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Conserved domains on  [gi|1237937843|ref|NP_001341381|]
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phospholipid phosphatase 5 isoform 4 [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to mammalian phospholipid phosphatases that catalyzes the conversion of phosphatidic acid to diacylglycerol

EC:  3.1.3.-
Gene Ontology:  GO:0006644|GO:0008195|GO:0046839
PubMed:  12447906

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 43-213 1.01e-73

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 222.48  E-value: 1.01e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  43 WLYRNPYVEAEYFPTKPMF------------------KADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 104
Cdd:cd03390     1 PSISYPFAESETVPTWLLViisvgipllviilislffRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843 105 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAA 178
Cdd:cd03390    81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAI 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1237937843 179 VIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQY 213
Cdd:cd03390   159 LVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 43-213 1.01e-73

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 222.48  E-value: 1.01e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  43 WLYRNPYVEAEYFPTKPMF------------------KADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 104
Cdd:cd03390     1 PSISYPFAESETVPTWLLViisvgipllviilislffRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843 105 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAA 178
Cdd:cd03390    81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAI 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1237937843 179 VIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQY 213
Cdd:cd03390   159 LVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PLN02250 PLN02250
lipid phosphate phosphatase
 83-225 2.04e-55

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 180.12  E-value: 2.04e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  83 GVFTNTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFt 157
Cdd:PLN02250  111 GVITDAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVF- 189

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1237937843 158 pQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDAECHKP 225
Cdd:PLN02250  190 -DRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCYLQFFPPPYDIDGWGP 256
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 83-214 6.50e-25

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 95.18  E-value: 6.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  83 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSSFAFAGLAFASFYLAGklhcftpqgRG 162
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSATAFALALLLALLLRR---------LR 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1237937843 163 KSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYY 214
Cdd:pfam01569  72 KIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
85-210 3.35e-24

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 93.18  E-value: 3.35e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843   85 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpQGRGKS 164
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGR 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1237937843  165 WRFCAFLspLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCY 210
Cdd:smart00014  73 KLLIFLL--LLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 89-213 1.29e-11

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 61.59  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  89 IKLIVGRPRPdFFYRCFPDGLAHSDlmctgdkdvvnegRKSFPSGHSSFAFAGLAFASFYLagklhcftpqgrgksWRFC 168
Cdd:COG0671    92 LKYLFGRPRP-FVVPDLELLLGTAG-------------GYSFPSGHAAAAFALALVLALLL---------------PRRW 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1237937843 169 AFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQY 213
Cdd:COG0671   143 LAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 43-213 1.01e-73

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 222.48  E-value: 1.01e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  43 WLYRNPYVEAEYFPTKPMF------------------KADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRC 104
Cdd:cd03390     1 PSISYPFAESETVPTWLLViisvgipllviilislffRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843 105 FPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPqgRGKSWRFCAFLSPLLFAA 178
Cdd:cd03390    81 FPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDP--RGSSWRLLLALLPLLLAI 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1237937843 179 VIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQY 213
Cdd:cd03390   159 LVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PLN02250 PLN02250
lipid phosphate phosphatase
 83-225 2.04e-55

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 180.12  E-value: 2.04e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  83 GVFTNTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFt 157
Cdd:PLN02250  111 GVITDAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVF- 189

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1237937843 158 pQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDAECHKP 225
Cdd:PLN02250  190 -DRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCYLQFFPPPYDIDGWGP 256
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 83-241 2.15e-47

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 159.81  E-value: 2.15e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  83 GVFTNTIKLIVGRPRPDFFYRCFPDGLAH----SDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFtp 158
Cdd:PLN02731  130 AVLTDAIKNAVGRPRPDFFWRCFPDGKALydslGDVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSGKIQAF-- 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843 159 QGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDAECHKPFQDKLVLSTAQKP 238
Cdd:PLN02731  208 DGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAISTICYLQFFPPPYHTEGWGPYAYFQVLEAARVQ 287


                  ...
gi 1237937843 239 GDS 241
Cdd:PLN02731  288 GAA 290
PLN02715 PLN02715
lipid phosphate phosphatase
 83-241 3.61e-42

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 145.97  E-value: 3.61e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  83 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSD----LMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTP 158
Cdd:PLN02715  136 GVITDSIKVATGRPRPNFYWRCFPDGKELYDalggVICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNG 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843 159 QGRGKswRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDAECHKPF------QDKLVL 232
Cdd:PLN02715  216 EGHVA--KLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCYRQFYPNPYHEEGWGPYayfkaaQERGVP 293


                  ....*....
gi 1237937843 233 STAQKPGDS 241
Cdd:PLN02715  294 VASSQNGDA 302
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 84-208 4.29e-31

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 112.34  E-value: 4.29e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  84 VFTNTIKLIVGRPRPDFFYRCFPDG----------LAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKL 153
Cdd:cd03384    18 LLTDLGKYVTGRLRPHFLDVCKPNYtdltcsldhqYIADCTCCTGDPDLIREARLSFPSGHASLSMYAAVFLALYLQARL 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1237937843 154 hcftpqgrgkSWRFCAFLSPLL------FAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYV 208
Cdd:cd03384    98 ----------KLRGSRLLRPLLqflllaLALYVGLSRISDYKHHWSDVLAGALLGSVIALF 148
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 82-210 2.33e-27

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 101.77  E-value: 2.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  82 NGVFTNTIKLIVGRPRPDFFYRCFPDGlahsdlmctgDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLhcftpqgr 161
Cdd:cd01610    15 GLLLTGVLKYLFGRPRPYFLLRCGPDG----------DPLLLTEGGYSFPSGHAAFAFALALFLALLLPRRL-------- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1237937843 162 gksWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCY 210
Cdd:cd01610    77 ---LRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 83-214 6.50e-25

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 95.18  E-value: 6.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  83 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSSFAFAGLAFASFYLAGklhcftpqgRG 162
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSATAFALALLLALLLRR---------LR 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1237937843 163 KSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYY 214
Cdd:pfam01569  72 KIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
85-210 3.35e-24

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 93.18  E-value: 3.35e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843   85 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpQGRGKS 164
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGR 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1237937843  165 WRFCAFLspLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCY 210
Cdd:smart00014  73 KLLIFLL--LLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 83-213 2.49e-12

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 63.49  E-value: 2.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  83 GVFTNTIKLIVGRPRPDFFyrcFPDGLAHSDLMCTGDkdvvneGRKSFPSGHSSFAFAgLAFASFYLAGKlhcftpqgrg 162
Cdd:cd03389    82 GILVNLLKFIIGRARPKLL---FDDGLYGFDPFHADY------AFTSFPSGHSATAGA-AAAALALLFPR---------- 141

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1237937843 163 ksWRFCAflspLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQY 213
Cdd:cd03389   142 --YRWAF----ILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQRF 186
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 86-207 7.36e-12

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 60.42  E-value: 7.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  86 TNTIKLIVGRPRPDffyrcfpdglahsdlmctGDkdvvNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpqgrGKSW 165
Cdd:cd03394    19 TEGLKFAVGRARPD------------------GS----NNGYRSFPSGHTASAFAAATFLQYRY------------GWRW 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1237937843 166 rfcAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAY 207
Cdd:cd03394    65 ---YGIPAYALASLVGASRVVANRHWLSDVLAGAAIGILVGY 103
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 89-213 1.29e-11

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 61.59  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  89 IKLIVGRPRPdFFYRCFPDGLAHSDlmctgdkdvvnegRKSFPSGHSSFAFAGLAFASFYLagklhcftpqgrgksWRFC 168
Cdd:COG0671    92 LKYLFGRPRP-FVVPDLELLLGTAG-------------GYSFPSGHAAAAFALALVLALLL---------------PRRW 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1237937843 169 AFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQY 213
Cdd:COG0671   143 LAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 83-213 2.87e-11

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 60.32  E-value: 2.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  83 GVFTNTIKLIVGRPRPDFFYRCFPDGLahsdlmctgdkdvvnegrkSFPSGHSSFAFAGLAFASFYLAGKLHcftpqgrG 162
Cdd:cd03392    75 GALNTLLKLLVQRPRPPLHLLVPEGGY-------------------SFPSGHAMGATVLYGFLAYLLARRLP-------R 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1237937843 163 KSWRFCAFLSPLLFAAVIALSRTcdYKH-HW-QDVLVGSMIGMTFAYVCYRQY 213
Cdd:cd03392   129 RRVRILLLILAAILILLVGLSRL--YLGvHYpSDVLAGWLLGLAWLALLILLY 179
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 82-211 6.04e-08

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 51.11  E-value: 6.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  82 NGVFTNTIKLIVGRPRPdffyrCFPDGLAHsdlmctgDKDVVNEGRK-SFPSGHSSFAFAGLAFASFYlagklhcftpqg 160
Cdd:cd03395    69 DQLASGFLKPLVARLRP-----CNALDGVR-------LVVLGDQGGSySFASSHAANSFALALFIWLF------------ 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1237937843 161 rgksWRFCAFLSPLLF-AAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYR 211
Cdd:cd03395   125 ----FRRGLFSPVLLLwALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYL 172
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 89-202 9.50e-07

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 47.31  E-value: 9.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  89 IKLIVGRPRPdffyrcfpdglAHsdlMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHcftpqgrgkswrfc 168
Cdd:cd03391    66 LKALVRRRRP-----------AY---NSPDMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLAVP-------------- 117

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1237937843 169 aFLSPL-LFAAVIALSRTCDYKHHWQDVLVGSMIG 202
Cdd:cd03391   118 -LRVLLvLWATVVGISRVLLGRHHVLDVLAGAFLG 151
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 82-210 8.92e-06

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 44.57  E-value: 8.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  82 NGVFTNTIKLIVGRPRPDFfyrcfpdglaHSDLMCTGdkdvvnegrKSFPSGHSSFAFaglaFASFYLAGKLHCFTPQGR 161
Cdd:cd03382    54 NEALNYVLKRIIKEPRPCS----------GAYFVRSG---------YGMPSSHSQFMG----FFAVYLLLFIYLRLGRLN 110

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1237937843 162 GKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCY 210
Cdd:cd03382   111 SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGILWF 159
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 84-211 2.77e-03

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 37.66  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937843  84 VFTNTIKLIVGRPRPdFFYRCFPDGLAHSDLMCTGDKDvvNEGRKSFPSGHSSFAFAGLAFASFYLAgklhcftpqgRGK 163
Cdd:cd03396    81 LVVAILKSHWGRPRP-WDLTEFGGDAPYTPLFSGPSNG--CGKGCSFPSGHASAGFALLALYFLFRR----------RRP 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1237937843 164 SWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYR 211
Cdd:cd03396   148 RLARLVLAAGLALGALMGLARMARGAHFLSDVLWSLLLVWLIALLLYR 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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