UBM2 |
cd19318 |
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
626-651 |
4.58e-03 |
|
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.
Pssm-ID: 412037 Cd Length: 36 Bit Score: 35.28 E-value: 4.58e-03
10 20
....*....|....*....|....*.
gi 1192732161 626 PSDIDPQVFYELPEAVQKELLAEWKR 651
Cdd:cd19318 9 FSQVDPSVLAALPPDLQEELEAAYAQ 34
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
56-358 |
7.62e-141 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 416.10 E-value: 7.62e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 56 VHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVT 135
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEDLTPFRDMSKKVY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 136 ELLEEFSP--VVERLGFDENFVDLTEM---VEKRL-----QQLQ------------SDELSAVTVSG-HVYNNQC----- 187
Cdd:cd01703 81 RLLRSYSWndRVERLGFDENFMDVTEMrllVASHIayemrERIEnelgltccagiaSNKLLAKLVGSvNKPNQQTtllpp 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 188 -------------------IGYKTAKCLEALGINSVRDLQTFSP---------------KILEKELGISVAQRIQKLSFG 233
Cdd:cd01703 161 scadlmdfmdlhdlrkipgIGYKTAAKLEAHGISSVRDLQEFSNrnrqtvgaapsllelLLMVKEFGEGIGQRIWKLLFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 234 EDNSPVI-LSGPPQSFSEEDSFKKCSSEV--EAKNKIEELLASLLNRVCQ--------DGRKPHTVRLIIRRYSSEKH-Y 301
Cdd:cd01703 241 RDTSPVKpASDFPQQISIEDSYKKCSLEEirEARNKIEELLASLLERMKQdlqevkagDGRRPHTLRLTLRRYTSTKKhY 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1192732161 302 GRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMVNVK--MPFHLTLLSVCFCN 358
Cdd:cd01703 321 NRESKQAPIPSHVFQKLTGGNEIAARPIEKILMRLFRELVPPKnvKGFNLTLLNVCFTN 379
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
56-357 |
2.95e-93 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 291.96 E-value: 2.95e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 56 VHVDLDCFYAQVEMISNPELKDKPLGVQQKY----LVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTRYREMS 131
Cdd:cd00424 1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNsdstCVIACSYEARKYGVKRGMPVREARKMCPNLILVP-ARLDLYRRLS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 132 YKVTELLEEFSPVVERLGFDENFVDLTEMVEK---------RLQQLQSDELSAVTVSGHVYNN---------------QC 187
Cdd:cd00424 80 ERLLSELEEVAPLVEVASIDELFLDLTGSARLlglgsevalRIKRHIAEQLGGITASIGIASNkllaklaakyakpdgLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 188 ---------------------IGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQ 246
Cdd:cd00424 160 ildpedlpgflsklpltdlpgIGAVTAKRLEAVGINPIGDLLAASPDALLALWGGVSGERLWYALRGIDDEPLSPPRPRK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 247 SFSEEDSFKKCSSEVE-AKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSSE--KHYGRESRQCPIPSHViqklgtgny 323
Cdd:cd00424 240 SFSHERVLPRDSRNAEdARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDGRwsGHADIPSRSAPRPIST--------- 310
|
330 340 350
....*....|....*....|....*....|....
gi 1192732161 324 dVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFC 357
Cdd:cd00424 311 -EDGELLHALDKLWRALLDDKGPRRLRRLGVRLS 343
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
56-314 |
2.04e-54 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 189.27 E-value: 2.04e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 56 VHVDLDCFYAQVEMISNPELKDKPLGV---QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSY 132
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVggsSDRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPP-RFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 133 KVTELLEEFSPVVERLGFDENFVDLTEMVE---------KRLQQLQSDELSaVTVSGHVYNN---------------QC- 187
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRlfgsateiaKEIRARIREETG-LTASAGIAPNkflakiasdlnkpngLTv 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 188 --------------------IGYKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQS 247
Cdd:cd03586 159 ippedveeflaplpvrkipgVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFG-KSGRRLYELARGIDNRPVEPDRERKS 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1192732161 248 FSEEDSF-KKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSSEKHygreSRQCPIPSHV 314
Cdd:cd03586 238 IGVERTFsEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTR----TRSRTLPEPT 301
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
53-294 |
5.81e-53 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 185.35 E-value: 5.81e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 53 RVIVHVDLDCFYAQVEMISNPELKDKPLGV---QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYRE 129
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVggdNNRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPP-DFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 130 MSYKVTELLEEFSPVVERLGFDENFVDLTEMV------EKRLQQLQSD--ELSAVTVS-G--------------HVYNNQ 186
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSArlfgsaEAIARRIRRRirRETGLTVSvGiapnkflakiasdlAKPDGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 187 C---------------------IGYKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPP 245
Cdd:COG0389 160 TvippgevaaflaplpveklwgVGPKTAEKLARLGIRTIGDLAALPRAELRRRFG-KVGERLYRLARGIDPRPVEPRRPR 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1192732161 246 QSFSEEDSFKKcssEVEAKNKIEELLASLLNRVC----QDGRKPHTVRLIIRR 294
Cdd:COG0389 239 KSIGVERTFGE---DLTDLEELEAALRRLAERLAerlrRQGLGARTVTVKLRT 288
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
52-303 |
5.76e-41 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 154.42 E-value: 5.76e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 52 SRVIVHVDLDCFYAQVEMISNPELKDKPLGV-----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTR 126
Cdd:PRK01810 4 GRVIFHVDMNSFFASVEIAYDPSLQGKPLAVagnekERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRR-PNFDR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 127 YREMSYKVTELLEEFSPVVERLGFDENFVDLT------------EMVEKRLQQ--------------------------- 167
Cdd:PRK01810 83 YREASRQMFQILSEFTPLVQPVSIDEGYLDITdcyalgspleiaKMIQQRLLTelqlpcsigiapnkflakmasdmkkpl 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 168 ----LQSDELSAVTVSGHVYNNQCIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISvAQRIQKLSFGEDNSPVilsg 243
Cdd:PRK01810 163 gitvLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGIN-GVRLQRRANGIDDRPV---- 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1192732161 244 PPQSFSEEDS------FKKCSSEV-EAKNKIEELLASLLNRVCQDGRKPHTVRLIIrRYSSEKHYGR 303
Cdd:PRK01810 238 DPEAIYQFKSvgnsttLSHDMDEEkELLDVLRRLSKSVSKRLQKKTVVSYNVQIMI-RYHDRRTITR 303
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
56-358 |
1.07e-40 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 152.08 E-value: 1.07e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 56 VHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLV------NGED------ 123
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILAhvatykKGEDeadyhe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 124 ----------LTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSG------------- 180
Cdd:cd01702 81 npsparhkvsLDPYRRASRKILNILKRFGDVVEKASIDEAYLDLGSRIVEEIRQQVYDELGYTCSAGiahnkmlaklasg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 181 -HVYNNQCI---------------------GYKTAKCL-EALGINSVRDLQTF--SPKILEKELGISVAQRIQKLSFGED 235
Cdd:cd01702 161 mNKPNAQTIlrndavasflsslpitsirglGGKLGEEIiDLLGLPTEGDVAGFrsSESDLQEHFGEKLGEWLYNLLRGID 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 236 NSPVILSGPPQSFSEEDSF--KKCSSEVEAKNKIEELLASLLNRVCQD----GRKPHTVRLiirRYSSEKHYGRESRQCP 309
Cdd:cd01702 241 HEPVKPRPLPKSMGSSKNFpgKTALSTEDVQHWLLVLASELNSRLEDDryenNRRPKTLVL---SLRQRGDGVRRSRSCA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1192732161 310 IPSHVIQKLgtgnydvMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCN 358
Cdd:cd01702 318 LPRYDAQKI-------VKDAFKLIKAINEEGLGLAWNYPLTLLSLSFTK 359
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
58-179 |
6.82e-38 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 137.71 E-value: 6.82e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 58 VDLDCFYAQVEMISNPELKDKPLGVQQKY---LVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVnGEDLTRYREMSYKV 134
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGGNgrgIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVV-PPDLELYRRASRKI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1192732161 135 TELLEEFSPV-VERLGFDENFVDLTEMVE---------KRLQQLQSDELSaVTVS 179
Cdd:pfam00817 80 FEILRRFSTPkVEQASIDEAFLDLTGLEKlfgaeealaKRLRREIAEETG-LTCS 133
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
61-288 |
3.72e-32 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 127.54 E-value: 3.72e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 61 DCFYAQVEMISNPELKDKPLGV----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSYKVTE 136
Cdd:PRK02406 2 DCFYAAVEMRDNPELRGKPVAVggspGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPG-RFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 137 LLEEFSPVVERLGFDENFVDLTE---------MVEKRLQQLQSDELSaVTVSGHVYNN---------------QC----- 187
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVTDnklcigsatLIAQEIRQDIFEELG-LTASAGVAPNkflakiasdwnkpngLFvitpe 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 188 ----------------IGYKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEE 251
Cdd:PRK02406 160 evdaflatlpvekipgVGKVTAEKLHALGIYTCADLQKYDLAELIRHFG-KFGRRLYERARGIDERPVKPDRERKSVGVE 238
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1192732161 252 DSFKK-CSSEVEAKNKIEEL---LASLLNRVcQDGRKPHTV 288
Cdd:PRK02406 239 RTFAEdLYDLEACLAELPRLaekLERRLERA-KPDKRIKTV 278
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
53-300 |
1.26e-26 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 111.73 E-value: 1.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 53 RVIVHVDLDCFYAQVEMISNPELKDKPL---GVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEdLTRYRE 129
Cdd:PRK14133 3 RVIIHVDMDAFFASVEQMDNPKLKGKPVivgGISERGVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVR-HERYKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 130 MSYKVTELLEEFSPVVERLGFDENFVDLTEMVE----------------------------KRLQQLQSDE--------- 172
Cdd:PRK14133 82 VSKNIFKILYEVTPIVEPVSIDEAYLDITNIKEepikiakyikkkvkketgltlsvgisynKFLAKLASDWnkpdgikii 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 173 --------LSAVTVSgHVYNnqcIGYKTAKCLEALGINSVRDLQTFSPKILEK---ELGISVAQRIQklsfGEDNSPVIL 241
Cdd:PRK14133 162 tedmipdiLKPLPIS-KVHG---IGKKSVEKLNNIGIYTIEDLLKLSREFLIEyfgKFGVEIYERIR----GIDYREVEV 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1192732161 242 SGPPQSFSEEDSFKKcssEVEAKNKIEELLASLLNRVCQDGRKPH----TVRLIIRRYSSEKH 300
Cdd:PRK14133 234 SRERKSIGKETTLKK---DTKDKEELKKYLKDFSNIISEELKKRNlygkTVTVKIKTSDFQTH 293
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
23-294 |
2.16e-26 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 112.02 E-value: 2.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 23 AWAMELADVGAAASSQ-GVHDQVLPTPNASSRVIVHVDLDCFYAQVEMISNPELKDKPLGV-QQKYL---VVTCNYEARK 97
Cdd:cd01701 16 TWKARLKDFFRELSNGsKEADPSNSIHPDLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVcHGKGPnseIASCNYEARS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 98 LGVKKLMNVRDAKEKCPQLVLVnGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKR---LQQLQS---D 171
Cdd:cd01701 96 YGIKNGMWVGQAKKLCPQLVTL-PYDFEAYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETyelPEELAEairN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 172 ELSAVT-------VSGHVY-----------NNQC---------------------IGYKTA-KCLEALG-INSVRDLQTF 210
Cdd:cd01701 175 EIRETTgcsasvgIGPNILlarlatrkakpDGQYhlsaekveeflsqlkvgdlpgVGSSLAeKLVKLFGdTCGGLELRSK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 211 SPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDS----FKKcssEVEAKNKIEELLASLLNRVCQDGRKPH 286
Cdd:cd01701 255 TKEKLQKVLGPKTGEKLYDYCRGIDDRPVTGEKERKSVSAEINygirFTN---VDDVEQFLQRLSEELSKRLEESNVTGR 331
|
....*....
gi 1192732161 287 TVRL-IIRR 294
Cdd:cd01701 332 QITLkLMKR 340
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
55-254 |
1.76e-25 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 109.64 E-value: 1.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 55 IVHVDLDCFYAQVEMISNPELKDKPL--GVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSY 132
Cdd:PRK02794 38 IAHIDCDAFYASVEKRDNPELRDKPViiGGGKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKP-DMEKYVRVGR 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 133 KVTELLEEFSPVVERLGFDENFVDL--TEMVEK--------RLQQLQSDELsAVTVS-GHVYNN---------------- 185
Cdd:PRK02794 117 EVRAMMQALTPLVEPLSIDEAFLDLsgTERLHGappavvlaRFARRVEREI-GITVSvGLSYNKflakiasdldkprgfs 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 186 -------------------QCIGYKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQ 246
Cdd:PRK02794 196 vigraealaflapkpvgiiWGVGPATAARLARDGIRTIGDLQRADEADLMRRFG-SMGLRLWRLARGIDDRKVSPDREAK 274
|
....*...
gi 1192732161 247 SFSEEDSF 254
Cdd:PRK02794 275 SVSAETTF 282
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
53-293 |
9.18e-25 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 105.87 E-value: 9.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 53 RVIVHVDLDCFYAQVEMISNPELKDKPLGV------QQKYLVVTC-NYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLT 125
Cdd:PRK03352 5 RWVLHVDLDQFIAAVELLRRPELAGLPVIVggngdpTEPRKVVTCaSYEARAFGVRAGMPLRTAARRCPDAVFLP-SDPA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 126 RYREMSYKVTELLEEFSPVVERLGFDENFVDLT----EMVEKRLQQLQSDE-------------LSAVTVSGH-----VY 183
Cdd:PRK03352 84 AYDAASEEVMATLRDLGVPVEVWGWDEAFLGVDtddpEALAEEIRAAVLERtglscsvgigdnkLRAKIATGFakpagVF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 184 ----NNQC-------------IGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVIlSGP-- 244
Cdd:PRK03352 164 rltdANWMavmgdrptdalwgVGPKTAKRLAALGITTVADLAAADPAELAATFGPTTGPWLLLLARGGGDTEVS-AEPwv 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1192732161 245 PQSFSEEDSFKK---CSSEVEAknKIEELLASLLNRVCQDGRKPHTVRLIIR 293
Cdd:PRK03352 243 PRSRSREVTFPQdltDRAEVES--AVRELARRVLDEVVAEGRPVTRVAVKVR 292
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
50-295 |
2.83e-23 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 103.48 E-value: 2.83e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 50 ASSRVIVHVDLDCFYAQVEMISNPELKDKPL---GVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTR 126
Cdd:PRK03348 2 RAQRWVLHLDMDAFFASVEQLTRPTLRGRPVlvgGLGGRGVVAGASYEARVFGARSAMPMHQARRLVGNGAVVLPPRFVV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 127 YREMSYKVTELLEEFSPVVERLGFDENFVDLTEM-------VEKRLQQLQS----------------------------- 170
Cdd:PRK03348 82 YRAASRRVFDTLRELSPVVEQLSFDEAFVEPAELagasaeeVEAFAERLRArvreetglpasvgagsgkqiakiasglak 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 171 ----------------DELSAVTVSGhvynnqcIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGE 234
Cdd:PRK03348 162 pdgirvvppgeerellAPLPVRRLWG-------IGPVTEEKLHRLGIETIGDLAALSEAEVANLLGATVGPALHRLARGI 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1192732161 235 DNSPVILSGPPQSFSEEDSFKK-CSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRY 295
Cdd:PRK03348 235 DDRPVAERAEAKQISAESTFAVdLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKS 296
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
58-318 |
4.90e-21 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 94.92 E-value: 4.90e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 58 VDLDCFYAQVEMISNPELKDKPLGVqqkyL------VVTCNYEARKLGVKKLMNVRDAKEKCPQL-VLVNGEDLTRYREM 130
Cdd:cd01700 3 VDCNSFYASCERVFRPLLLGRPLVV----LsnndgcVIARSPEAKALGIKMGSPYFKVPDLLERHgVAVFSSNYALYGDM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 131 SYKVTELLEEFSPVVERLGFDENFVDLTEM--------VEKRLQQLQSDELS-AVTV---------------------SG 180
Cdd:cd01700 79 SRRIMSILERFSPDVEVYSIDESFLDLTGSlrfgdleeLARKIRRRILQETGiPVTVgigptktlaklandlakkknpYG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 181 HV----YNNQC--------------IGYKTAKCLEALGINSVRDLQTFSPKILEKELGIsVAQRIQKLSFGEDNSPVILS 242
Cdd:cd01700 159 GVvdltDEEVRdkllkilpvgdvwgIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGV-VGERLVRELNGIDCLPLEEY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 243 GPP-QSFSEEDSFKKcssEVEAKNKIEELLASLLNRVC----QDGRKPHTVRLIIR--RYSSEKHYGRESRQCPIPSHVI 315
Cdd:cd01700 238 PPPkKSIGSSRSFGR---DVTDLDELKQALAEYAERAAeklrRQKSVARTISVFIGtsGFSRQPKYYSATNTLPYPTNDT 314
|
...
gi 1192732161 316 QKL 318
Cdd:cd01700 315 REI 317
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
53-313 |
2.50e-20 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 93.91 E-value: 2.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 53 RVIVHVDLDCFYAQVEMISNPELKDKPLGV-----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEdLTRY 127
Cdd:PRK03103 3 RVILLVDMQSFYASVEKAANPELKGRPVIVsgdpeRRSGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPR-MQRY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 128 REMSYKVTELLEEFSPVVERLGFDENFVDLT---------EMVEKRLQQ------------------------------- 167
Cdd:PRK03103 82 IDVSLQITRILEDFTDLVEPFSIDEQFLDVTgsqklfgspLEIAQKIQQrimretgvyarvgigpnkllakmacdnfakk 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 168 -------LQSDELSAVTVSGHVYNNQCIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIsVAQRIQKLSFGEDNSPVi 240
Cdd:PRK03103 162 npdglftLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGI-NGEVLWRTANGIDYSPV- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 241 lsgPPQSFSEEDSFKKCSS---EVEAKNKIEELLASLLNRVCQDGRKPH----TVRLIIRrySSEKHYGRE-SRQCPIPS 312
Cdd:PRK03103 240 ---TPHSLDRQKAIGHQMTlprDYRGFEEIKVVLLELCEEVCRRARAKGymgrTVSVSLR--GADFDWPTGfSRQMTLPE 314
|
.
gi 1192732161 313 H 313
Cdd:PRK03103 315 P 315
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
55-156 |
4.21e-20 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 93.13 E-value: 4.21e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 55 IVHVDLDCFYAQVEMISNPELKDKPL----GVqqkylVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEdLTRYREM 130
Cdd:PRK03858 6 ILHADLDSFYASVEQRDDPALRGRPVivggGV-----VLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPR-MSAYSRA 79
|
90 100
....*....|....*....|....*.
gi 1192732161 131 SYKVTELLEEFSPVVERLGFDENFVD 156
Cdd:PRK03858 80 SKAVFEVFRDTTPLVEGLSIDEAFLD 105
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
54-239 |
2.06e-18 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 87.15 E-value: 2.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 54 VIVHVDLDCFYAQVEMISNPELKDKPLGV-------QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTr 126
Cdd:PRK01216 2 IILFVDFDYFFAQVEEVLNPSLKGKPVVVcvysgrfEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEV- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 127 YREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVE----------KRLQQLQSDELSAVTVS----------------- 179
Cdd:PRK01216 81 YQQVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKnyqdaynlglEIKNKILEKEKITVTVGisknkvfakiaadmakp 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1192732161 180 ---GHVYNNQC--------------IGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPV 239
Cdd:PRK01216 161 ngiKVIDDEEVkrfineldiadipgIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIGEAKAKYLFSLARNEYNEPV 237
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
56-163 |
1.22e-11 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 67.74 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 56 VHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTRYREMSYKVT 135
Cdd:PTZ00205 136 IHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILP-PDFDAYNEESNTVR 214
|
90 100
....*....|....*....|....*...
gi 1192732161 136 ELLEEFSPVVERLGFDENFVDLTEMVEK 163
Cdd:PTZ00205 215 RIVAEYDPNYISFGLDELTLEVSAYIER 242
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
57-158 |
1.20e-09 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 60.93 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 57 HVDLDCFYAQVEMISNPELKDKPLGV--QQKYLVVTCNYEARKLGVK---KLMNVRDAKEKCPQLVLVNGEDLtrYREMS 131
Cdd:PRK03609 4 LCDVNSFYASCETVFRPDLRGKPVVVlsNNDGCVIARSAEAKALGIKmgdPWFKQKDLFRRCGVVCFSSNYEL--YADMS 81
|
90 100
....*....|....*....|....*..
gi 1192732161 132 YKVTELLEEFSPVVERLGFDENFVDLT 158
Cdd:PRK03609 82 NRVMSTLEELSPRVEIYSIDEAFCDLT 108
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
245-359 |
9.92e-07 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 47.55 E-value: 9.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732161 245 PQSFSEEDSF-KKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYssekHYGRESRQCPIPSHviqklgTGNY 323
Cdd:pfam11799 1 RKSIGAERTFgRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYS----DFRTITRSVTLPSP------TDDT 70
|
90 100 110
....*....|....*....|....*....|....*.
gi 1192732161 324 DVMTpmvDILMKLFRNMVNvkmPFHLTLLSVCFCNL 359
Cdd:pfam11799 71 DEIY---RAALRLLRRLYR---GRPVRLLGVSLSNL 100
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
73-158 |
4.97e-05 |
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DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 45.84 E-value: 4.97e-05
10 20 30 40 50 60 70 80
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gi 1192732161 73 PELKDKPLGV--QQKYLVVT-CNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTRYREMSYKVTELLEEFSPVVERLG 149
Cdd:cd03468 18 PADDEAPLAVveRKKAGRILaCNAAARAAGVRPGMPLAEALALCPNLQVVE-YDPEADARALQELALWLLRFTPLVALDG 96
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....*....
gi 1192732161 150 FDENFVDLT 158
Cdd:cd03468 97 PDGLLLDVT 105
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| Rev1_UBM2 |
cd19318 |
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
626-651 |
4.58e-03 |
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Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.
Pssm-ID: 412037 Cd Length: 36 Bit Score: 35.28 E-value: 4.58e-03
10 20
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gi 1192732161 626 PSDIDPQVFYELPEAVQKELLAEWKR 651
Cdd:cd19318 9 FSQVDPSVLAALPPDLQEELEAAYAQ 34
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